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The map label for this gene is msrAB [H]

Identifier: 161869062

GI number: 161869062

Start: 39022

End: 40590

Strand: Reverse

Name: msrAB [H]

Synonym: NMCC_0045

Alternate gene names: 161869062

Gene position: 40590-39022 (Counterclockwise)

Preceding gene: 161869065

Following gene: 161869058

Centisome position: 1.88

GC content: 54.75

Gene sequence:

>1569_bases
ATGAAACACCGTACTTTCTTTTCCCTTTGCGCCAAGTTCGGCTGCCTGCTTGCGCTGGGTGCTTGTTCGCCCAAAATCGT
CGATGCCGGAGCCGCGACCGTGCCGCACACTTTATCCACTTTGAAAACTGCGGACAACCGCCCCGCCAGTGTTTACTTGA
AAAAAGACAAACCGACGCTGATTAAATTTTGGGCGAGCTGGTGTCCTTTGTGTCTGTCCGAATTGGGACAGACCGAAAAA
TGGGCGCAAGATGCAAAATTCAGCTCCGCCAACCTGATTACCGTCGCGTCTCCGGGCTTTTTGCACGAGAAAAAAGACGG
CGACTTCCAAAAATGGTATGCCGGTTTGAATTATCCCAAGCTGCCCGTCGTAACCGACAACGGCGGCACGATCGCCCAAA
GCCTGAATATCAGCGTTTACCCTTCGTGGGCGTTAATCGGTAAAGACGGCGACGTGCAGCGCATCGTCAAAGGCAGCATC
AACGAAGCGCAGGCGTTGGCGTTAATCCGCGACCCGAATGCCGATTTGGGCAGCTTGAAACATTCGTTCTACAAACCCGA
CACTCAGAAAAAGGATTCAAAAATCATGAACACGCGCACCATCTACCTCGCCGGCGGCTGCTTCTGGGGCTTGGAAGCCT
ATTTCCAACGCATCGACGGCGTGGTTGACGCGGTATCCGGCTACGCCAACGGCAACACGAAAAATCCGAGCTATGAAGAC
GTGTCCTACCGCCATACGGGCCACGCCGAAACCGTCAAAGTGACCTACGATGCCGACAAACTCAGCCTAGACGACATCCT
GCAATATTTCTTCCGCGTCGTTGATCCGACCAGCCTCAACAAACAGGGCAACGACACCGGTACGCAATACCGCAGCGGCG
TGTACTACACCGACCCCGCCGAAAAAGCCGTCATCGCCGCCGCCCTCAAACGCGAGCAGCAAAAATACCAACTGCCCCTC
GTTGTTGAAAACGAGCCGCTGAAAAACTTCTACGATGCCGAGGAATACCATCAGGACTACCTGATTAAAAACCCCAACGG
CTACTGCCACATCGATATCCGCAAAGCCGACGAACCGCTGCCGGGCAAAACCAAGACCGCCCCGCAAGGCAAAGGCTTCG
ATGCGGCAACGTATAAAAAACCGAGTGACGCCGAACTCAAACGCACCCTGACCGAAGAGCAATACCAAGTTACCCAAAAC
AGCGCGACCGAATATGCCTTCAGCCACGAATACGACCATTTGTTCAAACCCGGCATTTATGTGGACGTTGTCAGCGGCGA
ACCTTTGTTCAGCTCCGCCGACAAATATGATTCCGGCTGCGGCTGGCCGAGCTTCACGCGCCCGATTGATGCAAAATCCG
TTACCGAACACGATGATTTCAGCTACAACATGCGCCGCACCGAAGTGCGCAGCCACGCCGCCGATTCGCATTTGGGACAC
GTCTTCCCCGACGGCCCGCGCGACAAAGGCGGACTGCGCTACTGCATCAACGGCGCGAGCTTGAAATTCATCCCGCTGGA
ACAAATGGACGCGGCAGGCTACGGCGCGTTGAAGAGTAAAGTGAAATAA

Upstream 100 bases:

>100_bases
TAGCGTATTTTACGCGGCAAGGTTGTCTGAAAATCCGAGCTGTAAGGTTTCGGCATCTCAAACGTCTAATCATGCAAACC
GTCCACACAGGAAACTCAAA

Downstream 100 bases:

>100_bases
GCCGCACCGCCGCCTAACCCGACAAAATACCGTCTGAAACCTGCAACGTTTCAGACGGTATTTTTTATCCGGCGGGGATT
TTGTCCAGACGGAGATTTTG

Product: trifunctional thioredoxin/methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Thioredoxin; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MKHRTFFSLCAKFGCLLALGACSPKIVDAGAATVPHTLSTLKTADNRPASVYLKKDKPTLIKFWASWCPLCLSELGQTEK
WAQDAKFSSANLITVASPGFLHEKKDGDFQKWYAGLNYPKLPVVTDNGGTIAQSLNISVYPSWALIGKDGDVQRIVKGSI
NEAQALALIRDPNADLGSLKHSFYKPDTQKKDSKIMNTRTIYLAGGCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYED
VSYRHTGHAETVKVTYDADKLSLDDILQYFFRVVDPTSLNKQGNDTGTQYRSGVYYTDPAEKAVIAAALKREQQKYQLPL
VVENEPLKNFYDAEEYHQDYLIKNPNGYCHIDIRKADEPLPGKTKTAPQGKGFDAATYKKPSDAELKRTLTEEQYQVTQN
SATEYAFSHEYDHLFKPGIYVDVVSGEPLFSSADKYDSGCGWPSFTRPIDAKSVTEHDDFSYNMRRTEVRSHAADSHLGH
VFPDGPRDKGGLRYCINGASLKFIPLEQMDAAGYGALKSKVK

Sequences:

>Translated_522_residues
MKHRTFFSLCAKFGCLLALGACSPKIVDAGAATVPHTLSTLKTADNRPASVYLKKDKPTLIKFWASWCPLCLSELGQTEK
WAQDAKFSSANLITVASPGFLHEKKDGDFQKWYAGLNYPKLPVVTDNGGTIAQSLNISVYPSWALIGKDGDVQRIVKGSI
NEAQALALIRDPNADLGSLKHSFYKPDTQKKDSKIMNTRTIYLAGGCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYED
VSYRHTGHAETVKVTYDADKLSLDDILQYFFRVVDPTSLNKQGNDTGTQYRSGVYYTDPAEKAVIAAALKREQQKYQLPL
VVENEPLKNFYDAEEYHQDYLIKNPNGYCHIDIRKADEPLPGKTKTAPQGKGFDAATYKKPSDAELKRTLTEEQYQVTQN
SATEYAFSHEYDHLFKPGIYVDVVSGEPLFSSADKYDSGCGWPSFTRPIDAKSVTEHDDFSYNMRRTEVRSHAADSHLGH
VFPDGPRDKGGLRYCINGASLKFIPLEQMDAAGYGALKSKVK
>Mature_522_residues
MKHRTFFSLCAKFGCLLALGACSPKIVDAGAATVPHTLSTLKTADNRPASVYLKKDKPTLIKFWASWCPLCLSELGQTEK
WAQDAKFSSANLITVASPGFLHEKKDGDFQKWYAGLNYPKLPVVTDNGGTIAQSLNISVYPSWALIGKDGDVQRIVKGSI
NEAQALALIRDPNADLGSLKHSFYKPDTQKKDSKIMNTRTIYLAGGCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYED
VSYRHTGHAETVKVTYDADKLSLDDILQYFFRVVDPTSLNKQGNDTGTQYRSGVYYTDPAEKAVIAAALKREQQKYQLPL
VVENEPLKNFYDAEEYHQDYLIKNPNGYCHIDIRKADEPLPGKTKTAPQGKGFDAATYKKPSDAELKRTLTEEQYQVTQN
SATEYAFSHEYDHLFKPGIYVDVVSGEPLFSSADKYDSGCGWPSFTRPIDAKSVTEHDDFSYNMRRTEVRSHAADSHLGH
VFPDGPRDKGGLRYCINGASLKFIPLEQMDAAGYGALKSKVK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=135, Percent_Identity=50.3703703703704, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI301336162, Length=135, Percent_Identity=50.3703703703704, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI73089054, Length=135, Percent_Identity=50.3703703703704, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI37620216, Length=135, Percent_Identity=50.3703703703704, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=40.251572327044, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=40.251572327044, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI117606353, Length=138, Percent_Identity=42.0289855072464, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI208609993, Length=148, Percent_Identity=39.1891891891892, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=50, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=41.2162162162162, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115532676, Length=129, Percent_Identity=40.3100775193798, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=129, Percent_Identity=40.3100775193798, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=30.0699300699301, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=43.6708860759494, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=33.0769230769231, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553335, Length=121, Percent_Identity=48.7603305785124, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21356369, Length=121, Percent_Identity=48.7603305785124, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24645799, Length=121, Percent_Identity=48.7603305785124, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI221378664, Length=121, Percent_Identity=48.7603305785124, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=128, Percent_Identity=46.09375, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24645804, Length=132, Percent_Identity=43.9393939393939, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645801, Length=132, Percent_Identity=43.9393939393939, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=31.4685314685315, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=31.4685314685315, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01625 PMSR; PF08534 Redoxin; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 58016; Mature: 58016

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRTFFSLCAKFGCLLALGACSPKIVDAGAATVPHTLSTLKTADNRPASVYLKKDKPTL
CCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHH
IKFWASWCPLCLSELGQTEKWAQDAKFSSANLITVASPGFLHEKKDGDFQKWYAGLNYPK
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCC
LPVVTDNGGTIAQSLNISVYPSWALIGKDGDVQRIVKGSINEAQALALIRDPNADLGSLK
CEEEECCCCEEEEEEEEEEECCEEEECCCCCHHHHHHCCCCCCEEEEEEECCCCCHHHHH
HSFYKPDTQKKDSKIMNTRTIYLAGGCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYED
HHHCCCCCCCCCCHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VSYRHTGHAETVKVTYDADKLSLDDILQYFFRVVDPTSLNKQGNDTGTQYRSGVYYTDPA
CCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCEEEECCH
EKAVIAAALKREQQKYQLPLVVENEPLKNFYDAEEYHQDYLIKNPNGYCHIDIRKADEPL
HHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHHHCCCCEEECCCCEEEEEEECCCCCC
PGKTKTAPQGKGFDAATYKKPSDAELKRTLTEEQYQVTQNSATEYAFSHEYDHLFKPGIY
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHEEECCCCHHHCCCCEE
VDVVSGEPLFSSADKYDSGCGWPSFTRPIDAKSVTEHDDFSYNMRRTEVRSHAADSHLGH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VFPDGPRDKGGLRYCINGASLKFIPLEQMDAAGYGALKSKVK
CCCCCCCCCCCEEEEECCCEEEEEEHHHHCCCCCHHHHHCCC
>Mature Secondary Structure
MKHRTFFSLCAKFGCLLALGACSPKIVDAGAATVPHTLSTLKTADNRPASVYLKKDKPTL
CCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHH
IKFWASWCPLCLSELGQTEKWAQDAKFSSANLITVASPGFLHEKKDGDFQKWYAGLNYPK
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCC
LPVVTDNGGTIAQSLNISVYPSWALIGKDGDVQRIVKGSINEAQALALIRDPNADLGSLK
CEEEECCCCEEEEEEEEEEECCEEEECCCCCHHHHHHCCCCCCEEEEEEECCCCCHHHHH
HSFYKPDTQKKDSKIMNTRTIYLAGGCFWGLEAYFQRIDGVVDAVSGYANGNTKNPSYED
HHHCCCCCCCCCCHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
VSYRHTGHAETVKVTYDADKLSLDDILQYFFRVVDPTSLNKQGNDTGTQYRSGVYYTDPA
CCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCEEEECCH
EKAVIAAALKREQQKYQLPLVVENEPLKNFYDAEEYHQDYLIKNPNGYCHIDIRKADEPL
HHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHHHCCCCEEECCCCEEEEEEECCCCCC
PGKTKTAPQGKGFDAATYKKPSDAELKRTLTEEQYQVTQNSATEYAFSHEYDHLFKPGIY
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHEEECCCCHHHCCCCEE
VDVVSGEPLFSSADKYDSGCGWPSFTRPIDAKSVTEHDDFSYNMRRTEVRSHAADSHLGH
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VFPDGPRDKGGLRYCINGASLKFIPLEQMDAAGYGALKSKVK
CCCCCCCCCCCEEEEECCCEEEEEEHHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2854063; 8755589 [H]