Click here to switch to the map view.

The map label for this gene is galE [H]

Identifier: 161869083

GI number: 161869083

Start: 68702

End: 69721

Strand: Reverse

Name: galE [H]

Synonym: NMCC_0072

Alternate gene names: 161869083

Gene position: 69721-68702 (Counterclockwise)

Preceding gene: 161869085

Following gene: 161869082

Centisome position: 3.24

GC content: 51.27

Gene sequence:

>1020_bases
ATGAAAAAAATTCTCGTTACCGGCGGCACCGGTTTTATCGGCTCGCATACCGTTGTTTCTTTGCTGAAAAGCGGCCATCA
AGTCGTGATTTTGGATAACCTATGCAATTCCAGCATCAATATCCTGCCACGCTTGAAAACGATTACCGGCCAAGAGATTC
CGTTTTATCAAGGCGATATCCGCGATCGTGAGATTTTGCGCCGTATTTTTGCGGAAAACCGCATTGATTCGGTGATTCAT
TTTGCCGGCTTGAAAGCGGTGGGTGAAAGTGTGGCCGAGCCGATGAAATATTATGATAATAATGTTTCCGGCAGCTTGGT
GTTGGCGGAAGAAATGGCGCGTGCCGGCGTATTTAAGATTGTGTTCAGCTCATCGGCTACGGTTTATGGCGATCCGGGCA
AAGTGCCTTATACCGAGGATATGCCACTGGGCGATACCACCAGCCCTTACGGCACATCGAAATCAATGGTTGAGCGCATT
CTCACTGATATTCAAAAAGCCGATCCGCGCTGGAGCGTGATTTTGTTGCGCTATTTCAACCCGATTGGGGCGCACGAAAG
CGGCTTGATCGGCGAACAGCCCAACGGTATTCCCAACAACCTTTTGCCCTATATCTGCCAAGTGGCTTCGGGCAGGCTGC
CGCAACTGTCGGTATTCGGCGGCGATTATCCGACCCCCGACGGTACGGGAATGCGCGACTACATTCATGTGATGGATTTG
GCAGAAGGCCATGTCGCGGCTATGCAGGCAAAAAGTAATGTAGCAGGCACGCATTTGTTGAACTTAGGTTCCGGTCGCGC
TTCTTCGGTGTTGGAAATCATCCGCGCATTTGAAGCGGCTTCGGGTTTGACGATTCCGTATGAAGTCAAACCGCGCCGTG
CCGGTGATTTGGCGTGCTTCTATGCCGACCCTTCCTATACAAAGGCGCAAATCGGCTGGCAAACCCAGCGTGATTTGGCG
CAGATGATGGAAGACTCATGGCGTTGGGTCAGCAACAACCCAAATGGCTACGACGATTAA

Upstream 100 bases:

>100_bases
AAATCTGAAGAAATCTACTGCTACTTCAGGGATAATTATTTCATTAAGATTTTACAACCATTATTATCAATCTATCAAAG
TATTTTTAGTATTTTATTCT

Downstream 100 bases:

>100_bases
GTTGACCTGATACAGGCCGTCTGAAAGAGATGTTTTCAGACGGCCTCTTTATCTGAAAAACACACATTCTGTCTGCTATA
ATCTGTTTATATTTTTTGGC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIH
FAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKIVFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERI
LTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDL
AEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLA
QMMEDSWRWVSNNPNGYDD

Sequences:

>Translated_339_residues
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIH
FAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKIVFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERI
LTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDL
AEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLA
QMMEDSWRWVSNNPNGYDD
>Mature_339_residues
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIH
FAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKIVFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERI
LTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDL
AEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLA
QMMEDSWRWVSNNPNGYDD

Specific function: Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=342, Percent_Identity=50.5847953216374, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI56118217, Length=342, Percent_Identity=50.5847953216374, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI189083684, Length=342, Percent_Identity=50.5847953216374, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI7657641, Length=280, Percent_Identity=28.2142857142857, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1786974, Length=337, Percent_Identity=56.0830860534125, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI48994969, Length=363, Percent_Identity=25.8953168044077, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788353, Length=365, Percent_Identity=23.8356164383562, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=343, Percent_Identity=48.6880466472303, Blast_Score=347, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI71982038, Length=346, Percent_Identity=48.5549132947977, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=23.8805970149254, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=51.8840579710145, Blast_Score=358, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=55.2631578947368, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI21356223, Length=339, Percent_Identity=24.188790560472, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37090; Mature: 37090

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDI
CCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEECHHHCCCCCCCCCCCCC
RDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHCCEEEE
VFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERILTDIQKADPRWSVILLRYFN
EECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
PIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
AEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACF
CCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEE
YADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
ECCCCCCEEECCCCHHHHHHHHHHHCCEEECCCCCCCCC
>Mature Secondary Structure
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDI
CCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEECHHHCCCCCCCCCCCCC
RDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHCCEEEE
VFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERILTDIQKADPRWSVILLRYFN
EECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
PIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
AEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACF
CCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEE
YADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
ECCCCCCEEECCCCHHHHHHHHHHHCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]