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The map label for this gene is mazG

Identifier: 161621771

GI number: 161621771

Start: 3977113

End: 3977919

Strand: Direct

Name: mazG

Synonym: LIC13240

Alternate gene names: 161621771

Gene position: 3977113-3977919 (Clockwise)

Preceding gene: 45659059

Following gene: 45659062

Centisome position: 92.98

GC content: 35.56

Gene sequence:

>807_bases
ATGCGAACAAAATCAATTGTAGAAGAAATCACTAAACTCCAAGAAGTGACAGCTATTCTCCGAGGAGAAAACGGATGTCC
TTGGGATAAAGAACAGGACCACCAAACTTTAGTTCCCTACTTGATAGAAGAATCCCAAGAAGTGATCGAAGCAATTTTAA
AAAAGGACGATGATCTTCTTAAAGAAGAATTGGGAGACCTACTATTTCAAGTAGTGTTTCATGCAAGGCTTGCAGAAGAA
AGACGCTCATTCGATTTAGGAGACATAGCAAAGAGAGTTTCTGATAAACTCATTTTTAGACATCCTCACGTTTTCAAACC
CGAAGAGCTTACTCTTTCTACTTCTCAAGAAGTTTTAGAGAACTGGGAAAAAATCAAAGATAAAGAAAAAAAGAATTCAA
AAGATTCATCTATCTTCTCAAACATTCCAGAAAATTTCTCTTCCCTTTTAAAAGCAGAAAAATACCAAAAGAAAGCAGCC
AAAGTAGGATTTGATTGGAACGATATTTCGGATGTTCAAAAAAAAGTTAAGGAAGAAATGGAAGAATTTCTTACGGAATT
GAACCGTTCCAAAGACAACCAAGTTCGTATCGAAGAAGAATTTGGAGATTTATTATTCAGTTTAGTAAATTTCGGAAGAC
ACCTTGGAATTTCTTCCGAGTCCGCGCTTACAAAAGCGAATGCAAAATTTAAGAAAAGATTTCAATATATAGAAAAAGTC
CTCCAAGAACGCGGTAAAAACCCGAACACATCCGATTTAAAAGAAATGGATCGTCTTTGGAACGAGGCAAAAGAGTTGGA
AAAATGA

Upstream 100 bases:

>100_bases
CAATCCCGATTTGGAACTGAGCGAAAAAGAGTGGGTACCCGCTCCGGAGATAAAAAATGGAACAAATTTCGACTATTTCT
TTGTTCTTGAAAGAGGATGT

Downstream 100 bases:

>100_bases
ATGGGCCCGATTCATTCAAAAATAGAATCGAACAAACAGAAACTTTGATTTCTTTTTTTTCCAAAGGTTTTTTTTTGAAG
TTAGAATCTAATTTAGAAGA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MRTKSIVEEITKLQEVTAILRGENGCPWDKEQDHQTLVPYLIEESQEVIEAILKKDDDLLKEELGDLLFQVVFHARLAEE
RRSFDLGDIAKRVSDKLIFRHPHVFKPEELTLSTSQEVLENWEKIKDKEKKNSKDSSIFSNIPENFSSLLKAEKYQKKAA
KVGFDWNDISDVQKKVKEEMEEFLTELNRSKDNQVRIEEEFGDLLFSLVNFGRHLGISSESALTKANAKFKKRFQYIEKV
LQERGKNPNTSDLKEMDRLWNEAKELEK

Sequences:

>Translated_268_residues
MRTKSIVEEITKLQEVTAILRGENGCPWDKEQDHQTLVPYLIEESQEVIEAILKKDDDLLKEELGDLLFQVVFHARLAEE
RRSFDLGDIAKRVSDKLIFRHPHVFKPEELTLSTSQEVLENWEKIKDKEKKNSKDSSIFSNIPENFSSLLKAEKYQKKAA
KVGFDWNDISDVQKKVKEEMEEFLTELNRSKDNQVRIEEEFGDLLFSLVNFGRHLGISSESALTKANAKFKKRFQYIEKV
LQERGKNPNTSDLKEMDRLWNEAKELEK
>Mature_268_residues
MRTKSIVEEITKLQEVTAILRGENGCPWDKEQDHQTLVPYLIEESQEVIEAILKKDDDLLKEELGDLLFQVVFHARLAEE
RRSFDLGDIAKRVSDKLIFRHPHVFKPEELTLSTSQEVLENWEKIKDKEKKNSKDSSIFSNIPENFSSLLKAEKYQKKAA
KVGFDWNDISDVQKKVKEEMEEFLTELNRSKDNQVRIEEEFGDLLFSLVNFGRHLGISSESALTKANAKFKKRFQYIEKV
LQERGKNPNTSDLKEMDRLWNEAKELEK

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=260, Percent_Identity=45.3846153846154, Blast_Score=236, Evalue=9e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31348; Mature: 31348

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00268 CECROPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKSIVEEITKLQEVTAILRGENGCPWDKEQDHQTLVPYLIEESQEVIEAILKKDDDLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
KEELGDLLFQVVFHARLAEERRSFDLGDIAKRVSDKLIFRHPHVFKPEELTLSTSQEVLE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NWEKIKDKEKKNSKDSSIFSNIPENFSSLLKAEKYQKKAAKVGFDWNDISDVQKKVKEEM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EEFLTELNRSKDNQVRIEEEFGDLLFSLVNFGRHLGISSESALTKANAKFKKRFQYIEKV
HHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LQERGKNPNTSDLKEMDRLWNEAKELEK
HHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTKSIVEEITKLQEVTAILRGENGCPWDKEQDHQTLVPYLIEESQEVIEAILKKDDDLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
KEELGDLLFQVVFHARLAEERRSFDLGDIAKRVSDKLIFRHPHVFKPEELTLSTSQEVLE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NWEKIKDKEKKNSKDSSIFSNIPENFSSLLKAEKYQKKAAKVGFDWNDISDVQKKVKEEM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EEFLTELNRSKDNQVRIEEEFGDLLFSLVNFGRHLGISSESALTKANAKFKKRFQYIEKV
HHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LQERGKNPNTSDLKEMDRLWNEAKELEK
HHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]