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The map label for this gene is emrY [H]

Identifier: 162146818

GI number: 162146818

Start: 1015058

End: 1016779

Strand: Reverse

Name: emrY [H]

Synonym: GDI_1000

Alternate gene names: 162146818

Gene position: 1016779-1015058 (Counterclockwise)

Preceding gene: 162146820

Following gene: 162146817

Centisome position: 25.78

GC content: 64.05

Gene sequence:

>1722_bases
ATGGGATGTTTCTTCAAGACTGCCGACACGAGATCAAACGATGCTGTTGCGAGGTATCCTGTGGACCACGCTGATACGCT
GGCGCTGTCGCGTCCCGACGGGCTGCCCGTGCCCGTGCTGCTGCAACCGGAACCACCTCCGGCGCCGCCGAAGGCTGCGG
TGTTCGGTCCGCGCCTGGCCACGGGGCTGGCGGGCGTGCTGCTGGCAGTTCTGCTGGCGGGGTTCAACGAGCACACGACC
GAGGCTGGGCTCGCCGATATCCGGGGCGCATTCCATCTCGGGCATGACGAGGGGACCTGGATCACCGCCGTGTTCGAGGC
GTTCAACATCGCTGCGATGGCGTTCGCGCCCTGGTGTTCGGTGACGTTCTCCATCCGACGCCTGACGATCGCGATGACGG
GGCTAGTGGGCGTGCTGGGTACGGCGGCACCCTTCATGCCGAACCTGTCGTCTCTTCTTCTGCTGCGCTGCGTGCAGGGA
TTGGCTTGCGGTAGCCTGCCGCCAATGCTGATGACGGTGGCGCTGCGCTTCCTGCCGCCCAATATCAAGATCTACGGTCT
GGGCGCCTATGCCCTGACCGCGACTTTCGGGCCGAATATTGGCGGCGCGCCGCTGGCGGGATTCTGGTTCGAGTATGTCG
GCTGGCCGTTCCTGTTCTGGCAGATCGTGCCGCTGTGCCTGATCTCGATGGTGTGCGTGGCGTGGGGCCTGCCGCAGGAC
CCGATCCGGCTGGAGCGTTTTCGCCAGTTCGATTGGCGTGGCCTGCTGACCGGCTTGCCTGCGATCTGCATGCTGGTGAT
CGCGCTGGAGCAGGGGGACCGGCTGGACTGGTTTCGCTCGCCGTTGATCACCCACCTCTTCTTCGGCGGCGGGTTCCTGT
TCGTGCTCTTCATCGTCAATGAATGGTTCCATCCGGTGCCGTTTTTCCGCATCCAGTTGCTCAAGCAGCGCAACGTGACG
GATGCGCTGCTGACGCTGGCGGCGGTTCTGGTATTGGGGGCGGTCACGGCGGAAATCCCTGCGGTCTATCTGGAGGAGGT
GCGCGGCTATCGCCCGATCCAGATCGCGCCGGTCATGCTGATCCTCGCGCTGCCACAAGTGCTAGCGCTGCCGCTGGTCT
CGGCCCTGTGCAACATCCGCCGGGTGGATTGCCGTCATGTGCTGATGGCAGGCCTTGCGATCCAGGGGCTGTCCTATTTC
CTTGGCACCTGGATCGATGCTGACTGGGTGCGCGAGAACTTCTATGCCATGCAGCTCCTGCAGGTGGCCAGCGAACCGAT
GATGGTCATTGCAATCCTGATGCTGGCGACGATGGGCCTGGGTCCGGCCGATGGACCGTTCATCTCGGGCATGTTCAACA
TGACCAAGGGAGTGGCCAACGCCATTGCTGCGGGCGTTATTTCCGCCCTGCTGCGCCGGCGCGAGCAATTCCATTCCACC
ATGCTGCTCGACACCTATGGCACCAACCATACCGCGTTGCAGTCCTGGGGCGACCCGGCGCAGGCGCTGCTGGCGCCGCA
CATCGTTGATCCGGCCCGGCTGGACTGGAACATGACCGTCTTGCTGCACGGCGAGGCGTCGGAGCAGGCGCTCATTCTGG
CCTGTGCAGATATCTACACGATCATGATCGGCGTCTGCGCCGCCCTGTTCATGCTCAATCTGGTTCTGCCGCAACGGGTT
TATCCGCCCCGCGCGCCGTCCACCTCCGCTCCTGCACGCTGA

Upstream 100 bases:

>100_bases
GCCAACGCTGGCAGAGACATCGCCGCGTCGCAACGGGAATCTGACATCCGACCGTTCCATATCTGCTTCCCGACGATTTC
ATAATTGAGCGTTCCCAAAC

Downstream 100 bases:

>100_bases
CGGAGACGGACAGTATGTCATGTGAGACCAATATGAAGACCAGTTCGTATCGGGATACGCGCCGCGTGCGGCATCCAGAC
ATCCTATCATCGGATCAGAC

Product: multidrug efflux transporter protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MGCFFKTADTRSNDAVARYPVDHADTLALSRPDGLPVPVLLQPEPPPAPPKAAVFGPRLATGLAGVLLAVLLAGFNEHTT
EAGLADIRGAFHLGHDEGTWITAVFEAFNIAAMAFAPWCSVTFSIRRLTIAMTGLVGVLGTAAPFMPNLSSLLLLRCVQG
LACGSLPPMLMTVALRFLPPNIKIYGLGAYALTATFGPNIGGAPLAGFWFEYVGWPFLFWQIVPLCLISMVCVAWGLPQD
PIRLERFRQFDWRGLLTGLPAICMLVIALEQGDRLDWFRSPLITHLFFGGGFLFVLFIVNEWFHPVPFFRIQLLKQRNVT
DALLTLAAVLVLGAVTAEIPAVYLEEVRGYRPIQIAPVMLILALPQVLALPLVSALCNIRRVDCRHVLMAGLAIQGLSYF
LGTWIDADWVRENFYAMQLLQVASEPMMVIAILMLATMGLGPADGPFISGMFNMTKGVANAIAAGVISALLRRREQFHST
MLLDTYGTNHTALQSWGDPAQALLAPHIVDPARLDWNMTVLLHGEASEQALILACADIYTIMIGVCAALFMLNLVLPQRV
YPPRAPSTSAPAR

Sequences:

>Translated_573_residues
MGCFFKTADTRSNDAVARYPVDHADTLALSRPDGLPVPVLLQPEPPPAPPKAAVFGPRLATGLAGVLLAVLLAGFNEHTT
EAGLADIRGAFHLGHDEGTWITAVFEAFNIAAMAFAPWCSVTFSIRRLTIAMTGLVGVLGTAAPFMPNLSSLLLLRCVQG
LACGSLPPMLMTVALRFLPPNIKIYGLGAYALTATFGPNIGGAPLAGFWFEYVGWPFLFWQIVPLCLISMVCVAWGLPQD
PIRLERFRQFDWRGLLTGLPAICMLVIALEQGDRLDWFRSPLITHLFFGGGFLFVLFIVNEWFHPVPFFRIQLLKQRNVT
DALLTLAAVLVLGAVTAEIPAVYLEEVRGYRPIQIAPVMLILALPQVLALPLVSALCNIRRVDCRHVLMAGLAIQGLSYF
LGTWIDADWVRENFYAMQLLQVASEPMMVIAILMLATMGLGPADGPFISGMFNMTKGVANAIAAGVISALLRRREQFHST
MLLDTYGTNHTALQSWGDPAQALLAPHIVDPARLDWNMTVLLHGEASEQALILACADIYTIMIGVCAALFMLNLVLPQRV
YPPRAPSTSAPAR
>Mature_572_residues
GCFFKTADTRSNDAVARYPVDHADTLALSRPDGLPVPVLLQPEPPPAPPKAAVFGPRLATGLAGVLLAVLLAGFNEHTTE
AGLADIRGAFHLGHDEGTWITAVFEAFNIAAMAFAPWCSVTFSIRRLTIAMTGLVGVLGTAAPFMPNLSSLLLLRCVQGL
ACGSLPPMLMTVALRFLPPNIKIYGLGAYALTATFGPNIGGAPLAGFWFEYVGWPFLFWQIVPLCLISMVCVAWGLPQDP
IRLERFRQFDWRGLLTGLPAICMLVIALEQGDRLDWFRSPLITHLFFGGGFLFVLFIVNEWFHPVPFFRIQLLKQRNVTD
ALLTLAAVLVLGAVTAEIPAVYLEEVRGYRPIQIAPVMLILALPQVLALPLVSALCNIRRVDCRHVLMAGLAIQGLSYFL
GTWIDADWVRENFYAMQLLQVASEPMMVIAILMLATMGLGPADGPFISGMFNMTKGVANAIAAGVISALLRRREQFHSTM
LLDTYGTNHTALQSWGDPAQALLAPHIVDPARLDWNMTVLLHGEASEQALILACADIYTIMIGVCAALFMLNLVLPQRVY
PPRAPSTSAPAR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=509, Percent_Identity=22.2003929273084, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789042, Length=437, Percent_Identity=22.6544622425629, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 62367; Mature: 62235

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCFFKTADTRSNDAVARYPVDHADTLALSRPDGLPVPVLLQPEPPPAPPKAAVFGPRLA
CCCCCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCHHH
TGLAGVLLAVLLAGFNEHTTEAGLADIRGAFHLGHDEGTWITAVFEAFNIAAMAFAPWCS
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VTFSIRRLTIAMTGLVGVLGTAAPFMPNLSSLLLLRCVQGLACGSLPPMLMTVALRFLPP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
NIKIYGLGAYALTATFGPNIGGAPLAGFWFEYVGWPFLFWQIVPLCLISMVCVAWGLPQD
CEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PIRLERFRQFDWRGLLTGLPAICMLVIALEQGDRLDWFRSPLITHLFFGGGFLFVLFIVN
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EWFHPVPFFRIQLLKQRNVTDALLTLAAVLVLGAVTAEIPAVYLEEVRGYRPIQIAPVML
HHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ILALPQVLALPLVSALCNIRRVDCRHVLMAGLAIQGLSYFLGTWIDADWVRENFYAMQLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QVASEPMMVIAILMLATMGLGPADGPFISGMFNMTKGVANAIAAGVISALLRRREQFHST
HHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
MLLDTYGTNHTALQSWGDPAQALLAPHIVDPARLDWNMTVLLHGEASEQALILACADIYT
EEEECCCCCCHHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEHHHHHHHH
IMIGVCAALFMLNLVLPQRVYPPRAPSTSAPAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GCFFKTADTRSNDAVARYPVDHADTLALSRPDGLPVPVLLQPEPPPAPPKAAVFGPRLA
CCCCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCHHH
TGLAGVLLAVLLAGFNEHTTEAGLADIRGAFHLGHDEGTWITAVFEAFNIAAMAFAPWCS
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VTFSIRRLTIAMTGLVGVLGTAAPFMPNLSSLLLLRCVQGLACGSLPPMLMTVALRFLPP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
NIKIYGLGAYALTATFGPNIGGAPLAGFWFEYVGWPFLFWQIVPLCLISMVCVAWGLPQD
CEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PIRLERFRQFDWRGLLTGLPAICMLVIALEQGDRLDWFRSPLITHLFFGGGFLFVLFIVN
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EWFHPVPFFRIQLLKQRNVTDALLTLAAVLVLGAVTAEIPAVYLEEVRGYRPIQIAPVML
HHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ILALPQVLALPLVSALCNIRRVDCRHVLMAGLAIQGLSYFLGTWIDADWVRENFYAMQLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QVASEPMMVIAILMLATMGLGPADGPFISGMFNMTKGVANAIAAGVISALLRRREQFHST
HHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
MLLDTYGTNHTALQSWGDPAQALLAPHIVDPARLDWNMTVLLHGEASEQALILACADIYT
EEEECCCCCCHHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEHHHHHHHH
IMIGVCAALFMLNLVLPQRVYPPRAPSTSAPAR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]