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The map label for this gene is lspA [H]

Identifier: 161760693

GI number: 161760693

Start: 1722163

End: 1722624

Strand: Direct

Name: lspA [H]

Synonym: BLi01765

Alternate gene names: 161760693

Gene position: 1722163-1722624 (Clockwise)

Preceding gene: 52785523

Following gene: 52785525

Centisome position: 40.78

GC content: 44.37

Gene sequence:

>462_bases
GTGCCTTATTACATAATTGCGCTGCTCATTATCGGTATCGATCAATTTACAAAATGGCTGGTCGTCAGCAAAATGGAGTA
CGGTGAAAGCATCCCCGTCATCGATGGCTTCTTTCAGATTACGTCGCACAGGAATACAGGTGCGGCATGGGGCATTTTGG
CCGGGCAGATGTGGTTTTTTTACATCATTACGACGGTGGTGATCATCGGCATTGTATACTACATTCAAAAACATGCAAAA
GGACAAATCCTGCTCGGAATCGCTCTCGGTTTGATGCTTGGCGGTGCTGTCGGCAATTTCATCGACCGCGTGTTCAGACA
AGAAGTTGTCGATTTTATCCACGTGACGATCGTCAATTATCACTATCCGATTTTCAACATTGCCGATTCATCTTTATGTA
TCGGAGTCCTGCTCTTATTTATACAAATGCTGTTAGACGGAAAGAAGAAGAAGGAGCTGTAA

Upstream 100 bases:

>100_bases
TTTGCCCTCTTGCAGGATGTCAATGAATATTCCTTTACTCCTTTTCTTTTTCTTGTTAAAATGCTTAAATGAAGAGAAAC
AGAAACTGGAGGAACGGTTT

Downstream 100 bases:

>100_bases
CATGGAGCATTATGATATGACCGTTCATGAAGAACATAAAGGTGAACGGATTGACAAGTACTTGACCGCAGTTGAAGCGG
ATTGGTCGCGGACTCAAGTA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MPYYIIALLIIGIDQFTKWLVVSKMEYGESIPVIDGFFQITSHRNTGAAWGILAGQMWFFYIITTVVIIGIVYYIQKHAK
GQILLGIALGLMLGGAVGNFIDRVFRQEVVDFIHVTIVNYHYPIFNIADSSLCIGVLLLFIQMLLDGKKKKEL

Sequences:

>Translated_153_residues
MPYYIIALLIIGIDQFTKWLVVSKMEYGESIPVIDGFFQITSHRNTGAAWGILAGQMWFFYIITTVVIIGIVYYIQKHAK
GQILLGIALGLMLGGAVGNFIDRVFRQEVVDFIHVTIVNYHYPIFNIADSSLCIGVLLLFIQMLLDGKKKKEL
>Mature_152_residues
PYYIIALLIIGIDQFTKWLVVSKMEYGESIPVIDGFFQITSHRNTGAAWGILAGQMWFFYIITTVVIIGIVYYIQKHAKG
QILLGIALGLMLGGAVGNFIDRVFRQEVVDFIHVTIVNYHYPIFNIADSSLCIGVLLLFIQMLLDGKKKKEL

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=146, Percent_Identity=33.5616438356164, Blast_Score=81, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 17289; Mature: 17158

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYYIIALLIIGIDQFTKWLVVSKMEYGESIPVIDGFFQITSHRNTGAAWGILAGQMWFF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
YIITTVVIIGIVYYIQKHAKGQILLGIALGLMLGGAVGNFIDRVFRQEVVDFIHVTIVNY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HYPIFNIADSSLCIGVLLLFIQMLLDGKKKKEL
CCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PYYIIALLIIGIDQFTKWLVVSKMEYGESIPVIDGFFQITSHRNTGAAWGILAGQMWFF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
YIITTVVIIGIVYYIQKHAKGQILLGIALGLMLGGAVGNFIDRVFRQEVVDFIHVTIVNY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HYPIFNIADSSLCIGVLLLFIQMLLDGKKKKEL
CCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9141696; 9384377; 10497172 [H]