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The map label for this gene is hemH [H]

Identifier: 161869660

GI number: 161869660

Start: 690329

End: 691411

Strand: Reverse

Name: hemH [H]

Synonym: NMCC_0677

Alternate gene names: 161869660

Gene position: 691411-690329 (Counterclockwise)

Preceding gene: 161869661

Following gene: 161869659

Centisome position: 32.11

GC content: 55.68

Gene sequence:

>1083_bases
ATGCCGTCTGAAGCCGCTTCAGACGGCATTTTGCCGCTTTACCCTACCCGCACTATTTTTCAGAAACCGATCATGCTTCC
ATTCCTTCCAGAACCCTCCCTTTCCTATACGCAACAAAACCGTACCGCCGTTTTGCTGTTGAACCTCGGCACGCCCGACG
CGCCGACCGCGCAGACGGTACGACCTTATCTGAAGTCCTTTCTGACCGACCGGCGCGTCGTCGAACTGCCCAAATGGCTG
TGGTATCCCATTCTGCATGGTCTGGTACTGACGTTGCGCCCCAAAAAAAGCGCGCACGCCTATGAAAAAATCTGGTTTAA
GGAAGGTTCGCCCTTAGAAGTTTACACAGCACGCCAAGCTGCCGCGCTTGCCGAACGTATGCCCGACCTCATCGTCCGCC
ACGCCATGACCTACGGCAATCCTTCGGTGGCAGACGTATTGTCGGAACTGAAGGCGCAAGGCGCGGGCAGACTGCTGGTC
ATCCCGATGTACCCGCAATATGCCGCTTCCAGCAGCGGCGCGGCAGTAGATAAGGTGTGCGAACAATTACTGCTGCAACG
GAACCAAATGAGCGTCCGCACCGTTTCGCGCTTTTATGACGATACCGGCTACATTGATGCGATGAAAAACCACATCCTCC
GATATTGGGCGGAACACGGACGTGGGAAAAAACTGATGTTGAGTTTTCACGGCGTACCGCAGAAGCACCACGACCTCGGC
GACCCCTATCCCGACGAGTGCCGCCACACCGCCAAACTGCTTGCCGAAGCACTGGAACTGGCCGAAGACCAATATGTCGT
ATCGTTCCAAAGCCAATTCGGCAGGGCAAAATGGGTTACACCGAGCACGCAGGATTTGTTCGGCAAACTGCCCAAACAGG
GGGTAACCGAGCTGGACGTATTCTGCCCGGGCTTTTTGGCAGACTGTTTGGAAACACTGGAAGAAATCGCCCTGATGGGG
CGGGAACAGTTTTATGAAGCAGGCGGCAAAAGCTACCGCTATATCCCCTGCCTCAACGACAACCCCGACTGGATAGACGC
ACTCGTCGCACTTGCCGAAGAAAACCTTGGCGGCTGGCGTTGA

Upstream 100 bases:

>100_bases
TATGGCGGAAATGCGCGATGCCATAGAACAAGGCAAATTTGCCGACTGGCAGGCACAATTCCACGAAAACCGCGCACGCG
GCACAGACTGATTCCCGGCA

Downstream 100 bases:

>100_bases
AACTGTTTGACCCATGTCTAAAAATGCCGTCTGAACGCCGTGTTCAGACGGCATTTTCCCGCTACTTTAGCGTATGATGG
CATCTATGCTGGACAACACA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MPSEAASDGILPLYPTRTIFQKPIMLPFLPEPSLSYTQQNRTAVLLLNLGTPDAPTAQTVRPYLKSFLTDRRVVELPKWL
WYPILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQAAALAERMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLV
IPMYPQYAASSSGAAVDKVCEQLLLQRNQMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSFHGVPQKHHDLG
DPYPDECRHTAKLLAEALELAEDQYVVSFQSQFGRAKWVTPSTQDLFGKLPKQGVTELDVFCPGFLADCLETLEEIALMG
REQFYEAGGKSYRYIPCLNDNPDWIDALVALAEENLGGWR

Sequences:

>Translated_360_residues
MPSEAASDGILPLYPTRTIFQKPIMLPFLPEPSLSYTQQNRTAVLLLNLGTPDAPTAQTVRPYLKSFLTDRRVVELPKWL
WYPILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQAAALAERMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLV
IPMYPQYAASSSGAAVDKVCEQLLLQRNQMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSFHGVPQKHHDLG
DPYPDECRHTAKLLAEALELAEDQYVVSFQSQFGRAKWVTPSTQDLFGKLPKQGVTELDVFCPGFLADCLETLEEIALMG
REQFYEAGGKSYRYIPCLNDNPDWIDALVALAEENLGGWR
>Mature_359_residues
PSEAASDGILPLYPTRTIFQKPIMLPFLPEPSLSYTQQNRTAVLLLNLGTPDAPTAQTVRPYLKSFLTDRRVVELPKWLW
YPILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQAAALAERMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLVI
PMYPQYAASSSGAAVDKVCEQLLLQRNQMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSFHGVPQKHHDLGD
PYPDECRHTAKLLAEALELAEDQYVVSFQSQFGRAKWVTPSTQDLFGKLPKQGVTELDVFCPGFLADCLETLEEIALMGR
EQFYEAGGKSYRYIPCLNDNPDWIDALVALAEENLGGWR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=336, Percent_Identity=24.702380952381, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=24.8484848484848, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786681, Length=314, Percent_Identity=44.2675159235669, Blast_Score=282, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6324750, Length=345, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=23.5820895522388, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651774, Length=263, Percent_Identity=22.4334600760456, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 40587; Mature: 40456

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSEAASDGILPLYPTRTIFQKPIMLPFLPEPSLSYTQQNRTAVLLLNLGTPDAPTAQTV
CCCCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCHHCCCCEEEEEEECCCCCCCCHHHH
RPYLKSFLTDRRVVELPKWLWYPILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCEEEEHHHHH
AALAERMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLVIPMYPQYAASSSGAAVDKVC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHCCCCCHHHHHHH
EQLLLQRNQMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSFHGVPQKHHDLG
HHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCC
DPYPDECRHTAKLLAEALELAEDQYVVSFQSQFGRAKWVTPSTQDLFGKLPKQGVTELDV
CCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHCCCEECCCCCHHHHHHHCCCCCCCHHHH
FCPGFLADCLETLEEIALMGREQFYEAGGKSYRYIPCLNDNPDWIDALVALAEENLGGWR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PSEAASDGILPLYPTRTIFQKPIMLPFLPEPSLSYTQQNRTAVLLLNLGTPDAPTAQTV
CCCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCHHCCCCEEEEEEECCCCCCCCHHHH
RPYLKSFLTDRRVVELPKWLWYPILHGLVLTLRPKKSAHAYEKIWFKEGSPLEVYTARQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCEEEEHHHHH
AALAERMPDLIVRHAMTYGNPSVADVLSELKAQGAGRLLVIPMYPQYAASSSGAAVDKVC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHCCCCCHHHHHHH
EQLLLQRNQMSVRTVSRFYDDTGYIDAMKNHILRYWAEHGRGKKLMLSFHGVPQKHHDLG
HHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCC
DPYPDECRHTAKLLAEALELAEDQYVVSFQSQFGRAKWVTPSTQDLFGKLPKQGVTELDV
CCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHCCCEECCCCCHHHHHHHCCCCCCCHHHH
FCPGFLADCLETLEEIALMGREQFYEAGGKSYRYIPCLNDNPDWIDALVALAEENLGGWR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA