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The map label for this gene is pyrD [H]

Identifier: 162146684

GI number: 162146684

Start: 879033

End: 880106

Strand: Direct

Name: pyrD [H]

Synonym: GDI_0862

Alternate gene names: 162146684

Gene position: 879033-880106 (Clockwise)

Preceding gene: 162146683

Following gene: 162146685

Centisome position: 22.29

GC content: 71.97

Gene sequence:

>1074_bases
ATGATGGATATCATGTCGAACATGCTGATGCCGCTGGTGCGGCGGCTGGACCCCGAGGACGCGCATCGCCTCGGCCTGAA
CGCGCTCCTGCTCGGCCTGGGGGGCGGCAGCGGGTCGGGCCAGGACGATCCGGCGCTGGCGGTGCGGGCGCTGGGCCTGC
GCTTTCCCAATCCGATCGGCATCGCCGCCGGGTTCGACAAGAACGCGCTGGTGGTCCGGCCGCTGGCCCGGATCGGTTTC
GGCTTTGTCGAAGCCGGAACCGTGACCCCCCGGCCGCAGCCCGGCAACCCGCGCCCGCGCCTGTTCCGCCTGGACGAAGA
CCGCGCGATCATCAACCGCATGGGCTTCAACAACCAGGGGATCGACCGCTTCGCGGTGCGGCTGGCCCGACTGCATCGGG
TCTCGCCCGCCGGCCGGCATGCTGGGGCGCGGGTGCCGGTCGGGGCCAATCTGGGCATCAACAAGTTCGGCGCGGACCCC
GAGCGCGATTATCCCCGCCTGGTCGGGCGGGTGAAGCACTATGCCGATTACGTGGTGCTGAACCTGTCGTCGCCCAACAC
GCCGGGCCTGCGCGACCTGCAGGAGGCCTCGCGCCTGGGCGCGCTGCTGCAGGCGATCGGCGAGGCCCATCCCGACCGGC
CGCCGCTGCTGGTCAAGCTGTCGCCCGACCTGGCACGCGACGATATCGGCCCGATCGTCGAGGCCGCGATCGCGGGCGGG
GCGCAGGGGCTGATCGTGACCAATACCACCATCTCGCGCCCCGCCGGGCTGCGCAGCCCCCATGCGGGCGAGGCCGGCGG
CCTGTCGGGCCGTCCGTTGCGCCCGCTGGCGGCCGATATCTTCCGCGCGGTCGCGCAGGTCGCCGCCGGCCGTCTGGCAC
TGGTGGCCTGCGGCGGGATCGAAACCGGGGCCGACATCGTGGACCGGGTGCGCGCCGGGGCCGACCTGGTGCAGCTCTAC
AGCGCGTTTGCCTATGAAGGCCCGGGGATCGTGCGCCGGCTGAAGCGCGAGACCGTGCGGGTCCTCAACGCCGAAGGGTT
CGAAACCCTGGCGGATGCGAAGGGAACCGCATGA

Upstream 100 bases:

>100_bases
GGCACGACCTGCGCGTGCCCCCCTATTTCCTGATCCGCTGCCCGACCGACGTCGCGGCGCCTCTTTCCTCGATCGGAGAT
GTACGGCAGAAAATCCAGCC

Downstream 100 bases:

>100_bases
TGGACAGCCTGGACGGCTTCGCCCCGCTGGCCGGGCGGTATGACGGGTTCATCGTCGATCTGTGGGGCGTCGTGCATGAC
GGCGTCAGCCCGTATCCCGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MMDIMSNMLMPLVRRLDPEDAHRLGLNALLLGLGGGSGSGQDDPALAVRALGLRFPNPIGIAAGFDKNALVVRPLARIGF
GFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQGIDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADP
ERDYPRLVGRVKHYADYVVLNLSSPNTPGLRDLQEASRLGALLQAIGEAHPDRPPLLVKLSPDLARDDIGPIVEAAIAGG
AQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRLALVACGGIETGADIVDRVRAGADLVQLY
SAFAYEGPGIVRRLKRETVRVLNAEGFETLADAKGTA

Sequences:

>Translated_357_residues
MMDIMSNMLMPLVRRLDPEDAHRLGLNALLLGLGGGSGSGQDDPALAVRALGLRFPNPIGIAAGFDKNALVVRPLARIGF
GFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQGIDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADP
ERDYPRLVGRVKHYADYVVLNLSSPNTPGLRDLQEASRLGALLQAIGEAHPDRPPLLVKLSPDLARDDIGPIVEAAIAGG
AQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRLALVACGGIETGADIVDRVRAGADLVQLY
SAFAYEGPGIVRRLKRETVRVLNAEGFETLADAKGTA
>Mature_357_residues
MMDIMSNMLMPLVRRLDPEDAHRLGLNALLLGLGGGSGSGQDDPALAVRALGLRFPNPIGIAAGFDKNALVVRPLARIGF
GFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQGIDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADP
ERDYPRLVGRVKHYADYVVLNLSSPNTPGLRDLQEASRLGALLQAIGEAHPDRPPLLVKLSPDLARDDIGPIVEAAIAGG
AQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRLALVACGGIETGADIVDRVRAGADLVQLY
SAFAYEGPGIVRRLKRETVRVLNAEGFETLADAKGTA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=359, Percent_Identity=45.4038997214485, Blast_Score=279, Evalue=3e-75,
Organism=Escherichia coli, GI1787177, Length=342, Percent_Identity=37.719298245614, Blast_Score=220, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17509475, Length=359, Percent_Identity=42.0612813370474, Blast_Score=269, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322633, Length=326, Percent_Identity=24.2331288343558, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281361352, Length=360, Percent_Identity=40.8333333333333, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17137316, Length=360, Percent_Identity=40.8333333333333, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37727; Mature: 37727

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDIMSNMLMPLVRRLDPEDAHRLGLNALLLGLGGGSGSGQDDPALAVRALGLRFPNPIG
CHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCC
IAAGFDKNALVVRPLARIGFGFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQG
EECCCCCCCEEECCHHHHCCCCEECCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCC
IDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADPERDYPRLVGRVKHYADYVVL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEE
NLSSPNTPGLRDLQEASRLGALLQAIGEAHPDRPPLLVKLSPDLARDDIGPIVEAAIAGG
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
AQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRLALVACGGI
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCC
ETGADIVDRVRAGADLVQLYSAFAYEGPGIVRRLKRETVRVLNAEGFETLADAKGTA
CCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure
MMDIMSNMLMPLVRRLDPEDAHRLGLNALLLGLGGGSGSGQDDPALAVRALGLRFPNPIG
CHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCC
IAAGFDKNALVVRPLARIGFGFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQG
EECCCCCCCEEECCHHHHCCCCEECCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCC
IDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADPERDYPRLVGRVKHYADYVVL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEE
NLSSPNTPGLRDLQEASRLGALLQAIGEAHPDRPPLLVKLSPDLARDDIGPIVEAAIAGG
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
AQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRLALVACGGI
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCC
ETGADIVDRVRAGADLVQLYSAFAYEGPGIVRRLKRETVRVLNAEGFETLADAKGTA
CCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA