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The map label for this gene is envZ [H]

Identifier: 162147184

GI number: 162147184

Start: 1394402

End: 1395793

Strand: Direct

Name: envZ [H]

Synonym: GDI_1389

Alternate gene names: 162147184

Gene position: 1394402-1395793 (Clockwise)

Preceding gene: 162147183

Following gene: 162147187

Centisome position: 35.35

GC content: 71.91

Gene sequence:

>1392_bases
ATGGCGGGCCCTGCTTCCCAGAACGCGCCGCCCGGTGTCCGGCGGATCACGCTCTGGCCGCGCGGGCTGGTGGGGCGGGT
CACGGTCGTGCTGCTGGCCGCCGTCGCCCTGGTGTTCATCGGCAGTTCCGTCTTCTACGAGGAAGCCGAGACCTATACCG
TCGACGACGCCCAACTGGACCAGATCGGCGAACGGCTGACGATCGACGCGCGGGTGCTGCTGGCCACGCCTGTGTCGCAG
CGGCCCATCCTGGCCACCATGCTGTCGACCGGCGACCTGACGCTGGACTGGAGTGCGCCGGAACCCGTCGCGCCGCCGCG
TGCGGAACCGCCGGCCCTGCGCGACCTGCACGGCCGGCTGGCGGCGAACCATGATTTTCTGCGCGGCCCGGCGCTGAACC
TGGCGCCGACCAAGATCGGGACGGCCGATATTCGCGGCATCCTGCGCCTGCCCGACGGCAGCCGGATCGGCTTCGTCGCC
CCCGATATCCTGCAGCCGCACCACACGACCCGGGGCGTCGCCTCGGCCGCGGTGCTGGCCGGGGCGGTGCTGATGGCGGC
GGCGATGCTGGTCCATACGCTCAGCATGCCGCTGCGGGCGCTGGCGGATGTGGCGGACGGCGTGGGATCGGGCCAATGGA
TTCCGGTCGAGGAAAAGGGCCCCCGGGAAGTGCGCTACCTGGCGCGGGCGATCAACGCCATGCAGGACCGCATCCGGCGG
TTGATCGCGGACCGGACCGAGGCCCTGGCCGCCGTGTCGCACGACCTGCGCACGCCGCTGGCGCGCCTGCGCCTGCGGGC
CGGCTTTCTGGACGACCCGGAGGTGCAGGGCGCGATCGAGAGCGACGTGGCCGAGATGGAGGCGATGGTCGGCGGGGTCC
TGGCCTATCTGTCCGGCGAGAACGATCCCGAATCCGCCCGTCCGGTCGACCTGGCCTCGATCCTGATGACGCTGGCCGAC
GACGCCGCCGACCAGGGGCGGGACGTCAGCTATGATGGGCCGCCGCAATGGCAGGCCCGGGTGCGGCCGCTGGCGATGAA
GCGGGTCTTCGGCAACCTGATCGACAATGCCGTCAATTACGGCCGCCGGGCGCGGATCAGGCTGTCGGTGGAACCCAGGC
AGTTGCGGATCCGCATCGACGATGACGGGCCGGGCCTGCCCGAGGCCGAACTGACGCGGGTGCTGACCCCGTTCTACCGG
GTCGAGGGCTCACGCTCGCGCGCCACCGGCGGGCTGGGGCTGGGGCTGGCCATCGTCAACCGCGAGGTGGCGCGCGAAGG
CGGGCAGTTCGTGCTGTCCAACCGGACCGGCGGAGGATTGCGGGCGGAAATCCTGTTGCCCCGCACCGGTCACGGCGTGG
GCGGCGCCGGCAGGTCGGCCATCGACAGGTGA

Upstream 100 bases:

>100_bases
CGCCTGCGCCGCAAGCTGGGCAATGAATCGGAAACCCTGATCCGCACCGTGCGGGGCCTGGGTTACATCTTCACCGCGCC
GGTGGACCGAACCTGAACCC

Downstream 100 bases:

>100_bases
AGTGCGGGTTCGTTGGTGTTCAGCCAGATCCCGTGCGGCGAGCGGCCGGTGCGGATGGTGTCCACGATCTCGCCGCTGTT
GGGGTCGATGATCGCGACAT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAGPASQNAPPGVRRITLWPRGLVGRVTVVLLAAVALVFIGSSVFYEEAETYTVDDAQLDQIGERLTIDARVLLATPVSQ
RPILATMLSTGDLTLDWSAPEPVAPPRAEPPALRDLHGRLAANHDFLRGPALNLAPTKIGTADIRGILRLPDGSRIGFVA
PDILQPHHTTRGVASAAVLAGAVLMAAAMLVHTLSMPLRALADVADGVGSGQWIPVEEKGPREVRYLARAINAMQDRIRR
LIADRTEALAAVSHDLRTPLARLRLRAGFLDDPEVQGAIESDVAEMEAMVGGVLAYLSGENDPESARPVDLASILMTLAD
DAADQGRDVSYDGPPQWQARVRPLAMKRVFGNLIDNAVNYGRRARIRLSVEPRQLRIRIDDDGPGLPEAELTRVLTPFYR
VEGSRSRATGGLGLGLAIVNREVAREGGQFVLSNRTGGGLRAEILLPRTGHGVGGAGRSAIDR

