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The map label for this gene is cbf2 [H]

Identifier: 162146617

GI number: 162146617

Start: 812210

End: 813136

Strand: Reverse

Name: cbf2 [H]

Synonym: GDI_0795

Alternate gene names: 162146617

Gene position: 813136-812210 (Counterclockwise)

Preceding gene: 162146618

Following gene: 162146616

Centisome position: 20.62

GC content: 67.75

Gene sequence:

>927_bases
ATGCGGCCTTCCAGCCCGGCAGCCTCCTTTCTGGCGGCGGCCCTGCTCGTCCCTGCGCTTTCCGTCACTCAAGCCCATGC
CGCAGCACCCGCGGCGTCCGCCGCCCCCGCCGCGGCACCGGCCGCGCCGGCCAATCCGAATCCTCTCGTCGCCAGCGTGA
ATGGCGAGGATATCCACCTGAACGACGTGCGGCAGGCCGCGGCGAACATGCCCGCGCAACTGCGCCAGCTTCCGCCGAAC
ATGATCTTCCCGATGCTGCTGAACCAGTTGATCGACCAGAAGGCGATCCAGGCGGCCGCCACGCATGCGGGCCTGGACAA
GCAGCCCGACGTGCAGCAGCAGATGCATGCCGCCGCGATGAACGCGCTGCAGAACGCCTATCTGTCGCAGCAGGTCACGC
CGACGCTGACCGATGCCGCCGTGCAGGCCTATTACACGCAGCATTACGCCAACAAGAAGCCCGAGGCCGAAATCCACGCC
CGCCACATCCTGGTCGCGACCGAGGCCGAGGCGAAGGACGTGATCAAGCAGCTGAAGGCCGGCGCCGATTTCGGGGCCCT
GGCCACCAAGCTGTCGACCGACAAGGCGTCGGCCAAGCAGAATGGCGGCGACCTGGGCTGGTTCAAGAAGGGCGACATGC
TGCCCGCGTTCTCGGACGCCGCGTTCGCGATGAAGCCCCACACGTTCAGCCAGACGCCGGTCCACACCCAATATGGCTGG
CACGTCATCGAAGTGCTGGACACCCGGACCGCCGACGTGCCCAAACTGGACGCGGTGCGTGACGAGATCCGCCAGAAGCT
GATCCAGCAGGGCGTTCGCGATGCGGTCGAAAAGGCCGTGGCCGGTGTGAAGGTCGTCCGCTACGACCCCAGCGGCAAGC
CGGTTCCCGCCACGCCGGCCCCGGCCCCCGCAGCCGCGGCCAAATAA

Upstream 100 bases:

>100_bases
CCGTAGGATCACGCGACTGACGGCCGCATAAACGCCGTCGTCGCCATCACTCATCACTACGGCAGCGCCCAATCCGACAG
CCTGCTAGGGTATTCAACAT

Downstream 100 bases:

>100_bases
GGGCGGGCACCCGGCGCGCCCCCCGACCCCGGCCTGGTCCCCATCCAGGGGGCGGGCCGGTTTCCCGATCATGCGGAAGC
AAGAAGGCCGAACCGATGGC

Product: peptidylprolyl isomerase

Products: Isomerized Proline [C]

Alternate protein names: Major antigen peb4A [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRPSSPAASFLAAALLVPALSVTQAHAAAPAASAAPAAAPAAPANPNPLVASVNGEDIHLNDVRQAAANMPAQLRQLPPN
MIFPMLLNQLIDQKAIQAAATHAGLDKQPDVQQQMHAAAMNALQNAYLSQQVTPTLTDAAVQAYYTQHYANKKPEAEIHA
RHILVATEAEAKDVIKQLKAGADFGALATKLSTDKASAKQNGGDLGWFKKGDMLPAFSDAAFAMKPHTFSQTPVHTQYGW
HVIEVLDTRTADVPKLDAVRDEIRQKLIQQGVRDAVEKAVAGVKVVRYDPSGKPVPATPAPAPAAAAK

Sequences:

>Translated_308_residues
MRPSSPAASFLAAALLVPALSVTQAHAAAPAASAAPAAAPAAPANPNPLVASVNGEDIHLNDVRQAAANMPAQLRQLPPN
MIFPMLLNQLIDQKAIQAAATHAGLDKQPDVQQQMHAAAMNALQNAYLSQQVTPTLTDAAVQAYYTQHYANKKPEAEIHA
RHILVATEAEAKDVIKQLKAGADFGALATKLSTDKASAKQNGGDLGWFKKGDMLPAFSDAAFAMKPHTFSQTPVHTQYGW
HVIEVLDTRTADVPKLDAVRDEIRQKLIQQGVRDAVEKAVAGVKVVRYDPSGKPVPATPAPAPAAAAK
>Mature_308_residues
MRPSSPAASFLAAALLVPALSVTQAHAAAPAASAAPAAAPAAPANPNPLVASVNGEDIHLNDVRQAAANMPAQLRQLPPN
MIFPMLLNQLIDQKAIQAAATHAGLDKQPDVQQQMHAAAMNALQNAYLSQQVTPTLTDAAVQAYYTQHYANKKPEAEIHA
RHILVATEAEAKDVIKQLKAGADFGALATKLSTDKASAKQNGGDLGWFKKGDMLPAFSDAAFAMKPHTFSQTPVHTQYGW
HVIEVLDTRTADVPKLDAVRDEIRQKLIQQGVRDAVEKAVAGVKVVRYDPSGKPVPATPAPAPAAAAK

Specific function: Assist In The Folding Of Extracytoplasmic Proteins. Essential For The Survival Of E.Coli In Stationary Phase. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=94, Percent_Identity=38.2978723404255, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786238, Length=106, Percent_Identity=42.4528301886792, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790211, Length=87, Percent_Identity=47.1264367816092, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786645, Length=140, Percent_Identity=32.8571428571429, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17537235, Length=94, Percent_Identity=41.4893617021277, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356303, Length=100, Percent_Identity=37, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 32459; Mature: 32459

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSSPAASFLAAALLVPALSVTQAHAAAPAASAAPAAAPAAPANPNPLVASVNGEDIHL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
NDVRQAAANMPAQLRQLPPNMIFPMLLNQLIDQKAIQAAATHAGLDKQPDVQQQMHAAAM
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
NALQNAYLSQQVTPTLTDAAVQAYYTQHYANKKPEAEIHARHILVATEAEAKDVIKQLKA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCHHHHHHHHHHHC
GADFGALATKLSTDKASAKQNGGDLGWFKKGDMLPAFSDAAFAMKPHTFSQTPVHTQYGW
CCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCC
HVIEVLDTRTADVPKLDAVRDEIRQKLIQQGVRDAVEKAVAGVKVVRYDPSGKPVPATPA
EEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
PAPAAAAK
CCCCCCCC
>Mature Secondary Structure
MRPSSPAASFLAAALLVPALSVTQAHAAAPAASAAPAAAPAAPANPNPLVASVNGEDIHL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
NDVRQAAANMPAQLRQLPPNMIFPMLLNQLIDQKAIQAAATHAGLDKQPDVQQQMHAAAM
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
NALQNAYLSQQVTPTLTDAAVQAYYTQHYANKKPEAEIHARHILVATEAEAKDVIKQLKA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCHHHHHHHHHHHC
GADFGALATKLSTDKASAKQNGGDLGWFKKGDMLPAFSDAAFAMKPHTFSQTPVHTQYGW
CCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCC
HVIEVLDTRTADVPKLDAVRDEIRQKLIQQGVRDAVEKAVAGVKVVRYDPSGKPVPATPA
EEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
PAPAAAAK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proline Imidic Peptide Bonds In Oligopeptides [C]

Specific reaction: Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]