Click here to switch to the map view.

The map label for this gene is xanQ [H]

Identifier: 161869842

GI number: 161869842

Start: 875843

End: 877234

Strand: Direct

Name: xanQ [H]

Synonym: NMCC_0873

Alternate gene names: 161869842

Gene position: 875843-877234 (Clockwise)

Preceding gene: 161869839

Following gene: 161869847

Centisome position: 40.67

GC content: 57.04

Gene sequence:

>1392_bases
ATGAGCGGTCATATGGGAAAAGGGGCGGATGCGCCTGATTTGGTGTACGGTTTGGAGGATAGGCCGCCGTTCGGTAATGC
GCTGTTGAGCGCGGTTACCCATCTTTTGGCGATTTTCGTGCCGATGATTACGCCCGCGCTGATTGTGGGCGGCGCGCTGG
AACTGCCGGTGGAGATGACGGCGTATCTCGTGTCGATGGCGATGGTTGCGTCGGGTGTCGGCACTTATTTGCAGGTCAAC
CGCTTCGGGCCGGTCGGTTCGGGGATGCTGTCCATCCAGTCGGTGAATTTCTCGTTCGTTACCGTCATGATTGCGCTGGG
CGCGGGGATGAAAGAGGGCGGTTTGACTAAGGATGCGATGATTTCGACGCTCTTGGGCGTATCGTTTGTCGGCGCGTTTT
TGGTGTGTTTCTCGGCGTGGCTTCTGCCGTATTTGAAAAAAGTGATTACGCCGACGGTCAGCGGCGTGGTCGTGATGCTC
ATTGGTTTGAGTTTGGTACACGTCGGCATTACCGATTTCGGCGGCGGCTTCGGCGCGAAGGCGGACGGCACGTTCGGCTC
GATGGAAAACTTGGGGCTGGCTTCGCTGGTGTTGCTGATTGTGTTGGTGTTCAACTGCATGAAAAACCCGCTGTTGCGCA
TGAGCGGCATTGCGGTCGGGCTGATTGCCGGCTATATCGTCGCGCTGTTTTTGGGCAAGGTGGATTTTTCCGCGCTGCAA
AACCTGCCGCTGGTTACGCTGCCCGTACCGTTTAAATACGGTTTTGCTTTCGACTGGCACGCGTTTATTGTGGCGGGCGC
GATTTTCTTGTTGAGCGTGTTTGAGGCGGTCGGCGATTTAACCGCGACGGCAATGGTGTCCGACCAGCCGATTGAAGGCG
AGGAATACACCAAACGCCTGCGCGGCGGCGTGTTGGCTGACGGCTTGGTGTCGGTGATTGCGACGGCTTTGGGTTCGCTG
CCGCTGACGACGTTTGCGCAAAACAACGGCGTGATTCAGATGACCGGCGTGGCTTCGCGCCATGTGGGCAAATATATTGC
CGTGATTTTGGTGCTGTTGGGTCTGTTCCCCGTTGTCGGACGCGCGTTTACGACGATTCCGAGTCCGGTGTTGGGCGGCG
CGATGGTTTTGATGTTCGGCTTGATTGCGATTGCGGGCGTGCGGATTTTGGTCAGTCACGGCATCCGCAGGCGCGAAGCG
GTAATTGCGGCAACGTCGGTCGGTTTGGGCTTGGGTGTCGCGTTTGAGCCGGAAGTGTTTAAAAACCTGCCCGTCTTGTT
CCAAAACTCTATTTCCGCCGGCGGCATTACGGCAGTCTTGCTGAATTTGGTCTTGCCCGAAGATAAAACCGAGGCGGCGG
TCAAGTTTGATACCGACCACTTGGAACACTGA

Upstream 100 bases:

>100_bases
GACGGGCGCGTATGCCGTCCGAAATCGAAATTGAAGCGGTATGGCGGATTCGCTACAATCCGCGCTTTGGTTTTTTCAAC
ATTTGAAGCAAGGAAACATT

Downstream 100 bases:

>100_bases
TTTTGAAAATGAATGCCGTCTGAAACAGAATCCCTGTTTCAGACGGCATTGTTTTTGAGGCTTATACTTTTTCGTTTTTT
AATACGCGTTGTCGGCGTGT

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSGHMGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMTAYLVSMAMVASGVGTYLQVN
RFGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAMISTLLGVSFVGAFLVCFSAWLLPYLKKVITPTVSGVVVML
IGLSLVHVGITDFGGGFGAKADGTFGSMENLGLASLVLLIVLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQ
NLPLVTLPVPFKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRLRGGVLADGLVSVIATALGSL
PLTTFAQNNGVIQMTGVASRHVGKYIAVILVLLGLFPVVGRAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREA
VIAATSVGLGLGVAFEPEVFKNLPVLFQNSISAGGITAVLLNLVLPEDKTEAAVKFDTDHLEH

Sequences:

>Translated_463_residues
MSGHMGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMTAYLVSMAMVASGVGTYLQVN
RFGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAMISTLLGVSFVGAFLVCFSAWLLPYLKKVITPTVSGVVVML
IGLSLVHVGITDFGGGFGAKADGTFGSMENLGLASLVLLIVLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQ
NLPLVTLPVPFKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRLRGGVLADGLVSVIATALGSL
PLTTFAQNNGVIQMTGVASRHVGKYIAVILVLLGLFPVVGRAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREA
VIAATSVGLGLGVAFEPEVFKNLPVLFQNSISAGGITAVLLNLVLPEDKTEAAVKFDTDHLEH
>Mature_462_residues
SGHMGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMTAYLVSMAMVASGVGTYLQVNR
FGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAMISTLLGVSFVGAFLVCFSAWLLPYLKKVITPTVSGVVVMLI
GLSLVHVGITDFGGGFGAKADGTFGSMENLGLASLVLLIVLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQN
LPLVTLPVPFKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRLRGGVLADGLVSVIATALGSLP
LTTFAQNNGVIQMTGVASRHVGKYIAVILVLLGLFPVVGRAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREAV
IAATSVGLGLGVAFEPEVFKNLPVLFQNSISAGGITAVLLNLVLPEDKTEAAVKFDTDHLEH

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082178, Length=446, Percent_Identity=68.3856502242152, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1790087, Length=448, Percent_Identity=44.6428571428571, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI87082181, Length=441, Percent_Identity=27.6643990929705, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI87081818, Length=409, Percent_Identity=27.8728606356968, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788843, Length=410, Percent_Identity=25.609756097561, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=196, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48267; Mature: 48136

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGHMGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMT
CCCCCCCCCCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AYLVSMAMVASGVGTYLQVNRFGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAM
HHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCHHHH
ISTLLGVSFVGAFLVCFSAWLLPYLKKVITPTVSGVVVMLIGLSLVHVGITDFGGGFGAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ADGTFGSMENLGLASLVLLIVLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQ
CCCCCCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
NLPLVTLPVPFKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRL
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHH
RGGVLADGLVSVIATALGSLPLTTFAQNNGVIQMTGVASRHVGKYIAVILVLLGLFPVVG
HCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREAVIAATSVGLGLGVAFEPEVF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHH
KNLPVLFQNSISAGGITAVLLNLVLPEDKTEAAVKFDTDHLEH
HCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEECHHHCCC
>Mature Secondary Structure 
SGHMGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMT
CCCCCCCCCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH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HCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]