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The map label for this gene is cysB [H]

Identifier: 162146560

GI number: 162146560

Start: 754657

End: 755694

Strand: Reverse

Name: cysB [H]

Synonym: GDI_0737

Alternate gene names: 162146560

Gene position: 755694-754657 (Counterclockwise)

Preceding gene: 162146562

Following gene: 162146557

Centisome position: 19.16

GC content: 69.65

Gene sequence:

>1038_bases
ATGGCCGAAAGTGCAAATCCGTCCGCCGTCGGCTGGACCACGTCATCCCCGGACATGACCGCCGCGATCGGCCATACGCC
TCTGATCCGCCTGCGCCGCGCATCGGAACTGACGGGATGCGACATCCTGGCCAAGGCCGAATTCATGAATCCCGGCGGGT
CGGTCAAGGACCGCGCGGCGCTTGCGATCATCGACGATGCCGAACGGCGCGGCGTGCTGAAGCCGGGCGGCATGGTGGTG
GAGGGCACGGCGGGCAATACCGGCATCGGCCTGACGCTGGTCGCGAACGCGCGCGGCTATCGCTCGGTCATCGTCATGCC
CGAGACGCAGAGCCAGGAGAAGATCGATTTCCTGCGCATGATCGGCGCCGACCTGCGCCTGGTGCCGGCCAAGCCCTTTC
GCGATCCGGGCAACTACGTCCATGTCTCGCGCCGGCTGGCCGAGGAAACCGGGGGCGTGTGGGCCAACCAGTTCGACAAC
CTGGCCAACCGCGAGGGCCATCGCGCCACCACCGGGCCCGAGATCTGGACGCAGACCGACGGGCGGATCGACGCCTTCAC
CTGTTCCTGCGGGACCGGCGGCACGCTGGCCGGCGTGGCGCTGGGGCTGGAGGATTCCGCCCGGGCCGCCGGGGCCGCGC
GGCCCCGGATCGTCCTGGCCGACCCCGAGGGATCGGGCCTGTACGGATGGGTCAAGTCCGGCGACCTGGGCGTCAGCGGC
AGTTCGATCACCGAGGGAATCGGCCAGTCGCGGGTCACGGCCAACCTGGACGGAATCGCCATCGACGACGCCGTGCGGAT
TCCCGACCCCGAGGCGCTGGAGCTGATCTACGACCTGCTGATCCACGAGGGCGTGTCGGTCGGCGGGTCCTCGGGGATCA
ACATCGCGGCGGCGATCCGGGTGGCGCGGCAGATGGGTCCGGGCCACCGCATCGTCACCATCCTGTCGGACGGCGGCGGC
CGCTACCAGTCCAAGCTGTTCAATCCGGCCTTCCTGCGGGAACGGAACCTGCCGGTTCCCGCCTGGCTGGATCGGTAG

Upstream 100 bases:

>100_bases
TACGTCGTCGATCATCTTGTGTCCTATCGCAAGAATGCACATTGTGCGCGACACGGGCGGCGGCTGACCGCCACGCACGT
TGCAGAGAGGGTGCTGCCTT

Downstream 100 bases:

>100_bases
CCGGCGGAGTACGCCCGAACGGGCTCCGCGAGACCCCGTTCGGGCGGCTGGTATCGCCCATCAGCAGCCACACCAGCACC
ACGCACAGCAGCCCCGCAGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAESANPSAVGWTTSSPDMTAAIGHTPLIRLRRASELTGCDILAKAEFMNPGGSVKDRAALAIIDDAERRGVLKPGGMVV
EGTAGNTGIGLTLVANARGYRSVIVMPETQSQEKIDFLRMIGADLRLVPAKPFRDPGNYVHVSRRLAEETGGVWANQFDN
LANREGHRATTGPEIWTQTDGRIDAFTCSCGTGGTLAGVALGLEDSARAAGAARPRIVLADPEGSGLYGWVKSGDLGVSG
SSITEGIGQSRVTANLDGIAIDDAVRIPDPEALELIYDLLIHEGVSVGGSSGINIAAAIRVARQMGPGHRIVTILSDGGG
RYQSKLFNPAFLRERNLPVPAWLDR

Sequences:

>Translated_345_residues
MAESANPSAVGWTTSSPDMTAAIGHTPLIRLRRASELTGCDILAKAEFMNPGGSVKDRAALAIIDDAERRGVLKPGGMVV
EGTAGNTGIGLTLVANARGYRSVIVMPETQSQEKIDFLRMIGADLRLVPAKPFRDPGNYVHVSRRLAEETGGVWANQFDN
LANREGHRATTGPEIWTQTDGRIDAFTCSCGTGGTLAGVALGLEDSARAAGAARPRIVLADPEGSGLYGWVKSGDLGVSG
SSITEGIGQSRVTANLDGIAIDDAVRIPDPEALELIYDLLIHEGVSVGGSSGINIAAAIRVARQMGPGHRIVTILSDGGG
RYQSKLFNPAFLRERNLPVPAWLDR
>Mature_344_residues
AESANPSAVGWTTSSPDMTAAIGHTPLIRLRRASELTGCDILAKAEFMNPGGSVKDRAALAIIDDAERRGVLKPGGMVVE
GTAGNTGIGLTLVANARGYRSVIVMPETQSQEKIDFLRMIGADLRLVPAKPFRDPGNYVHVSRRLAEETGGVWANQFDNL
ANREGHRATTGPEIWTQTDGRIDAFTCSCGTGGTLAGVALGLEDSARAAGAARPRIVLADPEGSGLYGWVKSGDLGVSGS
SITEGIGQSRVTANLDGIAIDDAVRIPDPEALELIYDLLIHEGVSVGGSSGINIAAAIRVARQMGPGHRIVTILSDGGGR
YQSKLFNPAFLRERNLPVPAWLDR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=333, Percent_Identity=39.3393393393393, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI295821200, Length=333, Percent_Identity=39.3393393393393, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4557415, Length=333, Percent_Identity=39.3393393393393, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=35.5987055016181, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788754, Length=323, Percent_Identity=39.0092879256966, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17535051, Length=329, Percent_Identity=34.3465045592705, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17562970, Length=318, Percent_Identity=35.5345911949685, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=36.2745098039216, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI115535073, Length=308, Percent_Identity=36.3636363636364, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=33.434650455927, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=33.1288343558282, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17561720, Length=322, Percent_Identity=33.8509316770186, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71996324, Length=362, Percent_Identity=28.1767955801105, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI32566672, Length=222, Percent_Identity=32.4324324324324, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=40.9090909090909, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6321594, Length=328, Percent_Identity=33.5365853658537, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24643623, Length=329, Percent_Identity=35.5623100303951, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20129101, Length=329, Percent_Identity=35.5623100303951, Blast_Score=181, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36304; Mature: 36172

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESANPSAVGWTTSSPDMTAAIGHTPLIRLRRASELTGCDILAKAEFMNPGGSVKDRAA
CCCCCCCCEEEEECCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEE
LAIIDDAERRGVLKPGGMVVEGTAGNTGIGLTLVANARGYRSVIVMPETQSQEKIDFLRM
EEEEECHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
IGADLRLVPAKPFRDPGNYVHVSRRLAEETGGVWANQFDNLANREGHRATTGPEIWTQTD
HCCCEEEECCCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCC
GRIDAFTCSCGTGGTLAGVALGLEDSARAAGAARPRIVLADPEGSGLYGWVKSGDLGVSG
CCEEEEEECCCCCCCCEEEEECCCCCHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCC
SSITEGIGQSRVTANLDGIAIDDAVRIPDPEALELIYDLLIHEGVSVGGSSGINIAAAIR
CHHHHCCCCCEEEECCCCEEECCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
VARQMGPGHRIVTILSDGGGRYQSKLFNPAFLRERNLPVPAWLDR
HHHHCCCCCEEEEEEECCCCHHHHHCCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AESANPSAVGWTTSSPDMTAAIGHTPLIRLRRASELTGCDILAKAEFMNPGGSVKDRAA
CCCCCCCEEEEECCCCCCEEECCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEE
LAIIDDAERRGVLKPGGMVVEGTAGNTGIGLTLVANARGYRSVIVMPETQSQEKIDFLRM
EEEEECHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
IGADLRLVPAKPFRDPGNYVHVSRRLAEETGGVWANQFDNLANREGHRATTGPEIWTQTD
HCCCEEEECCCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCC
GRIDAFTCSCGTGGTLAGVALGLEDSARAAGAARPRIVLADPEGSGLYGWVKSGDLGVSG
CCEEEEEECCCCCCCCEEEEECCCCCHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCC
SSITEGIGQSRVTANLDGIAIDDAVRIPDPEALELIYDLLIHEGVSVGGSSGINIAAAIR
CHHHHCCCCCEEEECCCCEEECCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
VARQMGPGHRIVTILSDGGGRYQSKLFNPAFLRERNLPVPAWLDR
HHHHCCCCCEEEEEEECCCCHHHHHCCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA