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The map label for this gene is hldD [H]

Identifier: 162146750

GI number: 162146750

Start: 944188

End: 945165

Strand: Direct

Name: hldD [H]

Synonym: GDI_0928

Alternate gene names: 162146750

Gene position: 944188-945165 (Clockwise)

Preceding gene: 162146745

Following gene: 162146751

Centisome position: 23.94

GC content: 69.02

Gene sequence:

>978_bases
ATGATCATCATCACCGGCGGGGCCGGCTTCATCGGATCGTGCCTGCAGGCGGCGCTTCAGGCGCGGGGCGAGCAGACGGT
CGTCGTCGACTGGCTGGGCAGCCAGGGCAAGTGGCGCAACATCGCGCGCCACCCGCCCGACCACCTGCTGACGCCCGAGG
CACTGGACGATTTCCTGGCCGGCCGGCCCGCCGTGTCCGCCATCCTGCATATGGGCGCGATCAGCGAGACGACGGCCTGT
GACGGCGACCTGGCCTGGCGCACCAATGTCGACCTGTCGGCGCGGCTGTGGGCGTGGTGCGCGCGGCATGGCGTGCGCTT
CATCTACGCGTCCTCGGCCGCGACCTATGGCGCGGCCGGGGACGAATCGTTTTCCGACGATCCCGCGGGGCTGGAGGCAT
TGCGGCCGCTGAACCTGTACGGCTGGTCGAAGCATGTGTTCGACCGGCAGGTCGTGGCCGGCCTGGCCCGCGGCGCGTCG
TCGCCGCCGCAATGGGCGGGACTGAAATTCTTCAACGTCTATGGCCCGAACGAATATCACAAGGGCCCGATGGTCTCGGT
CGTGAAGGTCAAGTACGACGAGGTCCGCCGGGGCCAGCCGGCGCGGCTTGTTCGCTCGGACGTTCCCGGCCTGGCCGATT
GGGCGCAGGCGCGGGATTTCATCTGGGTCGGCGACGTGGTGGACGTGACGCTGTGGCTGCTGGACAGCCCGCATGTCAGC
GGCCTGTTCAATTGCGGCACCGGGGTCGCGCGCAGCTACCTGGACCTGGCCCATGCGGTCTGCGACGCCGCCGGCCGGCC
GCGCCAGGTCGAATTCGTCGACATGCCCGACGCGCTGCGCGGCCATTACCAGTCCTATACCCGCGCCGACATGACGCGGC
TGCGCCAGGCGGGATATGCCCGGCCCTTCACGTCGCTGGAAGACGGCATCCGTCGCTACGTCCAGGATTACCTGGCCACC
GACGACGCCTACCTGTAA

Upstream 100 bases:

>100_bases
GTCGATGCACAGCATATAGCCAGTCCCGCCCCCGAAGACCATGCGCCTGCGCATTTCGGGGGCGGGACAGGGGGCGCGAT
CTGCTCTATAGAACGGGCTC

Downstream 100 bases:

>100_bases
CGCGCGCCCCGGTCATGCCGCCCCGGTCATGTCATTGAAGCAGAAAGACGCCGCATGCTGCCTGTCCTGATTTTCCCGCA
ATTCGATCCGGTCATGGTGC

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIIITGGAGFIGSCLQAALQARGEQTVVVDWLGSQGKWRNIARHPPDHLLTPEALDDFLAGRPAVSAILHMGAISETTAC
DGDLAWRTNVDLSARLWAWCARHGVRFIYASSAATYGAAGDESFSDDPAGLEALRPLNLYGWSKHVFDRQVVAGLARGAS
SPPQWAGLKFFNVYGPNEYHKGPMVSVVKVKYDEVRRGQPARLVRSDVPGLADWAQARDFIWVGDVVDVTLWLLDSPHVS
GLFNCGTGVARSYLDLAHAVCDAAGRPRQVEFVDMPDALRGHYQSYTRADMTRLRQAGYARPFTSLEDGIRRYVQDYLAT
DDAYL

Sequences:

>Translated_325_residues
MIIITGGAGFIGSCLQAALQARGEQTVVVDWLGSQGKWRNIARHPPDHLLTPEALDDFLAGRPAVSAILHMGAISETTAC
DGDLAWRTNVDLSARLWAWCARHGVRFIYASSAATYGAAGDESFSDDPAGLEALRPLNLYGWSKHVFDRQVVAGLARGAS
SPPQWAGLKFFNVYGPNEYHKGPMVSVVKVKYDEVRRGQPARLVRSDVPGLADWAQARDFIWVGDVVDVTLWLLDSPHVS
GLFNCGTGVARSYLDLAHAVCDAAGRPRQVEFVDMPDALRGHYQSYTRADMTRLRQAGYARPFTSLEDGIRRYVQDYLAT
DDAYL
>Mature_325_residues
MIIITGGAGFIGSCLQAALQARGEQTVVVDWLGSQGKWRNIARHPPDHLLTPEALDDFLAGRPAVSAILHMGAISETTAC
DGDLAWRTNVDLSARLWAWCARHGVRFIYASSAATYGAAGDESFSDDPAGLEALRPLNLYGWSKHVFDRQVVAGLARGAS
SPPQWAGLKFFNVYGPNEYHKGPMVSVVKVKYDEVRRGQPARLVRSDVPGLADWAQARDFIWVGDVVDVTLWLLDSPHVS
GLFNCGTGVARSYLDLAHAVCDAAGRPRQVEFVDMPDALRGHYQSYTRADMTRLRQAGYARPFTSLEDGIRRYVQDYLAT
DDAYL

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=318, Percent_Identity=40.5660377358491, Blast_Score=211, Evalue=5e-56,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 35700; Mature: 35700

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIITGGAGFIGSCLQAALQARGEQTVVVDWLGSQGKWRNIARHPPDHLLTPEALDDFLA
CEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHC
GRPAVSAILHMGAISETTACDGDLAWRTNVDLSARLWAWCARHGVRFIYASSAATYGAAG
CCHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCC
DESFSDDPAGLEALRPLNLYGWSKHVFDRQVVAGLARGASSPPQWAGLKFFNVYGPNEYH
CCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
KGPMVSVVKVKYDEVRRGQPARLVRSDVPGLADWAQARDFIWVGDVVDVTLWLLDSPHVS
CCCCEEEEEEEHHHHHCCCCHHHHHHCCCCHHHHHHHCCCEEECHHHHHHHHHCCCCCCC
GLFNCGTGVARSYLDLAHAVCDAAGRPRQVEFVDMPDALRGHYQSYTRADMTRLRQAGYA
CHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
RPFTSLEDGIRRYVQDYLATDDAYL
CCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIIITGGAGFIGSCLQAALQARGEQTVVVDWLGSQGKWRNIARHPPDHLLTPEALDDFLA
CEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHC
GRPAVSAILHMGAISETTACDGDLAWRTNVDLSARLWAWCARHGVRFIYASSAATYGAAG
CCHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCC
DESFSDDPAGLEALRPLNLYGWSKHVFDRQVVAGLARGASSPPQWAGLKFFNVYGPNEYH
CCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
KGPMVSVVKVKYDEVRRGQPARLVRSDVPGLADWAQARDFIWVGDVVDVTLWLLDSPHVS
CCCCEEEEEEEHHHHHCCCCHHHHHHCCCCHHHHHHHCCCEEECHHHHHHHHHCCCCCCC
GLFNCGTGVARSYLDLAHAVCDAAGRPRQVEFVDMPDALRGHYQSYTRADMTRLRQAGYA
CHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
RPFTSLEDGIRRYVQDYLATDDAYL
CCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]