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The map label for this gene is upp [H]

Identifier: 161869718

GI number: 161869718

Start: 741668

End: 742294

Strand: Direct

Name: upp [H]

Synonym: NMCC_0738

Alternate gene names: 161869718

Gene position: 741668-742294 (Clockwise)

Preceding gene: 161869717

Following gene: 161869719

Centisome position: 34.44

GC content: 55.82

Gene sequence:

>627_bases
ATGAACGTTAATGTTATCAACCATCCGCTCGTCCGCCACAAATTAACCCTGATGAGGGAGGCGGATTGCAGCACCTACAA
ATTCCGGACGCTTGCCATCGAGCTGGCGCGCCTGATGGCATACGAGGCAAGCCGTGATTTTGAAATCGAAAAATACCTTA
TCGACGGATGGTGCGGTCAGATTGAAGGCGACCGCATCAAGGGCAAAACATTGACCGTCGTTCCCATTCTGCGTGCAGGT
TTGGGTATGCTTGACGGCGTACTCGACCTGATTCCGACTGCCAAAATCAGCGTAGTCGGACTGCAGCGCGACGAGGAAAC
GCTGAAACCCGTTTCCTACTTCGAGAAATTCGTGGACAGCATGGACGAACGTCCTGCCCTGATTATCGACCCGATGCTGG
CGACGGGCGGTTCGATGGTTGCCACCATCGACCTTTTGAAAGCCAAGGGCTGCAAAAACATCAAGGCACTGGTGCTGGTT
GCCGCGCCCGAGGGTGTGAAGGCGGTCAACGACGCGCATCCCGACGTTACGATTTACACCGCCGCGCTCGACAGCCACTT
GAACGAGAACGGCTACATCATCCCCGGCTTGGGCGATGCGGGCGACAAGATTTTCGGCACGCGCTAA

Upstream 100 bases:

>100_bases
TCGGCAATGCCGTCTGAACGTGTTTCAGACGGCATTTTCTTTTCCGGCAAATCAAAAAAAAGTATAATGGCGCGTCTCAA
AATCACACTGGAACACCGCG

Downstream 100 bases:

>100_bases
CTGACTGATTTTCGGAGTTGATATGAATTTTCAAGACTATCTCGCCACATTTCCTTCAATCGACCATCTGGGCGGTTTGG
ACGTTCAGGATGCAGATGGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNVNVINHPLVRHKLTLMREADCSTYKFRTLAIELARLMAYEASRDFEIEKYLIDGWCGQIEGDRIKGKTLTVVPILRAG
LGMLDGVLDLIPTAKISVVGLQRDEETLKPVSYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLV
AAPEGVKAVNDAHPDVTIYTAALDSHLNENGYIIPGLGDAGDKIFGTR

Sequences:

>Translated_208_residues
MNVNVINHPLVRHKLTLMREADCSTYKFRTLAIELARLMAYEASRDFEIEKYLIDGWCGQIEGDRIKGKTLTVVPILRAG
LGMLDGVLDLIPTAKISVVGLQRDEETLKPVSYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLV
AAPEGVKAVNDAHPDVTIYTAALDSHLNENGYIIPGLGDAGDKIFGTR
>Mature_208_residues
MNVNVINHPLVRHKLTLMREADCSTYKFRTLAIELARLMAYEASRDFEIEKYLIDGWCGQIEGDRIKGKTLTVVPILRAG
LGMLDGVLDLIPTAKISVVGLQRDEETLKPVSYFEKFVDSMDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLV
AAPEGVKAVNDAHPDVTIYTAALDSHLNENGYIIPGLGDAGDKIFGTR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.2178217821782, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.2178217821782, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI21450816, Length=173, Percent_Identity=27.7456647398844, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=65.8653846153846, Blast_Score=290, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=26.6990291262136, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=26.6990291262136, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=34.7150259067358, Blast_Score=114, Evalue=8e-27,
Organism=Drosophila melanogaster, GI45550449, Length=202, Percent_Identity=29.7029702970297, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28573516, Length=202, Percent_Identity=29.7029702970297, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573514, Length=202, Percent_Identity=29.7029702970297, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573512, Length=202, Percent_Identity=29.7029702970297, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22741; Mature: 22741

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVNVINHPLVRHKLTLMREADCSTYKFRTLAIELARLMAYEASRDFEIEKYLIDGWCGQ
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCC
IEGDRIKGKTLTVVPILRAGLGMLDGVLDLIPTAKISVVGLQRDEETLKPVSYFEKFVDS
CCCCEECCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
MDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLVAAPEGVKAVNDAHPDVTIYT
HCCCCEEEECCHHHCCCCEEEEEEHHHHCCCCCCEEEEEEECCCCCCHHCCCCCCEEEEE
AALDSHLNENGYIIPGLGDAGDKIFGTR
EEHHHCCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNVNVINHPLVRHKLTLMREADCSTYKFRTLAIELARLMAYEASRDFEIEKYLIDGWCGQ
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCC
IEGDRIKGKTLTVVPILRAGLGMLDGVLDLIPTAKISVVGLQRDEETLKPVSYFEKFVDS
CCCCEECCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
MDERPALIIDPMLATGGSMVATIDLLKAKGCKNIKALVLVAAPEGVKAVNDAHPDVTIYT
HCCCCEEEECCHHHCCCCEEEEEEHHHHCCCCCCEEEEEEECCCCCCHHCCCCCCEEEEE
AALDSHLNENGYIIPGLGDAGDKIFGTR
EEHHHCCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA