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The map label for this gene is dnaX [H]

Identifier: 162007986

GI number: 162007986

Start: 759840

End: 761567

Strand: Direct

Name: dnaX [H]

Synonym: ELI_03680

Alternate gene names: 162007986

Gene position: 759840-761567 (Clockwise)

Preceding gene: 85373562

Following gene: 85373564

Centisome position: 24.89

GC content: 63.02

Gene sequence:

>1728_bases
ATGTTTGGTGACCCGGCGGCTGCAGAAGACACCGCTGCTCCCGCGCCGTCTGCACCTCCACCACCGGTTTCCGCCCCGTC
GGAGAGTTCCAGCCAGCCCTATCGCGTCCTCGCACGCAAGTACCGGCCGCAGACATTCTCGCAGCTTATCGGGCAAGAGC
CGATGGTGCGGACGCTGGCGAATGCGATTGAGCGCGACCGGCTGGCGCATGCCTTCCTGATGACCGGCGTGCGCGGTGTC
GGCAAAACCTCGACCGCACGGCTGATTGCCAAGTCGCTCAATTGCATCGGGCCGGATGGGCAAGGCGGTCCGACAATCGA
TCCTTGCGGCCAGTGCGAACCGTGCACCGCGATTGCCGAGGGGCGTCATATCGACGTGATCGAAATGGACGCTGCGAGCC
ATACCGGCGTCGACGATGTGCGCGAAATCATCGAGGCGGTGCGATATGCGGCGGTCTCGGCCCGATTCAAGATCTACATC
ATCGACGAGGTGCACATGCTCTCGCGCAATGCTTTCAACGCATTGCTCAAGACGCTGGAAGAACCGCCCGCGCATGTGAA
ATTCCTCTTCGCGACCACCGAAGTCGACAAATTGCCGGTAACGGTGTTGAGCCGCACCCAGCGCTTCGACTTGCGGCGCA
TCCCTGCCGATCTCTTGCAGAAGCACTTCGGCTGGGTGTGCGAGCAAGAACAGGTCGAAGCCGAAGACGAAGCGCTGGCA
ATGATCGCCGCCGCTGCCGAAGGGTCCGTCCGCGACGGGCTCTCGATCCTCGACCAAGCCATCGCTCATGCCGACCTCGA
TGCGGACGGGAAAGTCACCGCCACCCGCGTGCGCGACATGCTGGGGCTGGCCGATAAAGGTGCTCAGCGCCGGATGTTCG
GGACTATCCTCGAAGGTGATGCCAAGGCACTGCTCGCCGCTATCGAAGACCAGTATTCGCTCGGTGTCGAGCCGCTCGCG
CTTGTGCGATCCCAGATGGAATTGGCTCACCGCATCACCCTCGCGCAATTGGGCGGCTCGCTCCCGGGTGCAGTGAGCGA
GGAAGAGCAGGCTGCGCTTACGGCTTGGGGCGAACAGCTGTCGCAGGGTCAGCTGCATCGGCTCTGGCAATTGCTGCTCA
AAGCCTACGAGGAAGTGAAGACGGCCCCTGACCCTCTGGTCTCGGCGCAGATGGGGTTGCTGCGCCTCCTGCATGCCTCC
GAGTTGCCCGATCCGGGTAAGCTCGTGAAGACGCTGGAAATCTTGACCGCTAATCCGCCGGTACAAAGTCCCGCACCGCC
CCCAAGCGATGATCCTGCAGCCACGCCGACCGGAGAGGCGGGCGCAGAAGTGCCTGCACCATCGGATTTCGCGTCCCTCG
TCGATCGCGTCGAGCAGGCGGGACACGGATTTGCCGCCAGCATCATGCGCCTGCAATTGCGCGTAATTGAATGCGAAGAG
CGGCGACTCGTGTTCAGTCGTGCTTCTTCCTACACCGAGGAGATTGCTCCACAACTGCGTGAGGCTTTGCTGGCCGCCAC
CGGCCAGCGCTGGCAGCTGGAGGAGCGCGATTGGGTAGATGCGCCGCCCAGCCTGATGGAACAGGCGGAAGCACGGGAAG
AGGAAAAGAAAGCGCGGATCGACGGACATCCGCTGGTCGCCGCTACCAAGACTGCGTTTCCCGACGCGGAGATTATACCC
GAAGAAGAGACGGGCGCCCCCCGCCCGCAATGGAGCAAGAGCGCATGA

Upstream 100 bases:

>100_bases
GGGTGATTCACCGGATAATTCGGATGCGCCGCCGTGGCAGGGTGAGGAGCAGGACTCCGCTCCGAGTGCTGCCGAGCTTG
AGGCGGCAGGCCAGAATTCG

Downstream 100 bases:

>100_bases
AATCGATGGAAGAAATGATCCAGGCGGCGCAGCAGGCCGCCGAGACGATCCAAACCCAGATGAACGAAGCCCAGGCGAAG
CTCGACGCCATCGAAGTCGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MFGDPAAAEDTAAPAPSAPPPPVSAPSESSSQPYRVLARKYRPQTFSQLIGQEPMVRTLANAIERDRLAHAFLMTGVRGV
GKTSTARLIAKSLNCIGPDGQGGPTIDPCGQCEPCTAIAEGRHIDVIEMDAASHTGVDDVREIIEAVRYAAVSARFKIYI
IDEVHMLSRNAFNALLKTLEEPPAHVKFLFATTEVDKLPVTVLSRTQRFDLRRIPADLLQKHFGWVCEQEQVEAEDEALA
MIAAAAEGSVRDGLSILDQAIAHADLDADGKVTATRVRDMLGLADKGAQRRMFGTILEGDAKALLAAIEDQYSLGVEPLA
LVRSQMELAHRITLAQLGGSLPGAVSEEEQAALTAWGEQLSQGQLHRLWQLLLKAYEEVKTAPDPLVSAQMGLLRLLHAS
ELPDPGKLVKTLEILTANPPVQSPAPPPSDDPAATPTGEAGAEVPAPSDFASLVDRVEQAGHGFAASIMRLQLRVIECEE
RRLVFSRASSYTEEIAPQLREALLAATGQRWQLEERDWVDAPPSLMEQAEAREEEKKARIDGHPLVAATKTAFPDAEIIP
EEETGAPRPQWSKSA

Sequences:

>Translated_575_residues
MFGDPAAAEDTAAPAPSAPPPPVSAPSESSSQPYRVLARKYRPQTFSQLIGQEPMVRTLANAIERDRLAHAFLMTGVRGV
GKTSTARLIAKSLNCIGPDGQGGPTIDPCGQCEPCTAIAEGRHIDVIEMDAASHTGVDDVREIIEAVRYAAVSARFKIYI
IDEVHMLSRNAFNALLKTLEEPPAHVKFLFATTEVDKLPVTVLSRTQRFDLRRIPADLLQKHFGWVCEQEQVEAEDEALA
MIAAAAEGSVRDGLSILDQAIAHADLDADGKVTATRVRDMLGLADKGAQRRMFGTILEGDAKALLAAIEDQYSLGVEPLA
LVRSQMELAHRITLAQLGGSLPGAVSEEEQAALTAWGEQLSQGQLHRLWQLLLKAYEEVKTAPDPLVSAQMGLLRLLHAS
ELPDPGKLVKTLEILTANPPVQSPAPPPSDDPAATPTGEAGAEVPAPSDFASLVDRVEQAGHGFAASIMRLQLRVIECEE
RRLVFSRASSYTEEIAPQLREALLAATGQRWQLEERDWVDAPPSLMEQAEAREEEKKARIDGHPLVAATKTAFPDAEIIP
EEETGAPRPQWSKSA
>Mature_575_residues
MFGDPAAAEDTAAPAPSAPPPPVSAPSESSSQPYRVLARKYRPQTFSQLIGQEPMVRTLANAIERDRLAHAFLMTGVRGV
GKTSTARLIAKSLNCIGPDGQGGPTIDPCGQCEPCTAIAEGRHIDVIEMDAASHTGVDDVREIIEAVRYAAVSARFKIYI
IDEVHMLSRNAFNALLKTLEEPPAHVKFLFATTEVDKLPVTVLSRTQRFDLRRIPADLLQKHFGWVCEQEQVEAEDEALA
MIAAAAEGSVRDGLSILDQAIAHADLDADGKVTATRVRDMLGLADKGAQRRMFGTILEGDAKALLAAIEDQYSLGVEPLA
LVRSQMELAHRITLAQLGGSLPGAVSEEEQAALTAWGEQLSQGQLHRLWQLLLKAYEEVKTAPDPLVSAQMGLLRLLHAS
ELPDPGKLVKTLEILTANPPVQSPAPPPSDDPAATPTGEAGAEVPAPSDFASLVDRVEQAGHGFAASIMRLQLRVIECEE
RRLVFSRASSYTEEIAPQLREALLAATGQRWQLEERDWVDAPPSLMEQAEAREEEKKARIDGHPLVAATKTAFPDAEIIP
EEETGAPRPQWSKSA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=245, Percent_Identity=27.3469387755102, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194306571, Length=248, Percent_Identity=27.0161290322581, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI194306567, Length=248, Percent_Identity=27.0161290322581, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI4506491, Length=280, Percent_Identity=24.2857142857143, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI31881687, Length=280, Percent_Identity=24.2857142857143, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786676, Length=368, Percent_Identity=43.75, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1787119, Length=257, Percent_Identity=26.4591439688716, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787341, Length=157, Percent_Identity=31.8471337579618, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=294, Percent_Identity=24.1496598639456, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=285, Percent_Identity=22.1052631578947, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=285, Percent_Identity=24.9122807017544, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=235, Percent_Identity=24.2553191489362, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859927, Length=272, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62197; Mature: 62197

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDPAAAEDTAAPAPSAPPPPVSAPSESSSQPYRVLARKYRPQTFSQLIGQEPMVRTLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHH
NAIERDRLAHAFLMTGVRGVGKTSTARLIAKSLNCIGPDGQGGPTIDPCGQCEPCTAIAE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHC
GRHIDVIEMDAASHTGVDDVREIIEAVRYAAVSARFKIYIIDEVHMLSRNAFNALLKTLE
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHC
EPPAHVKFLFATTEVDKLPVTVLSRTQRFDLRRIPADLLQKHFGWVCEQEQVEAEDEALA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHCHHHHHHH
MIAAAAEGSVRDGLSILDQAIAHADLDADGKVTATRVRDMLGLADKGAQRRMFGTILEGD
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCH
AKALLAAIEDQYSLGVEPLALVRSQMELAHRITLAQLGGSLPGAVSEEEQAALTAWGEQL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
SQGQLHRLWQLLLKAYEEVKTAPDPLVSAQMGLLRLLHASELPDPGKLVKTLEILTANPP
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
VQSPAPPPSDDPAATPTGEAGAEVPAPSDFASLVDRVEQAGHGFAASIMRLQLRVIECEE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RRLVFSRASSYTEEIAPQLREALLAATGQRWQLEERDWVDAPPSLMEQAEAREEEKKARI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
DGHPLVAATKTAFPDAEIIPEEETGAPRPQWSKSA
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFGDPAAAEDTAAPAPSAPPPPVSAPSESSSQPYRVLARKYRPQTFSQLIGQEPMVRTLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHH
NAIERDRLAHAFLMTGVRGVGKTSTARLIAKSLNCIGPDGQGGPTIDPCGQCEPCTAIAE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHC
GRHIDVIEMDAASHTGVDDVREIIEAVRYAAVSARFKIYIIDEVHMLSRNAFNALLKTLE
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHC
EPPAHVKFLFATTEVDKLPVTVLSRTQRFDLRRIPADLLQKHFGWVCEQEQVEAEDEALA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHCHHHHHHH
MIAAAAEGSVRDGLSILDQAIAHADLDADGKVTATRVRDMLGLADKGAQRRMFGTILEGD
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCH
AKALLAAIEDQYSLGVEPLALVRSQMELAHRITLAQLGGSLPGAVSEEEQAALTAWGEQL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
SQGQLHRLWQLLLKAYEEVKTAPDPLVSAQMGLLRLLHASELPDPGKLVKTLEILTANPP
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
VQSPAPPPSDDPAATPTGEAGAEVPAPSDFASLVDRVEQAGHGFAASIMRLQLRVIECEE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RRLVFSRASSYTEEIAPQLREALLAATGQRWQLEERDWVDAPPSLMEQAEAREEEKKARI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
DGHPLVAATKTAFPDAEIIPEEETGAPRPQWSKSA
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]