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The map label for this gene is accC [H]

Identifier: 162147142

GI number: 162147142

Start: 1347538

End: 1348881

Strand: Reverse

Name: accC [H]

Synonym: GDI_1347

Alternate gene names: 162147142

Gene position: 1348881-1347538 (Counterclockwise)

Preceding gene: 162147143

Following gene: 162147136

Centisome position: 34.2

GC content: 67.49

Gene sequence:

>1344_bases
ATGTTTTCCAAGATCCTCATCGCCAATCGCGGCGAAATCGCCCTGCGGGTCCTGCGCGCATGCCGCGAGCTGGGAATCCG
CACGGTCGCGATCCATTCCACCGCCGACGCCGACGCCATGCATGTGCGCCTGGCCGACGAAGCCGTGTGCGTCGGGCCGC
CGGCCACGCGGGATTCGTACCTGAACGTCGCCGCCATCCTGTCGGCCGCGACCATCACTGGGGCGGACGCGATCCATCCG
GGATACGGCTTCCTGTCGGAAAACGCCGATTTCGCCGAGACGGTCGAGGCCCACGGCCTGGCCTTCATCGGGCCGACCGG
ACACCATATCCGGATCATGGGCGACAAGATCACCGCCAAGACCACCATGCGCGCGCTGGGCGTGCCGCTGGTGCCCGGGT
CGGACGGCGCGCTGGCCAGCCTGGACGAGGCCCGCGTGGTGGCGGCCCAGGTCGGCTATCCGGTGCTGATCAAGGCGACG
GCCGGCGGCGGCGGGCGCGGCATGAAGGTCGCCCGCACCCCCGACGAGATCGAGGAAGCCTGGAGCGTCGCGCGGACCGA
GGCCCGGGCCGCGTTCGGCAATGACGAGGTCTATCTCGAAAAATACATGGACCGGCCCCGGCATATCGAGCTGCAGATCC
TGGCCGATACCCACGGCAACGTCGTGCATTTCGGCGAACGCGACTGTTCGCTGCAGCGGCGGCACCAGAAGCTGCTGGAA
GAGGCCGGATCACCGGCGCTGACCGCCGAGCAGCGCGACGGGATCGGCGCCATCGCGACCGCGGCGCTGAGCAAGCTGGG
ATACCGCAACGCGGGCACGCTGGAATTCCTGTACCAGGACGGGCAGTTCTGCTTCATCGAGATGAACACCCGCCTGCAGG
TGGAACATCCGGTGACCGAGATGGTCTGCGACGTCGACCTGGTGCGCGAGCAGATCCGCATCGCGGCGGGCGAGCCGCTG
GGCTACGACCAGTCGGACATCCGCTTCAGCGGCCATGCCATCGAATGCCGCATCAACGCCGAAGACCCGGTGACCTTCCT
GCCCACCCCCGGAACGGTGACGATGTACCACCCGCCCGGCGGCCTGGGCGTGCGCATCGACAGCGCGCTGTACGCCGGCT
ATCGCGTGCCGCCCTATTACGACAGCATGATCGGCAAGCTGATCGTCCATGCCCCCACCCGTGCCGACGCCATCGCGCGA
ATGCGCCGCGCGCTGGATGAATTCGTCATCGAAGGCGTGAAGACGGTCATCCCGCTGCATCGCCAGATCCTGGACGACCC
GGAATTCCAGAAGGGCGATTACACCATCCACTGGCTGGAACGCTTCGTCGCGTCGCGCGGGTAA

Upstream 100 bases:

>100_bases
TCAACCAGATCAAGGCCCCCCGCGCGGGCACGCTGAAGACGCTGCTGGTCGCATCGGGCGATCCGGTGGAATTCGGCGAA
GCCCTGGCCATCATCGAGTA

Downstream 100 bases:

>100_bases
GGTCGAAAGGCCAGGGCCCTGCCCTGGACCCGCCAAAGGCCGGCGGCCTTTGGAAACCATTCCATTATCGGGGTGCAGGG
CATCACGCCCTGCCGGGTCC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFSKILIANRGEIALRVLRACRELGIRTVAIHSTADADAMHVRLADEAVCVGPPATRDSYLNVAAILSAATITGADAIHP
GYGFLSENADFAETVEAHGLAFIGPTGHHIRIMGDKITAKTTMRALGVPLVPGSDGALASLDEARVVAAQVGYPVLIKAT
AGGGGRGMKVARTPDEIEEAWSVARTEARAAFGNDEVYLEKYMDRPRHIELQILADTHGNVVHFGERDCSLQRRHQKLLE
EAGSPALTAEQRDGIGAIATAALSKLGYRNAGTLEFLYQDGQFCFIEMNTRLQVEHPVTEMVCDVDLVREQIRIAAGEPL
GYDQSDIRFSGHAIECRINAEDPVTFLPTPGTVTMYHPPGGLGVRIDSALYAGYRVPPYYDSMIGKLIVHAPTRADAIAR
MRRALDEFVIEGVKTVIPLHRQILDDPEFQKGDYTIHWLERFVASRG

Sequences:

>Translated_447_residues
MFSKILIANRGEIALRVLRACRELGIRTVAIHSTADADAMHVRLADEAVCVGPPATRDSYLNVAAILSAATITGADAIHP
GYGFLSENADFAETVEAHGLAFIGPTGHHIRIMGDKITAKTTMRALGVPLVPGSDGALASLDEARVVAAQVGYPVLIKAT
AGGGGRGMKVARTPDEIEEAWSVARTEARAAFGNDEVYLEKYMDRPRHIELQILADTHGNVVHFGERDCSLQRRHQKLLE
EAGSPALTAEQRDGIGAIATAALSKLGYRNAGTLEFLYQDGQFCFIEMNTRLQVEHPVTEMVCDVDLVREQIRIAAGEPL
GYDQSDIRFSGHAIECRINAEDPVTFLPTPGTVTMYHPPGGLGVRIDSALYAGYRVPPYYDSMIGKLIVHAPTRADAIAR
MRRALDEFVIEGVKTVIPLHRQILDDPEFQKGDYTIHWLERFVASRG
>Mature_447_residues
MFSKILIANRGEIALRVLRACRELGIRTVAIHSTADADAMHVRLADEAVCVGPPATRDSYLNVAAILSAATITGADAIHP
GYGFLSENADFAETVEAHGLAFIGPTGHHIRIMGDKITAKTTMRALGVPLVPGSDGALASLDEARVVAAQVGYPVLIKAT
AGGGGRGMKVARTPDEIEEAWSVARTEARAAFGNDEVYLEKYMDRPRHIELQILADTHGNVVHFGERDCSLQRRHQKLLE
EAGSPALTAEQRDGIGAIATAALSKLGYRNAGTLEFLYQDGQFCFIEMNTRLQVEHPVTEMVCDVDLVREQIRIAAGEPL
GYDQSDIRFSGHAIECRINAEDPVTFLPTPGTVTMYHPPGGLGVRIDSALYAGYRVPPYYDSMIGKLIVHAPTRADAIAR
MRRALDEFVIEGVKTVIPLHRQILDDPEFQKGDYTIHWLERFVASRG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=50, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=50, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=50, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI116805327, Length=435, Percent_Identity=46.4367816091954, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=45.3932584269663, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=45.3932584269663, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=45.3932584269663, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI38679971, Length=515, Percent_Identity=31.6504854368932, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679960, Length=515, Percent_Identity=31.6504854368932, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679974, Length=515, Percent_Identity=31.6504854368932, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI38679977, Length=515, Percent_Identity=31.6504854368932, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI38679967, Length=515, Percent_Identity=31.6504854368932, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=31.3953488372093, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=59.9547511312217, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.4040632054176, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=436, Percent_Identity=47.0183486238532, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.7589285714286, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=29.6146044624746, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=28.8235294117647, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=28.8235294117647, Blast_Score=195, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=40.4494382022472, Blast_Score=346, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.1901565995526, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.413870246085, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=30.4597701149425, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=31.9057815845824, Blast_Score=209, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24651757, Length=433, Percent_Identity=47.3441108545035, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.1910112359551, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.1910112359551, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.1910112359551, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.1910112359551, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.1910112359551, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=395, Percent_Identity=46.0759493670886, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=30.952380952381, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=30.952380952381, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=30.952380952381, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=30.952380952381, Blast_Score=218, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48703; Mature: 48703

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKILIANRGEIALRVLRACRELGIRTVAIHSTADADAMHVRLADEAVCVGPPATRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCHH
LNVAAILSAATITGADAIHPGYGFLSENADFAETVEAHGLAFIGPTGHHIRIMGDKITAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCCEEEEECCCEEHH
TTMRALGVPLVPGSDGALASLDEARVVAAQVGYPVLIKATAGGGGRGMKVARTPDEIEEA
HHHHHHCCCCCCCCCCCCCCCCHHHEEEEECCCEEEEEEECCCCCCCCEEECCHHHHHHH
WSVARTEARAAFGNDEVYLEKYMDRPRHIELQILADTHGNVVHFGERDCSLQRRHQKLLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAGSPALTAEQRDGIGAIATAALSKLGYRNAGTLEFLYQDGQFCFIEMNTRLQVEHPVTE
HCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MVCDVDLVREQIRIAAGEPLGYDQSDIRFSGHAIECRINAEDPVTFLPTPGTVTMYHPPG
HHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEEEECCCCCEEEECCCCEEEEEECCC
GLGVRIDSALYAGYRVPPYYDSMIGKLIVHAPTRADAIARMRRALDEFVIEGVKTVIPLH
CCEEEECCCEECCCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQILDDPEFQKGDYTIHWLERFVASRG
HHHCCCCCCCCCCEEHHHHHHHHHCCC
>Mature Secondary Structure
MFSKILIANRGEIALRVLRACRELGIRTVAIHSTADADAMHVRLADEAVCVGPPATRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCHH
LNVAAILSAATITGADAIHPGYGFLSENADFAETVEAHGLAFIGPTGHHIRIMGDKITAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCCEEEEECCCEEHH
TTMRALGVPLVPGSDGALASLDEARVVAAQVGYPVLIKATAGGGGRGMKVARTPDEIEEA
HHHHHHCCCCCCCCCCCCCCCCHHHEEEEECCCEEEEEEECCCCCCCCEEECCHHHHHHH
WSVARTEARAAFGNDEVYLEKYMDRPRHIELQILADTHGNVVHFGERDCSLQRRHQKLLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAGSPALTAEQRDGIGAIATAALSKLGYRNAGTLEFLYQDGQFCFIEMNTRLQVEHPVTE
HCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MVCDVDLVREQIRIAAGEPLGYDQSDIRFSGHAIECRINAEDPVTFLPTPGTVTMYHPPG
HHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEEEECCCCCEEEECCCCEEEEEECCC
GLGVRIDSALYAGYRVPPYYDSMIGKLIVHAPTRADAIARMRRALDEFVIEGVKTVIPLH
CCEEEECCCEECCCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQILDDPEFQKGDYTIHWLERFVASRG
HHHCCCCCCCCCCEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]