Sequences:

>Translated_463_residues
MAGPASQNAPPGVRRITLWPRGLVGRVTVVLLAAVALVFIGSSVFYEEAETYTVDDAQLDQIGERLTIDARVLLATPVSQ
RPILATMLSTGDLTLDWSAPEPVAPPRAEPPALRDLHGRLAANHDFLRGPALNLAPTKIGTADIRGILRLPDGSRIGFVA
PDILQPHHTTRGVASAAVLAGAVLMAAAMLVHTLSMPLRALADVADGVGSGQWIPVEEKGPREVRYLARAINAMQDRIRR
LIADRTEALAAVSHDLRTPLARLRLRAGFLDDPEVQGAIESDVAEMEAMVGGVLAYLSGENDPESARPVDLASILMTLAD
DAADQGRDVSYDGPPQWQARVRPLAMKRVFGNLIDNAVNYGRRARIRLSVEPRQLRIRIDDDGPGLPEAELTRVLTPFYR
VEGSRSRATGGLGLGLAIVNREVAREGGQFVLSNRTGGGLRAEILLPRTGHGVGGAGRSAIDR
>Mature_462_residues
AGPASQNAPPGVRRITLWPRGLVGRVTVVLLAAVALVFIGSSVFYEEAETYTVDDAQLDQIGERLTIDARVLLATPVSQR
PILATMLSTGDLTLDWSAPEPVAPPRAEPPALRDLHGRLAANHDFLRGPALNLAPTKIGTADIRGILRLPDGSRIGFVAP
DILQPHHTTRGVASAAVLAGAVLMAAAMLVHTLSMPLRALADVADGVGSGQWIPVEEKGPREVRYLARAINAMQDRIRRL
IADRTEALAAVSHDLRTPLARLRLRAGFLDDPEVQGAIESDVAEMEAMVGGVLAYLSGENDPESARPVDLASILMTLADD
AADQGRDVSYDGPPQWQARVRPLAMKRVFGNLIDNAVNYGRRARIRLSVEPRQLRIRIDDDGPGLPEAELTRVLTPFYRV
EGSRSRATGGLGLGLAIVNREVAREGGQFVLSNRTGGGLRAEILLPRTGHGVGGAGRSAIDR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=271, Percent_Identity=33.210332103321, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=29.811320754717, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=32.0833333333333, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=29.1946308724832, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=26.5454545454545, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=26.0330578512397, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=23.7012987012987, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=277, Percent_Identity=24.5487364620939, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789149, Length=218, Percent_Identity=27.9816513761468, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49550; Mature: 49419

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPASQNAPPGVRRITLWPRGLVGRVTVVLLAAVALVFIGSSVFYEEAETYTVDDAQLD
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEECCCHHHH
QIGERLTIDARVLLATPVSQRPILATMLSTGDLTLDWSAPEPVAPPRAEPPALRDLHGRL
HHCCEEEECEEEEEECCCCCCCHHHEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHH
AANHDFLRGPALNLAPTKIGTADIRGILRLPDGSRIGFVAPDILQPHHTTRGVASAAVLA
HCCCCHHCCCCCCCCCCCCCHHHCCEEEECCCCCEECEECHHHCCCCCHHHHHHHHHHHH
GAVLMAAAMLVHTLSMPLRALADVADGVGSGQWIPVEEKGPREVRYLARAINAMQDRIRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
LIADRTEALAAVSHDLRTPLARLRLRAGFLDDPEVQGAIESDVAEMEAMVGGVLAYLSGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCC
NDPESARPVDLASILMTLADDAADQGRDVSYDGPPQWQARVRPLAMKRVFGNLIDNAVNY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRRARIRLSVEPRQLRIRIDDDGPGLPEAELTRVLTPFYRVEGSRSRATGGLGLGLAIVN
CCEEEEEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
REVAREGGQFVLSNRTGGGLRAEILLPRTGHGVGGAGRSAIDR
HHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
AGPASQNAPPGVRRITLWPRGLVGRVTVVLLAAVALVFIGSSVFYEEAETYTVDDAQLD
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEECCCHHHH
QIGERLTIDARVLLATPVSQRPILATMLSTGDLTLDWSAPEPVAPPRAEPPALRDLHGRL
HHCCEEEECEEEEEECCCCCCCHHHEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHH
AANHDFLRGPALNLAPTKIGTADIRGILRLPDGSRIGFVAPDILQPHHTTRGVASAAVLA
HCCCCHHCCCCCCCCCCCCCHHHCCEEEECCCCCEECEECHHHCCCCCHHHHHHHHHHHH
GAVLMAAAMLVHTLSMPLRALADVADGVGSGQWIPVEEKGPREVRYLARAINAMQDRIRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
LIADRTEALAAVSHDLRTPLARLRLRAGFLDDPEVQGAIESDVAEMEAMVGGVLAYLSGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCC
NDPESARPVDLASILMTLADDAADQGRDVSYDGPPQWQARVRPLAMKRVFGNLIDNAVNY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GRRARIRLSVEPRQLRIRIDDDGPGLPEAELTRVLTPFYRVEGSRSRATGGLGLGLAIVN
CCEEEEEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
REVAREGGQFVLSNRTGGGLRAEILLPRTGHGVGGAGRSAIDR
HHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]