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The map label for this gene is prs [H]

Identifier: 162146755

GI number: 162146755

Start: 948992

End: 949972

Strand: Direct

Name: prs [H]

Synonym: GDI_0933

Alternate gene names: 162146755

Gene position: 948992-949972 (Clockwise)

Preceding gene: 162146754

Following gene: 162146756

Centisome position: 24.06

GC content: 66.46

Gene sequence:

>981_bases
ATGAAGATCGTCGCCTGTAACAGCAACCTGCCTCTTGCCGAAAAGGTTGCGTCCGAGCTGCGGATGCCCCTGTGCAACGT
ATCGGTCCGGCGCTTCGCGGACATGGAGGTCTTCGTCGAGATCCACGAGAACGTCCGGGGCGAGGACGTGTTCGTGATCC
AGAGCACCTGCGCGCCGACCAACGACAACCTGATGGAACTGCTGATCATGCTGGACGCGTTGCGTCGCGGGTCGGCACGG
CGCGTCACGGCGGTGATGCCCTATTTCGGCTACGCGCGGCAGGATCGCAAATCCGGCCCCCGCACCCCCATCAGCGCCAA
GCTGGTGGCCAACCTGCTGGTCGAAGCCGGCGCGAACCGGGTGCTGACGATGGACCTGCACGCGATGCAGATCCAGGGCT
TCTTCGACATCCCGGTCGACAACCTGTATGCGGCGCCCCTGTTCACCCGCGACATCAAGGGGCGTATCGATCACGGAACG
CTGCCCTATCTCGCGCCGCCGATGTCCATTCCCGGCGGGTTCCAGAACCTGATGATCGTCTCGCCCGACGTCGGCGGCGT
GGTGCGCGCCCGGCAACTGGCGCAGCGCCTGAACGTGGACCTGGCGATCATCGACAAGCGGCGCGAGCGCGCCGGCGTGT
CCGAGGTCATGAACGTCATCGGCGACGTGCGCGGCCGCTATTGCATCATGATCGACGATATCGTCGATAGCGGCGGGTCG
CTGTGCAACGCCGCCGCAGCCCTGGTCAAGGAAGGGGCGGTGGCGGTCGAGGCCTACGTGACCCACGGCGTCCTGACCGG
CGGCGCGGTGCAGCGCATCGCGCAGTCGCCCATCGGCATGCTGACCCTGACCGACAGCATCGCCGCGACCGAGGCGGTGG
CGCAGGCCACGAACATCCGCCAGATCAGCACCGCCAACCTGCTCTCGCGCGCCATGCGCGCCGTGTCGGACGAAAGCTCG
GTCTCCTCCCTCTTCGATTAG

Upstream 100 bases:

>100_bases
CGGCATGCGCGACCGTTGCGGGAGACGGATGACACGGCCCGGCGCGATTGCTAGAACCCGCGCGCCAGCATACGAGACCG
CCGCCCAGGAGCGTCGCCAT

Downstream 100 bases:

>100_bases
GCCGTTCGGTCCCGCCAGCCTCCGATTGACCTGGTGCGGAGATGCACCTATCGGGGAAAGCGAATCGAGAGGAGCCGTCC
GACATGACCAAGCTGATCGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKIVACNSNLPLAEKVASELRMPLCNVSVRRFADMEVFVEIHENVRGEDVFVIQSTCAPTNDNLMELLIMLDALRRGSAR
RVTAVMPYFGYARQDRKSGPRTPISAKLVANLLVEAGANRVLTMDLHAMQIQGFFDIPVDNLYAAPLFTRDIKGRIDHGT
LPYLAPPMSIPGGFQNLMIVSPDVGGVVRARQLAQRLNVDLAIIDKRRERAGVSEVMNVIGDVRGRYCIMIDDIVDSGGS
LCNAAAALVKEGAVAVEAYVTHGVLTGGAVQRIAQSPIGMLTLTDSIAATEAVAQATNIRQISTANLLSRAMRAVSDESS
VSSLFD

Sequences:

>Translated_326_residues
MKIVACNSNLPLAEKVASELRMPLCNVSVRRFADMEVFVEIHENVRGEDVFVIQSTCAPTNDNLMELLIMLDALRRGSAR
RVTAVMPYFGYARQDRKSGPRTPISAKLVANLLVEAGANRVLTMDLHAMQIQGFFDIPVDNLYAAPLFTRDIKGRIDHGT
LPYLAPPMSIPGGFQNLMIVSPDVGGVVRARQLAQRLNVDLAIIDKRRERAGVSEVMNVIGDVRGRYCIMIDDIVDSGGS
LCNAAAALVKEGAVAVEAYVTHGVLTGGAVQRIAQSPIGMLTLTDSIAATEAVAQATNIRQISTANLLSRAMRAVSDESS
VSSLFD
>Mature_326_residues
MKIVACNSNLPLAEKVASELRMPLCNVSVRRFADMEVFVEIHENVRGEDVFVIQSTCAPTNDNLMELLIMLDALRRGSAR
RVTAVMPYFGYARQDRKSGPRTPISAKLVANLLVEAGANRVLTMDLHAMQIQGFFDIPVDNLYAAPLFTRDIKGRIDHGT
LPYLAPPMSIPGGFQNLMIVSPDVGGVVRARQLAQRLNVDLAIIDKRRERAGVSEVMNVIGDVRGRYCIMIDDIVDSGGS
LCNAAAALVKEGAVAVEAYVTHGVLTGGAVQRIAQSPIGMLTLTDSIAATEAVAQATNIRQISTANLLSRAMRAVSDESS
VSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=325, Percent_Identity=44.6153846153846, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI4506129, Length=319, Percent_Identity=44.8275862068966, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI28557709, Length=325, Percent_Identity=44, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI84875539, Length=322, Percent_Identity=44.4099378881988, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4506133, Length=357, Percent_Identity=32.4929971988796, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI194018537, Length=351, Percent_Identity=31.9088319088319, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787458, Length=328, Percent_Identity=49.0853658536585, Blast_Score=323, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI17554702, Length=325, Percent_Identity=44, Blast_Score=272, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI25149168, Length=325, Percent_Identity=44, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71989924, Length=325, Percent_Identity=44, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17554704, Length=319, Percent_Identity=44.5141065830721, Blast_Score=270, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI17570245, Length=352, Percent_Identity=30.3977272727273, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319403, Length=327, Percent_Identity=40.6727828746177, Blast_Score=241, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6321776, Length=326, Percent_Identity=40.4907975460123, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6320946, Length=327, Percent_Identity=40.0611620795107, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322667, Length=210, Percent_Identity=39.5238095238095, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=101, Percent_Identity=44.5544554455446, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355239, Length=325, Percent_Identity=43.0769230769231, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI45551540, Length=348, Percent_Identity=40.2298850574713, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24651458, Length=366, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651456, Length=366, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281362873, Length=366, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651454, Length=366, Percent_Identity=31.1475409836066, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552010, Length=378, Percent_Identity=30.1587301587302, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24651462, Length=378, Percent_Identity=30.1587301587302, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24651464, Length=378, Percent_Identity=30.1587301587302, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35226; Mature: 35226

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVACNSNLPLAEKVASELRMPLCNVSVRRFADMEVFVEIHENVRGEDVFVIQSTCAPT
CEEEEECCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
NDNLMELLIMLDALRRGSARRVTAVMPYFGYARQDRKSGPRTPISAKLVANLLVEAGANR
CHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCE
VLTMDLHAMQIQGFFDIPVDNLYAAPLFTRDIKGRIDHGTLPYLAPPMSIPGGFQNLMIV
EEEEEEEEEEECCEEECCCCCEEECCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SPDVGGVVRARQLAQRLNVDLAIIDKRRERAGVSEVMNVIGDVRGRYCIMIDDIVDSGGS
CCCCCHHHHHHHHHHHHCCCEEEEECHHHHCCHHHHHHHHHHCCCCEEEEEEHHHCCCCH
LCNAAAALVKEGAVAVEAYVTHGVLTGGAVQRIAQSPIGMLTLTDSIAATEAVAQATNIR
HHHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCH
QISTANLLSRAMRAVSDESSVSSLFD
HHHHHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MKIVACNSNLPLAEKVASELRMPLCNVSVRRFADMEVFVEIHENVRGEDVFVIQSTCAPT
CEEEEECCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
NDNLMELLIMLDALRRGSARRVTAVMPYFGYARQDRKSGPRTPISAKLVANLLVEAGANR
CHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCE
VLTMDLHAMQIQGFFDIPVDNLYAAPLFTRDIKGRIDHGTLPYLAPPMSIPGGFQNLMIV
EEEEEEEEEEECCEEECCCCCEEECCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SPDVGGVVRARQLAQRLNVDLAIIDKRRERAGVSEVMNVIGDVRGRYCIMIDDIVDSGGS
CCCCCHHHHHHHHHHHHCCCEEEEECHHHHCCHHHHHHHHHHCCCCEEEEEEHHHCCCCH
LCNAAAALVKEGAVAVEAYVTHGVLTGGAVQRIAQSPIGMLTLTDSIAATEAVAQATNIR
HHHHHHHHHHCCCCEEEHHHHHHHHCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCH
QISTANLLSRAMRAVSDESSVSSLFD
HHHHHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA