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The map label for this gene is sucC [H]

Identifier: 162147213

GI number: 162147213

Start: 1421036

End: 1422781

Strand: Direct

Name: sucC [H]

Synonym: GDI_1418

Alternate gene names: 162147213

Gene position: 1421036-1422781 (Clockwise)

Preceding gene: 162147212

Following gene: 162147214

Centisome position: 36.03

GC content: 68.5

Gene sequence:

>1746_bases
ATGACCATTGAAATCAAGGTGCCGACTCTCGGTGAGAGCGTCACGACCGCCACGATCGGAAAATGGCTGAAGCAGCCGGG
CGACAGCGTTGCTGCCGACGAACCGGTGGTGGAACTGGAAACCGACAAGGTCAGCGTCGAGGTCGCGGCCCCCGCCGCCG
GCCGCCTGGGCGCGCATGCCGTCGCCGAGGGCGAGGAGGTCGCGGTCGGCGCCCTGCTGACCAGTGTCGAGGAAGGCGCC
GCCGGTGCCGCCCCCAAGGCGGCTGCCCCAGCCGCCGCCAAGCCCGCGCCGAAGGCGGAGGCCAAGCCGGCCGCCGCTCC
GGCCCCGGCCGCGACCCCTGCCGCCGCCCCGCCGGCGGAAACCGATTACGACGTCATCGTCATCGGGGCCGGCCCGGGCG
GGTATGTCTGCGCCATTCGCGCGGCGCAGCTTGGTTTCAAGGTCGCCTGCGTCGAGAAGCGCGCGACCCTGGGCGGAACC
TGCCTGAATGTCGGCTGCATTCCCTCGAAGGCACTGCTGCAATCGTCCGAGAACTATCATGCCGCGGCGCATGACTATGC
CGGGCACGGCATCGTGCTCGACAGCGTGAAGCTGGACCTGGCCCGCATGATGGCCCGCAAGGGCGAGGTGGTCGAGGCCA
ACGTCAAGGGCGTCGAATTCCTGTTCAAGAAGAACAAGGTCACCTGGCTGAAGGGCACCGGGAAGCTGGAAGGCACCGGC
CGCATCACGGTGGACGGCAAGCCGGTGACGGCGAAGCACATCGTGATCGCCAGCGGCAGCGACAGTGCCGGCCTGCCGGG
CGTCGAAGTGGACGAGAAGGTCATCGTGACCTCGACCGGCGCGCTGGAACTGTCCGCCGTGCCGAAGAAGATGGTGGTGA
TCGGCGGCGGCGTCATCGGCCTGGAGCTGGGCAGCGTGTGGCACCGCCTGGGCGCCGAGGTGACGGTGGTCGAATTCCTC
GACCGCCTGGTACCGGGGACCGATGGCGAAATCGCCAAGCAGTTCCAGCGCATCCTGACCAAGCAGGGCCTGCAGTTCAA
GCTGGGCCACAAGGTCACCAAGGCGGACAAGACCGGCAAGGGCGTGACCCTGACGGTTGAGCCGGCGGCGGGCGGCACGG
CCGAGACGCTGGAGGCGGACATCGTCCTGCTGGCGATCGGCCGCAACGCCTACAGCAAGGGCCTGGGTGTGGAAGAGGCC
GGCGTCGCACTGGACAAGCGCGGCCGGATCATCACCGACGGTCATTTCGCGACCAGCGTGCCGGGCGTCTATGCGATCGG
CGACGTGATCGCCGGCCCGATGCTGGCGCACAAGGCCGAGGAGGAAGGCGTCGCGATCGCGGAAATCCTGGCCGGCCAGG
CGGGCCATGTGAATTACGACGCGATCCCGGGCGTGGTCTATACGTGGCCCGAGGTCGCGACCGTGGGGCGGACCGAAGAG
GACCTGAAATCGTCCGGCGTGACCTACAAGGTCGGCAAGTTCCCCTTCACCGCCAACGGCCGCGCGCGTGCCATCGGCAT
GACGGACGGCTTCGTGAAGGTGCTGGCCGAAGCGACCACGGACCGCGTGCTGGGCGTGCATATCATCGGCCCCGGCGCCG
GCGAAATGATCGCCGAGGCCACGCTGGCGATGGAATTCGGGGCTTCCTCGGAAGACATCGCCCGCACCTGCCACGCGCAT
CCGACCCTCAGCGAGGCGTTGAAGGAGGCCGCGCTGGACGTCGAGAAGCGCGCCATCCACATCTGA

Upstream 100 bases:

>100_bases
GTCGTCTGCTGCTCGAGGTCTGATGCGCCGGGCCGGGTCGGGTTCCTAATCCCAGCCCGGCCCGCCGATCCATCCGACCC
ATCGAACGCAGGACAGAAAC

Downstream 100 bases:

>100_bases
CCGACCGGCCGCACGGATGGGCGGCCCCTGGGCCCGCCCATCCGTGCATCACGTCCCGTCCGGGAACGCGAAGCCGTGCC
GGGCGTCATGACACAGGGTT

Product: 2-oxoglutarate dehydrogenase E3 component

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTIEIKVPTLGESVTTATIGKWLKQPGDSVAADEPVVELETDKVSVEVAAPAAGRLGAHAVAEGEEVAVGALLTSVEEGA
AGAAPKAAAPAAAKPAPKAEAKPAAAPAPAATPAAAPPAETDYDVIVIGAGPGGYVCAIRAAQLGFKVACVEKRATLGGT
CLNVGCIPSKALLQSSENYHAAAHDYAGHGIVLDSVKLDLARMMARKGEVVEANVKGVEFLFKKNKVTWLKGTGKLEGTG
RITVDGKPVTAKHIVIASGSDSAGLPGVEVDEKVIVTSTGALELSAVPKKMVVIGGGVIGLELGSVWHRLGAEVTVVEFL
DRLVPGTDGEIAKQFQRILTKQGLQFKLGHKVTKADKTGKGVTLTVEPAAGGTAETLEADIVLLAIGRNAYSKGLGVEEA
GVALDKRGRIITDGHFATSVPGVYAIGDVIAGPMLAHKAEEEGVAIAEILAGQAGHVNYDAIPGVVYTWPEVATVGRTEE
DLKSSGVTYKVGKFPFTANGRARAIGMTDGFVKVLAEATTDRVLGVHIIGPGAGEMIAEATLAMEFGASSEDIARTCHAH
PTLSEALKEAALDVEKRAIHI

Sequences:

>Translated_581_residues
MTIEIKVPTLGESVTTATIGKWLKQPGDSVAADEPVVELETDKVSVEVAAPAAGRLGAHAVAEGEEVAVGALLTSVEEGA
AGAAPKAAAPAAAKPAPKAEAKPAAAPAPAATPAAAPPAETDYDVIVIGAGPGGYVCAIRAAQLGFKVACVEKRATLGGT
CLNVGCIPSKALLQSSENYHAAAHDYAGHGIVLDSVKLDLARMMARKGEVVEANVKGVEFLFKKNKVTWLKGTGKLEGTG
RITVDGKPVTAKHIVIASGSDSAGLPGVEVDEKVIVTSTGALELSAVPKKMVVIGGGVIGLELGSVWHRLGAEVTVVEFL
DRLVPGTDGEIAKQFQRILTKQGLQFKLGHKVTKADKTGKGVTLTVEPAAGGTAETLEADIVLLAIGRNAYSKGLGVEEA
GVALDKRGRIITDGHFATSVPGVYAIGDVIAGPMLAHKAEEEGVAIAEILAGQAGHVNYDAIPGVVYTWPEVATVGRTEE
DLKSSGVTYKVGKFPFTANGRARAIGMTDGFVKVLAEATTDRVLGVHIIGPGAGEMIAEATLAMEFGASSEDIARTCHAH
PTLSEALKEAALDVEKRAIHI
>Mature_580_residues
TIEIKVPTLGESVTTATIGKWLKQPGDSVAADEPVVELETDKVSVEVAAPAAGRLGAHAVAEGEEVAVGALLTSVEEGAA
GAAPKAAAPAAAKPAPKAEAKPAAAPAPAATPAAAPPAETDYDVIVIGAGPGGYVCAIRAAQLGFKVACVEKRATLGGTC
LNVGCIPSKALLQSSENYHAAAHDYAGHGIVLDSVKLDLARMMARKGEVVEANVKGVEFLFKKNKVTWLKGTGKLEGTGR
ITVDGKPVTAKHIVIASGSDSAGLPGVEVDEKVIVTSTGALELSAVPKKMVVIGGGVIGLELGSVWHRLGAEVTVVEFLD
RLVPGTDGEIAKQFQRILTKQGLQFKLGHKVTKADKTGKGVTLTVEPAAGGTAETLEADIVLLAIGRNAYSKGLGVEEAG
VALDKRGRIITDGHFATSVPGVYAIGDVIAGPMLAHKAEEEGVAIAEILAGQAGHVNYDAIPGVVYTWPEVATVGRTEED
LKSSGVTYKVGKFPFTANGRARAIGMTDGFVKVLAEATTDRVLGVHIIGPGAGEMIAEATLAMEFGASSEDIARTCHAHP
TLSEALKEAALDVEKRAIHI

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=472, Percent_Identity=56.7796610169492, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=29.5010845986985, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI22035672, Length=506, Percent_Identity=30.6324110671937, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI148277065, Length=490, Percent_Identity=28.3673469387755, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI33519430, Length=490, Percent_Identity=28.3673469387755, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI33519428, Length=490, Percent_Identity=28.3673469387755, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI33519426, Length=490, Percent_Identity=28.3673469387755, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI148277071, Length=490, Percent_Identity=28.3673469387755, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI291045266, Length=491, Percent_Identity=28.7169042769857, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI291045268, Length=482, Percent_Identity=28.0082987551867, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=41.0087719298246, Blast_Score=325, Evalue=6e-90,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=29.5503211991435, Blast_Score=208, Evalue=9e-55,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=30.2961275626424, Blast_Score=169, Evalue=6e-43,
Organism=Escherichia coli, GI87081717, Length=465, Percent_Identity=28.6021505376344, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1786946, Length=140, Percent_Identity=37.8571428571429, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=57.3304157549234, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17557007, Length=493, Percent_Identity=30.4259634888438, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=28.8032454361055, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=468, Percent_Identity=28.2051282051282, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=458, Percent_Identity=28.6026200873362, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25146366, Length=127, Percent_Identity=43.3070866141732, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=52.3305084745763, Blast_Score=478, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=34.5415778251599, Blast_Score=246, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=29.3361884368308, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=57.9295154185022, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640551, Length=523, Percent_Identity=29.8279158699809, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=30.6418219461698, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=30.6418219461698, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17737741, Length=498, Percent_Identity=27.9116465863454, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 59543; Mature: 59412

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEIKVPTLGESVTTATIGKWLKQPGDSVAADEPVVELETDKVSVEVAAPAAGRLGAHA
CEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCHH
VAEGEEVAVGALLTSVEEGAAGAAPKAAAPAAAKPAPKAEAKPAAAPAPAATPAAAPPAE
HCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TDYDVIVIGAGPGGYVCAIRAAQLGFKVACVEKRATLGGTCLNVGCIPSKALLQSSENYH
CCCCEEEEECCCCCEEEEEEEHHCCEEEEEEECCCCCCCCEEEECCCCCHHHHCCCCCCE
AAAHDYAGHGIVLDSVKLDLARMMARKGEVVEANVKGVEFLFKKNKVTWLKGTGKLEGTG
EECCCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCEEEEECCCEECCCE
RITVDGKPVTAKHIVIASGSDSAGLPGVEVDEKVIVTSTGALELSAVPKKMVVIGGGVIG
EEEECCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCEEEECCCCEEEEEECCEEE
LELGSVWHRLGAEVTVVEFLDRLVPGTDGEIAKQFQRILTKQGLQFKLGHKVTKADKTGK
EHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCC
GVTLTVEPAAGGTAETLEADIVLLAIGRNAYSKGLGVEEAGVALDKRGRIITDGHFATSV
CEEEEEECCCCCCHHHEECCEEEEEECCCHHHCCCCCCHHCCEECCCCCEEECCCCCCCC
PGVYAIGDVIAGPMLAHKAEEEGVAIAEILAGQAGHVNYDAIPGVVYTWPEVATVGRTEE
CCHHHHHHHHHCCHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEECCCHHCCCCCHH
DLKSSGVTYKVGKFPFTANGRARAIGMTDGFVKVLAEATTDRVLGVHIIGPGAGEMIAEA
HHHHCCCEEEECCCEECCCCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
TLAMEFGASSEDIARTCHAHPTLSEALKEAALDVEKRAIHI
HHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCHHHHEECC
>Mature Secondary Structure 
TIEIKVPTLGESVTTATIGKWLKQPGDSVAADEPVVELETDKVSVEVAAPAAGRLGAHA
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCHH
VAEGEEVAVGALLTSVEEGAAGAAPKAAAPAAAKPAPKAEAKPAAAPAPAATPAAAPPAE
HCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TDYDVIVIGAGPGGYVCAIRAAQLGFKVACVEKRATLGGTCLNVGCIPSKALLQSSENYH
CCCCEEEEECCCCCEEEEEEEHHCCEEEEEEECCCCCCCCEEEECCCCCHHHHCCCCCCE
AAAHDYAGHGIVLDSVKLDLARMMARKGEVVEANVKGVEFLFKKNKVTWLKGTGKLEGTG
EECCCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCEEEEECCCEECCCE
RITVDGKPVTAKHIVIASGSDSAGLPGVEVDEKVIVTSTGALELSAVPKKMVVIGGGVIG
EEEECCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCEEEECCCCEEEEEECCEEE
LELGSVWHRLGAEVTVVEFLDRLVPGTDGEIAKQFQRILTKQGLQFKLGHKVTKADKTGK
EHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCC
GVTLTVEPAAGGTAETLEADIVLLAIGRNAYSKGLGVEEAGVALDKRGRIITDGHFATSV
CEEEEEECCCCCCHHHEECCEEEEEECCCHHHCCCCCCHHCCEECCCCCEEECCCCCCCC
PGVYAIGDVIAGPMLAHKAEEEGVAIAEILAGQAGHVNYDAIPGVVYTWPEVATVGRTEE
CCHHHHHHHHHCCHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEECCCHHCCCCCHH
DLKSSGVTYKVGKFPFTANGRARAIGMTDGFVKVLAEATTDRVLGVHIIGPGAGEMIAEA
HHHHCCCEEEECCCEECCCCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
TLAMEFGASSEDIARTCHAHPTLSEALKEAALDVEKRAIHI
HHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]