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The map label for this gene is pdc [H]

Identifier: 162146004

GI number: 162146004

Start: 181033

End: 182709

Strand: Reverse

Name: pdc [H]

Synonym: GDI_0172

Alternate gene names: 162146004

Gene position: 182709-181033 (Counterclockwise)

Preceding gene: 162146006

Following gene: 162146003

Centisome position: 4.63

GC content: 68.87

Gene sequence:

>1677_bases
ATGACCTATACCGTTGGACGCTATCTCGCGGATCGGCTGGCCCAGATCGGGCTGAAGCACCATTTCGCGGTGGCCGGCGA
CTACAACCTGGTGCTGCTGGACCAGCTTCTGCTCAACACCGACATGCAGCAGATCTATTGCAGCAACGAGCTGAATTGCG
GGTTCAGCGCCGAGGGCTATGCCCGCGCCAACGGGGCCGCCGCCGCGATCGTGACCTTCAGCGTCGGCGCCCTGTCGGCC
TTCAACGCGCTGGGCGGCGCCTATGCCGAAAACCTGCCCGTGATCCTGATTTCCGGCGCACCGAACGCGAACGACCACGG
GACCGGTCACATCCTGCATCACACGCTGGGCACCACCGATTACGGCTATCAGCTTGAGATGGCGCGGCATATCACCTGCG
CCGCCGAATCCATCGTGGCGGCCGAGGACGCGCCCGCCAAGATCGACCACGTGATCCGCACCGCCCTGCGCGAGAAGAAG
CCCGCCTATCTGGAAATCGCCTGCAACGTCGCGGGGGCGCCCTGCGTGCGTCCGGGCGGGATCGACGCGCTGCTGAGCCC
GCCGGCCCCGGACGAGGCCAGCCTGAAGGCGGCGGTGGATGCGGCGCTTGCCTTCATCGAACAGCGCGGCAGCGTGACGA
TGCTGGTCGGCAGCCGCATCCGCGCGGCGGGCGCGCAGGCCCAGGCCGTGGCCCTGGCCGACGCGCTGGGCTGCGCCGTC
ACCACCATGGCCGCCGCCAAGAGCTTCTTCCCCGAAGACCATCCCGGCTATCGCGGCCATTACTGGGGCGAGGTCAGCAG
CCCGGGCGCGCAGCAGGCGGTCGAAGGCGCGGACGGCGTGATCTGCCTGGCGCCGGTCTTCAACGACTACGCGACCGTCG
GCTGGTCGGCCTGGCCCAAGGGCGACAATGTGATGCTGGTGGAACGCCACGCGGTCACGGTGGGCGGCGTTGCCTATGCG
GGCATCGACATGCGCGACTTCCTGACCCGGCTGGCCGCGCATACCGTGCGGCGCGACGCCACCGCCCGGGGCGGCGCCTA
CGTGACGCCGCAGACGCCAGCCGCAGCCCCGACCGCGCCGCTGAACAATGCCGAAATGGCCCGCCAGATCGGCGCCCTGC
TGACGCCACGGACCACCCTGACCGCCGAAACCGGCGATTCCTGGTTCAACGCCGTGCGCATGAAGCTGCCGCACGGCGCG
CGGGTGGAACTGGAAATGCAGTGGGGGCATATCGGCTGGTCGGTTCCCGCCGCGTTCGGCAATGCCCTGGCCGCCCCCGA
GCGGCAGCATGTACTGATGGTGGGCGACGGGTCGTTCCAGCTGACGGCGCAGGAAGTCGCGCAGATGATCCGCCACGACC
TGCCGGTGATCATCTTCCTGATCAACAATCATGGCTACACGATCGAAGTCATGATTCATGACGGCCCGTACAACAACGTC
AAGAACTGGGATTATGCGGGCCTGATGGAGGTCTTCAACGCCGGCGAGGGCAACGGGCTGGGCCTGCGCGCCCGCACCGG
GGGGGAACTGGCCGCCGCCATCGAGCAGGCGCGCGCCAACCGCAACGGCCCGACGCTGATCGAATGCACGCTGGACCGCG
ACGACTGCACGCAGGAGCTGGTCACGTGGGGCAAGCGCGTGGCCGCCGCCAACGCCCGCCCGCCGCGCGCGGGCTGA

Upstream 100 bases:

>100_bases
CCATATCCATATATCCTGTATATGGAATCGACACATACCATATATTTGACGTTGGCATAAGGCAGGATCACCATGGCCGG
ACGATGCAAGGAGCCATGTG

Downstream 100 bases:

>100_bases
CCGGCGGGCCGCCCCGCCGGCCCGTCAGGGCGGCGCGGTGACCGGCGGGGGTGCCGAGGGCGGACGGCTCGGCTTTTTCG
GCACCTCGCTGGATGGCGGG

Product: pyruvate decarboxylase

Products: NA

Alternate protein names: PDC [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MTYTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGYARANGAAAAIVTFSVGALSA
FNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTDYGYQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKK
PAYLEIACNVAGAPCVRPGGIDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAV
TTMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPKGDNVMLVERHAVTVGGVAYA
GIDMRDFLTRLAAHTVRRDATARGGAYVTPQTPAAAPTAPLNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGA
RVELEMQWGHIGWSVPAAFGNALAAPERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIHDGPYNNV
KNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDRDDCTQELVTWGKRVAAANARPPRAG

Sequences:

>Translated_558_residues
MTYTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGYARANGAAAAIVTFSVGALSA
FNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTDYGYQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKK
PAYLEIACNVAGAPCVRPGGIDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAV
TTMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPKGDNVMLVERHAVTVGGVAYA
GIDMRDFLTRLAAHTVRRDATARGGAYVTPQTPAAAPTAPLNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGA
RVELEMQWGHIGWSVPAAFGNALAAPERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIHDGPYNNV
KNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDRDDCTQELVTWGKRVAAANARPPRAG
>Mature_557_residues
TYTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGYARANGAAAAIVTFSVGALSAF
NALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTDYGYQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKKP
AYLEIACNVAGAPCVRPGGIDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAVT
TMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPKGDNVMLVERHAVTVGGVAYAG
IDMRDFLTRLAAHTVRRDATARGGAYVTPQTPAAAPTAPLNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGAR
VELEMQWGHIGWSVPAAFGNALAAPERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIHDGPYNNVK
NWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDRDDCTQELVTWGKRVAAANARPPRAG

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=562, Percent_Identity=23.3096085409253, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323073, Length=564, Percent_Identity=32.6241134751773, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323163, Length=563, Percent_Identity=31.7939609236234, Blast_Score=260, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6321524, Length=566, Percent_Identity=30.9187279151943, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6320123, Length=556, Percent_Identity=26.0791366906475, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320588, Length=604, Percent_Identity=23.6754966887417, Blast_Score=150, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.1 [H]

Molecular weight: Translated: 59136; Mature: 59004

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGY
CCEEHHHHHHHHHHHHCCHHEEEEECCCCEEEHHHHHHCCCHHHHEECCCCCCCCCCCCC
ARANGAAAAIVTFSVGALSAFNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTD
CCCCCCEEEEEEEEHHHHHHHHHHCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCC
YGYQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKKPAYLEIACNVAGAPCVRPGG
CCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
IDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAV
CCEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCHHHHHHHHHHHHHH
TTMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPK
HHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHCCCCCEEEEEECCCCHHHCCCCCCCC
GDNVMLVERHAVTVGGVAYAGIDMRDFLTRLAAHTVRRDATARGGAYVTPQTPAAAPTAP
CCCEEEEEECEEEECCEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
LNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGARVELEMQWGHIGWSVPAAFG
CCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHEECCCCCEEEEEEEECCCCEECHHHHC
NALAAPERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIHDGPYNNV
CHHCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCCCC
KNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDRDDCTQEL
CCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
VTWGKRVAAANARPPRAG
HHHHHHEEECCCCCCCCC
>Mature Secondary Structure 
TYTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGY
CEEHHHHHHHHHHHHCCHHEEEEECCCCEEEHHHHHHCCCHHHHEECCCCCCCCCCCCC
ARANGAAAAIVTFSVGALSAFNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTD
CCCCCCEEEEEEEEHHHHHHHHHHCCHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCC
YGYQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKKPAYLEIACNVAGAPCVRPGG
CCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
IDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAV
CCEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCHHHHHHHHHHHHHH
TTMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPK
HHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHCCCCCEEEEEECCCCHHHCCCCCCCC
GDNVMLVERHAVTVGGVAYAGIDMRDFLTRLAAHTVRRDATARGGAYVTPQTPAAAPTAP
CCCEEEEEECEEEECCEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
LNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGARVELEMQWGHIGWSVPAAFG
CCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHEECCCCCEEEEEEEECCCCEECHHHHC
NALAAPERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIHDGPYNNV
CHHCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCCCC
KNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDRDDCTQEL
CCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
VTWGKRVAAANARPPRAG
HHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3546263; 3029726; 3029037; 2838467; 8645153; 9655927; 9685367 [H]