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The map label for this gene is uvrD

Identifier: 161723247

GI number: 161723247

Start: 2063715

End: 2065880

Strand: Reverse

Name: uvrD

Synonym: lpg1842

Alternate gene names: 161723247

Gene position: 2065880-2063715 (Counterclockwise)

Preceding gene: 52842073

Following gene: 52842068

Centisome position: 60.8

GC content: 42.52

Gene sequence:

>2166_bases
ATGACCATAGCAGCACTTCTCAAGGGATTAAACGAAAAGCAACGTGACGCTGTAACCTCCCCATTAGGTAATATGCTGGT
TTTAGCTGGTGCAGGCAGTGGTAAAACAAAAGTATTGGTGAGCCGAATTGCCTGGTTAATTGAAGAACAGCATCTCTCCC
CGCACGCTATATTAGCAGTAACATTTACGAATAAAGCGGCCGGTGAAATGAGATCGAGACTTAGCAGTATGTTGTCTACA
CCGACGTTGGGTTTATGGGTTGGTACTTTTCATGGATTATGTCATCGTTTATTACGCCGCCACTACAAGGAGGCTAACCT
TCCAGAACAGTTTCATATTCTGGATTCGGAAGACCAGGCACGAGTTATCAAGCGAGTCATTCTTTCACTTAATCTTGATC
CTGAGCAATGGCAAGTCAAACAAGCGCAAGCATTTATTAATAGTAAAAAGGATGAAGGCTTGCGTCCACAACATATTAAT
GCACTGCATTATGGTCCGGCCAAGACTTTGGTTGCAATTTATAAAGCGTATGAAGACGTTTGCCAAACCTCAGGGGTAAT
CGATTTCGCTGAACTATTACTACGAACTCATGAATTGCTACGAGATAATGAAGAGATACTTGCTCATTACCGCGAACGCT
TCCAGGCTATTTTAGTTGATGAATTTCAGGATACCAATACGATTCAATATGCATGGATCCGCTTGCTTGCTGGTGATCAT
ACAGCGGTATTGGCTGTAGGAGATGATGATCAGTCAATTTATGGTTGGCGTGGAGCCAAAGTGGAAAATATTCAGCAGTT
TGTTCATGATTTTAAAGATACACATATCATAAGGCTTGAACAAAACTACAGGTCGACCGCAATGATATTAAATGCAGCAA
ATGCATTGATTCTCAATAACAGTACTCGTATGGGCAAAGAGTTATGGACCGCTGGTAGTGAGGGAGAAAAAATTCTTGTA
TACAGTGCATTCAATGAATTGGATGAGGCACGTTTTGTTACTGAACGAATTGGCATGGAATTAAATCAGGGCGCCAGTGC
GGATGAGATTGCAGTGTTGTATCGTTCGAATGCCCAATCCCGTGTTTTGGAAGAGGCTTTGTTACGTGCAGGTATAGCCT
ACAGGATATATGGAGGAGTCCGTTTCTTTGACAGGGCAGAAATTAAAGATACTTTGGCTTACTTACGATTGTTAGTTAAT
CCAAATGACGATACTGCGTTTGAAAGAGTAGTTAATTTTCCTACTCGAGGAATAGGAGAAAAAACATTGGATGAGGTTCG
CCAGTACGCCAGAGCAGAACAGTGTTCGTTGTGGGGCGCTTCCAAGGGCATACTTCAATCCACAGGATTAGGGCAAAGGG
GGAGCTTGGCATTAGCCAAGTTTATTGATTTGATCGAAAAATTACAGGTTGTGGTTGCTAATAAGGAGTTGGATGAGCAG
ATCTCTGATGTAATACAGCATAGTGGTTTATACGCCCACTTTAGCAAAATCAAAGGTGATAAATCAGAATCACGTGTGGA
TAACCTGCAAGAATTAATTAATGCTGCCAAACAATTTCGATATGAGTACGATGAAGAGGAGGAGTTACCGTTGGTTAATT
CATTCCTTGCTCATGCTTCATTAGAATCGGGGGAATTGCAGGCTGATGAACATGAACGCTCCGTTCACTTGATGACCTTA
CATGCAGCCAAAGGGCTTGAGTTTCCGATTGTGTTTTTGGTTGGTATGGAAGAAGGAATATTTCCAGGCAGACAATCGCT
TGAAGAGCCTGGTCGCTTGGAGGAAGAGCGTCGATTATGTTATGTCGGCATGACTCGTGCCATGCGTAAATTGGTTTTAT
CCTATGCTGAGGTCAGAAGACAATATGGTCGTGAAGAGTATCACAGATCATCAAGATTTTTGCGTGAAATTCCTCAACAA
TTTCTTGATGAAGTAAGAGTTAAATCACGTTCTCAGTGGCCTGGAACTACAAAAAGCAAATTGCCAGTGGCTGACGAGGT
GTCGGGCATTACAATTGGGCAAAATGTGCAGCATGCCAAATTTGGACAGGGTGTCGTTCTTGCCATTGAGGGCAGCGGGG
CTCATACAAGAGTTCAAGTAAAATTCAGTGAACATGGTGTAAAATGGTTGGTTTTGGCCTATGCTAATTTGACTGAATGC
CTGTAG

