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The map label for this gene is pth [H]

Identifier: 162146758

GI number: 162146758

Start: 951463

End: 952002

Strand: Direct

Name: pth [H]

Synonym: GDI_0936

Alternate gene names: 162146758

Gene position: 951463-952002 (Clockwise)

Preceding gene: 162146757

Following gene: 162146759

Centisome position: 24.12

GC content: 66.11

Gene sequence:

>540_bases
ATGAGCCGGCACCGGCATAATGTCGGTTTCATGGCCGTCGACCGGATCGCGACCCGCCATGGCTTTGCGCCATGGCGGAA
ACGCTTCCGGGGCGAGGTGGCGGAGGGCCGGGTGGGCACGCACAAGGTGCTGCTGCTCAAACCCCTGACCTATATGAACC
TTTCCGGTGAGAGCGTTCAGCAGGCCGCCGCCTTCTATAAAATTCCCGTGGAGTCCATCACCGCGTTTCATGACGAACTG
GACCTGGCGCCGGGCCGGGTGCGGGTGAAGCGGGGCGGCGGGGCCGCTGGCCATAACGGCCTGCGCTCGATGGACAAGAT
GCTGGGCAGCCAGGATTACTGGCGTGTCCGCATCGGCATCGGCCATCCCGGCGTGCGCGAGCGCGTGACGGGCCATGTGC
TGGGCGATTTCGCGAAAAGCGACCAGGACTGGCTGGAGCGCATGCTCGACGCCATGTCCGACACGGCGCCGGTCCTGGCG
GACGGGCAGCCCGAACTGTTCATGACGAAGATGGCCTTGCTGGCCGGGGAGAAGGGCTGA

Upstream 100 bases:

>100_bases
GCCCGAGCCCGCCGCTGCCCCCGCCGCGGCTCCCGCGAAGAAGTAAGTCCGGGGAGACGGCATGCTGCTCTGGACCGGGC
TCGGAAATCCTGAGCCGGGG

Downstream 100 bases:

>100_bases
TGGGGTTCAATTGCGGCATCGTGGGCCTGCCGAATGTCGGCAAGTCCACTCTGTTCAACGCCCTGACCGAAACCGCGTCG
GCCCAGGCCGCGAACTATCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSRHRHNVGFMAVDRIATRHGFAPWRKRFRGEVAEGRVGTHKVLLLKPLTYMNLSGESVQQAAAFYKIPVESITAFHDEL
DLAPGRVRVKRGGGAAGHNGLRSMDKMLGSQDYWRVRIGIGHPGVRERVTGHVLGDFAKSDQDWLERMLDAMSDTAPVLA
DGQPELFMTKMALLAGEKG

Sequences:

>Translated_179_residues
MSRHRHNVGFMAVDRIATRHGFAPWRKRFRGEVAEGRVGTHKVLLLKPLTYMNLSGESVQQAAAFYKIPVESITAFHDEL
DLAPGRVRVKRGGGAAGHNGLRSMDKMLGSQDYWRVRIGIGHPGVRERVTGHVLGDFAKSDQDWLERMLDAMSDTAPVLA
DGQPELFMTKMALLAGEKG
>Mature_178_residues
SRHRHNVGFMAVDRIATRHGFAPWRKRFRGEVAEGRVGTHKVLLLKPLTYMNLSGESVQQAAAFYKIPVESITAFHDELD
LAPGRVRVKRGGGAAGHNGLRSMDKMLGSQDYWRVRIGIGHPGVRERVTGHVLGDFAKSDQDWLERMLDAMSDTAPVLAD
GQPELFMTKMALLAGEKG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=153, Percent_Identity=39.2156862745098, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1787455, Length=149, Percent_Identity=43.6241610738255, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 19849; Mature: 19718

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHRHNVGFMAVDRIATRHGFAPWRKRFRGEVAEGRVGTHKVLLLKPLTYMNLSGESVQ
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHCCCCCHHHH
QAAAFYKIPVESITAFHDELDLAPGRVRVKRGGGAAGHNGLRSMDKMLGSQDYWRVRIGI
HHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEC
GHPGVRERVTGHVLGDFAKSDQDWLERMLDAMSDTAPVLADGQPELFMTKMALLAGEKG
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRHRHNVGFMAVDRIATRHGFAPWRKRFRGEVAEGRVGTHKVLLLKPLTYMNLSGESVQ
CCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEEEECCCHHCCCCCHHHH
QAAAFYKIPVESITAFHDELDLAPGRVRVKRGGGAAGHNGLRSMDKMLGSQDYWRVRIGI
HHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEEC
GHPGVRERVTGHVLGDFAKSDQDWLERMLDAMSDTAPVLADGQPELFMTKMALLAGEKG
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA