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The map label for this gene is ispB [H]

Identifier: 162147610

GI number: 162147610

Start: 1859081

End: 1860157

Strand: Direct

Name: ispB [H]

Synonym: GDI_1826

Alternate gene names: 162147610

Gene position: 1859081-1860157 (Clockwise)

Preceding gene: 162147608

Following gene: 162147613

Centisome position: 47.13

GC content: 67.78

Gene sequence:

>1077_bases
TTGGGCGTTGCAGTCACTCTGCCGGAATCCGAGAGAACGGCAAGCGCGAAGAACGCGGAATCCAGCGATCCGGTGACGGA
GAGCGCGGAAACGGCGCTGCGGGACCTCTCGGACTATCTTGGCGACGACATGGCGGCGTGCAACCGCGCGATCGTCGAAC
GGATGGACAGTCCGGTCGCCCTGATTCCGCAACTGGCCGCCCACCTGGTGGCGGCCGGGGGGAAGCGGCTGCGGCCCTTG
CTGACCCTGGCGGCGGCGCGGCTGTGCGACTATCCGGCCGGACCGGAGCACCAGCGCCATGTCTCGCTGGCCGCGTGCGT
GGAATTCATCCACACGGCCACGCTGCTGCATGACGACGTGGTGGATGAAAGCCTGCTTCGGCGCGGCCTGGCCAGCGCGA
ACGCCGTGTTCGGCAACAAGGCGTCGGTGCTGGTGGGCGATTTCCTGTTCGCCCGGTCGTTCCAGTTGATGACCGATGAC
GGGTCGCTGAAGGTGATGGCCATCCTGTCCTCGGCCTCGGCGACGATCGCCGAGGGCGAAGTCCTGCAGATGTCCACGCA
GAACGATCTCTCGACCTCGGTCGAACAGTATCTGGAGGTCATCCACGGCAAGACGGCGGCCCTGTTCGCCGCGGCATGCC
GCGTCGGCGCCGTCGTCGCCGAACGGCCGGAAGCCGAGGAACTGGCCCTGGAATCCTTCGGCACCAATCTGGGCATGGCG
TTCCAGCTTGTGGACGACGCGCTGGATTATGCCGCCGACCAGGCAGTGCTGGGCAAGACGGTGGGCGACGATTTCCGCGA
GGGCAAGATCACCCTGCCGGTCCTGGCCGCCTATGCCGCCGGAGACGAGGAGGAGCGCGTCTTCTGGCGCCGGGTCATCG
AGCAGAGCGAGCAGGCGCCGGAAGACCTGGACCGTGCCCTGGCCCTGATCGCCAAGACCGATGCGATCGGGGTGACGCTG
GACCGGGCCGCGCTCTACGCCCAGGCGGCCCGCGACGCGCTGGAAATCTTCCCCGACAGCCGCCTGCGCCGCCTGTTGCA
GGATACGGCGGCCTACACGGTCAGTCGCGGCCGATAA

Upstream 100 bases:

>100_bases
CGGCATCGCCTCATGCATCGTGTCCTTCGGCTTGACCGTCATTCCCGCGCCGCTCATATGTTCTGAAGACCAACCCTACG
GAGCCGGGGAGCTTAACCTT

Downstream 100 bases:

>100_bases
AAACGACCGGGTTTCCAAAGGGCTCGGCCCTTTGGTGGGTCAAGGGCAAAGCCCTTGCGCGACATTTTCGAACAAGACCG
GCGCCCCATAGCCCAGCGGA

Product: octaprenyl-diphosphate synthase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MGVAVTLPESERTASAKNAESSDPVTESAETALRDLSDYLGDDMAACNRAIVERMDSPVALIPQLAAHLVAAGGKRLRPL
LTLAAARLCDYPAGPEHQRHVSLAACVEFIHTATLLHDDVVDESLLRRGLASANAVFGNKASVLVGDFLFARSFQLMTDD
GSLKVMAILSSASATIAEGEVLQMSTQNDLSTSVEQYLEVIHGKTAALFAAACRVGAVVAERPEAEELALESFGTNLGMA
FQLVDDALDYAADQAVLGKTVGDDFREGKITLPVLAAYAAGDEEERVFWRRVIEQSEQAPEDLDRALALIAKTDAIGVTL
DRAALYAQAARDALEIFPDSRLRRLLQDTAAYTVSRGR

Sequences:

>Translated_358_residues
MGVAVTLPESERTASAKNAESSDPVTESAETALRDLSDYLGDDMAACNRAIVERMDSPVALIPQLAAHLVAAGGKRLRPL
LTLAAARLCDYPAGPEHQRHVSLAACVEFIHTATLLHDDVVDESLLRRGLASANAVFGNKASVLVGDFLFARSFQLMTDD
GSLKVMAILSSASATIAEGEVLQMSTQNDLSTSVEQYLEVIHGKTAALFAAACRVGAVVAERPEAEELALESFGTNLGMA
FQLVDDALDYAADQAVLGKTVGDDFREGKITLPVLAAYAAGDEEERVFWRRVIEQSEQAPEDLDRALALIAKTDAIGVTL
DRAALYAQAARDALEIFPDSRLRRLLQDTAAYTVSRGR
>Mature_357_residues
GVAVTLPESERTASAKNAESSDPVTESAETALRDLSDYLGDDMAACNRAIVERMDSPVALIPQLAAHLVAAGGKRLRPLL
TLAAARLCDYPAGPEHQRHVSLAACVEFIHTATLLHDDVVDESLLRRGLASANAVFGNKASVLVGDFLFARSFQLMTDDG
SLKVMAILSSASATIAEGEVLQMSTQNDLSTSVEQYLEVIHGKTAALFAAACRVGAVVAERPEAEELALESFGTNLGMAF
QLVDDALDYAADQAVLGKTVGDDFREGKITLPVLAAYAAGDEEERVFWRRVIEQSEQAPEDLDRALALIAKTDAIGVTLD
RAALYAQAARDALEIFPDSRLRRLLQDTAAYTVSRGR

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=293, Percent_Identity=30.7167235494881, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1789578, Length=326, Percent_Identity=47.239263803681, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1786623, Length=262, Percent_Identity=33.587786259542, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505681, Length=303, Percent_Identity=33.993399339934, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319475, Length=228, Percent_Identity=34.6491228070175, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6325188, Length=227, Percent_Identity=25.1101321585903, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24651612, Length=297, Percent_Identity=30.6397306397306, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 38320; Mature: 38188

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVAVTLPESERTASAKNAESSDPVTESAETALRDLSDYLGDDMAACNRAIVERMDSPVA
CCEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
LIPQLAAHLVAAGGKRLRPLLTLAAARLCDYPAGPEHQRHVSLAACVEFIHTATLLHDDV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDESLLRRGLASANAVFGNKASVLVGDFLFARSFQLMTDDGSLKVMAILSSASATIAEGE
HHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCHHCCCC
VLQMSTQNDLSTSVEQYLEVIHGKTAALFAAACRVGAVVAERPEAEELALESFGTNLGMA
EEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
FQLVDDALDYAADQAVLGKTVGDDFREGKITLPVLAAYAAGDEEERVFWRRVIEQSEQAP
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHCCH
EDLDRALALIAKTDAIGVTLDRAALYAQAARDALEIFPDSRLRRLLQDTAAYTVSRGR
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GVAVTLPESERTASAKNAESSDPVTESAETALRDLSDYLGDDMAACNRAIVERMDSPVA
CEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
LIPQLAAHLVAAGGKRLRPLLTLAAARLCDYPAGPEHQRHVSLAACVEFIHTATLLHDDV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDESLLRRGLASANAVFGNKASVLVGDFLFARSFQLMTDDGSLKVMAILSSASATIAEGE
HHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCHHCCCC
VLQMSTQNDLSTSVEQYLEVIHGKTAALFAAACRVGAVVAERPEAEELALESFGTNLGMA
EEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
FQLVDDALDYAADQAVLGKTVGDDFREGKITLPVLAAYAAGDEEERVFWRRVIEQSEQAP
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHCCH
EDLDRALALIAKTDAIGVTLDRAALYAQAARDALEIFPDSRLRRLLQDTAAYTVSRGR
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8312607; 9278503; 2670911; 8037730 [H]