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The map label for this gene is argE [H]

Identifier: 162146287

GI number: 162146287

Start: 459620

End: 460837

Strand: Reverse

Name: argE [H]

Synonym: GDI_0462

Alternate gene names: 162146287

Gene position: 460837-459620 (Counterclockwise)

Preceding gene: 162146297

Following gene: 162146286

Centisome position: 11.68

GC content: 68.64

Gene sequence:

>1218_bases
TTGCGGTATGATCTATCGAAATGCCGTCCACATTCGCAACGCCGCCTTGCCGCATCCGTGGGACAAATCGACAAACGGGA
ACGCGGGGGAATGATGACGGTCGTCGACATACTGGAACGCCTGATCGCCTTTCCGTCCGTCGTCGGCACGCCCAATGGCG
CGATCGTCCAGTGGGTCCGCGCCTATCTGGAGGAACACGGCGCCACGGTATCCGTCCTGCCGGGGCCGGAGGGCGACCGG
TTCAACCTGTTCGCCACCATCGGCCCCGCCGACCGGCCGGGTTATATCCTGTCGGGCCACACCGACGTCGTTCCCGCCGG
CGAACCGGAATGGTCATCCGACCCGTTTTGCATGCGCGCGGACGGCGATGCGCTGTTCGGGCGCGGGACGTCCGACATGA
AGGGCTTCCTTGCCGCCGTCCTGGCGAGCGTCCCCGCGCTGGCGCGGATGAAGCTGGCCCGGCCGATCCATATCGCCTTT
TCCTATGACGAGGAGGCCGGCGCGCGCGGCGTGCCGCACATGATCGCCCGCCTGCCCGAGCTTTGCGCTCGCCCCCTGGG
CGCCATCATCGGCGAACCCAGCCTGATGCGCGGAATCCGCGCCCATAAGGGCAAGGTGGCGGCACGGATCACGCTGCGGG
GCAGGCCGGGCCATTCCTCCCGCCCCGACCTGGGCGCGAATGCCATCCACGCGATGGCCGGCATCCTCGGCGCCACCGTC
GCGCAGGCGCGAAAGCTGACCGAGGGCCCGCTGCACCCGGCTTTCCAGCCCCCGTATTCGTCGCTGCAGGCGGGGGTGAT
CTCCGGCGGGCAGGCCATCAACGTGATCCCGGAACGCTGCACGATGGATGTCGAGGCGCGCGCCATCCATGGCGTCGAGC
CGGCGGACCTTCTGGCGCCCATCCGCGAGGCGGTCGAAACCCTCACCATCGACGGCGTGCGGGCGGAGTGGGAGCAGATC
AGCGCCTACCCTGCCCTGCTGCTGGCGCCGGACACCGGACTGGCCCGCCTGGTCGAAGACCTGACCGGCCAGGACACCCT
TCCGGCGGTCAGCTACGGCACCGAGGCGGGGCTGTTCCAGCAGGCCGGCATCGATGCGATCATCTGCGGACCGGGCGATA
TCGGCCGCGCGCACAAGCCCGACGAATTCATACTGGAAAGCGAACTGGCCGCATGCCTGCGCATGATCGCGGCACTCGGT
CAACGCTGTGCGTCGTGA

Upstream 100 bases:

>100_bases
GGAGCGCGTCTTCGCGGCCGGAGAGAGGAGATTCTGTCGTTTCGTCCCCCGTTCGCGGCAGAGCGTGTCGCACGGCAGCA
CGTGCTTCACGGCGGAACGA

Downstream 100 bases:

>100_bases
CGCCGACGCAGCAGGAATACAACAGGATTTCCCGATGAGCCTGAGCTTCGACCCGGATACGCTTCCCCTGCCCGTCGGCC
ATTTCATCGGCGGGGACCTT

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MRYDLSKCRPHSQRRLAASVGQIDKRERGGMMTVVDILERLIAFPSVVGTPNGAIVQWVRAYLEEHGATVSVLPGPEGDR
FNLFATIGPADRPGYILSGHTDVVPAGEPEWSSDPFCMRADGDALFGRGTSDMKGFLAAVLASVPALARMKLARPIHIAF
SYDEEAGARGVPHMIARLPELCARPLGAIIGEPSLMRGIRAHKGKVAARITLRGRPGHSSRPDLGANAIHAMAGILGATV
AQARKLTEGPLHPAFQPPYSSLQAGVISGGQAINVIPERCTMDVEARAIHGVEPADLLAPIREAVETLTIDGVRAEWEQI
SAYPALLLAPDTGLARLVEDLTGQDTLPAVSYGTEAGLFQQAGIDAIICGPGDIGRAHKPDEFILESELAACLRMIAALG
QRCAS

Sequences:

>Translated_405_residues
MRYDLSKCRPHSQRRLAASVGQIDKRERGGMMTVVDILERLIAFPSVVGTPNGAIVQWVRAYLEEHGATVSVLPGPEGDR
FNLFATIGPADRPGYILSGHTDVVPAGEPEWSSDPFCMRADGDALFGRGTSDMKGFLAAVLASVPALARMKLARPIHIAF
SYDEEAGARGVPHMIARLPELCARPLGAIIGEPSLMRGIRAHKGKVAARITLRGRPGHSSRPDLGANAIHAMAGILGATV
AQARKLTEGPLHPAFQPPYSSLQAGVISGGQAINVIPERCTMDVEARAIHGVEPADLLAPIREAVETLTIDGVRAEWEQI
SAYPALLLAPDTGLARLVEDLTGQDTLPAVSYGTEAGLFQQAGIDAIICGPGDIGRAHKPDEFILESELAACLRMIAALG
QRCAS
>Mature_405_residues
MRYDLSKCRPHSQRRLAASVGQIDKRERGGMMTVVDILERLIAFPSVVGTPNGAIVQWVRAYLEEHGATVSVLPGPEGDR
FNLFATIGPADRPGYILSGHTDVVPAGEPEWSSDPFCMRADGDALFGRGTSDMKGFLAAVLASVPALARMKLARPIHIAF
SYDEEAGARGVPHMIARLPELCARPLGAIIGEPSLMRGIRAHKGKVAARITLRGRPGHSSRPDLGANAIHAMAGILGATV
AQARKLTEGPLHPAFQPPYSSLQAGVISGGQAINVIPERCTMDVEARAIHGVEPADLLAPIREAVETLTIDGVRAEWEQI
SAYPALLLAPDTGLARLVEDLTGQDTLPAVSYGTEAGLFQQAGIDAIICGPGDIGRAHKPDEFILESELAACLRMIAALG
QRCAS

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=266, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790395, Length=369, Percent_Identity=34.9593495934959, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788816, Length=257, Percent_Identity=31.5175097276265, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551016, Length=380, Percent_Identity=27.1052631578947, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 42982; Mature: 42982

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDLSKCRPHSQRRLAASVGQIDKRERGGMMTVVDILERLIAFPSVVGTPNGAIVQWVR
CCCCCHHCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCHHCCCCCHHHHHHHH
AYLEEHGATVSVLPGPEGDRFNLFATIGPADRPGYILSGHTDVVPAGEPEWSSDPFCMRA
HHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEC
DGDALFGRGTSDMKGFLAAVLASVPALARMKLARPIHIAFSYDEEAGARGVPHMIARLPE
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHH
LCARPLGAIIGEPSLMRGIRAHKGKVAARITLRGRPGHSSRPDLGANAIHAMAGILGATV
HHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AQARKLTEGPLHPAFQPPYSSLQAGVISGGQAINVIPERCTMDVEARAIHGVEPADLLAP
HHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEECHHHHCCCCHHHHHCCCCHHHHHHH
IREAVETLTIDGVRAEWEQISAYPALLLAPDTGLARLVEDLTGQDTLPAVSYGTEAGLFQ
HHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
QAGIDAIICGPGDIGRAHKPDEFILESELAACLRMIAALGQRCAS
HCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYDLSKCRPHSQRRLAASVGQIDKRERGGMMTVVDILERLIAFPSVVGTPNGAIVQWVR
CCCCCHHCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCHHCCCCCHHHHHHHH
AYLEEHGATVSVLPGPEGDRFNLFATIGPADRPGYILSGHTDVVPAGEPEWSSDPFCMRA
HHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEC
DGDALFGRGTSDMKGFLAAVLASVPALARMKLARPIHIAFSYDEEAGARGVPHMIARLPE
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHH
LCARPLGAIIGEPSLMRGIRAHKGKVAARITLRGRPGHSSRPDLGANAIHAMAGILGATV
HHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AQARKLTEGPLHPAFQPPYSSLQAGVISGGQAINVIPERCTMDVEARAIHGVEPADLLAP
HHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEECHHHHCCCCHHHHHCCCCHHHHHHH
IREAVETLTIDGVRAEWEQISAYPALLLAPDTGLARLVEDLTGQDTLPAVSYGTEAGLFQ
HHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
QAGIDAIICGPGDIGRAHKPDEFILESELAACLRMIAALGQRCAS
HCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10692366 [H]