Upstream 100 bases:

>100_bases
ATCCAGGAGAATTTTTAGATTTTTTACCGCATCGATTATATCTTTGCTTTAGCAATTAAATTGAAGATAATACTTGGACT
TTTTCTGTTGGAAATATTCT

Downstream 100 bases:

>100_bases
TTATTGCATTTAATTTTTATAAAATATCTGAGGTACCCTGACTTGCAGTTTGCTATTGTAATATTGAATTTTTTTTTCAT
GAATGCTAGGGTGCGTTAGG

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MTIAALLKGLNEKQRDAVTSPLGNMLVLAGAGSGKTKVLVSRIAWLIEEQHLSPHAILAVTFTNKAAGEMRSRLSSMLST
PTLGLWVGTFHGLCHRLLRRHYKEANLPEQFHILDSEDQARVIKRVILSLNLDPEQWQVKQAQAFINSKKDEGLRPQHIN
ALHYGPAKTLVAIYKAYEDVCQTSGVIDFAELLLRTHELLRDNEEILAHYRERFQAILVDEFQDTNTIQYAWIRLLAGDH
TAVLAVGDDDQSIYGWRGAKVENIQQFVHDFKDTHIIRLEQNYRSTAMILNAANALILNNSTRMGKELWTAGSEGEKILV
YSAFNELDEARFVTERIGMELNQGASADEIAVLYRSNAQSRVLEEALLRAGIAYRIYGGVRFFDRAEIKDTLAYLRLLVN
PNDDTAFERVVNFPTRGIGEKTLDEVRQYARAEQCSLWGASKGILQSTGLGQRGSLALAKFIDLIEKLQVVVANKELDEQ
ISDVIQHSGLYAHFSKIKGDKSESRVDNLQELINAAKQFRYEYDEEEELPLVNSFLAHASLESGELQADEHERSVHLMTL
HAAKGLEFPIVFLVGMEEGIFPGRQSLEEPGRLEEERRLCYVGMTRAMRKLVLSYAEVRRQYGREEYHRSSRFLREIPQQ
FLDEVRVKSRSQWPGTTKSKLPVADEVSGITIGQNVQHAKFGQGVVLAIEGSGAHTRVQVKFSEHGVKWLVLAYANLTEC
L

Sequences:

>Translated_721_residues
MTIAALLKGLNEKQRDAVTSPLGNMLVLAGAGSGKTKVLVSRIAWLIEEQHLSPHAILAVTFTNKAAGEMRSRLSSMLST
PTLGLWVGTFHGLCHRLLRRHYKEANLPEQFHILDSEDQARVIKRVILSLNLDPEQWQVKQAQAFINSKKDEGLRPQHIN
ALHYGPAKTLVAIYKAYEDVCQTSGVIDFAELLLRTHELLRDNEEILAHYRERFQAILVDEFQDTNTIQYAWIRLLAGDH
TAVLAVGDDDQSIYGWRGAKVENIQQFVHDFKDTHIIRLEQNYRSTAMILNAANALILNNSTRMGKELWTAGSEGEKILV
YSAFNELDEARFVTERIGMELNQGASADEIAVLYRSNAQSRVLEEALLRAGIAYRIYGGVRFFDRAEIKDTLAYLRLLVN
PNDDTAFERVVNFPTRGIGEKTLDEVRQYARAEQCSLWGASKGILQSTGLGQRGSLALAKFIDLIEKLQVVVANKELDEQ
ISDVIQHSGLYAHFSKIKGDKSESRVDNLQELINAAKQFRYEYDEEEELPLVNSFLAHASLESGELQADEHERSVHLMTL
HAAKGLEFPIVFLVGMEEGIFPGRQSLEEPGRLEEERRLCYVGMTRAMRKLVLSYAEVRRQYGREEYHRSSRFLREIPQQ
FLDEVRVKSRSQWPGTTKSKLPVADEVSGITIGQNVQHAKFGQGVVLAIEGSGAHTRVQVKFSEHGVKWLVLAYANLTEC
L
>Mature_720_residues
TIAALLKGLNEKQRDAVTSPLGNMLVLAGAGSGKTKVLVSRIAWLIEEQHLSPHAILAVTFTNKAAGEMRSRLSSMLSTP
TLGLWVGTFHGLCHRLLRRHYKEANLPEQFHILDSEDQARVIKRVILSLNLDPEQWQVKQAQAFINSKKDEGLRPQHINA
LHYGPAKTLVAIYKAYEDVCQTSGVIDFAELLLRTHELLRDNEEILAHYRERFQAILVDEFQDTNTIQYAWIRLLAGDHT
AVLAVGDDDQSIYGWRGAKVENIQQFVHDFKDTHIIRLEQNYRSTAMILNAANALILNNSTRMGKELWTAGSEGEKILVY
SAFNELDEARFVTERIGMELNQGASADEIAVLYRSNAQSRVLEEALLRAGIAYRIYGGVRFFDRAEIKDTLAYLRLLVNP
NDDTAFERVVNFPTRGIGEKTLDEVRQYARAEQCSLWGASKGILQSTGLGQRGSLALAKFIDLIEKLQVVVANKELDEQI
SDVIQHSGLYAHFSKIKGDKSESRVDNLQELINAAKQFRYEYDEEEELPLVNSFLAHASLESGELQADEHERSVHLMTLH
AAKGLEFPIVFLVGMEEGIFPGRQSLEEPGRLEEERRLCYVGMTRAMRKLVLSYAEVRRQYGREEYHRSSRFLREIPQQF
LDEVRVKSRSQWPGTTKSKLPVADEVSGITIGQNVQHAKFGQGVVLAIEGSGAHTRVQVKFSEHGVKWLVLAYANLTECL

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=718, Percent_Identity=58.2172701949861, Blast_Score=864, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=643, Percent_Identity=39.50233281493, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=362, Percent_Identity=27.9005524861878, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=748, Percent_Identity=28.0748663101604, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6324477, Length=644, Percent_Identity=22.8260869565217, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81408; Mature: 81277

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAALLKGLNEKQRDAVTSPLGNMLVLAGAGSGKTKVLVSRIAWLIEEQHLSPHAILAV
CCHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
TFTNKAAGEMRSRLSSMLSTPTLGLWVGTFHGLCHRLLRRHYKEANLPEQFHILDSEDQA
EECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHH
RVIKRVILSLNLDPEQWQVKQAQAFINSKKDEGLRPQHINALHYGPAKTLVAIYKAYEDV
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
CQTSGVIDFAELLLRTHELLRDNEEILAHYRERFQAILVDEFQDTNTIQYAWIRLLAGDH
HHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCC
TAVLAVGDDDQSIYGWRGAKVENIQQFVHDFKDTHIIRLEQNYRSTAMILNAANALILNN
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHEECCCEEEECC
STRMGKELWTAGSEGEKILVYSAFNELDEARFVTERIGMELNQGASADEIAVLYRSNAQS
CHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHH
RVLEEALLRAGIAYRIYGGVRFFDRAEIKDTLAYLRLLVNPNDDTAFERVVNFPTRGIGE
HHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCH
KTLDEVRQYARAEQCSLWGASKGILQSTGLGQRGSLALAKFIDLIEKLQVVVANKELDEQ
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHH
ISDVIQHSGLYAHFSKIKGDKSESRVDNLQELINAAKQFRYEYDEEEELPLVNSFLAHAS
HHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
LESGELQADEHERSVHLMTLHAAKGLEFPIVFLVGMEEGIFPGRQSLEEPGRLEEERRLC
CCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHHHHH
YVGMTRAMRKLVLSYAEVRRQYGREEYHRSSRFLREIPQQFLDEVRVKSRSQWPGTTKSK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPVADEVSGITIGQNVQHAKFGQGVVLAIEGSGAHTRVQVKFSEHGVKWLVLAYANLTEC
CCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEEHHHHHHC
L
C
>Mature Secondary Structure 
TIAALLKGLNEKQRDAVTSPLGNMLVLAGAGSGKTKVLVSRIAWLIEEQHLSPHAILAV
CHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
TFTNKAAGEMRSRLSSMLSTPTLGLWVGTFHGLCHRLLRRHYKEANLPEQFHILDSEDQA
EECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHH
RVIKRVILSLNLDPEQWQVKQAQAFINSKKDEGLRPQHINALHYGPAKTLVAIYKAYEDV
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
CQTSGVIDFAELLLRTHELLRDNEEILAHYRERFQAILVDEFQDTNTIQYAWIRLLAGDH
HHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCC
TAVLAVGDDDQSIYGWRGAKVENIQQFVHDFKDTHIIRLEQNYRSTAMILNAANALILNN
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHEECCCEEEECC
STRMGKELWTAGSEGEKILVYSAFNELDEARFVTERIGMELNQGASADEIAVLYRSNAQS
CHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHH
RVLEEALLRAGIAYRIYGGVRFFDRAEIKDTLAYLRLLVNPNDDTAFERVVNFPTRGIGE
HHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCH
KTLDEVRQYARAEQCSLWGASKGILQSTGLGQRGSLALAKFIDLIEKLQVVVANKELDEQ
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHH
ISDVIQHSGLYAHFSKIKGDKSESRVDNLQELINAAKQFRYEYDEEEELPLVNSFLAHAS
HHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
LESGELQADEHERSVHLMTLHAAKGLEFPIVFLVGMEEGIFPGRQSLEEPGRLEEERRLC
CCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHHHHH
YVGMTRAMRKLVLSYAEVRRQYGREEYHRSSRFLREIPQQFLDEVRVKSRSQWPGTTKSK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPVADEVSGITIGQNVQHAKFGQGVVLAIEGSGAHTRVQVKFSEHGVKWLVLAYANLTEC
CCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEEHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]