Click here to switch to the map view.

The map label for this gene is pepV [H]

Identifier: 162139184

GI number: 162139184

Start: 898297

End: 899706

Strand: Direct

Name: pepV [H]

Synonym: MGAS10750_Spy0941

Alternate gene names: 162139184

Gene position: 898297-899706 (Clockwise)

Preceding gene: 94994336

Following gene: 162139183

Centisome position: 46.37

GC content: 43.12

Gene sequence:

>1410_bases
ATGACAACCATTGATTTTAAAGCAGAAGTTGACAAACGTAAAGAAGCTATGCTAGCAGATTTAGTTGACCTATTACGCAT
TAATTCAGAACGCGATGACAGATTGGCCGATGATCAGCATCCCTTTGGCCCAGGTCCAGTTAAGGCTTTGGAGCACTTCC
TCGCAATGGCTGAGCGTGATGGCTACAAAACGCGTAATATTGATAACTATGCAGGTGACTTTGAATTTGGTCAAGGTGAT
GAAGTACTAGGAATCTTTGGTCACCTTGATGTTGTGCCAGCTGGTAGCGGTTGGGATACAGACCCTTATGAGCCAGTGAT
TAAAGACGATCGCATCTATGCGCGTGGGTCTTCGGATGATAAGGGACCAACCATGGCGTGCTACTACGCTCTGAAAATCA
TTAAAGAATTGGGTCTTCCTGTGTCTAAAAAAGTTCGTTTCATTGTTGGTACCGATGAAGAATCTGGCTGGGGGGATATG
GATTATTACTTTGCTCATAATGGCTTGAAAAATCCAGATTTTGGTTTCTCACCAGATGCTGAATTTCCAATTATCAATGG
TGAGAAAGGAAATATCACCGAATACCTCCATTTCGCTGGTGACAACAAGGGCGCTTTTGTGCTTCATCGCTTCCAAGGTG
GGTTGCGTGAAAACATGGTACCAGAATCTGCAACAGCTGTCATTACGGCACCGCATGACCTTTATGTGCTAGAAGCAGCC
TTGGAGCAATTTTTATCAGAACATGGTGTTAAAGGTTCTATGAAGGCTACTGATGGTAAAATTGAAGTGACCATTATTGG
TAAGTCTGCTCACGGGTCGACTCCAGAAGCGGGTGTTAATGGTGCCACCTTGTTGGCTAAATTCCTGAATCAATTTACCT
TTGAAGGGGCTGCTAAGGATTATTTACATGTGGCAGGTGAGGTGCTTCATGAAGACTTTGCGGCAGAAAAACTAGGCCTT
GCTTATACCGATGACCGTATGGGAGCCCTGAGCATGAACGCAGGTGTCTTTACCTTTGATAGTCAATCAGCTGACAATAC
CATCGCCTTGAATTTCCGTTATCCAAAAGGGACTGATGCGGCAACCTTAAAATCAGGATTGGAAAAATTACCAGGTTTAA
CTAAGGTAAGCCTTTCTGAGCATGAACATACACCTCATTATGTGCCAATGGATGATGAATTAGTAACTACCTTACTTGCT
GTTTACGAAAAACAAACAGGTCTTAAAGGCTACGAACAAGTTATCGGCGGAGGAACCTTTGGTCGTTTGCTAGAACGTGG
TGTGGCCTTTGGAGCGATGTTCCCAGGCGATGAAAACACTATGCACCAAGCTAATGAATATATGCCTTTAGAAAATATTT
ATCGCTCAGCAGCTATTTATGCTGAAGCAATCTACGAATTAATTAAATAA

Upstream 100 bases:

>100_bases
ATGTCCAGATGCGCTACTGAGCGACCACTATTGTTAGACTGATACTATTTTGGCTTATTTTAAGTTAAACATTATCCCTA
AAACGAATAAGGAGAGTATA

Downstream 100 bases:

>100_bases
GATGCTTATGACAGCAAAAAGAGCTGGAACACTGTTCCAGCTCTTTTGTGATGATTAGAGAATGGTCTTATTTACCAAGA
CAAAATTGGCTAAAGAGTTG

Product: dipeptidase PepV

Products: succinate; LL-2,6-diaminoheptanedioate

Alternate protein names: Beta-Ala-His dipeptidase; Peptidase V [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTTIDFKAEVDKRKEAMLADLVDLLRINSERDDRLADDQHPFGPGPVKALEHFLAMAERDGYKTRNIDNYAGDFEFGQGD
EVLGIFGHLDVVPAGSGWDTDPYEPVIKDDRIYARGSSDDKGPTMACYYALKIIKELGLPVSKKVRFIVGTDEESGWGDM
DYYFAHNGLKNPDFGFSPDAEFPIINGEKGNITEYLHFAGDNKGAFVLHRFQGGLRENMVPESATAVITAPHDLYVLEAA
LEQFLSEHGVKGSMKATDGKIEVTIIGKSAHGSTPEAGVNGATLLAKFLNQFTFEGAAKDYLHVAGEVLHEDFAAEKLGL
AYTDDRMGALSMNAGVFTFDSQSADNTIALNFRYPKGTDAATLKSGLEKLPGLTKVSLSEHEHTPHYVPMDDELVTTLLA
VYEKQTGLKGYEQVIGGGTFGRLLERGVAFGAMFPGDENTMHQANEYMPLENIYRSAAIYAEAIYELIK

Sequences:

>Translated_469_residues
MTTIDFKAEVDKRKEAMLADLVDLLRINSERDDRLADDQHPFGPGPVKALEHFLAMAERDGYKTRNIDNYAGDFEFGQGD
EVLGIFGHLDVVPAGSGWDTDPYEPVIKDDRIYARGSSDDKGPTMACYYALKIIKELGLPVSKKVRFIVGTDEESGWGDM
DYYFAHNGLKNPDFGFSPDAEFPIINGEKGNITEYLHFAGDNKGAFVLHRFQGGLRENMVPESATAVITAPHDLYVLEAA
LEQFLSEHGVKGSMKATDGKIEVTIIGKSAHGSTPEAGVNGATLLAKFLNQFTFEGAAKDYLHVAGEVLHEDFAAEKLGL
AYTDDRMGALSMNAGVFTFDSQSADNTIALNFRYPKGTDAATLKSGLEKLPGLTKVSLSEHEHTPHYVPMDDELVTTLLA
VYEKQTGLKGYEQVIGGGTFGRLLERGVAFGAMFPGDENTMHQANEYMPLENIYRSAAIYAEAIYELIK
>Mature_468_residues
TTIDFKAEVDKRKEAMLADLVDLLRINSERDDRLADDQHPFGPGPVKALEHFLAMAERDGYKTRNIDNYAGDFEFGQGDE
VLGIFGHLDVVPAGSGWDTDPYEPVIKDDRIYARGSSDDKGPTMACYYALKIIKELGLPVSKKVRFIVGTDEESGWGDMD
YYFAHNGLKNPDFGFSPDAEFPIINGEKGNITEYLHFAGDNKGAFVLHRFQGGLRENMVPESATAVITAPHDLYVLEAAL
EQFLSEHGVKGSMKATDGKIEVTIIGKSAHGSTPEAGVNGATLLAKFLNQFTFEGAAKDYLHVAGEVLHEDFAAEKLGLA
YTDDRMGALSMNAGVFTFDSQSADNTIALNFRYPKGTDAATLKSGLEKLPGLTKVSLSEHEHTPHYVPMDDELVTTLLAV
YEKQTGLKGYEQVIGGGTFGRLLERGVAFGAMFPGDENTMHQANEYMPLENIYRSAAIYAEAIYELIK

Specific function: Is a relatively unspecific dipeptidase cleaving a variety of dipeptides, notably those with an N-terminal beta-Ala or D-Ala residue, e.g. carnosine (beta-Ala-His). To a lesser extent, also shows aminopeptidase activity, since it is able to catalyze the re

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI271398239, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17563146, Length=81, Percent_Identity=40.7407407407407, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193211059, Length=102, Percent_Identity=37.2549019607843, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR011291
- InterPro:   IPR010964
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF01546 Peptidase_M20 [H]

EC number: 3.5.1.18

Molecular weight: Translated: 51469; Mature: 51338

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIDFKAEVDKRKEAMLADLVDLLRINSERDDRLADDQHPFGPGPVKALEHFLAMAERD
CCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GYKTRNIDNYAGDFEFGQGDEVLGIFGHLDVVPAGSGWDTDPYEPVIKDDRIYARGSSDD
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEECCCCCCCCCCCCCCCCCEEEECCCCCC
KGPTMACYYALKIIKELGLPVSKKVRFIVGTDEESGWGDMDYYFAHNGLKNPDFGFSPDA
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCC
EFPIINGEKGNITEYLHFAGDNKGAFVLHRFQGGLRENMVPESATAVITAPHDLYVLEAA
CCCEEECCCCCHHHEEEECCCCCCEEEEEECCCCHHHCCCCCCCEEEEECCCHHHHHHHH
LEQFLSEHGVKGSMKATDGKIEVTIIGKSAHGSTPEAGVNGATLLAKFLNQFTFEGAAKD
HHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
YLHVAGEVLHEDFAAEKLGLAYTDDRMGALSMNAGVFTFDSQSADNTIALNFRYPKGTDA
HHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCEEEECCCCCCCEEEEEEECCCCCCH
ATLKSGLEKLPGLTKVSLSEHEHTPHYVPMDDELVTTLLAVYEKQTGLKGYEQVIGGGTF
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHH
GRLLERGVAFGAMFPGDENTMHQANEYMPLENIYRSAAIYAEAIYELIK
HHHHHHHHHEEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TTIDFKAEVDKRKEAMLADLVDLLRINSERDDRLADDQHPFGPGPVKALEHFLAMAERD
CEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GYKTRNIDNYAGDFEFGQGDEVLGIFGHLDVVPAGSGWDTDPYEPVIKDDRIYARGSSDD
CCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEECCCCCCCCCCCCCCCCCEEEECCCCCC
KGPTMACYYALKIIKELGLPVSKKVRFIVGTDEESGWGDMDYYFAHNGLKNPDFGFSPDA
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCC
EFPIINGEKGNITEYLHFAGDNKGAFVLHRFQGGLRENMVPESATAVITAPHDLYVLEAA
CCCEEECCCCCHHHEEEECCCCCCEEEEEECCCCHHHCCCCCCCEEEEECCCHHHHHHHH
LEQFLSEHGVKGSMKATDGKIEVTIIGKSAHGSTPEAGVNGATLLAKFLNQFTFEGAAKD
HHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
YLHVAGEVLHEDFAAEKLGLAYTDDRMGALSMNAGVFTFDSQSADNTIALNFRYPKGTDA
HHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCEEEECCCCCCCEEEEEEECCCCCCH
ATLKSGLEKLPGLTKVSLSEHEHTPHYVPMDDELVTTLLAVYEKQTGLKGYEQVIGGGTF
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHH
GRLLERGVAFGAMFPGDENTMHQANEYMPLENIYRSAAIYAEAIYELIK
HHHHHHHHHEEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-LL-2,6-diaminoheptanedioate; H2O

Specific reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7528082 [H]