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The map label for this gene is gpxA [H]

Identifier: 161870474

GI number: 161870474

Start: 1557957

End: 1558556

Strand: Reverse

Name: gpxA [H]

Synonym: NMCC_1530

Alternate gene names: 161870474

Gene position: 1558556-1557957 (Counterclockwise)

Preceding gene: 161870475

Following gene: 161870470

Centisome position: 72.38

GC content: 47.67

Gene sequence:

>600_bases
TTGCTGCTTTCATGCCGTCTGAAGCACGTTTCAGATGGCATCGGTTTACATCAGATAAGGATAAAAATGGGTATTTACGA
TTTTCAAATGAAAGATGCAGAAGGCAATGCGGTTGATTTGTCAGGCTATCGCGGCAAGGTTCTGCTGATTGTCAACACGG
CAACGCGTTGCGGTCTGACCCCGCAATACGAGGCTTTGCAGAAGCTGTATGCACAATATACCGCAGAAGGCTTGGAGATT
TTGGATTTTCCGTGCAACCAGTTCCGCGAACAGGCTCCCGAAAGCAGCGGAGAAATTGCCCAAGTGTGTATGATGAAGTT
TGGCACGAAGTTTAAGATTTTCGACAAAATCGAAGTCAATGGAGCAAATACCGCGCCCTTGTATGCCTACCTGAAATCCG
TCAAACCGCAAGATAAAGGCAATCATCTGTTTAAAGATTTCGTGTTGAAGCTCGCAGCTTTGGGAGAGAAGCGCGACGAA
GGCGACATCAAATGGAACTTTACCAAATTCCTCGTCAACCGCGACGGCGAAGTGGTCGAGCGTTTTGCGCCTAGTGTTAC
GCCCGAAGAAATCGAAGCCGATATTCGGGCATTGCTGTAA

Upstream 100 bases:

>100_bases
GAAATGAGCAACTGCACCCGTTTTCGGGTGCAGTTTTTTATTGCGGATTGGGACGGGAATGGAAAAGGATGTGGATTTTT
TATTTTAATCGGCTATACAA

Downstream 100 bases:

>100_bases
TCTGCCGCCGTCTTGGGAAATGCCGTCTGAAGGCTTCAGACGGCATTTGTCCGTTTGCGGGTTTATTCCGAAATATCGGC
AACACCGCTTTCGGGGAAGA

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLLSCRLKHVSDGIGLHQIRIKMGIYDFQMKDAEGNAVDLSGYRGKVLLIVNTATRCGLTPQYEALQKLYAQYTAEGLEI
LDFPCNQFREQAPESSGEIAQVCMMKFGTKFKIFDKIEVNGANTAPLYAYLKSVKPQDKGNHLFKDFVLKLAALGEKRDE
GDIKWNFTKFLVNRDGEVVERFAPSVTPEEIEADIRALL

Sequences:

>Translated_199_residues
MLLSCRLKHVSDGIGLHQIRIKMGIYDFQMKDAEGNAVDLSGYRGKVLLIVNTATRCGLTPQYEALQKLYAQYTAEGLEI
LDFPCNQFREQAPESSGEIAQVCMMKFGTKFKIFDKIEVNGANTAPLYAYLKSVKPQDKGNHLFKDFVLKLAALGEKRDE
GDIKWNFTKFLVNRDGEVVERFAPSVTPEEIEADIRALL
>Mature_199_residues
MLLSCRLKHVSDGIGLHQIRIKMGIYDFQMKDAEGNAVDLSGYRGKVLLIVNTATRCGLTPQYEALQKLYAQYTAEGLEI
LDFPCNQFREQAPESSGEIAQVCMMKFGTKFKIFDKIEVNGANTAPLYAYLKSVKPQDKGNHLFKDFVLKLAALGEKRDE
GDIKWNFTKFLVNRDGEVVERFAPSVTPEEIEADIRALL

Specific function: Important in the cellular metabolism or defense processes particular to this pathogen [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=177, Percent_Identity=38.9830508474576, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI90903240, Length=177, Percent_Identity=38.9830508474576, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI15618997, Length=176, Percent_Identity=35.7954545454545, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI192455698, Length=177, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI90903238, Length=152, Percent_Identity=38.8157894736842, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=36.4130434782609, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4557629, Length=184, Percent_Identity=34.7826086956522, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI32967607, Length=187, Percent_Identity=33.1550802139037, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI6006001, Length=186, Percent_Identity=32.258064516129, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI33186887, Length=182, Percent_Identity=31.3186813186813, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1788003, Length=167, Percent_Identity=43.7125748502994, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17506887, Length=176, Percent_Identity=42.6136363636364, Blast_Score=142, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17535473, Length=176, Percent_Identity=43.75, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71993584, Length=176, Percent_Identity=38.0681818181818, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193210707, Length=191, Percent_Identity=38.2198952879581, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550320, Length=179, Percent_Identity=36.3128491620112, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193209493, Length=174, Percent_Identity=36.7816091954023, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71999642, Length=91, Percent_Identity=40.6593406593407, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71993573, Length=76, Percent_Identity=43.421052631579, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193210709, Length=80, Percent_Identity=43.75, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507603, Length=114, Percent_Identity=38.5964912280702, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=175, Percent_Identity=41.7142857142857, Blast_Score=145, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322228, Length=168, Percent_Identity=42.2619047619048, Blast_Score=136, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322826, Length=175, Percent_Identity=38.2857142857143, Blast_Score=122, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24656767, Length=178, Percent_Identity=44.3820224719101, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24656772, Length=178, Percent_Identity=44.3820224719101, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24656777, Length=178, Percent_Identity=44.3820224719101, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI85726443, Length=186, Percent_Identity=37.0967741935484, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: 1.11.1.9

Molecular weight: Translated: 22429; Mature: 22429

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSCRLKHVSDGIGLHQIRIKMGIYDFQMKDAEGNAVDLSGYRGKVLLIVNTATRCGLT
CEEEEEHHHHCCCCCEEEEEEEECEEEEEEECCCCCEEEECCCCCEEEEEEECCHHCCCC
PQYEALQKLYAQYTAEGLEILDFPCNQFREQAPESSGEIAQVCMMKFGTKFKIFDKIEVN
CCHHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEEEC
GANTAPLYAYLKSVKPQDKGNHLFKDFVLKLAALGEKRDEGDIKWNFTKFLVNRDGEVVE
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHEEEEECCCHHHHH
RFAPSVTPEEIEADIRALL
HHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLLSCRLKHVSDGIGLHQIRIKMGIYDFQMKDAEGNAVDLSGYRGKVLLIVNTATRCGLT
CEEEEEHHHHCCCCCEEEEEEEECEEEEEEECCCCCEEEECCCCCEEEEEEECCHHCCCC
PQYEALQKLYAQYTAEGLEILDFPCNQFREQAPESSGEIAQVCMMKFGTKFKIFDKIEVN
CCHHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEEEC
GANTAPLYAYLKSVKPQDKGNHLFKDFVLKLAALGEKRDEGDIKWNFTKFLVNRDGEVVE
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEHEEEEECCCHHHHH
RFAPSVTPEEIEADIRALL
HHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10722605; 10761919 [H]