Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 162147224

GI number: 162147224

Start: 1432675

End: 1434021

Strand: Reverse

Name: ahcY [H]

Synonym: GDI_1429

Alternate gene names: 162147224

Gene position: 1434021-1432675 (Counterclockwise)

Preceding gene: 162147225

Following gene: 162147223

Centisome position: 36.36

GC content: 64.66

Gene sequence:

>1347_bases
GTGACCGCCTATACCTGCCGGGATTTTTCTCTACGGACAGGACGGAACATGACCGCCAGCACGGATTACAAGGTACGGGA
CATCTCGCTCGCCGAATGGGGCCGCAAGGAGATTTCGATCGCCGAGGGTGAAATGCCCGGCCTGATGGCACTGCGCGAGG
AATTCGGTGCCAGCCAGCCGCTGAAGGGCGCGCGCATCGCCGGCTGCCTGCACATGACGATCCAGACCGCCGTGCTGATC
GAGACCCTGACCGCGCTGGGCGCCACCGTGCGCTGGTCGTCGTGCAACATCTTTTCGACCCAGGACCACGCCGCCGCCGC
CATCGCCGCGACGGGCGTGCCGGTCTTCGCCTGGAAGGGCCTGTCCGAGGACGAATTCTGGTGGTGCATCGAGGCGACGG
TGAAGGGTCCGGACGGCTGGACGCCGAACATGATCCTGGACGATGGCGGCGACCTGACCGTGCTGATGCACGACAAGTAC
CCCGACATGCTGAAGGACGTGCGCGGCCTGTCCGAGGAGACGACCACCGGCGTGCATCGCCTGTGGGAAATGGCGAAGAA
GGGCACGCTGGCCGTGCCCGCGATCAACGTCAACGACAGCGTCACCAAGTCGAAATTCGACAATCTGTACGGCTGCCGCG
AGAGCCTGGTGGACGCGATCCGTCGCGGCACCGACGTGATGATGGCCGGCAAGATCGCCGTCGTCGCCGGCTATGGCGAC
GTGGGCAAGGGATCGGCCGCGTCGCTGCGCAATGCCGGCTGCCGCGTTCTGGTAACCGAGGCCGACCCGATCTGCGCCCT
GCAGGCGGCGATGGAAGGCTACGAGGTCGTGACGATGGAAGGCGCCGCCCCGCGCGGTGACATCTTCGTCACCTGCACCG
GCAATGTCGACATCATCACCATCGACCATATGCGCGAGATGAAGCACCGCGCCATCGTCTGCAATATCGGGCATTTCGAT
TCCGAGATCCAGATCGACGCGCTGCGCAACTTCCCCTGGGACAACATCAAGCCGCAGGTGGACGAGGTCGTCTTCCCCGA
CGGCAAGCGCCTGATCGTCCTGTCCGAGGGCCGTCTGGTCAATCTGGGCAACGCGACGGGTCACCCGTCCTTCGTGATGT
CGGCGTCCTTCACCAACCAGACGCTGGCGCAGATCGAACTGTGGACCGCGCCGGCCGGCAAGTACGAGCGCAAGGTCTAC
ACCCTGCCCAAGCACCTGGACGAAAAGGTCGCGGCCCTGCACCTGGCGAAGGTCGGCGCCGAATTGACGCGGATGACGGC
GAAACAGGCCGACTATATCGGCGTTCCGGTCAACGGGCCGTTCAAGAACGACCTGTACCGGTACTGA

Upstream 100 bases:

>100_bases
CAGATCGCCGCGATCTGGGGCGGCAATTTCCTGCGCGTGCTGCGGGCGGCCGAGGACGTCGCCGCATCCTGACGGGACGC
CGGCTCTAGCCCCGGGGAAC

Downstream 100 bases:

>100_bases
CGGTCCGGCGCACCGGATGCGCCGCATTGCATGCGGTCGCATCCGGTCCCCGGGACCAACGACCAGGGGAGTTTCAGACC
ATGAGCATCTTCGGAACCAT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTAYTCRDFSLRTGRNMTASTDYKVRDISLAEWGRKEISIAEGEMPGLMALREEFGASQPLKGARIAGCLHMTIQTAVLI
ETLTALGATVRWSSCNIFSTQDHAAAAIAATGVPVFAWKGLSEDEFWWCIEATVKGPDGWTPNMILDDGGDLTVLMHDKY
PDMLKDVRGLSEETTTGVHRLWEMAKKGTLAVPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTDVMMAGKIAVVAGYGD
VGKGSAASLRNAGCRVLVTEADPICALQAAMEGYEVVTMEGAAPRGDIFVTCTGNVDIITIDHMREMKHRAIVCNIGHFD
SEIQIDALRNFPWDNIKPQVDEVVFPDGKRLIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTAPAGKYERKVY
TLPKHLDEKVAALHLAKVGAELTRMTAKQADYIGVPVNGPFKNDLYRY

Sequences:

>Translated_448_residues
MTAYTCRDFSLRTGRNMTASTDYKVRDISLAEWGRKEISIAEGEMPGLMALREEFGASQPLKGARIAGCLHMTIQTAVLI
ETLTALGATVRWSSCNIFSTQDHAAAAIAATGVPVFAWKGLSEDEFWWCIEATVKGPDGWTPNMILDDGGDLTVLMHDKY
PDMLKDVRGLSEETTTGVHRLWEMAKKGTLAVPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTDVMMAGKIAVVAGYGD
VGKGSAASLRNAGCRVLVTEADPICALQAAMEGYEVVTMEGAAPRGDIFVTCTGNVDIITIDHMREMKHRAIVCNIGHFD
SEIQIDALRNFPWDNIKPQVDEVVFPDGKRLIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTAPAGKYERKVY
TLPKHLDEKVAALHLAKVGAELTRMTAKQADYIGVPVNGPFKNDLYRY
>Mature_447_residues
TAYTCRDFSLRTGRNMTASTDYKVRDISLAEWGRKEISIAEGEMPGLMALREEFGASQPLKGARIAGCLHMTIQTAVLIE
TLTALGATVRWSSCNIFSTQDHAAAAIAATGVPVFAWKGLSEDEFWWCIEATVKGPDGWTPNMILDDGGDLTVLMHDKYP
DMLKDVRGLSEETTTGVHRLWEMAKKGTLAVPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTDVMMAGKIAVVAGYGDV
GKGSAASLRNAGCRVLVTEADPICALQAAMEGYEVVTMEGAAPRGDIFVTCTGNVDIITIDHMREMKHRAIVCNIGHFDS
EIQIDALRNFPWDNIKPQVDEVVFPDGKRLIVLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTAPAGKYERKVYT
LPKHLDEKVAALHLAKVGAELTRMTAKQADYIGVPVNGPFKNDLYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=434, Percent_Identity=65.668202764977, Blast_Score=563, Evalue=1e-161,
Organism=Homo sapiens, GI239937451, Length=406, Percent_Identity=66.256157635468, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI298286489, Length=439, Percent_Identity=54.4419134396355, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI24308043, Length=439, Percent_Identity=54.4419134396355, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI195539337, Length=439, Percent_Identity=54.4419134396355, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI195539349, Length=439, Percent_Identity=54.4419134396355, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI21361647, Length=435, Percent_Identity=54.4827586206897, Blast_Score=490, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17506425, Length=430, Percent_Identity=67.906976744186, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6320882, Length=445, Percent_Identity=63.8202247191011, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24642172, Length=428, Percent_Identity=68.2242990654206, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24656245, Length=440, Percent_Identity=52.5, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45553387, Length=436, Percent_Identity=54.1284403669725, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45553385, Length=435, Percent_Identity=54.0229885057471, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 48984; Mature: 48852

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYTCRDFSLRTGRNMTASTDYKVRDISLAEWGRKEISIAEGEMPGLMALREEFGASQP
CCCEEECCCCCCCCCCCCCCCCEEEEEEEHHHCCCCEEEEECCCCCHHHHHHHHHCCCCC
LKGARIAGCLHMTIQTAVLIETLTALGATVRWSSCNIFSTQDHAAAAIAATGVPVFAWKG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEECCCCCHHEEEEECCCCEEEECC
LSEDEFWWCIEATVKGPDGWTPNMILDDGGDLTVLMHDKYPDMLKDVRGLSEETTTGVHR
CCCCCEEEEEEEEEECCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHH
LWEMAKKGTLAVPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTDVMMAGKIAVVAGYGD
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCC
VGKGSAASLRNAGCRVLVTEADPICALQAAMEGYEVVTMEGAAPRGDIFVTCTGNVDIIT
CCCCCHHHHHCCCCEEEEECCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCEEEEE
IDHMREMKHRAIVCNIGHFDSEIQIDALRNFPWDNIKPQVDEVVFPDGKRLIVLSEGRLV
HHHHHHHCCCEEEEECCCCCCEEEEEEHHCCCCCCCCCCHHEEECCCCCEEEEEECCCEE
NLGNATGHPSFVMSASFTNQTLAQIELWTAPAGKYERKVYTLPKHLDEKVAALHLAKVGA
EECCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
ELTRMTAKQADYIGVPVNGPFKNDLYRY
HHHHHHHHCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TAYTCRDFSLRTGRNMTASTDYKVRDISLAEWGRKEISIAEGEMPGLMALREEFGASQP
CCEEECCCCCCCCCCCCCCCCEEEEEEEHHHCCCCEEEEECCCCCHHHHHHHHHCCCCC
LKGARIAGCLHMTIQTAVLIETLTALGATVRWSSCNIFSTQDHAAAAIAATGVPVFAWKG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEECCCCCHHEEEEECCCCEEEECC
LSEDEFWWCIEATVKGPDGWTPNMILDDGGDLTVLMHDKYPDMLKDVRGLSEETTTGVHR
CCCCCEEEEEEEEEECCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHH
LWEMAKKGTLAVPAINVNDSVTKSKFDNLYGCRESLVDAIRRGTDVMMAGKIAVVAGYGD
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCC
VGKGSAASLRNAGCRVLVTEADPICALQAAMEGYEVVTMEGAAPRGDIFVTCTGNVDIIT
CCCCCHHHHHCCCCEEEEECCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCEEEEE
IDHMREMKHRAIVCNIGHFDSEIQIDALRNFPWDNIKPQVDEVVFPDGKRLIVLSEGRLV
HHHHHHHCCCEEEEECCCCCCEEEEEEHHCCCCCCCCCCHHEEECCCCCEEEEEECCCEE
NLGNATGHPSFVMSASFTNQTLAQIELWTAPAGKYERKVYTLPKHLDEKVAALHLAKVGA
EECCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
ELTRMTAKQADYIGVPVNGPFKNDLYRY
HHHHHHHHCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA