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The map label for this gene is emrY [H]

Identifier: 162146067

GI number: 162146067

Start: 246340

End: 247977

Strand: Direct

Name: emrY [H]

Synonym: GDI_0235

Alternate gene names: 162146067

Gene position: 246340-247977 (Clockwise)

Preceding gene: 162146065

Following gene: 162146068

Centisome position: 6.25

GC content: 65.81

Gene sequence:

>1638_bases
ATGAATAACGTCGTTCCTGTGCCATCGGCTGGCGAGCCGGTCATCCACGCCTCGCCCCCCCGGCCGTCCTATATCCCACC
CTTCGGGGTGCGCACGGTGATCGGCTGCCTGGGCATGCTGCTGGCCGTGCATGTGGCGGGCTTCAACGAACACGTGACCG
AGATCGGCCTGACCGATATCCGCGGCGCCATGCACATCGGCTACGATGAGGGAACGTGGCTGATCGCCATCTACGAATCC
TTCAACATCGCGGCCATGGCCTTCACGCCGTGGTTCTACATGACGTTTTCCATCTACCGCTTCTCGATCTTCGTGACGGC
CGTCATGGCGCTGCTGGCGATCCCGGCGCCGTTCATGCCCGATGTCACGTCGCTGTGCATCCTGCGGGCCTTCCAGGGGC
TGATGGCCGGGTGCCTGCCGCCGGTGCTGATGACGGTGATGCTGAAATACCTGCCGCCGGAAATCCGCGTGTTCGGCATC
GGCGGCTACGCGATGAGCGCGACCTTCGGCCCCAACCTGGGCCTGCCGCTGGAGGCCTTCTGGTTCGAACGTGTCGGCTG
GCACTGGCTCTATTGGGAAATCATCCCGCTTGCCGCGCTGTCGATCGCCATGATCGCGTACGGGCTGCCGCGCGATCCCA
TGCATTTCGAACGGTTCCAGAAGTTCAACTGGCTCGGCCTGCTGGTCGGCCTGCCCGCCATCTGCGCGCTGGTCATCGTG
CTCTACCAGGGGGACCGGCTGGACTGGTTCCGCTCGCCCGTCATCACCAACCTGTCCTTCTGGGGCGGGGCGGCGTTCAT
CGTCTTCGTCATCAACGAGGCGTACCATCCCAGCCCGTATTTCCGCGTGCAGTACTGGCGGTCGCGCAACATCCAGGCCT
CGCTGCTGTCGCTGGTCGGCATCCTGGCCATCTGCGCCATGATGGGCGAAATCCCCGGCATCTACCTGGAGGCCGTGCGC
GGCTATCGCCCGATCCAGGCGGCCCCCGTCTCACTGGTCGTGGCGCTGCCGCAGCTCCTGATGCTTCCGCTGATCGCGGC
CATCTGCAACAGCCGCAGGGTGGATTGCCGCTACGTGCTCTCGGGCGGAATGCTCTGCCTGGCCGGCGCGGCCTGGCTGG
GCACGTGGCTGACCGTGGACTGGGTGCGGGACAATTTCTACGCGCTGCAGGTCCTGCAGATCTTCGGCCAGCCCATGACC
GTCATTCCCACGCTGATGCTCGCCACCCTCGCGATGGGGCCCGCCGACGGTCCGTTCATCTCGGGCATGGTGAACATGCT
CAAGGGCCTGGCCAACGCGGTGGCATACGCCGTGTTCGCGGCCCTGACCCGGCGGCGGGAGCAATATCATTCCACCATGC
TGCTGGACCATCACGGCACGCACGGCCTGGCGCTGCAGGGGATGGGCGATCCGGTCAACCGGCAGCTTGCCGCCACGTCG
CCCGACAGCGCGCATGTCGCGCGCAACACGCTCCAGGTCTTTCATACCTTCGTGCACGAGCAGTCGCTCGTCCTCGCGCT
GGCCGACATCTACTTCGTGCTGATCTGGGTCTGCCTCGGCTACGCGGTCATGAACCTCATCCTGCCGCGCCGGGTCTATC
CGCCGCGCGCGCCGTCGCCGAACACTCCCGCCCGCTAA

Upstream 100 bases:

>100_bases
ACCGCTGCGGGAACCGGGCGTCTCGCTTCCGGAAATCGAAGTCGTCTCTTGCGGGAAACGGGGGTTGTCCGCGGCTTCCG
GCTCGGGATTATCGGTTTTC

Downstream 100 bases:

>100_bases
TCCGGAACGACCGATCATGATCTACAAGAAACCGCTTCTCTACGCGGGATGCACCGCCTGCGTGCTCGCCCTCGCCGCCT
GGGGGGGAACGCGCCTGGTC

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNNVVPVPSAGEPVIHASPPRPSYIPPFGVRTVIGCLGMLLAVHVAGFNEHVTEIGLTDIRGAMHIGYDEGTWLIAIYES
FNIAAMAFTPWFYMTFSIYRFSIFVTAVMALLAIPAPFMPDVTSLCILRAFQGLMAGCLPPVLMTVMLKYLPPEIRVFGI
GGYAMSATFGPNLGLPLEAFWFERVGWHWLYWEIIPLAALSIAMIAYGLPRDPMHFERFQKFNWLGLLVGLPAICALVIV
LYQGDRLDWFRSPVITNLSFWGGAAFIVFVINEAYHPSPYFRVQYWRSRNIQASLLSLVGILAICAMMGEIPGIYLEAVR
GYRPIQAAPVSLVVALPQLLMLPLIAAICNSRRVDCRYVLSGGMLCLAGAAWLGTWLTVDWVRDNFYALQVLQIFGQPMT
VIPTLMLATLAMGPADGPFISGMVNMLKGLANAVAYAVFAALTRRREQYHSTMLLDHHGTHGLALQGMGDPVNRQLAATS
PDSAHVARNTLQVFHTFVHEQSLVLALADIYFVLIWVCLGYAVMNLILPRRVYPPRAPSPNTPAR

Sequences:

>Translated_545_residues
MNNVVPVPSAGEPVIHASPPRPSYIPPFGVRTVIGCLGMLLAVHVAGFNEHVTEIGLTDIRGAMHIGYDEGTWLIAIYES
FNIAAMAFTPWFYMTFSIYRFSIFVTAVMALLAIPAPFMPDVTSLCILRAFQGLMAGCLPPVLMTVMLKYLPPEIRVFGI
GGYAMSATFGPNLGLPLEAFWFERVGWHWLYWEIIPLAALSIAMIAYGLPRDPMHFERFQKFNWLGLLVGLPAICALVIV
LYQGDRLDWFRSPVITNLSFWGGAAFIVFVINEAYHPSPYFRVQYWRSRNIQASLLSLVGILAICAMMGEIPGIYLEAVR
GYRPIQAAPVSLVVALPQLLMLPLIAAICNSRRVDCRYVLSGGMLCLAGAAWLGTWLTVDWVRDNFYALQVLQIFGQPMT
VIPTLMLATLAMGPADGPFISGMVNMLKGLANAVAYAVFAALTRRREQYHSTMLLDHHGTHGLALQGMGDPVNRQLAATS
PDSAHVARNTLQVFHTFVHEQSLVLALADIYFVLIWVCLGYAVMNLILPRRVYPPRAPSPNTPAR
>Mature_545_residues
MNNVVPVPSAGEPVIHASPPRPSYIPPFGVRTVIGCLGMLLAVHVAGFNEHVTEIGLTDIRGAMHIGYDEGTWLIAIYES
FNIAAMAFTPWFYMTFSIYRFSIFVTAVMALLAIPAPFMPDVTSLCILRAFQGLMAGCLPPVLMTVMLKYLPPEIRVFGI
GGYAMSATFGPNLGLPLEAFWFERVGWHWLYWEIIPLAALSIAMIAYGLPRDPMHFERFQKFNWLGLLVGLPAICALVIV
LYQGDRLDWFRSPVITNLSFWGGAAFIVFVINEAYHPSPYFRVQYWRSRNIQASLLSLVGILAICAMMGEIPGIYLEAVR
GYRPIQAAPVSLVVALPQLLMLPLIAAICNSRRVDCRYVLSGGMLCLAGAAWLGTWLTVDWVRDNFYALQVLQIFGQPMT
VIPTLMLATLAMGPADGPFISGMVNMLKGLANAVAYAVFAALTRRREQYHSTMLLDHHGTHGLALQGMGDPVNRQLAATS
PDSAHVARNTLQVFHTFVHEQSLVLALADIYFVLIWVCLGYAVMNLILPRRVYPPRAPSPNTPAR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=424, Percent_Identity=24.7641509433962, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789042, Length=435, Percent_Identity=20.6896551724138, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 60291; Mature: 60291

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVVPVPSAGEPVIHASPPRPSYIPPFGVRTVIGCLGMLLAVHVAGFNEHVTEIGLTDI
CCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHH
RGAMHIGYDEGTWLIAIYESFNIAAMAFTPWFYMTFSIYRFSIFVTAVMALLAIPAPFMP
CCCEEECCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DVTSLCILRAFQGLMAGCLPPVLMTVMLKYLPPEIRVFGIGGYAMSATFGPNLGLPLEAF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCCCCCHHHH
WFERVGWHWLYWEIIPLAALSIAMIAYGLPRDPMHFERFQKFNWLGLLVGLPAICALVIV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYQGDRLDWFRSPVITNLSFWGGAAFIVFVINEAYHPSPYFRVQYWRSRNIQASLLSLVG
HHCCCCCHHHHCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHH
ILAICAMMGEIPGIYLEAVRGYRPIQAAPVSLVVALPQLLMLPLIAAICNSRRVDCRYVL
HHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
SGGMLCLAGAAWLGTWLTVDWVRDNFYALQVLQIFGQPMTVIPTLMLATLAMGPADGPFI
HCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
SGMVNMLKGLANAVAYAVFAALTRRREQYHSTMLLDHHGTHGLALQGMGDPVNRQLAATS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEECCCCCCCCCCEECCC
PDSAHVARNTLQVFHTFVHEQSLVLALADIYFVLIWVCLGYAVMNLILPRRVYPPRAPSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NTPAR
CCCCC
>Mature Secondary Structure
MNNVVPVPSAGEPVIHASPPRPSYIPPFGVRTVIGCLGMLLAVHVAGFNEHVTEIGLTDI
CCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHH
RGAMHIGYDEGTWLIAIYESFNIAAMAFTPWFYMTFSIYRFSIFVTAVMALLAIPAPFMP
CCCEEECCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DVTSLCILRAFQGLMAGCLPPVLMTVMLKYLPPEIRVFGIGGYAMSATFGPNLGLPLEAF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCCCCCHHHH
WFERVGWHWLYWEIIPLAALSIAMIAYGLPRDPMHFERFQKFNWLGLLVGLPAICALVIV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYQGDRLDWFRSPVITNLSFWGGAAFIVFVINEAYHPSPYFRVQYWRSRNIQASLLSLVG
HHCCCCCHHHHCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHH
ILAICAMMGEIPGIYLEAVRGYRPIQAAPVSLVVALPQLLMLPLIAAICNSRRVDCRYVL
HHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
SGGMLCLAGAAWLGTWLTVDWVRDNFYALQVLQIFGQPMTVIPTLMLATLAMGPADGPFI
HCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHH
SGMVNMLKGLANAVAYAVFAALTRRREQYHSTMLLDHHGTHGLALQGMGDPVNRQLAATS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEECCCCCCCCCCEECCC
PDSAHVARNTLQVFHTFVHEQSLVLALADIYFVLIWVCLGYAVMNLILPRRVYPPRAPSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NTPAR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]