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The map label for this gene is thlA [H]

Identifier: 162147035

GI number: 162147035

Start: 1234245

End: 1235483

Strand: Reverse

Name: thlA [H]

Synonym: GDI_1240

Alternate gene names: 162147035

Gene position: 1235483-1234245 (Counterclockwise)

Preceding gene: 162147036

Following gene: 162147031

Centisome position: 31.32

GC content: 71.75

Gene sequence:

>1239_bases
ATGAAACATGCCATCATGCCGCCGACAGGAACAGCACACCGCCCGGAACCCTCGGCCATGACCAGCATCTTCGTCGTCTC
GGCCGTACGCAGCGCGATCGGCGGTTTCGGGGGCGCCCTGCGCGGTACCGCCCCTTCGGTGCTGGCGGCGCGGCTGATCG
CGGCCGCCGTGGACCGGGCCGGGCTGCCGGCGGATGCGGTGGGGCAGGTGGTGCTGGGACAGGTGATCCCGACCGAACCG
GCCGATCTGTACCTCGCGCGCCACGCTGCGCTGCGGGCGGGCCTGCCGGTCGAGACGGTGGCGATGAACGTCAACCGGAT
CTGCGGTTCCGGCCTGCAGGCGATCATATCGGCCGCGCAGGCCATCCGCCTGGGCGATGCCGATATCGCCGTCGCCGGCG
GTGTCGAAATCATGAGCCGCGCGCCCTACCTGGCGACCGATGCCCGTTTCGGCGGGCGGCTGGGCAACCAGACCCTGCTG
GACCTGCTGGTCGGCGCGCTGACGGACCCGTTCGACCACGTGCATATGGGCGTCACGGCGGAAAACGTCGCCACCACCCA
CGGCATCACCCGCGCCATGCAGGACGACCTGGCGTTCGAAAGCCACCGCCGGGCGTCGGCGGCCATCCGCGCCGGCCGGT
TCGACGGCCAGATCGTCCCGATCGAAATCCGCGCCAATGGCCGCGCCACGCTGTTCGACCGGGACGAGCATGTGCGCCAC
GACGCCGTCCGGGCGGATTTCGATGCCCTGCGCCCGGCCTTCCGCAAGGATGGCGGCACGATCACGGCCGGCAATGCGTC
AGGGATCAATGACGGCGCCGGCATGGTCGTGCTGGCGTCCGGGGACGCGGTGCGGCGGCTGGACCTGACGCCGCTGGCGC
GACTGGTCGCCTATGGGCACGCGGGGGTGGAACCGTCGCAGATGGGCATGGGCCCGGTCCCCGCCACCCGTCGCGCGCTG
GATCGCGCCGGCCTGGGCATCGCGGACCTCGACCTGCTGGAAATGAACGAAGCCTTCGCCGCCCAGGCCTGCGCCGTCAG
CCGGGTGCTGGAACTGGACCCCGCACGGGTCAATCCGAACGGCAGCGGTATCTCGCTGGGCCACCCGATCGGGGCCAGCG
GCGCCATCGCCACCGTGCGCCTGGTCCATGAACTGGCCCGCATCGGCGGGCGCACCGGGCTGGTCAGCCTGTGTATCGGC
GGCGGGCAGGGGATCGCGGCGGTGTTCCAGCGGCCGTGA

Upstream 100 bases:

>100_bases
CCCTGCATGAGGGGCGCTTCCGGCCCACCAGGGGCCATACCGCGATCGTCGAGACCTGACACCCGGCCCGGACGGGGCGG
CGTCCGTGTAGAGCGGCGGC

Downstream 100 bases:

>100_bases
CGGCCGGGCTACAGGATGGCCTTCAGGCGCGTCTCGACGGTTTCGCGTAGTGTCGCGGCCTCGGGCCTGTCCATGCCGGC
CAGGGTGCGGGCCATGGCCT

Product: acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase)

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKHAIMPPTGTAHRPEPSAMTSIFVVSAVRSAIGGFGGALRGTAPSVLAARLIAAAVDRAGLPADAVGQVVLGQVIPTEP
ADLYLARHAALRAGLPVETVAMNVNRICGSGLQAIISAAQAIRLGDADIAVAGGVEIMSRAPYLATDARFGGRLGNQTLL
DLLVGALTDPFDHVHMGVTAENVATTHGITRAMQDDLAFESHRRASAAIRAGRFDGQIVPIEIRANGRATLFDRDEHVRH
DAVRADFDALRPAFRKDGGTITAGNASGINDGAGMVVLASGDAVRRLDLTPLARLVAYGHAGVEPSQMGMGPVPATRRAL
DRAGLGIADLDLLEMNEAFAAQACAVSRVLELDPARVNPNGSGISLGHPIGASGAIATVRLVHELARIGGRTGLVSLCIG
GGQGIAAVFQRP

Sequences:

>Translated_412_residues
MKHAIMPPTGTAHRPEPSAMTSIFVVSAVRSAIGGFGGALRGTAPSVLAARLIAAAVDRAGLPADAVGQVVLGQVIPTEP
ADLYLARHAALRAGLPVETVAMNVNRICGSGLQAIISAAQAIRLGDADIAVAGGVEIMSRAPYLATDARFGGRLGNQTLL
DLLVGALTDPFDHVHMGVTAENVATTHGITRAMQDDLAFESHRRASAAIRAGRFDGQIVPIEIRANGRATLFDRDEHVRH
DAVRADFDALRPAFRKDGGTITAGNASGINDGAGMVVLASGDAVRRLDLTPLARLVAYGHAGVEPSQMGMGPVPATRRAL
DRAGLGIADLDLLEMNEAFAAQACAVSRVLELDPARVNPNGSGISLGHPIGASGAIATVRLVHELARIGGRTGLVSLCIG
GGQGIAAVFQRP
>Mature_412_residues
MKHAIMPPTGTAHRPEPSAMTSIFVVSAVRSAIGGFGGALRGTAPSVLAARLIAAAVDRAGLPADAVGQVVLGQVIPTEP
ADLYLARHAALRAGLPVETVAMNVNRICGSGLQAIISAAQAIRLGDADIAVAGGVEIMSRAPYLATDARFGGRLGNQTLL
DLLVGALTDPFDHVHMGVTAENVATTHGITRAMQDDLAFESHRRASAAIRAGRFDGQIVPIEIRANGRATLFDRDEHVRH
DAVRADFDALRPAFRKDGGTITAGNASGINDGAGMVVLASGDAVRRLDLTPLARLVAYGHAGVEPSQMGMGPVPATRRAL
DRAGLGIADLDLLEMNEAFAAQACAVSRVLELDPARVNPNGSGISLGHPIGASGAIATVRLVHELARIGGRTGLVSLCIG
GGQGIAAVFQRP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=45.2442159383033, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=43.2225063938619, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=38.8613861386139, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4501853, Length=407, Percent_Identity=39.0663390663391, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=29.0094339622642, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI194353979, Length=403, Percent_Identity=30.5210918114144, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=48.8549618320611, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=47.9899497487437, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=43.1761786600496, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=37.6884422110553, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=31.4634146341463, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=43.8461538461538, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=38.676844783715, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=33.1645569620253, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17535917, Length=403, Percent_Identity=30.7692307692308, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=27.6995305164319, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=36.6583541147132, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322031, Length=409, Percent_Identity=34.718826405868, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=45.5470737913486, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=43.2911392405063, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=38.4039900249377, Blast_Score=257, Evalue=8e-69,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=29.9539170506912, Blast_Score=158, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42410; Mature: 42410

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAIMPPTGTAHRPEPSAMTSIFVVSAVRSAIGGFGGALRGTAPSVLAARLIAAAVDRA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
GLPADAVGQVVLGQVIPTEPADLYLARHAALRAGLPVETVAMNVNRICGSGLQAIISAAQ
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIRLGDADIAVAGGVEIMSRAPYLATDARFGGRLGNQTLLDLLVGALTDPFDHVHMGVTA
HHCCCCCCEEEECCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHEECCCH
ENVATTHGITRAMQDDLAFESHRRASAAIRAGRFDGQIVPIEIRANGRATLFDRDEHVRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEECCHHHHHH
DAVRADFDALRPAFRKDGGTITAGNASGINDGAGMVVLASGDAVRRLDLTPLARLVAYGH
HHHHHCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCEEEECHHHHHHHHHHCC
AGVEPSQMGMGPVPATRRALDRAGLGIADLDLLEMNEAFAAQACAVSRVLELDPARVNPN
CCCCHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
GSGISLGHPIGASGAIATVRLVHELARIGGRTGLVSLCIGGGQGIAAVFQRP
CCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCC
>Mature Secondary Structure
MKHAIMPPTGTAHRPEPSAMTSIFVVSAVRSAIGGFGGALRGTAPSVLAARLIAAAVDRA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
GLPADAVGQVVLGQVIPTEPADLYLARHAALRAGLPVETVAMNVNRICGSGLQAIISAAQ
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIRLGDADIAVAGGVEIMSRAPYLATDARFGGRLGNQTLLDLLVGALTDPFDHVHMGVTA
HHCCCCCCEEEECCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHEECCCH
ENVATTHGITRAMQDDLAFESHRRASAAIRAGRFDGQIVPIEIRANGRATLFDRDEHVRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEECCHHHHHH
DAVRADFDALRPAFRKDGGTITAGNASGINDGAGMVVLASGDAVRRLDLTPLARLVAYGH
HHHHHCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCEEEECHHHHHHHHHHCC
AGVEPSQMGMGPVPATRRALDRAGLGIADLDLLEMNEAFAAQACAVSRVLELDPARVNPN
CCCCHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
GSGISLGHPIGASGAIATVRLVHELARIGGRTGLVSLCIGGGQGIAAVFQRP
CCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]