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The map label for this gene is adk [H]

Identifier: 161869764

GI number: 161869764

Start: 791088

End: 791735

Strand: Direct

Name: adk [H]

Synonym: NMCC_0784

Alternate gene names: 161869764

Gene position: 791088-791735 (Clockwise)

Preceding gene: 161869762

Following gene: 161869765

Centisome position: 36.74

GC content: 54.17

Gene sequence:

>648_bases
ATGAAAGCATTACTTTTAGGCGCGCCGGGCGCGGGCAAAGGCACTCAGGCGCAATTCATCACCGCCGCGTTCGGCATTCC
GCAAATCTCTACCGGCGACATGCTCCGCGCCGCGATTAAGGCTGGCACGCCCTTGGGTTTGGAAGCGAAAAAAATCATTG
ACGAAGGCGGCTTGGTGCGCGACGACATCATTATCGGCATGGTCAAAGAACGCATCGCGCAAGACGACTGCAAAAACGGT
TTCCTGTTCGACGGTTTCCCGCGCACATTGGCACAAGCCGAAGCGATGGTTGAAGCAGGCGTGGATTTGGATGCAGTCGT
TGAAATCGACGTGCCTGACAGCGTGATTGTCGACCGTATGAGCGGCCGCCGCGTGCATTTGGCTTCCGGCCGTACTTACC
ACGTTACCTACAACCCGCCCAAAGTTGAAGGCAAAGACGACGTAACCGGCGAAGATTTGATTCAGCGCGACGACGACAAA
GAAGAAACCGTGAAAAAACGCCTTGCCGTTTACCACGAGCAAACCGAAGTTTTGGTCGATTTTTACAGCAAACTGGAAGG
CGAACACGCGCCTAAATACATCAAAGTTGACGGCACTCAGCCGGTAGAAGCCGTGAAAGCCGAAGTATTGGGCGCATTGG
GCAAATAA

Upstream 100 bases:

>100_bases
TGGCAGTTTGTGCAGTTGGTTTTTGAACTATTGTGCCAAGCCGTGTAGAATCGTAAACCATCTGTTTGATTCCAATAAAC
ACATTTCAAAGGATCACTTC

Downstream 100 bases:

>100_bases
ATCGAAAAGGTCGTACCCACGGGCAGGCTTCGCACTCTGAAAACAGAAAATCAGGTTTTCAGACGACCTGTTTTTGATAA
ACAGCGTGTTGCAACCGAAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAKKIIDEGGLVRDDIIIGMVKERIAQDDCKNG
FLFDGFPRTLAQAEAMVEAGVDLDAVVEIDVPDSVIVDRMSGRRVHLASGRTYHVTYNPPKVEGKDDVTGEDLIQRDDDK
EETVKKRLAVYHEQTEVLVDFYSKLEGEHAPKYIKVDGTQPVEAVKAEVLGALGK

Sequences:

>Translated_215_residues
MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAKKIIDEGGLVRDDIIIGMVKERIAQDDCKNG
FLFDGFPRTLAQAEAMVEAGVDLDAVVEIDVPDSVIVDRMSGRRVHLASGRTYHVTYNPPKVEGKDDVTGEDLIQRDDDK
EETVKKRLAVYHEQTEVLVDFYSKLEGEHAPKYIKVDGTQPVEAVKAEVLGALGK
>Mature_215_residues
MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAKKIIDEGGLVRDDIIIGMVKERIAQDDCKNG
FLFDGFPRTLAQAEAMVEAGVDLDAVVEIDVPDSVIVDRMSGRRVHLASGRTYHVTYNPPKVEGKDDVTGEDLIQRDDDK
EETVKKRLAVYHEQTEVLVDFYSKLEGEHAPKYIKVDGTQPVEAVKAEVLGALGK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=219, Percent_Identity=44.2922374429224, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI7524346, Length=219, Percent_Identity=44.2922374429224, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=46.2765957446808, Blast_Score=172, Evalue=1e-43,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=41.2087912087912, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=41.2087912087912, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=41.2087912087912, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=41.2087912087912, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=27.027027027027, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=29.6703296703297, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI7706497, Length=220, Percent_Identity=28.6363636363636, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI21450759, Length=254, Percent_Identity=23.6220472440945, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI237858799, Length=244, Percent_Identity=23.7704918032787, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI28144897, Length=197, Percent_Identity=25.3807106598985, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI28144899, Length=197, Percent_Identity=25.3807106598985, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=64.018691588785, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=43.6619718309859, Blast_Score=190, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=38.7096774193548, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=29.9065420560748, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17533833, Length=210, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=220, Percent_Identity=50.4545454545455, Blast_Score=220, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=46.2765957446808, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=28.169014084507, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI22026816, Length=204, Percent_Identity=49.5098039215686, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=46.7391304347826, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=46.7391304347826, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=25.1184834123223, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=25.1184834123223, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23217; Mature: 23217

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAKKIIDEGGLVR
CCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCH
DDIIIGMVKERIAQDDCKNGFLFDGFPRTLAQAEAMVEAGVDLDAVVEIDVPDSVIVDRM
HHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCC
SGRRVHLASGRTYHVTYNPPKVEGKDDVTGEDLIQRDDDKEETVKKRLAVYHEQTEVLVD
CCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FYSKLEGEHAPKYIKVDGTQPVEAVKAEVLGALGK
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKALLLGAPGAGKGTQAQFITAAFGIPQISTGDMLRAAIKAGTPLGLEAKKIIDEGGLVR
CCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCH
DDIIIGMVKERIAQDDCKNGFLFDGFPRTLAQAEAMVEAGVDLDAVVEIDVPDSVIVDRM
HHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCC
SGRRVHLASGRTYHVTYNPPKVEGKDDVTGEDLIQRDDDKEETVKKRLAVYHEQTEVLVD
CCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FYSKLEGEHAPKYIKVDGTQPVEAVKAEVLGALGK
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA