BacMap

Definition	Bacillus cereus E33L, complete genome.
Accession	NC_006274
Length	5,300,915

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The map label for this gene is fabG [H]

Identifier: 161763551

GI number: 161763551

Start: 4479935

End: 4480726

Strand: Reverse

Name: fabG [H]

Synonym: BCZK4369

Alternate gene names: 161763551

Gene position: 4480726-4479935 (Counterclockwise)

Preceding gene: 52140880

Following gene: 52140883

Centisome position: 84.53

GC content: 37.12

Gene sequence:

>792_bases
ATGAAGTATAGCAATTTAAAAGGAGGCATGTTTGTGAGACACGCGCTCATTACAGCCGGTACGAAAGGTTTAGGAAAGCA
AGTAACAGAAAAGTTATTGGCTAAAGGATATTCAGTAACAGTAACATATCATAGCGATATAGCAGCTATGGAAACGATGA
AAGAAACATATAAAAATATGGAAGAGCGTCTACAATTCGTGCAAGCGGATGTCACGAAAAAGGAAGATTTACATAAAATA
GTAGAAGAAGCGATAAGCCGTTTTGGCAAAATTGACTTTTTAATTAATAATGCTGGTCCATATGTATTTGAACGAAAAAA
GTTAGTCGATTATGAAGAAGACGAATGGAATGAGATGATTCAGGGTAATTTAACAGCTGTATTTCATTTGTTGAAGCTTG
TCGTTCCGATTATGAGAAAACAGAACTTTGGCCGTATTATTAATTACGGATTCCAAGGGGCAGATAGTGCACCGGGATGG
ATTTATCGTTCAGCTTTTGCAGCAGCGAAAGTAGGACTTGTTTCATTAACGAAAACTGTTGCTTACGAAGAAGCAGAATA
TGGAATTACTGCAAATATGGTATGTCCTGGTGATATTATTGGTGAAATGAAAGAAGCGACAATTCAAGAAGCACGTCAGT
TGAAAGAACGTAAAACACCAATTGGTAGATCTGGAACAGGCGAAGATATCGCAAGAACGATTTCGTTTTTATGCGAGGAA
GATTCCGATATGATTACCGGTACAATTATTGAAGTAACTGGTGCAGTAGATGTTATTCATAGACATCGATAG

Upstream 100 bases:

>100_bases
AAAACAAATTTTGGTAATGTGCTTGCCGGAAACGTTACAGAATTTCGAAAACTCTGTTTTGATTCATTTTAGTTGTAATT
GTTGCGAGAACTTGTTACAT

Downstream 100 bases:

>100_bases
AGAAAAATAAAGTGAAGTTTCGAATGATTGGACAGTTTATCCTTTATGCTGATAGGTGCGGATAATACTGTCCTTTAATA
TAAAATTAAATCTATCGGAA

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKYSNLKGGMFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDIAAMETMKETYKNMEERLQFVQADVTKKEDLHKI
VEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERKTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEVTGAVDVIHRHR

Sequences:

>Translated_263_residues
MKYSNLKGGMFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDIAAMETMKETYKNMEERLQFVQADVTKKEDLHKI
VEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERKTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEVTGAVDVIHRHR
>Mature_263_residues
MKYSNLKGGMFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDIAAMETMKETYKNMEERLQFVQADVTKKEDLHKI
VEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERKTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEVTGAVDVIHRHR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=248, Percent_Identity=27.0161290322581, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=29.2, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=29.2307692307692, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI59889578, Length=203, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66933014, Length=208, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI126723750, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=26.0536398467433, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=24.8979591836735, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4758504, Length=193, Percent_Identity=27.4611398963731, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=27.2277227722772, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4503301, Length=220, Percent_Identity=25, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=32.6446280991736, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=30.9917355371901, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082160, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=28.8617886178862, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=26.6932270916335, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=28.8, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=27.3809523809524, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=25.7936507936508, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=26.171875, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=23.0769230769231, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=24.5833333333333, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786812, Length=195, Percent_Identity=25.6410256410256, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=29.2, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=29.7297297297297, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=263, Percent_Identity=27.3764258555133, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=26.7441860465116, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=245, Percent_Identity=29.3877551020408, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=26.2948207171315, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=257, Percent_Identity=24.5136186770428, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=275, Percent_Identity=27.6363636363636, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=26.4367816091954, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=26.4822134387352, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=26.7924528301887, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=26.8199233716475, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=28.6259541984733, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=269, Percent_Identity=29.7397769516729, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=25.9398496240602, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=191, Percent_Identity=28.2722513089005, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=26.8199233716475, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=240, Percent_Identity=25.8333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=28.0442804428044, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=259, Percent_Identity=25.0965250965251, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=25.1908396946565, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=209, Percent_Identity=24.8803827751196, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=187, Percent_Identity=26.2032085561497, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=26.0536398467433, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=26.7716535433071, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=25.1968503937008, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=126, Percent_Identity=36.5079365079365, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=252, Percent_Identity=23.015873015873, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=28.7449392712551, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=27.3809523809524, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=26.8292682926829, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI18859837, Length=242, Percent_Identity=28.099173553719, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=26.7206477732794, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=25.8964143426295, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=24.901185770751, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356301, Length=226, Percent_Identity=26.5486725663717, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 29482; Mature: 29482

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYSNLKGGMFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDIAAMETMKETYKNM
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
EERLQFVQADVTKKEDLHKIVEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCCHHHHHHHH
QGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTV
HCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERKTPIGRSGTGEDIARTISFLCEE
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
DSDMITGTIIEVTGAVDVIHRHR
CCCEEEEHHEEHHHHHHHHHCCC
>Mature Secondary Structure
MKYSNLKGGMFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDIAAMETMKETYKNM
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
EERLQFVQADVTKKEDLHKIVEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCCHHHHHHHH
QGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTV
HCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERKTPIGRSGTGEDIARTISFLCEE
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
DSDMITGTIIEVTGAVDVIHRHR
CCCEEEEHHEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]