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The map label for this gene is hemH [H]

Identifier: 162147117

GI number: 162147117

Start: 1323188

End: 1324216

Strand: Reverse

Name: hemH [H]

Synonym: GDI_1322

Alternate gene names: 162147117

Gene position: 1324216-1323188 (Counterclockwise)

Preceding gene: 162147118

Following gene: 162147112

Centisome position: 33.57

GC content: 69.29

Gene sequence:

>1029_bases
ATGACCTTCCTGACCATTCGCCCGGCTAAGCCGATCGCCCCGTCCCGTATCGGCGTCCTGCTGACCAATCTGGGCACGCC
GGAAGGAACCGGCTATGGCGCCATCCGGCGCTATCTTTCCGAATTCCTGTCCGACCGCCGCATCATCGAGGCCAGTCCCG
CCCTGTGGCAGCCGATCCTGCAGGGACCGCTGCTGGCCCTGCGCCCCAGGCGGACCGGGGCGGCCTATCGGCGCATCTGG
CATACCGAGCGGGACGAGAGCCCGCTGCGCACCCATACAAGGGCCCAGGCCGAGGCCCTGGCCGCGCGCATGGAACCGGA
CGGCGTGGCGGTGGAATGGGCCATGCGCTACGGCACCCCGTCGATCGCATCGGGCATCGAACGGCTGCTGGCCCGGGGCT
GCGCGCGGGTGCTGCTGCTGCCGCTTTATCCGCAATACAGCGCCACGACGACGGCCACGGCCAACGACCATGCCTTTCGC
GCGCTGATGCGGCTGCGCAACCAGCCGGCGGTCCGCACCGCGCCGTCCTTCCCCGACCATCCGCTCTATATCGAAGCCCT
GGCCCGGTCGGTGCGCGAGACGCTGGCCGGCCTGCCCTTCGTGCCGCAACGGATCGTGGCGTCGTTCCATGGCCTGCCGC
GCGATTATGTCACGCGCGGCGACCCGTATCCCGAGGAATGCGAGCGCACGCTGGCGGCGCTGCGCCGGGCGCTGGACATG
GACGAGGAGACGATGACGCTGACCTATCAGTCGCGCTTCGGCCCCGCCCGATGGCTGGAACCCTATACCGCGCCGCTGGT
CGCCGGATTGCCCGCCCGGGGCGTCACGCGTGTCGCCGTCATCATGCCGGGCTTCATGGCCGACTGCATCGAGACGCTGG
ACGAGATCGGCAACGAGGTCCGGAAGGACTTCATTGCCGCCGGCGGAACCGATTTCGCGCTGGTTCCCTGCCTGAACGCG
GCGCCGGCCGCCATTGACCTGCTGGAAGGCCTGACGCGCCAGGAACTGGCGGGATGGTTGAAGGATTGA

Upstream 100 bases:

>100_bases
GCGGTGCCGGTCCGGGTCCGCCGCACCCGCCGCTAGGTTCGGTTTCGGACCACGAACGGCTCTTTGCAGGATGGGCGTCA
TCCTGTAGCGTTCCGGGCCG

Downstream 100 bases:

>100_bases
AGCGGGCGGGGACAGAAAGTCCCCGCCCGCTTCACCCGGTCAGTGACCGGCGGCGGCCGGCGGATGTTCGGCGTCCCACA
GGGTCGCCTTCTGTTCGTCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTFLTIRPAKPIAPSRIGVLLTNLGTPEGTGYGAIRRYLSEFLSDRRIIEASPALWQPILQGPLLALRPRRTGAAYRRIW
HTERDESPLRTHTRAQAEALAARMEPDGVAVEWAMRYGTPSIASGIERLLARGCARVLLLPLYPQYSATTTATANDHAFR
ALMRLRNQPAVRTAPSFPDHPLYIEALARSVRETLAGLPFVPQRIVASFHGLPRDYVTRGDPYPEECERTLAALRRALDM
DEETMTLTYQSRFGPARWLEPYTAPLVAGLPARGVTRVAVIMPGFMADCIETLDEIGNEVRKDFIAAGGTDFALVPCLNA
APAAIDLLEGLTRQELAGWLKD

Sequences:

>Translated_342_residues
MTFLTIRPAKPIAPSRIGVLLTNLGTPEGTGYGAIRRYLSEFLSDRRIIEASPALWQPILQGPLLALRPRRTGAAYRRIW
HTERDESPLRTHTRAQAEALAARMEPDGVAVEWAMRYGTPSIASGIERLLARGCARVLLLPLYPQYSATTTATANDHAFR
ALMRLRNQPAVRTAPSFPDHPLYIEALARSVRETLAGLPFVPQRIVASFHGLPRDYVTRGDPYPEECERTLAALRRALDM
DEETMTLTYQSRFGPARWLEPYTAPLVAGLPARGVTRVAVIMPGFMADCIETLDEIGNEVRKDFIAAGGTDFALVPCLNA
APAAIDLLEGLTRQELAGWLKD
>Mature_341_residues
TFLTIRPAKPIAPSRIGVLLTNLGTPEGTGYGAIRRYLSEFLSDRRIIEASPALWQPILQGPLLALRPRRTGAAYRRIWH
TERDESPLRTHTRAQAEALAARMEPDGVAVEWAMRYGTPSIASGIERLLARGCARVLLLPLYPQYSATTTATANDHAFRA
LMRLRNQPAVRTAPSFPDHPLYIEALARSVRETLAGLPFVPQRIVASFHGLPRDYVTRGDPYPEECERTLAALRRALDMD
EETMTLTYQSRFGPARWLEPYTAPLVAGLPARGVTRVAVIMPGFMADCIETLDEIGNEVRKDFIAAGGTDFALVPCLNAA
PAAIDLLEGLTRQELAGWLKD

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=322, Percent_Identity=25.776397515528, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI60499025, Length=322, Percent_Identity=25.776397515528, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=40.5660377358491, Blast_Score=228, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324750, Length=336, Percent_Identity=25.297619047619, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=26.099706744868, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=26.7924528301887, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37812; Mature: 37681

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLTIRPAKPIAPSRIGVLLTNLGTPEGTGYGAIRRYLSEFLSDRRIIEASPALWQPIL
CCEEEECCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
QGPLLALRPRRTGAAYRRIWHTERDESPLRTHTRAQAEALAARMEPDGVAVEWAMRYGTP
HCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCH
SIASGIERLLARGCARVLLLPLYPQYSATTTATANDHAFRALMRLRNQPAVRTAPSFPDH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
PLYIEALARSVRETLAGLPFVPQRIVASFHGLPRDYVTRGDPYPEECERTLAALRRALDM
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCC
DEETMTLTYQSRFGPARWLEPYTAPLVAGLPARGVTRVAVIMPGFMADCIETLDEIGNEV
CCCCEEEEECCCCCCHHHCCCHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHH
RKDFIAAGGTDFALVPCLNAAPAAIDLLEGLTRQELAGWLKD
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFLTIRPAKPIAPSRIGVLLTNLGTPEGTGYGAIRRYLSEFLSDRRIIEASPALWQPIL
CEEEECCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
QGPLLALRPRRTGAAYRRIWHTERDESPLRTHTRAQAEALAARMEPDGVAVEWAMRYGTP
HCCCEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCH
SIASGIERLLARGCARVLLLPLYPQYSATTTATANDHAFRALMRLRNQPAVRTAPSFPDH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
PLYIEALARSVRETLAGLPFVPQRIVASFHGLPRDYVTRGDPYPEECERTLAALRRALDM
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCC
DEETMTLTYQSRFGPARWLEPYTAPLVAGLPARGVTRVAVIMPGFMADCIETLDEIGNEV
CCCCEEEEECCCCCCHHHCCCHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHH
RKDFIAAGGTDFALVPCLNAAPAAIDLLEGLTRQELAGWLKD
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA