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The map label for this gene is hisB

Identifier: 162145911

GI number: 162145911

Start: 78086

End: 78682

Strand: Reverse

Name: hisB

Synonym: GDI_0073

Alternate gene names: 162145911

Gene position: 78682-78086 (Counterclockwise)

Preceding gene: 162145914

Following gene: 162145910

Centisome position: 1.99

GC content: 66.83

Gene sequence:

>597_bases
ATGGATACTGCCCGCACAGCCACGATTCATCGCGTCACCAGCGAGACCGACATCACGATCCGCCTGGACCTGGACGGCAC
CGGCCAGTCGCGCATCGCGACGGGGATCGGCTTCTTCGACCATATGCTGACGGCGCTGGCCCGGCATGGGATGTTCGACC
TGGATATCGAGGCCAAGGGCGACCTGCATATCGATTTCCATCATACCGTCGAGGATACCGGCATCGCGCTGGGCCAGGCC
TTCGTCCGGGCGATCGGCGACAAGCGGGGCATCAGGCGGTTCGGCCATGCGCTGGTGCCGCTGGACGAGGCGCTGAGCGA
GGTGGTGGCCGACATATCCGGCCGGCCCTACCTGGCGTGGGCGGTAGACTTCACCCGCGACAAGATCGGGGAGATGGACA
CCGAGCTGTTCGAGGAATTCTTTCGCGCCTTCGCCATGAGCGCGCTGGTGACGCTGCATGTTACGCAGAAGGCCGGCCGC
AACTGCCACCATATCGCCGAGGCGTCGTTCAAGGCGGCGGCGCGGGCGCTGCGGATGGCGACCGAGGCCGACCCCCGCGC
GGCGGGCGCGATTCCGTCCACCAAGGGCGTGCTGTGA

Upstream 100 bases:

>100_bases
GCCCCCCCACGGGCCGGACACTGCACACGTCCGGCGACCAGCGGGAGGAACGCACGGGAATGGTGGCCTAACGCGGCCTA
GTCCTGTAGGAGAACGGGAC

Downstream 100 bases:

>100_bases
CGACGTATTCCTCCTGGTTTCGGGCGGAGGGCAACCGGCCGCCGGTTCTGGTGGCCGAGCGCCTGTCCTGGCGGGTGCTG
ATCCTGGGCTGGCTGGGACT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MDTARTATIHRVTSETDITIRLDLDGTGQSRIATGIGFFDHMLTALARHGMFDLDIEAKGDLHIDFHHTVEDTGIALGQA
FVRAIGDKRGIRRFGHALVPLDEALSEVVADISGRPYLAWAVDFTRDKIGEMDTELFEEFFRAFAMSALVTLHVTQKAGR
NCHHIAEASFKAAARALRMATEADPRAAGAIPSTKGVL

Sequences:

>Translated_198_residues
MDTARTATIHRVTSETDITIRLDLDGTGQSRIATGIGFFDHMLTALARHGMFDLDIEAKGDLHIDFHHTVEDTGIALGQA
FVRAIGDKRGIRRFGHALVPLDEALSEVVADISGRPYLAWAVDFTRDKIGEMDTELFEEFFRAFAMSALVTLHVTQKAGR
NCHHIAEASFKAAARALRMATEADPRAAGAIPSTKGVL
>Mature_198_residues
MDTARTATIHRVTSETDITIRLDLDGTGQSRIATGIGFFDHMLTALARHGMFDLDIEAKGDLHIDFHHTVEDTGIALGQA
FVRAIGDKRGIRRFGHALVPLDEALSEVVADISGRPYLAWAVDFTRDKIGEMDTELFEEFFRAFAMSALVTLHVTQKAGR
NCHHIAEASFKAAARALRMATEADPRAAGAIPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50.5154639175258, Blast_Score=188, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=44.0909090909091, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_GLUDA (A9GZY1)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001600369.1
- RefSeq:   YP_002276012.1
- ProteinModelPortal:   A9GZY1
- SMR:   A9GZY1
- GeneID:   5788730
- GeneID:   6975035
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_1619
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21616; Mature: 21616

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTARTATIHRVTSETDITIRLDLDGTGQSRIATGIGFFDHMLTALARHGMFDLDIEAKG
CCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
DLHIDFHHTVEDTGIALGQAFVRAIGDKRGIRRFGHALVPLDEALSEVVADISGRPYLAW
CEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEE
AVDFTRDKIGEMDTELFEEFFRAFAMSALVTLHVTQKAGRNCHHIAEASFKAAARALRMA
EEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TEADPRAAGAIPSTKGVL
HCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTARTATIHRVTSETDITIRLDLDGTGQSRIATGIGFFDHMLTALARHGMFDLDIEAKG
CCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
DLHIDFHHTVEDTGIALGQAFVRAIGDKRGIRRFGHALVPLDEALSEVVADISGRPYLAW
CEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEE
AVDFTRDKIGEMDTELFEEFFRAFAMSALVTLHVTQKAGRNCHHIAEASFKAAARALRMA
EEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TEADPRAAGAIPSTKGVL
HCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA