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The map label for this gene is galM [H]

Identifier: 162146688

GI number: 162146688

Start: 882684

End: 883892

Strand: Direct

Name: galM [H]

Synonym: GDI_0866

Alternate gene names: 162146688

Gene position: 882684-883892 (Clockwise)

Preceding gene: 162146685

Following gene: 162146689

Centisome position: 22.38

GC content: 67.91

Gene sequence:

>1209_bases
ATGCTCAGAATCTCCCCGACCCGTCTTGCCACGTCGCTGCTGGCGGCCACGGCCCTGGTGTCCGCTACCCTGGCATCCGC
CACGCCCGTCCGGGCGGCCGATGCCCCGGTCGCGCTGGCCCGGGCCGGCTTCGGCACGATGGCGGACGGCAAGCCGGTCG
AGATTCTGACCCTGCGCAACGCCCATGGTGTCTCGGTGCGCTTCATCACCTATGGTGGCATCATCACCGCGATCGACACG
CCCGACCGGACCGGCCACACCGACGATATCGTCCTCGGCTTTCCCGACCTGCAGGGCTATACGGTGGACAGCGCCCAGGG
CGGCCTGTTCTTCGGCGCCATGATCGGCCGCTACGCCAACCGGATCGCGCGCGGCACCTTCACCCTGGACGGCGCGACGT
ATCACGTTCCCGTGACGGCGCCGCCGAATGCGCTGCATGGCGGCACCAGGGGCTTCGACAAGCATCTGTGGACCGTCGAC
GGCACCGCCACGGACGCCCATTCGGCCAGCGCCACGCTGTCGCTGACCAGCCCGGATGGGGACCAGGGCTTCCCCGGCAC
GCTGAAGGTCAGCGTGACCTACACGCTGGACGACCAGGACCGGCTGACGCTGCATTATCGCGCGACGACCGACAAGCCGA
CGGTGCTGAACCTGACCAACCACAGCTACTTCAACCTGGGCGGCGAGGGATCGGGCTCGATCGAGGATGAAATCCTGCAG
ATCAACGCCGATCACTTCACCCCCACCGACCCGACGGCGATTCCCACCGGGGACATTGCGCCGGTGGCCGGCACGCCGCT
GGATTTCCGCAAGCCGATGCGGATCGGCGTGCATCTGCGCGATTCCTATCCGCAACTGATGTTCGCGCGCGGCTACGACC
ATAACTGGGTCGTCAACGGCCCGGCCGGCGCCGCACCCCGTCCGGCCGCCCATATCGTGGACCCCCGGACCGGCCGCACG
ATGGACGTCCTGACGTCGCAGCCCGGCCTGCAGGTCTATACGTCGAACTCGCTGGATGGGGCCTATGCCGGGGTGTCGCA
TCGCGCCTACCGCCAGACCGACGCGATCGCGTTCGAGGCCGAGCATTATCCCGATTCGCCCAACCATCCGTCCTTCCCCA
CCACCACGCTGCGCCCGGGCGAGACGTTCGATTACACGACGATCTTCCATTTCGGCGTGCAGCCGGCCGCACCCCGTCAC
GGACAGTGA

Upstream 100 bases:

>100_bases
GCGCCCCCCGTCCGGGCCCGCAACGGGGATTCGGGCGCTTGCCTCCGACGAGAACTCTGGTCCACTGTGGCGCAAAATCC
ACAATGCCAAGAGGAACAGA

Downstream 100 bases:

>100_bases
TGGATCAGGGGCGCTGATGGAGGGGGGCGCCGATCCCTCCGGGGTGCGCGTCGCGTCCCTGCACGTCTATTCCGTCAAGT
CGCTGGGCGGGGTGACGGTG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLRISPTRLATSLLAATALVSATLASATPVRAADAPVALARAGFGTMADGKPVEILTLRNAHGVSVRFITYGGIITAIDT
PDRTGHTDDIVLGFPDLQGYTVDSAQGGLFFGAMIGRYANRIARGTFTLDGATYHVPVTAPPNALHGGTRGFDKHLWTVD
GTATDAHSASATLSLTSPDGDQGFPGTLKVSVTYTLDDQDRLTLHYRATTDKPTVLNLTNHSYFNLGGEGSGSIEDEILQ
INADHFTPTDPTAIPTGDIAPVAGTPLDFRKPMRIGVHLRDSYPQLMFARGYDHNWVVNGPAGAAPRPAAHIVDPRTGRT
MDVLTSQPGLQVYTSNSLDGAYAGVSHRAYRQTDAIAFEAEHYPDSPNHPSFPTTTLRPGETFDYTTIFHFGVQPAAPRH
GQ

Sequences:

>Translated_402_residues
MLRISPTRLATSLLAATALVSATLASATPVRAADAPVALARAGFGTMADGKPVEILTLRNAHGVSVRFITYGGIITAIDT
PDRTGHTDDIVLGFPDLQGYTVDSAQGGLFFGAMIGRYANRIARGTFTLDGATYHVPVTAPPNALHGGTRGFDKHLWTVD
GTATDAHSASATLSLTSPDGDQGFPGTLKVSVTYTLDDQDRLTLHYRATTDKPTVLNLTNHSYFNLGGEGSGSIEDEILQ
INADHFTPTDPTAIPTGDIAPVAGTPLDFRKPMRIGVHLRDSYPQLMFARGYDHNWVVNGPAGAAPRPAAHIVDPRTGRT
MDVLTSQPGLQVYTSNSLDGAYAGVSHRAYRQTDAIAFEAEHYPDSPNHPSFPTTTLRPGETFDYTTIFHFGVQPAAPRH
GQ
>Mature_402_residues
MLRISPTRLATSLLAATALVSATLASATPVRAADAPVALARAGFGTMADGKPVEILTLRNAHGVSVRFITYGGIITAIDT
PDRTGHTDDIVLGFPDLQGYTVDSAQGGLFFGAMIGRYANRIARGTFTLDGATYHVPVTAPPNALHGGTRGFDKHLWTVD
GTATDAHSASATLSLTSPDGDQGFPGTLKVSVTYTLDDQDRLTLHYRATTDKPTVLNLTNHSYFNLGGEGSGSIEDEILQ
INADHFTPTDPTAIPTGDIAPVAGTPLDFRKPMRIGVHLRDSYPQLMFARGYDHNWVVNGPAGAAPRPAAHIVDPRTGRT
MDVLTSQPGLQVYTSNSLDGAYAGVSHRAYRQTDAIAFEAEHYPDSPNHPSFPTTTLRPGETFDYTTIFHFGVQPAAPRH
GQ

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=357, Percent_Identity=44.2577030812325, Blast_Score=295, Evalue=7e-80,
Organism=Escherichia coli, GI1786971, Length=345, Percent_Identity=37.9710144927536, Blast_Score=221, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17557428, Length=338, Percent_Identity=30.4733727810651, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI115533334, Length=338, Percent_Identity=30.4733727810651, Blast_Score=168, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319493, Length=318, Percent_Identity=29.874213836478, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322004, Length=360, Percent_Identity=27.5, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324399, Length=331, Percent_Identity=26.8882175226586, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24659048, Length=353, Percent_Identity=41.643059490085, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24668278, Length=346, Percent_Identity=35.8381502890173, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24583720, Length=349, Percent_Identity=35.243553008596, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24668282, Length=355, Percent_Identity=35.2112676056338, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24641876, Length=351, Percent_Identity=31.0541310541311, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 42845; Mature: 42845

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRISPTRLATSLLAATALVSATLASATPVRAADAPVALARAGFGTMADGKPVEILTLRN
CEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEC
AHGVSVRFITYGGIITAIDTPDRTGHTDDIVLGFPDLQGYTVDSAQGGLFFGAMIGRYAN
CCCCEEEEEEECCEEEEECCCCCCCCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHHHH
RIARGTFTLDGATYHVPVTAPPNALHGGTRGFDKHLWTVDGTATDAHSASATLSLTSPDG
HHHCCEEEECCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCC
DQGFPGTLKVSVTYTLDDQDRLTLHYRATTDKPTVLNLTNHSYFNLGGEGSGSIEDEILQ
CCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEECCCCCCCCCCEEEEE
INADHFTPTDPTAIPTGDIAPVAGTPLDFRKPMRIGVHLRDSYPQLMFARGYDHNWVVNG
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCCCEEEEC
PAGAAPRPAAHIVDPRTGRTMDVLTSQPGLQVYTSNSLDGAYAGVSHRAYRQTDAIAFEA
CCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEECCCCCCHHCCCCCHHHHCCCCEEEEE
EHYPDSPNHPSFPTTTLRPGETFDYTTIFHFGVQPAAPRHGQ
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLRISPTRLATSLLAATALVSATLASATPVRAADAPVALARAGFGTMADGKPVEILTLRN
CEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEC
AHGVSVRFITYGGIITAIDTPDRTGHTDDIVLGFPDLQGYTVDSAQGGLFFGAMIGRYAN
CCCCEEEEEEECCEEEEECCCCCCCCCCEEEEECCCCCCEEECCCCCCCHHHHHHHHHHH
RIARGTFTLDGATYHVPVTAPPNALHGGTRGFDKHLWTVDGTATDAHSASATLSLTSPDG
HHHCCEEEECCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCC
DQGFPGTLKVSVTYTLDDQDRLTLHYRATTDKPTVLNLTNHSYFNLGGEGSGSIEDEILQ
CCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCEEEEECCCCEEECCCCCCCCCCEEEEE
INADHFTPTDPTAIPTGDIAPVAGTPLDFRKPMRIGVHLRDSYPQLMFARGYDHNWVVNG
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCCCEEEEC
PAGAAPRPAAHIVDPRTGRTMDVLTSQPGLQVYTSNSLDGAYAGVSHRAYRQTDAIAFEA
CCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEECCCCCCHHCCCCCHHHHCCCCEEEEE
EHYPDSPNHPSFPTTTLRPGETFDYTTIFHFGVQPAAPRHGQ
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]