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The map label for this gene is grxC [C]

Identifier: 161869858

GI number: 161869858

Start: 890189

End: 890926

Strand: Direct

Name: grxC [C]

Synonym: NMCC_0889

Alternate gene names: 161869858

Gene position: 890189-890926 (Clockwise)

Preceding gene: 161869857

Following gene: 161869859

Centisome position: 41.34

GC content: 48.24

Gene sequence:

>738_bases
ATGGCTTTGCAAGATCGTACCGGTCAAAAAGTACCTTCCGTAGTATTCCGCACCCGCGTCGGCGACACTTGGAAAGATGT
GTCTACCGATGATTTGTTCAAAGGCAAAAAAGTAGTCGTATTCTCCCTGCCCGGTGCATTTACCCCGACTTGTTCTTCTT
CACACCTGCCGCGTTACAACGAATTGTTCGGCGCGTTCAAAGAAAACGGCGTTGACGCAATCTACTGCGTATCTGTAAAC
GATACGTTCGTAATGAACGCTTGGGCTGCCGAAGAAGAATCCGACAACATCTACATGATTCCTGACGGCAACGGCGAATT
TACCGAAGGTATGGGTATGCTGGTCGGTAAAGAAGACTTGGGCTTCGGTAAACGCTCTTGGCGTTACTCCATGCTGGTTA
ACGACGGCGTGGTTGAAAAAATGTTCATCGAACCTGAAGAACCGGGCGATCCGTTCAAAGTATCCGATGCAGATACTATG
CTGAAATTCGTTGCTCCCGATTGGAAAGCTCAAGAGTCTGTTGCCATCTTTACCAAACCCGGCTGCCAATTCTGTGCTAA
AGCCAAACAAGCTTTGCAAGACAAAGGTTTGTCTTACGAAGAAATCGTATTGGGCAAAGATGCAACCGTTACTTCCGTAC
GCGCCATTACCGGCAAGATGACTACCCCTCAAGTCTTCATCGGCGGCAAATACATCGGCGGCAGCGAAGATTTGGAAGCC
TACTTGGCTAAAAACTAA

Upstream 100 bases:

>100_bases
TATATTATTTGAACTATAAATTATACAAATCATTTTGCTTGGGGTAGAATGCCCAGCGATTCACAATTATTTCTCAAACC
TATCTATTAAGGAGCTCAAA

Downstream 100 bases:

>100_bases
TTGCCTAGTGCTTAAGACGGTTTGAATAAAACCGTCTGAACAGGAAAATAGAGTTATTCAGACGATACGCTACACGGTCG
TTCTGAATAGCTCTATATTT

Product: peroxiredoxin 2 family protein/glutaredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MALQDRTGQKVPSVVFRTRVGDTWKDVSTDDLFKGKKVVVFSLPGAFTPTCSSSHLPRYNELFGAFKENGVDAIYCVSVN
DTFVMNAWAAEEESDNIYMIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVNDGVVEKMFIEPEEPGDPFKVSDADTM
LKFVAPDWKAQESVAIFTKPGCQFCAKAKQALQDKGLSYEEIVLGKDATVTSVRAITGKMTTPQVFIGGKYIGGSEDLEA
YLAKN

Sequences:

>Translated_245_residues
MALQDRTGQKVPSVVFRTRVGDTWKDVSTDDLFKGKKVVVFSLPGAFTPTCSSSHLPRYNELFGAFKENGVDAIYCVSVN
DTFVMNAWAAEEESDNIYMIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVNDGVVEKMFIEPEEPGDPFKVSDADTM
LKFVAPDWKAQESVAIFTKPGCQFCAKAKQALQDKGLSYEEIVLGKDATVTSVRAITGKMTTPQVFIGGKYIGGSEDLEA
YLAKN
>Mature_244_residues
ALQDRTGQKVPSVVFRTRVGDTWKDVSTDDLFKGKKVVVFSLPGAFTPTCSSSHLPRYNELFGAFKENGVDAIYCVSVND
TFVMNAWAAEEESDNIYMIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVNDGVVEKMFIEPEEPGDPFKVSDADTML
KFVAPDWKAQESVAIFTKPGCQFCAKAKQALQDKGLSYEEIVLGKDATVTSVRAITGKMTTPQVFIGGKYIGGSEDLEAY
LAKN

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=148, Percent_Identity=38.5135135135135, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323138, Length=134, Percent_Identity=32.089552238806, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78706776, Length=151, Percent_Identity=40.3973509933775, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI78709078, Length=151, Percent_Identity=40.3973509933775, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26942; Mature: 26811

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQDRTGQKVPSVVFRTRVGDTWKDVSTDDLFKGKKVVVFSLPGAFTPTCSSSHLPRYN
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCHH
ELFGAFKENGVDAIYCVSVNDTFVMNAWAAEEESDNIYMIPDGNGEFTEGMGMLVGKEDL
HHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCC
GFGKRSWRYSMLVNDGVVEKMFIEPEEPGDPFKVSDADTMLKFVAPDWKAQESVAIFTKP
CCCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECC
GCQFCAKAKQALQDKGLSYEEIVLGKDATVTSVRAITGKMTTPQVFIGGKYIGGSEDLEA
CHHHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEEEECCCCCCEEEECCEECCCCHHHHH
YLAKN
HCCCC
>Mature Secondary Structure 
ALQDRTGQKVPSVVFRTRVGDTWKDVSTDDLFKGKKVVVFSLPGAFTPTCSSSHLPRYN
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCHH
ELFGAFKENGVDAIYCVSVNDTFVMNAWAAEEESDNIYMIPDGNGEFTEGMGMLVGKEDL
HHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCC
GFGKRSWRYSMLVNDGVVEKMFIEPEEPGDPFKVSDADTMLKFVAPDWKAQESVAIFTKP
CCCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECC
GCQFCAKAKQALQDKGLSYEEIVLGKDATVTSVRAITGKMTTPQVFIGGKYIGGSEDLEA
CHHHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEEEECCCCCCEEEECCEECCCCHHHHH
YLAKN
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]