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The map label for this gene is guaA [H]

Identifier: 161869294

GI number: 161869294

Start: 306948

End: 308513

Strand: Reverse

Name: guaA [H]

Synonym: NMCC_0299

Alternate gene names: 161869294

Gene position: 308513-306948 (Counterclockwise)

Preceding gene: 161869295

Following gene: 161869293

Centisome position: 14.33

GC content: 55.24

Gene sequence:

>1566_bases
ATGACCCAAGACAAAATCCTCATCCTCGACTTCGGTTCTCAAGTTACCCAGCTGATTGCCCGCCGCGTGCGCGAAGCCCA
CGTTTACTGCGAACTGCATTCCTTCGATATGCCTTTGGACGAAATCAAAGCCTTCAACCCCAAAGGCATCATCCTTTCCG
GCGGCCCCAATTCCGTTTACGAATCCGACTATCAAGCCGATATCGGCATTTTTGATTTGGGTATTCCGGTTTTGGGTATT
TGCTACGGTATGCAGTTTATGGCGCACCACCTGGGCGGCGAAGTTACCCCGGGCAACCAGCGCGAATTCGGTTATGCGCA
AGTTAAAACCATCGACAGCGGACTGACGCGCGATATTTACGACGACGCGCCCAATACATTGGACGTATGGATGAGCCACG
GCGACAAAGTGTCCAAACTGCCCGACGGTTTCGCCGTCATCGGCGACACGCCGTCCTGCCCGATTGCGATGATGGAAAAC
GCCGAAAAACAATTCTACGGCATCCAATTCCATCCCGAAGTAACCCACACCAAACAAGGCCGCGCCCTGTTGAACCGCTT
TGTCTTGGACATCTGCGGCGCGCAACCGGGCTGGACGATGCCCAACTACATCGAAGAAGCCGTTGCCAAAATCCGCGAAC
AGGTCGGCAGCGACGAAGTGATTTTGGGTTTGTCCGGCGGCGTGGACTCTTCCGTAGCCGCCGCGCTGATCCACCGCGCC
ATCGGCGACCAACTGACCTGCGTGTTCGTCGATCACGGTTTGTTGCGCCTGAACGAAGGCAAAATGGTGATGGATATGTT
CGCCCGCAACTTGGGTGTGAAAGTGATTCACGTCGATGCCGAAGGGCAGTTTATGGCGAAACTCGCCGGCGTGACCGACC
CCGAGAAAAAACGCAAAATCATCGGCGCGGAATTTATCGAAGTATTTGATGCCGAAGAGAAAAAACTCACCAACGCCAAA
TGGCTGGCGCAAGGCACGATTTACCCCGACGTAATCGAATCCGCAGGCGCGAAAACCCAAAAAGCCCACGCCATCAAATC
CCACCACAATGTCGGCGGCCTGCCTGAAAACATGAAGCTCAAGCTGCTTGAGCCGTTGCGCGACTTGTTTAAAGACGAAG
TGCGCGAACTGGGCGTTGCTTTGGGTCTGCCGCGCGAAATGGTGTACCGCCATCCGTTCCCCGGCCCCGGTTTGGGCGTG
CGCATCTTGGGCGAAGTGAAAAAAGAATACGCCGACTTATTGCGTCAAGCAGACGATATTTTCATCCAAGAATTACGCAA
CACCACCGACGAAAACGGCACATCTTGGTACGACCTGACCAGCCAAGCCTTCGCCGTGTTCCTACCTGTGAAATCCGTCG
GCGTAATGGGCGACGGACGCACTTACGACTACGTCGTCGCACTGCGCGCAGTCATCACCAGCGACTTCATGACCGCACAC
TGGGCAGAACTGCCTTACTCACTGCTCGGACGCGTGTCCAACCGCATCATCAACGAAGTCAAAGGCATCAACCGCGTGGT
GTACGATGTCAGCGGCAAACCGCCTGCCACCATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
AACAAAATGCCGTCTGAAATGGTACAATCGCCCCGACCCTTTCAGACGGCATCATATCCGCCGACCCATCCGATTATCTT
CAATCACCGTAAAACCCATT

Downstream 100 bases:

>100_bases
CCAGCAAACAGGGCTGCACCGTCCGGCGCAGTCTTTCGATTATCGGAAAAAAGGAAAAAATATGAGCACACAAGATTTAA
GCGGCAAAATCGCTTTGGTA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MTQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYESDYQADIGIFDLGIPVLGI
CYGMQFMAHHLGGEVTPGNQREFGYAQVKTIDSGLTRDIYDDAPNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMEN
AEKQFYGIQFHPEVTHTKQGRALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRA
IGDQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAK
WLAQGTIYPDVIESAGAKTQKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGV
RILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAH
WAELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_521_residues
MTQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYESDYQADIGIFDLGIPVLGI
CYGMQFMAHHLGGEVTPGNQREFGYAQVKTIDSGLTRDIYDDAPNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMEN
AEKQFYGIQFHPEVTHTKQGRALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRA
IGDQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAK
WLAQGTIYPDVIESAGAKTQKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGV
RILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAH
WAELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE
>Mature_520_residues
TQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYESDYQADIGIFDLGIPVLGIC
YGMQFMAHHLGGEVTPGNQREFGYAQVKTIDSGLTRDIYDDAPNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMENA
EKQFYGIQFHPEVTHTKQGRALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAI
GDQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAKW
LAQGTIYPDVIESAGAKTQKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVR
ILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAHW
AELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=36.9090909090909, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=65.5238095238095, Blast_Score=702, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=574, Percent_Identity=35.8885017421603, Blast_Score=288, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI71992710, Length=574, Percent_Identity=36.0627177700348, Blast_Score=287, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=574, Percent_Identity=35.8885017421603, Blast_Score=287, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=527, Percent_Identity=51.6129032258064, Blast_Score=535, Evalue=1e-153,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=37.2093023255814, Blast_Score=309, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57677; Mature: 57546

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVY
CCCCCEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHCCCCCEEEEECCCCCCC
ESDYQADIGIFDLGIPVLGICYGMQFMAHHLGGEVTPGNQREFGYAQVKTIDSGLTRDIY
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEHHCCCCHHHH
DDAPNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMENAEKQFYGIQFHPEVTHTKQG
HCCCCHHHHHHCCCCCHHCCCCCEEEECCCCCCCHHHHCCCCHHEEEEEECCCCCCCHHH
RALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
IGDQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKI
HCCCEEEEEEECCEEEECCCCHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCHHHHHHH
IGAEFIEVFDAEEKKLTNAKWLAQGTIYPDVIESAGAKTQKAHAIKSHHNVGGLPENMKL
HHHHHHHHHCCHHHHHCCCHHEECCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHH
KLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVRILGEVKKEYADLLRQADDI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAH
HHHHHHCCCCCCCCEEEEHHHCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
WAELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE
HHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVY
CCCCEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHCCCCCEEEEECCCCCCC
ESDYQADIGIFDLGIPVLGICYGMQFMAHHLGGEVTPGNQREFGYAQVKTIDSGLTRDIY
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEHHCCCCHHHH
DDAPNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMENAEKQFYGIQFHPEVTHTKQG
HCCCCHHHHHHCCCCCHHCCCCCEEEECCCCCCCHHHHCCCCHHEEEEEECCCCCCCHHH
RALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
IGDQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKI
HCCCEEEEEEECCEEEECCCCHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCHHHHHHH
IGAEFIEVFDAEEKKLTNAKWLAQGTIYPDVIESAGAKTQKAHAIKSHHNVGGLPENMKL
HHHHHHHHHCCHHHHHCCCHHEECCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHH
KLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVRILGEVKKEYADLLRQADDI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAH
HHHHHHCCCCCCCCEEEEHHHCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
WAELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE
HHHCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA