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The map label for this gene is apt

Identifier: 162147139

GI number: 162147139

Start: 1343884

End: 1344414

Strand: Direct

Name: apt

Synonym: GDI_1344

Alternate gene names: 162147139

Gene position: 1343884-1344414 (Clockwise)

Preceding gene: 162147138

Following gene: 162147140

Centisome position: 34.07

GC content: 68.93

Gene sequence:

>531_bases
ATGACGACCGCCACGATGGACCTGAAGCAGCATATTCGCGGCATCCCGGATTTTCCGAAGCCGGGCATCCTGTTCTACGA
TATCTCCACCCTGATGCGGAACGCGGATGCGTGGCAGGTGGCGATGGGCCGGCTGACGCACGCTGTCGCCCCGTGGGCAC
CGGACATGCTGGCGGCGATCGAATCGCGCGGCTTCCTGACCGCCGCCCCGCTGGCCAGCAACCTGGGCTGCGGGCTGGTC
ATGCTGCGCAAGCCGGGCAAGCTGCCGGGTGAAACCGTGTCCCACACCTACGACCTGGAATATGGCAGCGACACGCTGCA
CATCCAGGCCGACGCCATCCGCCCCGGCCAGCGCGTGGTGGTGATGGACGACCTGCTGGCCACCGGCGGCACCCTCGCCG
CCTCGGTGGCGCTGCTGCGCAAGGTCGGGGCGGATGTCGTCGGCGCGTCGGTCCTGGTGGAACTGCGCGCCCTTGGCGGC
CGCCAGCGGCTGGACGTGCCGGTCCAGGCCCTGATTTCCTACGACGACTGA

Upstream 100 bases:

>100_bases
GTTACAGCAGGGCACGTTTTTCACGGTCCGGACGGCAGGTCCGGCCCGGTTCCTGTCATGGAATGACGAGTTTGGGGTGG
ATTGGGATTTGGGCACGGAC

Downstream 100 bases:

>100_bases
CGTCGATACCCCGCCGCCGGCCCGGTCGTCCGGCCCGCGCGGTGGGATACGTTTTGGTGGCCTCTGCTATTCGGTTCGCT
CCCTGTCGGCCGGCGGCGAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MTTATMDLKQHIRGIPDFPKPGILFYDISTLMRNADAWQVAMGRLTHAVAPWAPDMLAAIESRGFLTAAPLASNLGCGLV
MLRKPGKLPGETVSHTYDLEYGSDTLHIQADAIRPGQRVVVMDDLLATGGTLAASVALLRKVGADVVGASVLVELRALGG
RQRLDVPVQALISYDD

Sequences:

>Translated_176_residues
MTTATMDLKQHIRGIPDFPKPGILFYDISTLMRNADAWQVAMGRLTHAVAPWAPDMLAAIESRGFLTAAPLASNLGCGLV
MLRKPGKLPGETVSHTYDLEYGSDTLHIQADAIRPGQRVVVMDDLLATGGTLAASVALLRKVGADVVGASVLVELRALGG
RQRLDVPVQALISYDD
>Mature_175_residues
TTATMDLKQHIRGIPDFPKPGILFYDISTLMRNADAWQVAMGRLTHAVAPWAPDMLAAIESRGFLTAAPLASNLGCGLVM
LRKPGKLPGETVSHTYDLEYGSDTLHIQADAIRPGQRVVVMDDLLATGGTLAASVALLRKVGADVVGASVLVELRALGGR
QRLDVPVQALISYDD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=47.093023255814, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=49.6, Blast_Score=121, Evalue=4e-28,
Organism=Escherichia coli, GI1786675, Length=167, Percent_Identity=48.502994011976, Blast_Score=165, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=45.6647398843931, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=177, Percent_Identity=38.4180790960452, Blast_Score=114, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=34.7058823529412, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136334, Length=169, Percent_Identity=46.7455621301775, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_GLUDA (A9HEW1)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001601600.1
- RefSeq:   YP_002276425.1
- ProteinModelPortal:   A9HEW1
- SMR:   A9HEW1
- GeneID:   5792103
- GeneID:   6975477
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_2050
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18790; Mature: 18659

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTATMDLKQHIRGIPDFPKPGILFYDISTLMRNADAWQVAMGRLTHAVAPWAPDMLAAI
CCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ESRGFLTAAPLASNLGCGLVMLRKPGKLPGETVSHTYDLEYGSDTLHIQADAIRPGQRVV
HCCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEEE
VMDDLLATGGTLAASVALLRKVGADVVGASVLVELRALGGRQRLDVPVQALISYDD
EEHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEECCC
>Mature Secondary Structure 
TTATMDLKQHIRGIPDFPKPGILFYDISTLMRNADAWQVAMGRLTHAVAPWAPDMLAAI
CCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ESRGFLTAAPLASNLGCGLVMLRKPGKLPGETVSHTYDLEYGSDTLHIQADAIRPGQRVV
HCCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEEE
VMDDLLATGGTLAASVALLRKVGADVVGASVLVELRALGGRQRLDVPVQALISYDD
EEHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA