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The map label for this gene is serS [H]

Identifier: 161986627

GI number: 161986627

Start: 143141

End: 144415

Strand: Direct

Name: serS [H]

Synonym: jk0123

Alternate gene names: 161986627

Gene position: 143141-144415 (Clockwise)

Preceding gene: 68535185

Following gene: 68535189

Centisome position: 5.81

GC content: 62.82

Gene sequence:

>1275_bases
ATGATTGATCTGAAGTTTCTGCGCGATAACCCCGATGTAGCCCGTGAATCCCAGCGCACTCGTGGGGAGGACCCGGCGCT
GATCGACCAGCTGCTGGAAGCCGACTCTCAGCGCCGCGAGGCCATCAGCGCCGCCGACGCGGCCCGCGCGGATCAGAAGG
CATTCTCCAAGGAGATGGGGCAGAAGATGCGCTCCGCTTCCGACGAAGAGAAGCTGGCTCTGCGCGAGGAGGGCAAGCAG
AAGGCCGAGGCAGTCAAGAAGCTGGAGGAGGCTCAGTCCAGCGCCGAACAGGCCGTCCACGACCTGCAGATGCAGATCTC
CAACATTGTGGAGGAAGGTGCACCGGCCGGTGGCGAGGAAGACTTCGTCACCCTCGACGTGGTGGGCGAGCCGCCGCAGT
TCGACTTCGAGCCGAAGGACCACCTCGAGTTGGGCGAATCCCTGGGGCTGATCGACATGAAGCGCGGCACGAAGGTTTCC
GGCGCCCGCTTCTACTTCCTCACCGGCGATGGTGCGCTGCTGCAGCTGGGCATGCTGCAGTTGGCTGCCCAGAAGGCCGT
GGAGCACGGCTTTAAGCTCATGATCCCGCCGGTACTGGTGCGCCCCGAGATCATGTCCGGCACCGGTTTCCTGGGTGCTC
ACGCAGATGAGATCTACCACCTGGAAGAAGACGACATGTATCTGGTCGGTACCTCCGAGGTCGCGCTGGCTGGTTACCAC
TCCGAGGAGATCATCGACCTCTCCAATGGTCCGCTGCGCTACGCCGGCTGGTCCTCCTGCTTCCGCCGCGAGGCCGGTTC
TTATGGCAAGGACACCCGCGGCATCATCCGCGTCCACCAGTTCGACAAGGTGGAGATGTTCGTTTACTGCAAGCCCGAGG
AAGCCACCGAGGTCCACCAGGAACTGCTGGCAATGGAGCGCGAAATGCTGGGGGCCATTGAGGTTCCTTACCGCGTGATC
GACGTCGCCGGTGGCGACCTCGGTTCCTCGGCGGCCCGCAAGTTCGATACGGAGGCGTGGGTCCCGACTCAGCAGACCTA
CCGCGAGCTGACCAGTACCTCCAACTGCACCACCTTCCAGGGCCGTCGCCTGAAGACTCGCTACCGCGACGCTGATGGCA
AGGCGCAGACCGCTGCCACTCTGAACGGCACCCTGGCAACTACCCGCTGGTTGGTGGCTATTTTGGAGAACCACCAGCAG
GCCGACGGTTCTGTGGTTGTGCCGAAGGCGCTGCGTCCTTTCGTCGGTAAAGATATTCTGAAGCCCAGCAATTAG

Upstream 100 bases:

>100_bases
ACGGTATTCGACCGTAATTGTGAAGCCAGTCTAGTAGGGGTTGTGCCATAGGGGGAACTGGGCAGACAACTACGCGGGCG
AACCGGCTAAGCTAAACACC

Downstream 100 bases:

>100_bases
CTCAGCGAATCCGGCGCCTAAAGCGCCGACTCGGCCCAGTGTGCGACCCCCGCGTGCTGGTTGAGCCACAGTTTCCAAGG
ACTCAGGAGAGGTAACCGCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIDLKFLRDNPDVARESQRTRGEDPALIDQLLEADSQRREAISAADAARADQKAFSKEMGQKMRSASDEEKLALREEGKQ
KAEAVKKLEEAQSSAEQAVHDLQMQISNIVEEGAPAGGEEDFVTLDVVGEPPQFDFEPKDHLELGESLGLIDMKRGTKVS
GARFYFLTGDGALLQLGMLQLAAQKAVEHGFKLMIPPVLVRPEIMSGTGFLGAHADEIYHLEEDDMYLVGTSEVALAGYH
SEEIIDLSNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFVYCKPEEATEVHQELLAMEREMLGAIEVPYRVI
DVAGGDLGSSAARKFDTEAWVPTQQTYRELTSTSNCTTFQGRRLKTRYRDADGKAQTAATLNGTLATTRWLVAILENHQQ
ADGSVVVPKALRPFVGKDILKPSN

Sequences:

>Translated_424_residues
MIDLKFLRDNPDVARESQRTRGEDPALIDQLLEADSQRREAISAADAARADQKAFSKEMGQKMRSASDEEKLALREEGKQ
KAEAVKKLEEAQSSAEQAVHDLQMQISNIVEEGAPAGGEEDFVTLDVVGEPPQFDFEPKDHLELGESLGLIDMKRGTKVS
GARFYFLTGDGALLQLGMLQLAAQKAVEHGFKLMIPPVLVRPEIMSGTGFLGAHADEIYHLEEDDMYLVGTSEVALAGYH
SEEIIDLSNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFVYCKPEEATEVHQELLAMEREMLGAIEVPYRVI
DVAGGDLGSSAARKFDTEAWVPTQQTYRELTSTSNCTTFQGRRLKTRYRDADGKAQTAATLNGTLATTRWLVAILENHQQ
ADGSVVVPKALRPFVGKDILKPSN
>Mature_424_residues
MIDLKFLRDNPDVARESQRTRGEDPALIDQLLEADSQRREAISAADAARADQKAFSKEMGQKMRSASDEEKLALREEGKQ
KAEAVKKLEEAQSSAEQAVHDLQMQISNIVEEGAPAGGEEDFVTLDVVGEPPQFDFEPKDHLELGESLGLIDMKRGTKVS
GARFYFLTGDGALLQLGMLQLAAQKAVEHGFKLMIPPVLVRPEIMSGTGFLGAHADEIYHLEEDDMYLVGTSEVALAGYH
SEEIIDLSNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFVYCKPEEATEVHQELLAMEREMLGAIEVPYRVI
DVAGGDLGSSAARKFDTEAWVPTQQTYRELTSTSNCTTFQGRRLKTRYRDADGKAQTAATLNGTLATTRWLVAILENHQQ
ADGSVVVPKALRPFVGKDILKPSN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=365, Percent_Identity=37.5342465753425, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=39.8176291793313, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI16306548, Length=463, Percent_Identity=31.5334773218143, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=35.5971896955504, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=33.8362068965517, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17542084, Length=324, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=31.8284424379233, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=36.4583333333333, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24581334, Length=465, Percent_Identity=30.9677419354839, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17737985, Length=289, Percent_Identity=37.0242214532872, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24649556, Length=352, Percent_Identity=23.2954545454545, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46881; Mature: 46881

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKFLRDNPDVARESQRTRGEDPALIDQLLEADSQRREAISAADAARADQKAFSKEMG
CCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKMRSASDEEKLALREEGKQKAEAVKKLEEAQSSAEQAVHDLQMQISNIVEEGAPAGGEE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFVTLDVVGEPPQFDFEPKDHLELGESLGLIDMKRGTKVSGARFYFLTGDGALLQLGMLQ
CEEEEEEECCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCEEEEEEECCCHHHHHHHHH
LAAQKAVEHGFKLMIPPVLVRPEIMSGTGFLGAHADEIYHLEEDDMYLVGTSEVALAGYH
HHHHHHHHCCCEEECCCEEECCCCCCCCCCCCCCHHHEEEECCCCEEEEECCCEEEECCC
SEEIIDLSNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFVYCKPEEATEVHQ
CCCEEECCCCCEEECCHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEECCCHHHHHHH
ELLAMEREMLGAIEVPYRVIDVAGGDLGSSAARKFDTEAWVPTQQTYRELTSTSNCTTFQ
HHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCC
GRRLKTRYRDADGKAQTAATLNGTLATTRWLVAILENHQQADGSVVVPKALRPFVGKDIL
CCHHHHHHCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCC
KPSN
CCCC
>Mature Secondary Structure
MIDLKFLRDNPDVARESQRTRGEDPALIDQLLEADSQRREAISAADAARADQKAFSKEMG
CCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKMRSASDEEKLALREEGKQKAEAVKKLEEAQSSAEQAVHDLQMQISNIVEEGAPAGGEE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFVTLDVVGEPPQFDFEPKDHLELGESLGLIDMKRGTKVSGARFYFLTGDGALLQLGMLQ
CEEEEEEECCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCEEEEEEECCCHHHHHHHHH
LAAQKAVEHGFKLMIPPVLVRPEIMSGTGFLGAHADEIYHLEEDDMYLVGTSEVALAGYH
HHHHHHHHCCCEEECCCEEECCCCCCCCCCCCCCHHHEEEECCCCEEEEECCCEEEECCC
SEEIIDLSNGPLRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKVEMFVYCKPEEATEVHQ
CCCEEECCCCCEEECCHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEECCCHHHHHHH
ELLAMEREMLGAIEVPYRVIDVAGGDLGSSAARKFDTEAWVPTQQTYRELTSTSNCTTFQ
HHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCC
GRRLKTRYRDADGKAQTAATLNGTLATTRWLVAILENHQQADGSVVVPKALRPFVGKDIL
CCHHHHHHCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCC
KPSN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA