Definition Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession NC_005823
Length 4,277,185

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The map label for this gene is serC

Identifier: 161621778

GI number: 161621778

Start: 359072

End: 360163

Strand: Direct

Name: serC

Synonym: LIC10315

Alternate gene names: 161621778

Gene position: 359072-360163 (Clockwise)

Preceding gene: 45656217

Following gene: 45656220

Centisome position: 8.4

GC content: 37.27

Gene sequence:

>1092_bases
ATGTATTTGTTCCAAGAAAGAATCTATAATTTTGGTGCTGGACCCGCGATGTTGCCCAATGAAGTGATGGAGATTGCAGC
GGCTGAGTTTTTGAACTATAAGGGTTCCGGAATGTCCGTTATGGAAGTCAGTCATAGAGAACCTCTTTTTGAAGACGTAA
TTACGGAAGCAGAAATACTTTTGCGTAAACTTTTGAATCTTGGAGAGGATTATTCGATCGCTTTTTTTTCAGGAGGAGCT
ACGTTACATTTCTCTGCTCTTCCCCTCAATCTTTTGAAAGAAGGAGAAAGTTTCGACGTTGCTCATACTGGAATCTGGAC
TAAAAAAGCTTGGGAGGAGGGTCTTAAGTTTAATGAAGTTAATGTCATTTATGATTCGACTAACAATCATTTTACGGATG
TTCCTGTTCTGACCGATTCTAACCTTTCTGGAAAAGGAAAGTATCTTCATATTACTTCCAACAATACGATCTACGGAACT
CAATATCCGGAGATTCCAAAAATCAAACAAATTCCACTGGTAGCCGATATGACGAGCGAACTTCTTTCTCGTAAAATAGA
CGTTAAAGATTTCGGAGTTATATTTGCTGGTGCTCAAAAAAACATAGGACCTTCAGGGCTCAGTCTTGCAATCATTCGAA
ACGATTTACTCGGAATTTCAGGAAGAAAAATTCCGATTCTCTTAGATTATTCTGTCATGGTAAAGAATCGATCTCTTTAC
AATACTCCTTCTACGTATTCTATTTATATCGCCAAGCTTGTATTTGAGTGGCTTTTAAAATTAGGCGGAATCGAAGCGAT
CGAAAAGGTTAATGAACAAAAAGCAAAACTGATTTACGATTTTATTGATTCTTCTTCCTTGTATGTTTGTCCGGTTCAAA
AAAGGGCGCGTTCTAAAATGAATGTAGTATTTTTACTTAAGGATAAAAATTTAGATTCTAAATTTTTAGACGAGGCAGAA
AAAAACGGCTTACACGGTTTAGGCGGTCATAGGTTGGTAGGAGGTTTTAGGGCTTCTATCTACAATTCTATGCCTCTCAC
GGGAGTTCAAAAGTTGGTTTCCTTTATGAAGGATTTTGAATCTAAGATTTGA

Upstream 100 bases:

>100_bases
TCCTCAAGCGCTGTATTGAGACAAGGATTTTTCCCCATCTGTAGTCTCCTTTGTCGTAAGAAAGTTGATTCCCCACCTCC
CTTTTGCAACCTTATCCCTT

Downstream 100 bases:

>100_bases
TGAAGTTTTTATCCTTTAAAAAGTTTTTTCTAATTTTGATCCGAGTTTTTACATTAGTCGGAGCTTTGTCCGGAGGCCTC
TTAGCTTCGGGATTAAATTT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MYLFQERIYNFGAGPAMLPNEVMEIAAAEFLNYKGSGMSVMEVSHREPLFEDVITEAEILLRKLLNLGEDYSIAFFSGGA
TLHFSALPLNLLKEGESFDVAHTGIWTKKAWEEGLKFNEVNVIYDSTNNHFTDVPVLTDSNLSGKGKYLHITSNNTIYGT
QYPEIPKIKQIPLVADMTSELLSRKIDVKDFGVIFAGAQKNIGPSGLSLAIIRNDLLGISGRKIPILLDYSVMVKNRSLY
NTPSTYSIYIAKLVFEWLLKLGGIEAIEKVNEQKAKLIYDFIDSSSLYVCPVQKRARSKMNVVFLLKDKNLDSKFLDEAE
KNGLHGLGGHRLVGGFRASIYNSMPLTGVQKLVSFMKDFESKI

Sequences:

>Translated_363_residues
MYLFQERIYNFGAGPAMLPNEVMEIAAAEFLNYKGSGMSVMEVSHREPLFEDVITEAEILLRKLLNLGEDYSIAFFSGGA
TLHFSALPLNLLKEGESFDVAHTGIWTKKAWEEGLKFNEVNVIYDSTNNHFTDVPVLTDSNLSGKGKYLHITSNNTIYGT
QYPEIPKIKQIPLVADMTSELLSRKIDVKDFGVIFAGAQKNIGPSGLSLAIIRNDLLGISGRKIPILLDYSVMVKNRSLY
NTPSTYSIYIAKLVFEWLLKLGGIEAIEKVNEQKAKLIYDFIDSSSLYVCPVQKRARSKMNVVFLLKDKNLDSKFLDEAE
KNGLHGLGGHRLVGGFRASIYNSMPLTGVQKLVSFMKDFESKI
>Mature_363_residues
MYLFQERIYNFGAGPAMLPNEVMEIAAAEFLNYKGSGMSVMEVSHREPLFEDVITEAEILLRKLLNLGEDYSIAFFSGGA
TLHFSALPLNLLKEGESFDVAHTGIWTKKAWEEGLKFNEVNVIYDSTNNHFTDVPVLTDSNLSGKGKYLHITSNNTIYGT
QYPEIPKIKQIPLVADMTSELLSRKIDVKDFGVIFAGAQKNIGPSGLSLAIIRNDLLGISGRKIPILLDYSVMVKNRSLY
NTPSTYSIYIAKLVFEWLLKLGGIEAIEKVNEQKAKLIYDFIDSSSLYVCPVQKRARSKMNVVFLLKDKNLDSKFLDEAE
KNGLHGLGGHRLVGGFRASIYNSMPLTGVQKLVSFMKDFESKI

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=361, Percent_Identity=44.0443213296399, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI10863955, Length=356, Percent_Identity=39.0449438202247, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=45.4038997214485, Blast_Score=310, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI17506897, Length=360, Percent_Identity=40.2777777777778, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6324758, Length=393, Percent_Identity=40.7124681933842, Blast_Score=276, Evalue=4e-75,
Organism=Drosophila melanogaster, GI21356589, Length=358, Percent_Identity=41.0614525139665, Blast_Score=273, Evalue=1e-73,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_LEPIC (Q72VI2)

Other databases:

- EMBL:   AE016823
- ProteinModelPortal:   Q72VI2
- SMR:   Q72VI2
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10315
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   LINT267671:LIC_10315-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40587; Mature: 40587

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 46-46 BINDING 106-106 BINDING 156-156 BINDING 176-176 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MYLFQERIYNFGAGPAMLPNEVMEIAAAEFLNYKGSGMSVMEVSHREPLFEDVITEAEIL
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHH
LRKLLNLGEDYSIAFFSGGATLHFSALPLNLLKEGESFDVAHTGIWTKKAWEEGLKFNEV
HHHHHCCCCCCEEEEEECCCEEEEECCCHHHHCCCCCCCEEECCCCCHHHHHHCCCCCEE
NVIYDSTNNHFTDVPVLTDSNLSGKGKYLHITSNNTIYGTQYPEIPKIKQIPLVADMTSE
EEEEECCCCCEEECCEEECCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCHHHHHHH
LLSRKIDVKDFGVIFAGAQKNIGPSGLSLAIIRNDLLGISGRKIPILLDYSVMVKNRSLY
HHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEEHHHCCCCCCEEEEEEEEEEEEECCEEC
NTPSTYSIYIAKLVFEWLLKLGGIEAIEKVNEQKAKLIYDFIDSSSLYVCPVQKRARSKM
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCC
NVVFLLKDKNLDSKFLDEAEKNGLHGLGGHRLVGGFRASIYNSMPLTGVQKLVSFMKDFE
CEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SKI
HCC
>Mature Secondary Structure
MYLFQERIYNFGAGPAMLPNEVMEIAAAEFLNYKGSGMSVMEVSHREPLFEDVITEAEIL
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHH
LRKLLNLGEDYSIAFFSGGATLHFSALPLNLLKEGESFDVAHTGIWTKKAWEEGLKFNEV
HHHHHCCCCCCEEEEEECCCEEEEECCCHHHHCCCCCCCEEECCCCCHHHHHHCCCCCEE
NVIYDSTNNHFTDVPVLTDSNLSGKGKYLHITSNNTIYGTQYPEIPKIKQIPLVADMTSE
EEEEECCCCCEEECCEEECCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCHHHHHHH
LLSRKIDVKDFGVIFAGAQKNIGPSGLSLAIIRNDLLGISGRKIPILLDYSVMVKNRSLY
HHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEEHHHCCCCCCEEEEEEEEEEEEECCEEC
NTPSTYSIYIAKLVFEWLLKLGGIEAIEKVNEQKAKLIYDFIDSSSLYVCPVQKRARSKM
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCC
NVVFLLKDKNLDSKFLDEAEKNGLHGLGGHRLVGGFRASIYNSMPLTGVQKLVSFMKDFE
CEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SKI
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA