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The map label for this gene is thiL [H]

Identifier: 162147541

GI number: 162147541

Start: 1780637

End: 1781611

Strand: Direct

Name: thiL [H]

Synonym: GDI_1757

Alternate gene names: 162147541

Gene position: 1780637-1781611 (Clockwise)

Preceding gene: 162147540

Following gene: 162147543

Centisome position: 45.15

GC content: 73.85

Gene sequence:

>975_bases
ATGTCCGCCGCTCTTCCCCCCGCCGGTCCGCTGCCGCCCGAATTCGGCTTCATCCGCCGCCATTTCCTTGCCCTGGCGGG
CGAGGGCGCGCTGGGCCTGACCGACGACGCGGCGCTGCTGCGCGCGCCGGCGGGGCGGGAACTGGTCGTCGCGGTCGATA
CGATGGTCGAGGGCGTACATTTCCTGCCCGACGACCCGGCCGACACGGTCGGCCGCAAGCTGCTGCGCTGCAACCTGTCC
GACCTGGCGGCGATGGACGCGATGCCGCTGGGCTATCTGCTGGCGGTGACCACGCCGCCGGCACGGGACGAGGCCTGGTT
CGCCGGTTTCGCCCGGGGCCTGGCGGACGATCAGGGGCGTTATGGGCTCAGCCTGCTGGGGGGCGATACCACTTCCACGC
CGGGGCCATTGGTGCTGTCGCTGACCATCCTGGGGCATGGGGCACCCGGCCGGGCCCTGCGGCGCAACGGCGCGCGCGAC
GGCGACGGGATATGGGTGACCGGGACGATCGGCGACGGGGCGCTGGGCCTGCGCGCCCTGCGCGGGGAAGTGGCCGATCC
CGACGGGTTCCTGGCCGGCCGCTATCGGCTGCCGCGGCCGCGCCTGGGGCTGGGGTTGGGCGGAATCGCGTCGGCCGCCA
TGGATGTCTCGGACGGGCTGGTGCAGGATCTGGGCCACTTGGCCCGTGAAAGCGGCGTCGGCGCCCGGATCGACGCCGGC
CGCGTTCCCCTGTCGCCGGCCGCCAGGCAGGCGGGCCCCCGCTGGCTGCCGACCTGCCTGACCGGCGGGGATGATTACGA
ATTGCTGCTGGCCGTGCCCCCGGCGCACGAGGGCGCCCTGCGGGAAGCCGCCCGGACGCATGGGGTGGCGGTCACGCGGA
TCGGCGCGTTCGACGCCACGCTATCCGGCGTCCAGGTACTGGACGGGGTAGGGGGAATCCTGGCGCTGGAGCGCACCGGA
TGGAGTCACCTGTAG

Upstream 100 bases:

>100_bases
GATACGCTGGCCCGGCGCCTGCGCGCGGCCGACACCCCGGCGGATGTCCTGCCCGAAGACCCGCACGAGGCCGAAGAGGC
CTGATCCGGCGGATCGTGGA

Downstream 100 bases:

>100_bases
AAGACGATCAGCGGCCCAGCACCCGGTCATAGACCCGGTAGCGCTTGCAGGGTTCGGGGGCCAGGCGTTCGATCAGCCGG
CGCATCGGCAGGTTGGTCTC

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSAALPPAGPLPPEFGFIRRHFLALAGEGALGLTDDAALLRAPAGRELVVAVDTMVEGVHFLPDDPADTVGRKLLRCNLS
DLAAMDAMPLGYLLAVTTPPARDEAWFAGFARGLADDQGRYGLSLLGGDTTSTPGPLVLSLTILGHGAPGRALRRNGARD
GDGIWVTGTIGDGALGLRALRGEVADPDGFLAGRYRLPRPRLGLGLGGIASAAMDVSDGLVQDLGHLARESGVGARIDAG
RVPLSPAARQAGPRWLPTCLTGGDDYELLLAVPPAHEGALREAARTHGVAVTRIGAFDATLSGVQVLDGVGGILALERTG
WSHL

Sequences:

>Translated_324_residues
MSAALPPAGPLPPEFGFIRRHFLALAGEGALGLTDDAALLRAPAGRELVVAVDTMVEGVHFLPDDPADTVGRKLLRCNLS
DLAAMDAMPLGYLLAVTTPPARDEAWFAGFARGLADDQGRYGLSLLGGDTTSTPGPLVLSLTILGHGAPGRALRRNGARD
GDGIWVTGTIGDGALGLRALRGEVADPDGFLAGRYRLPRPRLGLGLGGIASAAMDVSDGLVQDLGHLARESGVGARIDAG
RVPLSPAARQAGPRWLPTCLTGGDDYELLLAVPPAHEGALREAARTHGVAVTRIGAFDATLSGVQVLDGVGGILALERTG
WSHL
>Mature_323_residues
SAALPPAGPLPPEFGFIRRHFLALAGEGALGLTDDAALLRAPAGRELVVAVDTMVEGVHFLPDDPADTVGRKLLRCNLSD
LAAMDAMPLGYLLAVTTPPARDEAWFAGFARGLADDQGRYGLSLLGGDTTSTPGPLVLSLTILGHGAPGRALRRNGARDG
DGIWVTGTIGDGALGLRALRGEVADPDGFLAGRYRLPRPRLGLGLGGIASAAMDVSDGLVQDLGHLARESGVGARIDAGR
VPLSPAARQAGPRWLPTCLTGGDDYELLLAVPPAHEGALREAARTHGVAVTRIGAFDATLSGVQVLDGVGGILALERTGW
SHL

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=326, Percent_Identity=43.2515337423313, Blast_Score=196, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33364; Mature: 33232

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAALPPAGPLPPEFGFIRRHFLALAGEGALGLTDDAALLRAPAGRELVVAVDTMVEGVH
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEEEEEHHHCCCC
FLPDDPADTVGRKLLRCNLSDLAAMDAMPLGYLLAVTTPPARDEAWFAGFARGLADDQGR
CCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCC
YGLSLLGGDTTSTPGPLVLSLTILGHGAPGRALRRNGARDGDGIWVTGTIGDGALGLRAL
CEEEEECCCCCCCCCCEEEEEEEEECCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHH
RGEVADPDGFLAGRYRLPRPRLGLGLGGIASAAMDVSDGLVQDLGHLARESGVGARIDAG
HCCCCCCCCEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
RVPLSPAARQAGPRWLPTCLTGGDDYELLLAVPPAHEGALREAARTHGVAVTRIGAFDAT
CCCCCHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEECCHHHH
LSGVQVLDGVGGILALERTGWSHL
HHHHHHHHCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SAALPPAGPLPPEFGFIRRHFLALAGEGALGLTDDAALLRAPAGRELVVAVDTMVEGVH
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCEEEEEEEHHHCCCC
FLPDDPADTVGRKLLRCNLSDLAAMDAMPLGYLLAVTTPPARDEAWFAGFARGLADDQGR
CCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCC
YGLSLLGGDTTSTPGPLVLSLTILGHGAPGRALRRNGARDGDGIWVTGTIGDGALGLRAL
CEEEEECCCCCCCCCCEEEEEEEEECCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHH
RGEVADPDGFLAGRYRLPRPRLGLGLGGIASAAMDVSDGLVQDLGHLARESGVGARIDAG
HCCCCCCCCEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
RVPLSPAARQAGPRWLPTCLTGGDDYELLLAVPPAHEGALREAARTHGVAVTRIGAFDAT
CCCCCHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCEEEEEECCHHHH
LSGVQVLDGVGGILALERTGWSHL
HHHHHHHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]