Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 162146417

GI number: 162146417

Start: 596827

End: 598698

Strand: Direct

Name: mutL [H]

Synonym: GDI_0592

Alternate gene names: 162146417

Gene position: 596827-598698 (Clockwise)

Preceding gene: 162146416

Following gene: 162146418

Centisome position: 15.13

GC content: 74.79

Gene sequence:

>1872_bases
ATGCGCGACTCGTCCAGCCCGCCCGCCCGTCCGGTCATCCGGCGCCTGTCGGAACAGGTCGTCAACCGCATCGCCGCCGG
CGAGGTCATCGAACGGCCGGCCGCGGCACTGAAGGAACTGGTCGAAAACGCCATCGATTCCGGGGCCCGGCGCATCGCCG
TCCTGCTGGAGCGCGGCGGCATCGAGCGGATCGAGGTCGTCGATGATGGCTGCGGCATGACGCCGGACGACCTGCTGCTG
GCGGTCGAGCGGCATTGCACCTCCAAATTGCGCGACGAGACGCTGGTGCGGATCGAAACGCTGGGCTTCCGGGGCGAGGC
CCTGCCATCGATCGGCGCCGCCGCGCGGCTGACCGTCACGTCCCGCCCCCATGGGGCCGACAGCGCGTGGCGCGTGTCGG
TGGAAGGCGGGCTGGTGGGCGCGCCCGCCCCCTGCGCCGGCCCCCCGGGCACCCGCGTGACGGTCGAGGACCTGTTCTTC
GCCACCCCGGCCCGGCGCAAATTCCTCAAGAGCCCCCGGGTCGAGGCCGGCCATGCCGACATTACGGTGCGCCGCCTGGC
CCTGTCGGTGCCGGACGTGGCGTTCCGCCTGCAACTGGACGACCGGGTGGTGTTCGACCTGCCGGCCCAGGACCTGGAAT
CCCGCGTCGCCGCAATTCTCGAATCCGAGGGCGCGGACGGCATGCTGCCGGTCGAAGGCCGGCGCGGCGACCTGGTGCTG
GACGGCTTCGCCTGCGGCCCCTCGGTACACCGGGCCACGGCGTCGGGGCAGATCCTGCTGGTCAACGGCCGGCCGGTGGT
CGACCCGGTGCTGCGCACGGCGGTGCGCGTGGCCTACCGGCATGTGATCGAACACGGCCGGCACGCGGTGGTCGCCCTGT
CGCTGACCATCCCGCCCGACCTGGTTGACGTGAACGTCCATCCGGCGAAGACCGAACTGCGCTTCGCCGACCCCGCCGCC
GTGCGTGGGCTGGTCATCGGCGCGCTGGGCCGTGCGCTGGGCAGCGGGGCCGGTGTCGCGGGGGTGCGGCCCGGCCTGCT
GCAATCGCGGCCCGCCACGGCGTCGCGGATCTGGTATCCGTCCGCCGACGCGCCATCGGCCGGCCTGGCGCCGGCCGCGG
CGCCCGCGCCCGCGATCTTCTCGGCCCCGGGCCGCGACTCGCTGGCCGGCACACGCCTGGATTTGGGCGCCCCGGCCGCG
CGGGTGCTGGACGACCCGCCCGCCGCCCCGCCGCCCGATGCCGGTGCGGCGGGCGGGGCAGGGGCCGGCGGCCCGGACGC
CGCGCCCCCGGACGCTGCCATTCTGGCCGATGCGGCCGATTATCCGCTGGGGGCGTCGGTGGCGCAGGTCATGGGGACCT
ATATCGTCGCGGTGTCCGGCGACGGATCGCTGGTGCTGGTGGACCAGCACGCGGCGCACGAACGGCTGACCCATGAACGG
CTGCGGGCGCGCTATCTGGACGGCACCCTGCGCGCCAAGCGCCTGCTGCTGCCGAAGTCGTACCCTGCCGCGCGGTACAG
GCCGACCTGCTGCTGTCCTTCGCCGGCACGCTGGCGGCGCTGGGGGTGGAAACTCGAACCGTTCGGCGGCGGCGCGGTAC
TGGTGCGCGCCCTGCCGGCCCTGCTGGGCACGGACGACCCCGCCGGCCTGCTGCGCGACATGGCCGACGAACTGGCCGAG
GACGACCTGGCCGACCCGGGCGACACCGGCGCCCTGGACGGCAGGCTGGATGCCGTCATCGCCCGCATGGCCTGCCACGG
CAGCGTCCGCGCCGGCCGCAGCCTGACCCGCGCGGAAATGACGCGCTGCTGCGCGACATGGAACGGACCCCCCGCGCCGG
CACCTGCTCGCACGGGCGGCCCACCTGGCTGA

Upstream 100 bases:

