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The map label for this gene is birA [H]

Identifier: 161869118

GI number: 161869118

Start: 111310

End: 113088

Strand: Direct

Name: birA [H]

Synonym: NMCC_0112

Alternate gene names: 161869118

Gene position: 111310-113088 (Clockwise)

Preceding gene: 161869117

Following gene: 161869119

Centisome position: 5.17

GC content: 60.31

Gene sequence:

>1779_bases
ATGACGGTTTTGAAGCTTTCGCACTGGCGGGTGTTGGCGGAGCTTGCCGACGGTTTGCCGCAACACGTCTCGCAACTGGC
GCGTATGGCGGATATGAAGCCGCAGCAGCTCAACGGTTTTTGGCAGCAGATGCCGGCGCACATACGCGGGCTGTTGCGCC
AACACGACGGCTATTGGCGGCTGGTGCGCCCATTGGCGGTTTTCGATGCCGAAGGTTTGCGCGAGCTGGGGGAAAGGTCG
GGTTTTCAGACGGCATTGAAGCACGAGTGCGCGTCCAGCAACGACGAGATACTGGAATTGGCGCGGATTGCGCCGGACAA
GGCGCACAAAACCATATGTGTGACCCACCTGCAAAGTAAGGGCAGGGGGCGGCAGGGGCGGAAGTGGTCGCACCGTTTGG
GCGAGTGTCTGATGTTCAGTTTTGGCTGGGTGTTTGACCGGCCGCAGTATGAGTTGGGTTCGCTGTCGCCTGTTGCGGCA
GTGGCGTGCCGGCGCGCCTTGTCGCGTTTGGGTTTGAAAACGCAAATCAAGTGGCCCAACGATTTGGTCGTGGGGCGCGA
TAAATTGGGCGGCATTCTGATTGAAACGGTCAGGGCGGGCGGCAAGACGGTTGCCGTCGTCGGTATCGGCATCAATTTTG
TCCTGCCCAAGGAAGTGGAAAATGCCGCTTCCGTGCAATCGCTGTTTCAGACGGCATCGCGGCGGGGAAATGCCGATGCC
GCCGTGTTGCTGGAAACGCTGTTGGCGGAACTTGATGCGGTGTTGTTGCAATATGCGCGGGACGGATTTGCGCCTTTTGT
GGCGGAATATCAGGCTGCCAACCGCGACCACGGCAAGGCGGTATTGCTGTTGCGCGACGGCGAAACCGTGTTCGAAGGCA
CGGTTAAAGGCGTGGACGGACAAGGCGTTTTGCACTTGGAAACGGCAGAGGGCAAACAGACGGTCGTCAGCGGCGAAATC
AGCCTGCGGTCCGACGACAGGCCGGTTTCCGTGCCGAAGCGGCGGGATTCGGAACGTTTTCTGCTGTTGGACGGCGGCAA
CAGCCGGCTCAAGTGGGCGTGGGTGGAAAACGGCACGTTCGCAACCGTCGGTAGCGCGCCGTACCGCGATTTGTCGCCTT
TGGGCGCGGAGTGGGCGGAAAAGGCGGATGGAAATGTCCGCATCGTCGGTTGCGCCGTGTGCGGAGAATTCAAAAAGGCA
CAAGTGCAGGAACAGCTCGCCCGAAAAATCGAGTGGCTGCCGTCTTCCGCACAGGCTTTGGGCATACGCAACCACTACCG
CCACCCCGAAGAACACGGTTCCGACCGCTGGTTCAACGCCTTGGGCAGCCGCCGCTTCAGCCGCAATGCCTGCGTCGTCG
TCAGTTGCGGCACGGCGGTAACGGTTGACGCGCTCACCGATGACGGACATTATCTCGGGGGAACCATCATGCCCGGTTTC
CACCTGATGAAAGAATCGCTCGCCGTCCGAACCGCCAACCTCAACCGGCACGCCGGTAAGCGTTATCCTTTCCCGACCAC
AACGGGCAATGCCGTCGCCAGCGGCATGATGGATGCGGTTTGCGGCTCGGTTATGATGATGCACGGGCGTTTGAAAGAAA
AAACCGGGGCGGGCAAGCCTGTCGATGTCATCATTACCGGCGGCGGCGCGGCAAAAGTTGCCGAAGCCCTGCCGCCTGCA
TTTTTGGCGGAAAATACCGTGCGCGTGGCGGACAACCTCGTCATTCACGGGCTGCTGAACCTGATTGCCGCCGAAGGCGG
GGAATCGGAACATACTTAA

Upstream 100 bases:

>100_bases
AAACGTTGGCGCGCGGCGGTCAGGTGTTTTCAATTCCGTTTCTGCACCAGACTTCGACAACGAAGACTTTGGCAAAAATC
CGTGCGGCAGAGGGCGGAAA

Downstream 100 bases:

>100_bases
AAAATACACCCTTTTTCAACACGGGGCGGCATCCGTCCGAATCCGTCCGGATTCTGCCGCCCGACAGACTGCCGCCCAGG
CGGGCGGGGTTTCAAACATT

Product: bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase

Products: NA

Alternate protein names: Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase; Type III pantothenate kinase; PanK-III; Pantothenic acid kinase [H]

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWRLVRPLAVFDAEGLRELGERS
GFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAA
VACRRALSRLGLKTQIKWPNDLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA
AVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVSGEI
SLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKA
QVQEQLARKIEWLPSSAQALGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF
HLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEALPPA
FLAENTVRVADNLVIHGLLNLIAAEGGESEHT

Sequences:

>Translated_592_residues
MTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWRLVRPLAVFDAEGLRELGERS
GFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAA
VACRRALSRLGLKTQIKWPNDLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA
AVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVSGEI
SLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKA
QVQEQLARKIEWLPSSAQALGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF
HLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEALPPA
FLAENTVRVADNLVIHGLLNLIAAEGGESEHT
>Mature_591_residues
TVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWRLVRPLAVFDAEGLRELGERSG
FQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAV
ACRRALSRLGLKTQIKWPNDLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADAA
VLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVSGEIS
LRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKAQ
VQEQLARKIEWLPSSAQALGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFH
LMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEALPPAF
LAENTVRVADNLVIHGLLNLIAAEGGESEHT

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis [H]

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the type III pantothenate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1790408, Length=272, Percent_Identity=31.9852941176471, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143
- InterPro:   IPR008988
- InterPro:   IPR004619 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB; PF03309 Bvg_acc_factor [H]

EC number: =6.3.4.15; =2.7.1.33 [H]

Molecular weight: Translated: 64427; Mature: 64296

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWR
CCEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSK
HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCHHCCEEEEEEHHHC
GRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLKTQIKWPN
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
DLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA
CEEECCHHHCCHHHHHHHCCCCEEEEEEECEEEEECHHHHHHHHHHHHHHHHHHCCCCHH
AVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCEEEECEEECCCC
QGVLHLETAEGKQTVVSGEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTF
CCEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCEE
ATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQAL
EEECCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHH
GIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF
CCHHHCCCCHHCCCHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCCEECCCCCCHH
HLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKP
HHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHT
EEEEEECCCHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWR
CEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSK
HHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCHHCCEEEEEEHHHC
GRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLKTQIKWPN
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCC
DLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA
CEEECCHHHCCHHHHHHHCCCCEEEEEEECEEEEECHHHHHHHHHHHHHHHHHHCCCCHH
AVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCEEEECEEECCCC
QGVLHLETAEGKQTVVSGEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTF
CCEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCEE
ATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQAL
EEECCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHH
GIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF
CCHHHCCCCHHCCCHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCCEECCCCCCHH
HLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKP
HHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHT
EEEEEECCCHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA