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The map label for this gene is serS [H]

Identifier: 161611255

GI number: 161611255

Start: 2845595

End: 2846899

Strand: Reverse

Name: serS [H]

Synonym: Reut_A2594

Alternate gene names: 161611255

Gene position: 2846899-2845595 (Counterclockwise)

Preceding gene: 73542280

Following gene: 73542278

Centisome position: 74.79

GC content: 64.37

Gene sequence:

>1305_bases
ATGCTCGACATCCAGCTGTTCCGCAAAGACATCGACGCCGTGGCGCAACGCCTTGCCACGCGCGGCTTCCAACTCGACGT
AGCGGCTTTCCAGGCGCTCGAAAGCGAGCGCAAGCAACTGCAGACCCAGACCGAGGAACTGCAGTCCCGCCGCAACAGCC
TGTCCAAGCAGATCGGCATGCTCAAGGGCAAGGGCGAAGACGCCTCGGCTGTGATGGCGGAAGTCGGTGGCATCGGCGAT
ACGCTGAAGGACTCGGCTGCGCGCCTCGAAGAAATCCAGGCCCAGCTTTCCGAACTGATGCTGTCGATCCCGAACCTGCC
GCACGAAAGCGTGCCGCTCGGCAAGGACGAAACCCAGAACGTCGAAGTGCGCCGCGTCGGCGAGCCGCGCAAGTTTGATT
TCGAAGTCCGTGACCACGTGGACGTCGGCGACAAGCTCGGCCTCGACTTCGATACCGCGGCCAAGGTCACCGGTTCGCGC
TTCTCCATGTTGCGTGGCGGCATGGCGCGCATGCACCGCGCGCTGGTGCAGCTGATGCTGGATACCCACACGCTGGAACA
CGGCTACACCGAGATGTACGTGCCGTACATTGTCAACGCCGCGTCGATGCGCGGCACTGGTCAGCTGCCGAAGTTCGAGG
AAGACCTGTTCAAGGTGCCGCGCAAGGTGGGCGGCGAGGATGGCGAGCGTACCGAGAACTTCTACCTGATCCCGACCGCC
GAGGTGCCGCTGACCAACATCGTGCGCGATGCCATCGTCGCGGGCGACAAGCTGCCGCTGCGCTTCGTCGCGCATACGCC
GTGCTTCCGCTCCGAAGCGGGTTCGTACGGCAAGGACACGCGCGGCATGATCCGCCAGCACCAGTTCGACAAGGTCGAGC
TCGTGCACGTCGTGCCGGCCGAGCAGTCGTTCGACGCGCTGGAACAGCTGACCGGCCACGCCGAGGCGATCCTGAAGAAG
CTCGAACTACCGTTCCGCACCATCGTGCTGTGCACCGGTGACATGGGCTTTGGCAGCACCAAGACCTATGACCTCGAAGT
GTGGATCCCGGCGCAGAACACGTACCGCGAAATCAGCTCGTGCTCGAACATGGGCGACTTCCAGGCGCGCCGCATGCAGG
CACGCTACCGCGTGGGGCAGGGCAAGCCGGAGCTGGTCCATACACTGAATGGCTCGGGCCTGGCCGTGGGTCGTACGCTG
GTGGCCATCCTCGAGAACTACCAGAACGCCGACGGCTCCGTCACCGTGCCGACCGCACTGCAGCCGTACATGGGCGGCAC
CACGCGTCTGGAACCGGAGCTGTAA

Upstream 100 bases:

>100_bases
GCGGCTCGTCCGTGCTGATCGGGTACGGCAGCCGGGCCGGGTGAAGTAAAATGGCGGGTCCGCTGGCATGTCGCCGGCCC
CGCACTTCCCACACCGCAAC

Downstream 100 bases:

>100_bases
AAAACTGCATGCCAGGCTCTTGCGCGGGCTGCAGGAACCTGTCTATAATCTTGGTTTCGCTGCACGCGACCAAGTTACCG
GAGAGGTGGCAGAGTGGTCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLDIQLFRKDIDAVAQRLATRGFQLDVAAFQALESERKQLQTQTEELQSRRNSLSKQIGMLKGKGEDASAVMAEVGGIGD
TLKDSAARLEEIQAQLSELMLSIPNLPHESVPLGKDETQNVEVRRVGEPRKFDFEVRDHVDVGDKLGLDFDTAAKVTGSR
FSMLRGGMARMHRALVQLMLDTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEEDLFKVPRKVGGEDGERTENFYLIPTA
EVPLTNIVRDAIVAGDKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVELVHVVPAEQSFDALEQLTGHAEAILKK
LELPFRTIVLCTGDMGFGSTKTYDLEVWIPAQNTYREISSCSNMGDFQARRMQARYRVGQGKPELVHTLNGSGLAVGRTL
VAILENYQNADGSVTVPTALQPYMGGTTRLEPEL

Sequences:

>Translated_434_residues
MLDIQLFRKDIDAVAQRLATRGFQLDVAAFQALESERKQLQTQTEELQSRRNSLSKQIGMLKGKGEDASAVMAEVGGIGD
TLKDSAARLEEIQAQLSELMLSIPNLPHESVPLGKDETQNVEVRRVGEPRKFDFEVRDHVDVGDKLGLDFDTAAKVTGSR
FSMLRGGMARMHRALVQLMLDTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEEDLFKVPRKVGGEDGERTENFYLIPTA
EVPLTNIVRDAIVAGDKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVELVHVVPAEQSFDALEQLTGHAEAILKK
LELPFRTIVLCTGDMGFGSTKTYDLEVWIPAQNTYREISSCSNMGDFQARRMQARYRVGQGKPELVHTLNGSGLAVGRTL
VAILENYQNADGSVTVPTALQPYMGGTTRLEPEL
>Mature_434_residues
MLDIQLFRKDIDAVAQRLATRGFQLDVAAFQALESERKQLQTQTEELQSRRNSLSKQIGMLKGKGEDASAVMAEVGGIGD
TLKDSAARLEEIQAQLSELMLSIPNLPHESVPLGKDETQNVEVRRVGEPRKFDFEVRDHVDVGDKLGLDFDTAAKVTGSR
FSMLRGGMARMHRALVQLMLDTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEEDLFKVPRKVGGEDGERTENFYLIPTA
EVPLTNIVRDAIVAGDKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVELVHVVPAEQSFDALEQLTGHAEAILKK
LELPFRTIVLCTGDMGFGSTKTYDLEVWIPAQNTYREISSCSNMGDFQARRMQARYRVGQGKPELVHTLNGSGLAVGRTL
VAILENYQNADGSVTVPTALQPYMGGTTRLEPEL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=471, Percent_Identity=32.484076433121, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI8923421, Length=439, Percent_Identity=32.3462414578588, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI225579074, Length=440, Percent_Identity=32.7272727272727, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=61.9158878504673, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17539260, Length=344, Percent_Identity=34.3023255813954, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=328, Percent_Identity=26.5243902439024, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=457, Percent_Identity=30.8533916849015, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=396, Percent_Identity=31.3131313131313, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=32.1353065539112, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17737985, Length=347, Percent_Identity=29.971181556196, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48215; Mature: 48215

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLFRKDIDAVAQRLATRGFQLDVAAFQALESERKQLQTQTEELQSRRNSLSKQIGM
CCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDASAVMAEVGGIGDTLKDSAARLEEIQAQLSELMLSIPNLPHESVPLGKDETQN
HCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRVGEPRKFDFEVRDHVDVGDKLGLDFDTAAKVTGSRFSMLRGGMARMHRALVQLML
EEEEECCCCCCCCEEECCCCCCCHHCCCCCCHHHHHCCHHHHHHHCCHHHHHHHHHHHHH
DTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEEDLFKVPRKVGGEDGERTENFYLIPTA
HHHHHHCCCHHEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC
EVPLTNIVRDAIVAGDKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVELVHVVPA
CCCHHHHHHHHHHCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECC
EQSFDALEQLTGHAEAILKKLELPFRTIVLCTGDMGFGSTKTYDLEVWIPAQNTYREISS
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHH
CSNMGDFQARRMQARYRVGQGKPELVHTLNGSGLAVGRTLVAILENYQNADGSVTVPTAL
HCCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCCCEECCCCC
QPYMGGTTRLEPEL
CCCCCCCCCCCCCC
>Mature Secondary Structure
MLDIQLFRKDIDAVAQRLATRGFQLDVAAFQALESERKQLQTQTEELQSRRNSLSKQIGM
CCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDASAVMAEVGGIGDTLKDSAARLEEIQAQLSELMLSIPNLPHESVPLGKDETQN
HCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRVGEPRKFDFEVRDHVDVGDKLGLDFDTAAKVTGSRFSMLRGGMARMHRALVQLML
EEEEECCCCCCCCEEECCCCCCCHHCCCCCCHHHHHCCHHHHHHHCCHHHHHHHHHHHHH
DTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEEDLFKVPRKVGGEDGERTENFYLIPTA
HHHHHHCCCHHEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECC
EVPLTNIVRDAIVAGDKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVELVHVVPA
CCCHHHHHHHHHHCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECC
EQSFDALEQLTGHAEAILKKLELPFRTIVLCTGDMGFGSTKTYDLEVWIPAQNTYREISS
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHH
CSNMGDFQARRMQARYRVGQGKPELVHTLNGSGLAVGRTLVAILENYQNADGSVTVPTAL
HCCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCCCEECCCCC
QPYMGGTTRLEPEL
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA