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The map label for this gene is nhaA [H]

Identifier: 161870990

GI number: 161870990

Start: 2114084

End: 2114995

Strand: Reverse

Name: nhaA [H]

Synonym: NMCC_2085

Alternate gene names: 161870990

Gene position: 2114995-2114084 (Counterclockwise)

Preceding gene: 161870991

Following gene: 161870989

Centisome position: 98.22

GC content: 56.47

Gene sequence:

>912_bases
ATGATGCGCGAAGTGCTGTTGTCCGCCTATCAGGACAGGCGCAGGGAGCGGATGTGGAAAAACATCTGGCGCGCCGTCAG
CACCCTGATTCTGGTTGCCCTGATTGCAGGCATTTTCCAAAAAGACGAAGCCGCATTGCAGTTGGCGGGCAACACGCCGC
ATACCGCAGTCGTCAACCTGTACGGCGAAATCGGCAACGGTGTAGAAGACCAGGTCAAAAAACTCAAAGACGGTATGGAG
GCCGCCTACAAAAACCCGCAGGCAAAAGCCATCGTCATCCGCGCCAACAGCCCCGGCGGTTCGCCCGTCGTCTCCAACAC
CGCTTTTGAAGAAATACGCCGTCTGAAAGCGCAACATCCCGACATTCCCGTTTATCTCGTGGCGGAGGATATGTGTGCAT
CCGGCTGCTACTATATTGCGGCGGCGGCAGACAAAATTTATGCGGACTCGTCCAGCATCGTCGGCAGCATCGGCGTTATC
GGCAGCAGTTTTGATGCTACTGAATTAATGGAAAAAATCGGCGTGAAACGCAGGGTTAAAATTGCAGGCAGCAACAAAGG
CATGGGCGATCCGTTTTCGCCCGAAACGCCCGAACAGTCGAAAATCTGGGAAGAAATGCTGACCGGCATACACGGCGAGT
TCATCAAAGCCGTCAAAACCGGACGCGGCGGCCGCCTCAAATTCCGACAATATCCCGACGTGTTCAGCGGTCGCGTGTAC
ACAGGCGCGGATGCGCTGAAAGTCGGGCTGGTGGACGGACTCGGCAATATTTACAGCGTGGCGCGAGACGTGGTCAAAGC
CCCCGATGTGGTGGATTACACTCCGAAGGACGATTTCGGCAGAATCTTGGGCAGACGCTTCGGCGCAGAACTCAAAGCAA
GCGTGCGCGAAGCCCTGCAGGCCGTCCGGTAG

Upstream 100 bases:

>100_bases
AATCGGACGATATTTAAGGAAAACCATGCAATACCGAATCAGAAGAGAAAACGAAGCACCCGAAGCAAAAAATGCGGGGG
AAACCTTATGGGAGCGCGAT

Downstream 100 bases:

>100_bases
CGTTGTTTACAGTATTTCTAAGGGAATACCAAAATAAAAATATACACAAAAACACTCACCTCCCCAGTATGCTGCCACTA
AGTCAGCCGCGTCACTATTT

Product: protease IV

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MMREVLLSAYQDRRRERMWKNIWRAVSTLILVALIAGIFQKDEAALQLAGNTPHTAVVNLYGEIGNGVEDQVKKLKDGME
AAYKNPQAKAIVIRANSPGGSPVVSNTAFEEIRRLKAQHPDIPVYLVAEDMCASGCYYIAAAADKIYADSSSIVGSIGVI
GSSFDATELMEKIGVKRRVKIAGSNKGMGDPFSPETPEQSKIWEEMLTGIHGEFIKAVKTGRGGRLKFRQYPDVFSGRVY
TGADALKVGLVDGLGNIYSVARDVVKAPDVVDYTPKDDFGRILGRRFGAELKASVREALQAVR

Sequences:

>Translated_303_residues
MMREVLLSAYQDRRRERMWKNIWRAVSTLILVALIAGIFQKDEAALQLAGNTPHTAVVNLYGEIGNGVEDQVKKLKDGME
AAYKNPQAKAIVIRANSPGGSPVVSNTAFEEIRRLKAQHPDIPVYLVAEDMCASGCYYIAAAADKIYADSSSIVGSIGVI
GSSFDATELMEKIGVKRRVKIAGSNKGMGDPFSPETPEQSKIWEEMLTGIHGEFIKAVKTGRGGRLKFRQYPDVFSGRVY
TGADALKVGLVDGLGNIYSVARDVVKAPDVVDYTPKDDFGRILGRRFGAELKASVREALQAVR
>Mature_303_residues
MMREVLLSAYQDRRRERMWKNIWRAVSTLILVALIAGIFQKDEAALQLAGNTPHTAVVNLYGEIGNGVEDQVKKLKDGME
AAYKNPQAKAIVIRANSPGGSPVVSNTAFEEIRRLKAQHPDIPVYLVAEDMCASGCYYIAAAADKIYADSSSIVGSIGVI
GSSFDATELMEKIGVKRRVKIAGSNKGMGDPFSPETPEQSKIWEEMLTGIHGEFIKAVKTGRGGRLKFRQYPDVFSGRVY
TGADALKVGLVDGLGNIYSVARDVVKAPDVVDYTPKDDFGRILGRRFGAELKASVREALQAVR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=220, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788064, Length=207, Percent_Identity=30.9178743961353, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 33070; Mature: 33070

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMREVLLSAYQDRRRERMWKNIWRAVSTLILVALIAGIFQKDEAALQLAGNTPHTAVVNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCHHHEEE
YGEIGNGVEDQVKKLKDGMEAAYKNPQAKAIVIRANSPGGSPVVSNTAFEEIRRLKAQHP
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCC
DIPVYLVAEDMCASGCYYIAAAADKIYADSSSIVGSIGVIGSSFDATELMEKIGVKRRVK
CCCEEEEECHHHHCCCEEEEEHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEEE
IAGSNKGMGDPFSPETPEQSKIWEEMLTGIHGEFIKAVKTGRGGRLKFRQYPDVFSGRVY
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHCCCEE
TGADALKVGLVDGLGNIYSVARDVVKAPDVVDYTPKDDFGRILGRRFGAELKASVREALQ
ECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
AVR
HCC
>Mature Secondary Structure
MMREVLLSAYQDRRRERMWKNIWRAVSTLILVALIAGIFQKDEAALQLAGNTPHTAVVNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCHHHEEE
YGEIGNGVEDQVKKLKDGMEAAYKNPQAKAIVIRANSPGGSPVVSNTAFEEIRRLKAQHP
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCC
DIPVYLVAEDMCASGCYYIAAAADKIYADSSSIVGSIGVIGSSFDATELMEKIGVKRRVK
CCCEEEEECHHHHCCCEEEEEHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEEE
IAGSNKGMGDPFSPETPEQSKIWEEMLTGIHGEFIKAVKTGRGGRLKFRQYPDVFSGRVY
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHCCCEE
TGADALKVGLVDGLGNIYSVARDVVKAPDVVDYTPKDDFGRILGRRFGAELKASVREALQ
ECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
AVR
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA