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The map label for this gene is gltR [H]

Identifier: 162146026

GI number: 162146026

Start: 208786

End: 209691

Strand: Direct

Name: gltR [H]

Synonym: GDI_0194

Alternate gene names: 162146026

Gene position: 208786-209691 (Clockwise)

Preceding gene: 162146025

Following gene: 162146027

Centisome position: 5.29

GC content: 56.84

Gene sequence:

>906_bases
ATGGCGATGAACCTCAAGTCGCTCGAGGTCCTTCTGTCGATAGACCGTCTGGGAGGGTTCAAGGCTGCGGCGGAGAGTCT
TCGCCTGACGCAGCCGGCAATTTCGATACGCATCGCGCAACTGGAACATGAACTGGGCGCGAAGCTGTTCTATCGTACGG
GCAATCAGGTCTCGCCGACGCCTATCGGCAAGACGCTGATCTATTATGCCGAGCGCATTCTCGAACTTCATGACGAGGCC
GTCGCGACGATCAAGGGGCACAGCGAGAAGAACGGAATCCTGCGTCTCGGGACGATAGAGACCGTCGTCCATACCTGGCT
GCCGCATCTTCTTTCGCGAATCGGCGTGAAATATCCGAATATCACGATCGATCTCGATATCGGGAATTCCGACGATATTC
AGCGCAAGGTTACGAAGGGGATGCTGGATCTCGGGATCTTCATCGGGCCGGTGAACTCTCCCGTCATGATCGAGACGTCC
GTCTACAAGTTCAAGCTCGGTCTTGTCGCCTCGAAGAAATTCAAGGATGCCAGGCTGGAGGAGATCGGACTCGGAAATCT
GCCCTCCCTGTCGCTCATGACGTTCTCGCGCAATACCGTCCCGCATTCGATGCTGTGCAGCCTCCTGGCCAGGGAAGGGA
TCAGTCGCCATCGTATTCATGCCATGAGTTCGGCGCCGATGATCGTCAACATGCTCCTCAAGCGTCCGGGACTGGCGCTG
ATCCCCCAGGCGGTCGTCAGGAACCATCTCGAATCCGGGGAACTCTGCCTTCTGGACGTCGGCATGCCCGTTCCAAAGGT
CAATTGCGTGGCGGGGCGCCTCATCAGGCATAATTCCGAAATTATCGAGGATGTCGTCAAGATTGCCCAGCAGGTTGCGA
TTGACGAATTCGGTGAGTCCGGATGA

Upstream 100 bases:

>100_bases
CGACCGACGTGATCAACGAATGGGTGGCGCGCCACGGATGTTGAGCGGGACCGTTCGCAGGATGGCGTGTTTCCGGAACC
GTGATGTCTGACAAGGGTGA

Downstream 100 bases:

>100_bases
TGCATCGATCGGTCCGGTGTGTGGCAAAGTAATGAAGTCATATATGACTGTATAACAATACCTTATCATCGTTGTTTTTC
TGGTTTTCGTTCAAAGTGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MAMNLKSLEVLLSIDRLGGFKAAAESLRLTQPAISIRIAQLEHELGAKLFYRTGNQVSPTPIGKTLIYYAERILELHDEA
VATIKGHSEKNGILRLGTIETVVHTWLPHLLSRIGVKYPNITIDLDIGNSDDIQRKVTKGMLDLGIFIGPVNSPVMIETS
VYKFKLGLVASKKFKDARLEEIGLGNLPSLSLMTFSRNTVPHSMLCSLLAREGISRHRIHAMSSAPMIVNMLLKRPGLAL
IPQAVVRNHLESGELCLLDVGMPVPKVNCVAGRLIRHNSEIIEDVVKIAQQVAIDEFGESG

Sequences:

>Translated_301_residues
MAMNLKSLEVLLSIDRLGGFKAAAESLRLTQPAISIRIAQLEHELGAKLFYRTGNQVSPTPIGKTLIYYAERILELHDEA
VATIKGHSEKNGILRLGTIETVVHTWLPHLLSRIGVKYPNITIDLDIGNSDDIQRKVTKGMLDLGIFIGPVNSPVMIETS
VYKFKLGLVASKKFKDARLEEIGLGNLPSLSLMTFSRNTVPHSMLCSLLAREGISRHRIHAMSSAPMIVNMLLKRPGLAL
IPQAVVRNHLESGELCLLDVGMPVPKVNCVAGRLIRHNSEIIEDVVKIAQQVAIDEFGESG
>Mature_300_residues
AMNLKSLEVLLSIDRLGGFKAAAESLRLTQPAISIRIAQLEHELGAKLFYRTGNQVSPTPIGKTLIYYAERILELHDEAV
ATIKGHSEKNGILRLGTIETVVHTWLPHLLSRIGVKYPNITIDLDIGNSDDIQRKVTKGMLDLGIFIGPVNSPVMIETSV
YKFKLGLVASKKFKDARLEEIGLGNLPSLSLMTFSRNTVPHSMLCSLLAREGISRHRIHAMSSAPMIVNMLLKRPGLALI
PQAVVRNHLESGELCLLDVGMPVPKVNCVAGRLIRHNSEIIEDVVKIAQQVAIDEFGESG

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=247, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI157672245, Length=252, Percent_Identity=25.3968253968254, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788481, Length=267, Percent_Identity=25.8426966292135, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082132, Length=262, Percent_Identity=26.7175572519084, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693105, Length=154, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789639, Length=263, Percent_Identity=27.3764258555133, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=24.390243902439, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=21.8430034129693, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994962, Length=176, Percent_Identity=29.5454545454545, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790262, Length=251, Percent_Identity=23.1075697211155, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787530, Length=211, Percent_Identity=25.1184834123223, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788626, Length=125, Percent_Identity=32.8, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33062; Mature: 32931

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMNLKSLEVLLSIDRLGGFKAAAESLRLTQPAISIRIAQLEHELGAKLFYRTGNQVSPT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCC
PIGKTLIYYAERILELHDEAVATIKGHSEKNGILRLGTIETVVHTWLPHLLSRIGVKYPN
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
ITIDLDIGNSDDIQRKVTKGMLDLGIFIGPVNSPVMIETSVYKFKLGLVASKKFKDARLE
EEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEHEEEEEHHHHCCCHHHHHHH
EIGLGNLPSLSLMTFSRNTVPHSMLCSLLAREGISRHRIHAMSSAPMIVNMLLKRPGLAL
HCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCC
IPQAVVRNHLESGELCLLDVGMPVPKVNCVAGRLIRHNSEIIEDVVKIAQQVAIDEFGES
CHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
G
C
>Mature Secondary Structure 
AMNLKSLEVLLSIDRLGGFKAAAESLRLTQPAISIRIAQLEHELGAKLFYRTGNQVSPT
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCC
PIGKTLIYYAERILELHDEAVATIKGHSEKNGILRLGTIETVVHTWLPHLLSRIGVKYPN
CCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
ITIDLDIGNSDDIQRKVTKGMLDLGIFIGPVNSPVMIETSVYKFKLGLVASKKFKDARLE
EEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEHEEEEEHHHHCCCHHHHHHH
EIGLGNLPSLSLMTFSRNTVPHSMLCSLLAREGISRHRIHAMSSAPMIVNMLLKRPGLAL
HCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCC
IPQAVVRNHLESGELCLLDVGMPVPKVNCVAGRLIRHNSEIIEDVVKIAQQVAIDEFGES
CHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]