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The map label for this gene is tmk

Identifier: 161723306

GI number: 161723306

Start: 1880421

End: 1881050

Strand: Direct

Name: tmk

Synonym: PM1673

Alternate gene names: 161723306

Gene position: 1880421-1881050 (Clockwise)

Preceding gene: 15603537

Following gene: 15603539

Centisome position: 83.3

GC content: 46.51

Gene sequence:

>630_bases
ATGACAACAGGAAAATTTATTGTACTTGAAGGCATTGAGGGCGCAGGTAAAACGACGGCGCGTGATAGCATAGTGCGTGC
ATTGCATGCTCATGGTATCCATGACATTGTGTTTACGCGAGAACCTGGTGGAACCCCCTTAGCAGAGAAATTACGCCAGC
TGATTAAACATGAAACAGAAGAACCCGTGACCGACAAAGCAGAGCTCCTCATGTTGTATGCTGCACGTATTCAATTGGTT
GAGAATGTAATCAAACCTGCTTTAGCACAAGGAAAGTGGGTAATTGGTGATCGTCATGATATGTCATCACAAGCCTATCA
AGGCGGAGGACGCCAACTCGATCAACATTTGCTCCATACCCTCAAACAAACTATTTTAGGTGAGTTTGAACCCGACTTAA
CCCTTTATTTAGATATCGATCCTGTCCTCGGCTTAAGCCGCGCAAAAGGGCGTGGGGCTTTAGATCGTATCGAACAACAA
AATTTGGATTTTTTCCACCGCACTCGCCAACGCTACCAAGAGTTGGTGCGCCATAACCCGAAAGCCGTGACCATTGATGC
CTCCCAGACGATGAGCAAAGTGGCAGAAGATGTGGAAAGCGCGATAGAGACTTGGTTGACTACACGTTAA

Upstream 100 bases:

>100_bases
GGTTCTGGTGGACATAAATTCAGCAAAACGCTGGCTGAACACAATCGTGCCGTACAACAGTATTTACGCTGGTATCGTAG
TCAAAAAAATGGAAATTAAT

Downstream 100 bases:

>100_bases
ACAGATGATGACATTGTATCCTTGGCTGTTGCCTTACTATCAACAACGTATTGATGCCTTCCAACAAGGACATGGGCATC
ATGCGCTCTTGTTTCAAGCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTTGKFIVLEGIEGAGKTTARDSIVRALHAHGIHDIVFTREPGGTPLAEKLRQLIKHETEEPVTDKAELLMLYAARIQLV
ENVIKPALAQGKWVIGDRHDMSSQAYQGGGRQLDQHLLHTLKQTILGEFEPDLTLYLDIDPVLGLSRAKGRGALDRIEQQ
NLDFFHRTRQRYQELVRHNPKAVTIDASQTMSKVAEDVESAIETWLTTR

Sequences:

>Translated_209_residues
MTTGKFIVLEGIEGAGKTTARDSIVRALHAHGIHDIVFTREPGGTPLAEKLRQLIKHETEEPVTDKAELLMLYAARIQLV
ENVIKPALAQGKWVIGDRHDMSSQAYQGGGRQLDQHLLHTLKQTILGEFEPDLTLYLDIDPVLGLSRAKGRGALDRIEQQ
NLDFFHRTRQRYQELVRHNPKAVTIDASQTMSKVAEDVESAIETWLTTR
>Mature_208_residues
TTGKFIVLEGIEGAGKTTARDSIVRALHAHGIHDIVFTREPGGTPLAEKLRQLIKHETEEPVTDKAELLMLYAARIQLVE
NVIKPALAQGKWVIGDRHDMSSQAYQGGGRQLDQHLLHTLKQTILGEFEPDLTLYLDIDPVLGLSRAKGRGALDRIEQQN
LDFFHRTRQRYQELVRHNPKAVTIDASQTMSKVAEDVESAIETWLTTR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=207, Percent_Identity=31.4009661835749, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=60.9756097560976, Blast_Score=261, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PASMU (Q9CKE9)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246612.2
- ProteinModelPortal:   Q9CKE9
- SMR:   Q9CKE9
- GeneID:   1245020
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1673
- NMPDR:   fig|272843.1.peg.1674
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   PMUL272843:PM1673-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23480; Mature: 23349

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGKFIVLEGIEGAGKTTARDSIVRALHAHGIHDIVFTREPGGTPLAEKLRQLIKHETE
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHCCC
EPVTDKAELLMLYAARIQLVENVIKPALAQGKWVIGDRHDMSSQAYQGGGRQLDQHLLHT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCHHHHHHHHHH
LKQTILGEFEPDLTLYLDIDPVLGLSRAKGRGALDRIEQQNLDFFHRTRQRYQELVRHNP
HHHHHHCCCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCC
KAVTIDASQTMSKVAEDVESAIETWLTTR
CEEEEEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTGKFIVLEGIEGAGKTTARDSIVRALHAHGIHDIVFTREPGGTPLAEKLRQLIKHETE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHCCC
EPVTDKAELLMLYAARIQLVENVIKPALAQGKWVIGDRHDMSSQAYQGGGRQLDQHLLHT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCHHHHHHHHHH
LKQTILGEFEPDLTLYLDIDPVLGLSRAKGRGALDRIEQQNLDFFHRTRQRYQELVRHNP
HHHHHHCCCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCC
KAVTIDASQTMSKVAEDVESAIETWLTTR
CEEEEEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100