>100_bases
GCCCGACGCAGGGCGCGACCCCCACGGTCCAGGGCAAGTCCTGATCCCTCTCCCGCGATCGGTTCTTCGGCGCGGTCGCG
TTCTGCTCTAGCCTGACATG

Downstream 100 bases:

>100_bases
AGCTGAGCCGCACGGACCTGGAAAAACTCTTCGGCCGCAAATAGTCCCATGCAGCCAATGCAAGGGAAATCGTACGTCCT
CGGCAGAACGTGAGCGGCGT

Product: DNA mismatch repair protein mutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MRDSSSPPARPVIRRLSEQVVNRIAAGEVIERPAAALKELVENAIDSGARRIAVLLERGGIERIEVVDDGCGMTPDDLLL
AVERHCTSKLRDETLVRIETLGFRGEALPSIGAAARLTVTSRPHGADSAWRVSVEGGLVGAPAPCAGPPGTRVTVEDLFF
ATPARRKFLKSPRVEAGHADITVRRLALSVPDVAFRLQLDDRVVFDLPAQDLESRVAAILESEGADGMLPVEGRRGDLVL
DGFACGPSVHRATASGQILLVNGRPVVDPVLRTAVRVAYRHVIEHGRHAVVALSLTIPPDLVDVNVHPAKTELRFADPAA
VRGLVIGALGRALGSGAGVAGVRPGLLQSRPATASRIWYPSADAPSAGLAPAAAPAPAIFSAPGRDSLAGTRLDLGAPAA
RVLDDPPAAPPPDAGAAGGAGAGGPDAAPPDAAILADAADYPLGASVAQVMGTYIVAVSGDGSLVLVDQHAAHERLTHER
LRARYLDGTLRAKRLLLPKSYPAARYRPTCCCPSPARWRRWGWKLEPFGGGAVLVRALPALLGTDDPAGLLRDMADELAE
DDLADPGDTGALDGRLDAVIARMACHGSVRAGRSLTRAEMTRCCATWNGPPAPAPARTGGPPG

Sequences:

>Translated_623_residues
MRDSSSPPARPVIRRLSEQVVNRIAAGEVIERPAAALKELVENAIDSGARRIAVLLERGGIERIEVVDDGCGMTPDDLLL
AVERHCTSKLRDETLVRIETLGFRGEALPSIGAAARLTVTSRPHGADSAWRVSVEGGLVGAPAPCAGPPGTRVTVEDLFF
ATPARRKFLKSPRVEAGHADITVRRLALSVPDVAFRLQLDDRVVFDLPAQDLESRVAAILESEGADGMLPVEGRRGDLVL
DGFACGPSVHRATASGQILLVNGRPVVDPVLRTAVRVAYRHVIEHGRHAVVALSLTIPPDLVDVNVHPAKTELRFADPAA
VRGLVIGALGRALGSGAGVAGVRPGLLQSRPATASRIWYPSADAPSAGLAPAAAPAPAIFSAPGRDSLAGTRLDLGAPAA
RVLDDPPAAPPPDAGAAGGAGAGGPDAAPPDAAILADAADYPLGASVAQVMGTYIVAVSGDGSLVLVDQHAAHERLTHER
LRARYLDGTLRAKRLLLPKSYPAARYRPTCCCPSPARWRRWGWKLEPFGGGAVLVRALPALLGTDDPAGLLRDMADELAE
DDLADPGDTGALDGRLDAVIARMACHGSVRAGRSLTRAEMTRCCATWNGPPAPAPARTGGPPG
>Mature_623_residues
MRDSSSPPARPVIRRLSEQVVNRIAAGEVIERPAAALKELVENAIDSGARRIAVLLERGGIERIEVVDDGCGMTPDDLLL
AVERHCTSKLRDETLVRIETLGFRGEALPSIGAAARLTVTSRPHGADSAWRVSVEGGLVGAPAPCAGPPGTRVTVEDLFF
ATPARRKFLKSPRVEAGHADITVRRLALSVPDVAFRLQLDDRVVFDLPAQDLESRVAAILESEGADGMLPVEGRRGDLVL
DGFACGPSVHRATASGQILLVNGRPVVDPVLRTAVRVAYRHVIEHGRHAVVALSLTIPPDLVDVNVHPAKTELRFADPAA
VRGLVIGALGRALGSGAGVAGVRPGLLQSRPATASRIWYPSADAPSAGLAPAAAPAPAIFSAPGRDSLAGTRLDLGAPAA
RVLDDPPAAPPPDAGAAGGAGAGGPDAAPPDAAILADAADYPLGASVAQVMGTYIVAVSGDGSLVLVDQHAAHERLTHER
LRARYLDGTLRAKRLLLPKSYPAARYRPTCCCPSPARWRRWGWKLEPFGGGAVLVRALPALLGTDDPAGLLRDMADELAE
DDLADPGDTGALDGRLDAVIARMACHGSVRAGRSLTRAEMTRCCATWNGPPAPAPARTGGPPG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=344, Percent_Identity=36.046511627907, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4505913, Length=360, Percent_Identity=24.7222222222222, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI310128478, Length=360, Percent_Identity=24.7222222222222, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI263191589, Length=249, Percent_Identity=29.718875502008, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=25.7668711656442, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=25.7668711656442, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI189458896, Length=314, Percent_Identity=26.4331210191083, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI91992162, Length=340, Percent_Identity=25.8823529411765, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI91992160, Length=340, Percent_Identity=25.8823529411765, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI310128480, Length=308, Percent_Identity=22.4025974025974, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790612, Length=320, Percent_Identity=41.875, Blast_Score=221, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=33.9622641509434, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=421, Percent_Identity=23.9904988123515, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=312, Percent_Identity=37.5, Blast_Score=194, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=364, Percent_Identity=27.4725274725275, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=738, Percent_Identity=22.3577235772358, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136968, Length=382, Percent_Identity=35.3403141361257, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17136970, Length=352, Percent_Identity=28.125, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 64869; Mature: 64869

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSSSPPARPVIRRLSEQVVNRIAAGEVIERPAAALKELVENAIDSGARRIAVLLERGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCC
IERIEVVDDGCGMTPDDLLLAVERHCTSKLRDETLVRIETLGFRGEALPSIGAAARLTVT
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEE
SRPHGADSAWRVSVEGGLVGAPAPCAGPPGTRVTVEDLFFATPARRKFLKSPRVEAGHAD
CCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEEHHHHHHCCHHHHHHHCCCCCCCCCCC
ITVRRLALSVPDVAFRLQLDDRVVFDLPAQDLESRVAAILESEGADGMLPVEGRRGDLVL
EEEEEHHHCCCCEEEEEEECCEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEE
DGFACGPSVHRATASGQILLVNGRPVVDPVLRTAVRVAYRHVIEHGRHAVVALSLTIPPD
ECCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCC
LVDVNVHPAKTELRFADPAAVRGLVIGALGRALGSGAGVAGVRPGLLQSRPATASRIWYP
EEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCEEECC
SADAPSAGLAPAAAPAPAIFSAPGRDSLAGTRLDLGAPAARVLDDPPAAPPPDAGAAGGA
CCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEECCCCCHHHHCCCCCCCCCCCCCCCCCC
GAGGPDAAPPDAAILADAADYPLGASVAQVMGTYIVAVSGDGSLVLVDQHAAHERLTHER
CCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCEEEEEECCCCCEEEEECHHHHHHHHHHH
LRARYLDGTLRAKRLLLPKSYPAARYRPTCCCPSPARWRRWGWKLEPFGGGAVLVRALPA
HHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCEECCCCCHHHHHHHHHH
LLGTDDPAGLLRDMADELAEDDLADPGDTGALDGRLDAVIARMACHGSVRAGRSLTRAEM
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHHH
TRCCATWNGPPAPAPARTGGPPG
HHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDSSSPPARPVIRRLSEQVVNRIAAGEVIERPAAALKELVENAIDSGARRIAVLLERGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCC
IERIEVVDDGCGMTPDDLLLAVERHCTSKLRDETLVRIETLGFRGEALPSIGAAARLTVT
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEEEE
SRPHGADSAWRVSVEGGLVGAPAPCAGPPGTRVTVEDLFFATPARRKFLKSPRVEAGHAD
CCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEEHHHHHHCCHHHHHHHCCCCCCCCCCC
ITVRRLALSVPDVAFRLQLDDRVVFDLPAQDLESRVAAILESEGADGMLPVEGRRGDLVL
EEEEEHHHCCCCEEEEEEECCEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEE
DGFACGPSVHRATASGQILLVNGRPVVDPVLRTAVRVAYRHVIEHGRHAVVALSLTIPPD
ECCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCC
LVDVNVHPAKTELRFADPAAVRGLVIGALGRALGSGAGVAGVRPGLLQSRPATASRIWYP
EEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCEEECC
SADAPSAGLAPAAAPAPAIFSAPGRDSLAGTRLDLGAPAARVLDDPPAAPPPDAGAAGGA
CCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEECCCCCHHHHCCCCCCCCCCCCCCCCCC
GAGGPDAAPPDAAILADAADYPLGASVAQVMGTYIVAVSGDGSLVLVDQHAAHERLTHER
CCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCEEEEEECCCCCEEEEECHHHHHHHHHHH
LRARYLDGTLRAKRLLLPKSYPAARYRPTCCCPSPARWRRWGWKLEPFGGGAVLVRALPA
HHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCEECCCCCHHHHHHHHHH
LLGTDDPAGLLRDMADELAEDDLADPGDTGALDGRLDAVIARMACHGSVRAGRSLTRAEM
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHHH
TRCCATWNGPPAPAPARTGGPPG
HHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA