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The map label for this gene is ubiE [H]

Identifier: 161869687

GI number: 161869687

Start: 716272

End: 717009

Strand: Direct

Name: ubiE [H]

Synonym: NMCC_0707

Alternate gene names: 161869687

Gene position: 716272-717009 (Clockwise)

Preceding gene: 161869686

Following gene: 161869688

Centisome position: 33.26

GC content: 51.08

Gene sequence:

>738_bases
ATGGGCGGACAGAAAACGCATTTCGGGTTCAGCACGGTCAACGAAGATGAGAAAGCCGGAAAAGTGGCGGAAGTGTTCCA
CTCCGTCGCCAAAAACTACGACATTATGAACGATGTGATGTCGGCAGGGCTGCACAGGGTGTGGAAGCATTTCACCATCA
ACACGGCGCACCTGAAAAAAGGCGATAAAGTGTTGGACATTGCGGGCGGTACGGGCGATTTGTCGCGCGGTTGGGCGAAA
CGGGTCGGCAAGGAAGGCGAGGTTTGGCTGACCGATATTAATTCCTCTATGCTGACCGTCGGGCGCGACTGTCTGTTGAA
CGAAGGCATGATTTTGCCAGTGTCGCTTGCCGATGCGGAAAAACTGCCTTTCCCTGACAATTATTTCAACTTGGTTTCCG
TGGCGTTCGGTTTGCGGAACATGACGCACAAGGATACCGCGCTGAAAGAGATGTGCCGTGTTTTGAAACCCGGCGGGACA
TTGCTGGTATTGGAGTTTTCCAAAATCTACAAGCCACTCGAAGGCGCGTATGATTTTTATTCGTTCAAGCTGCTGCCGGT
CATGGGCAAACTGATTGCCAAAGATGCGGAGAGTTATCAATATCTTGCCGAATCCATCCGTATGCACCCCGATCAGGAAA
CTTTGAAACAGATGATGCTGGATGCAGGCTTTGACAGCGTGGATTATCACAATATGAGTGCGGGCATCGTCGCGCTGCAT
AAGGGCGTGAAATTTTAA

Upstream 100 bases:

>100_bases
TTTGGACAAATTGGCGGCGGCGGGTGCTTCCCGTTTTGAAAAGCGATCAGATTGTTAAGTTTGGGATGCCGGAGGACGGC
ATCAGGGAGGTGGTTAGAAT

Downstream 100 bases:

>100_bases
ACGGACTGCCTGTGCAGCCAATGCCGTCTGAACACGTTTCAGACGGCATTTTTGTGTTTCTTGAGACAAAGGTTTTAAAT
CTTAAAAATTAATTTACATA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MGGQKTHFGFSTVNEDEKAGKVAEVFHSVAKNYDIMNDVMSAGLHRVWKHFTINTAHLKKGDKVLDIAGGTGDLSRGWAK
RVGKEGEVWLTDINSSMLTVGRDCLLNEGMILPVSLADAEKLPFPDNYFNLVSVAFGLRNMTHKDTALKEMCRVLKPGGT
LLVLEFSKIYKPLEGAYDFYSFKLLPVMGKLIAKDAESYQYLAESIRMHPDQETLKQMMLDAGFDSVDYHNMSAGIVALH
KGVKF

Sequences:

>Translated_245_residues
MGGQKTHFGFSTVNEDEKAGKVAEVFHSVAKNYDIMNDVMSAGLHRVWKHFTINTAHLKKGDKVLDIAGGTGDLSRGWAK
RVGKEGEVWLTDINSSMLTVGRDCLLNEGMILPVSLADAEKLPFPDNYFNLVSVAFGLRNMTHKDTALKEMCRVLKPGGT
LLVLEFSKIYKPLEGAYDFYSFKLLPVMGKLIAKDAESYQYLAESIRMHPDQETLKQMMLDAGFDSVDYHNMSAGIVALH
KGVKF
>Mature_244_residues
GGQKTHFGFSTVNEDEKAGKVAEVFHSVAKNYDIMNDVMSAGLHRVWKHFTINTAHLKKGDKVLDIAGGTGDLSRGWAKR
VGKEGEVWLTDINSSMLTVGRDCLLNEGMILPVSLADAEKLPFPDNYFNLVSVAFGLRNMTHKDTALKEMCRVLKPGGTL
LVLEFSKIYKPLEGAYDFYSFKLLPVMGKLIAKDAESYQYLAESIRMHPDQETLKQMMLDAGFDSVDYHNMSAGIVALHK
GVKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=278, Percent_Identity=46.0431654676259, Blast_Score=236, Evalue=1e-62,
Organism=Escherichia coli, GI48994983, Length=245, Percent_Identity=61.2244897959184, Blast_Score=311, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17557039, Length=246, Percent_Identity=44.3089430894309, Blast_Score=223, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6323526, Length=257, Percent_Identity=42.0233463035019, Blast_Score=172, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24641702, Length=256, Percent_Identity=44.921875, Blast_Score=225, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27255; Mature: 27124

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGQKTHFGFSTVNEDEKAGKVAEVFHSVAKNYDIMNDVMSAGLHRVWKHFTINTAHLKK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCC
GDKVLDIAGGTGDLSRGWAKRVGKEGEVWLTDINSSMLTVGRDCLLNEGMILPVSLADAE
CCEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCC
KLPFPDNYFNLVSVAFGLRNMTHKDTALKEMCRVLKPGGTLLVLEFSKIYKPLEGAYDFY
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
SFKLLPVMGKLIAKDAESYQYLAESIRMHPDQETLKQMMLDAGFDSVDYHNMSAGIVALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KGVKF
CCCCC
>Mature Secondary Structure 
GGQKTHFGFSTVNEDEKAGKVAEVFHSVAKNYDIMNDVMSAGLHRVWKHFTINTAHLKK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCC
GDKVLDIAGGTGDLSRGWAKRVGKEGEVWLTDINSSMLTVGRDCLLNEGMILPVSLADAE
CCEEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCC
KLPFPDNYFNLVSVAFGLRNMTHKDTALKEMCRVLKPGGTLLVLEFSKIYKPLEGAYDFY
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
SFKLLPVMGKLIAKDAESYQYLAESIRMHPDQETLKQMMLDAGFDSVDYHNMSAGIVALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KGVKF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA