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The map label for this gene is cynR [H]

Identifier: 161594052

GI number: 161594052

Start: 2043577

End: 2044464

Strand: Direct

Name: cynR [H]

Synonym: CV_1882

Alternate gene names: 161594052

Gene position: 2043577-2044464 (Clockwise)

Preceding gene: 34497334

Following gene: 34497339

Centisome position: 43.01

GC content: 70.38

Gene sequence:

>888_bases
ATGCTGCTACGACACATCCGTTATTTCCTGGCGGTGGCCGAACATCGCCATTTCACCCGCGCGGCTGAGGCGCTGCATGT
TTCCCAACCGACGCTGTCCCAGCAGATACGGCAGCTGGAAGAGGCGCTGGGCGCGGAACTGTTCGACAGGGGCAGCCGCC
GGCTGCGGCTGACCGATGCCGGCGAGGCTTACCAAGTCCATGCCCGCCGCGCATTGCGGGATCTGGATGCCGGGCGGCGC
GCGCTGCACGATGTGGCCACGCTGCAGCGCGGGCAGCTGCGGCTGGCGATGACCCCGACCTTCACCGCCTGGCTGGCGGG
GCCGCTGCTGGCGCGCTTCCATCGGCGGCATCCCGGCATCGCGCTGACGGTGAGGGAGATGTCCCAGGAGGCGATGGAGG
CGGGGCTGGCGGAAGACATTCTGGACATCGGCATCGGTTTCGCGCCGGCGCGGACGCTGGATGTGGAGGCGACGCCCTTG
CTGGATGAGCGCCTGGCCTTGATCGCCGGCGACAGCCATCCGCTGGCGGCGCGCGAAGCGGTCTTGTCGCTGGCGGATCT
GGAGGCGATGCCGCTGGTGCTGCTGAGCGCGGACTTCATCACCCGCCGCCATGTGGACGACTATTGCCTGCGGCACGGCA
TCCGGCCGACGGTGGCTGTCGAGGTGAACAGCATGGGCGCGGCGGTGGAGATCATCCGCCATGGCGAACTGGCCGGCATC
CTGCCGGCGGCCGTCGCCGCCAGCCAGCCCGGACTGGCGGTTCTGGCGTTGTCGCCGACGCTGCCGGGCCGCCAGGCCGC
GTTGCTGACGAAACGCGACGGCTATCGCAGCGCGGCCGCGCGCGCCTTCGCCGAGTTGGCGCGCGCAGGCTTGGGCGCTA
TGGCGTGA

Upstream 100 bases:

>100_bases
CCGTGTGGTGAAGCGATGAGCGGATGATGCGCCGTGTTTTTCATTGGGTCCAAGACTGATAAATTATCGTTTTAATAGGC
ATATCCAATACTTTGAGCCC

Downstream 100 bases:

>100_bases
CGGCCGAGTCGCGGAAAGCGGGCATGGAAGCGGCCAGCGTTTCCAGCAGCCTGGCGGCGGCGGGACTTAGCCTGCGGCCG
TGATGGGTGATCAGGTGCAC

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLLRHIRYFLAVAEHRHFTRAAEALHVSQPTLSQQIRQLEEALGAELFDRGSRRLRLTDAGEAYQVHARRALRDLDAGRR
ALHDVATLQRGQLRLAMTPTFTAWLAGPLLARFHRRHPGIALTVREMSQEAMEAGLAEDILDIGIGFAPARTLDVEATPL
LDERLALIAGDSHPLAAREAVLSLADLEAMPLVLLSADFITRRHVDDYCLRHGIRPTVAVEVNSMGAAVEIIRHGELAGI
LPAAVAASQPGLAVLALSPTLPGRQAALLTKRDGYRSAAARAFAELARAGLGAMA

Sequences:

>Translated_295_residues
MLLRHIRYFLAVAEHRHFTRAAEALHVSQPTLSQQIRQLEEALGAELFDRGSRRLRLTDAGEAYQVHARRALRDLDAGRR
ALHDVATLQRGQLRLAMTPTFTAWLAGPLLARFHRRHPGIALTVREMSQEAMEAGLAEDILDIGIGFAPARTLDVEATPL
LDERLALIAGDSHPLAAREAVLSLADLEAMPLVLLSADFITRRHVDDYCLRHGIRPTVAVEVNSMGAAVEIIRHGELAGI
LPAAVAASQPGLAVLALSPTLPGRQAALLTKRDGYRSAAARAFAELARAGLGAMA
>Mature_295_residues
MLLRHIRYFLAVAEHRHFTRAAEALHVSQPTLSQQIRQLEEALGAELFDRGSRRLRLTDAGEAYQVHARRALRDLDAGRR
ALHDVATLQRGQLRLAMTPTFTAWLAGPLLARFHRRHPGIALTVREMSQEAMEAGLAEDILDIGIGFAPARTLDVEATPL
LDERLALIAGDSHPLAAREAVLSLADLEAMPLVLLSADFITRRHVDDYCLRHGIRPTVAVEVNSMGAAVEIIRHGELAGI
LPAAVAASQPGLAVLALSPTLPGRQAALLTKRDGYRSAAARAFAELARAGLGAMA

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=287, Percent_Identity=54.7038327526132, Blast_Score=308, Evalue=2e-85,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=31.2757201646091, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=33.7301587301587, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081904, Length=296, Percent_Identity=29.3918918918919, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788887, Length=193, Percent_Identity=33.6787564766839, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693105, Length=180, Percent_Identity=29.4444444444444, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787601, Length=277, Percent_Identity=28.158844765343, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788748, Length=288, Percent_Identity=27.4305555555556, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=29.2490118577075, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI2367136, Length=273, Percent_Identity=31.5018315018315, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790208, Length=254, Percent_Identity=30.3149606299213, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789204, Length=297, Percent_Identity=28.6195286195286, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787530, Length=244, Percent_Identity=25.8196721311475, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789173, Length=146, Percent_Identity=36.3013698630137, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787806, Length=251, Percent_Identity=25.0996015936255, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786401, Length=166, Percent_Identity=30.1204819277108, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788481, Length=235, Percent_Identity=28.5106382978723, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI145693193, Length=140, Percent_Identity=32.8571428571429, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994962, Length=144, Percent_Identity=31.25, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786713, Length=203, Percent_Identity=30.5418719211823, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082132, Length=147, Percent_Identity=27.891156462585, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=28.6885245901639, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788706, Length=166, Percent_Identity=32.5301204819277, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790262, Length=215, Percent_Identity=26.5116279069767, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787589, Length=150, Percent_Identity=32, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786448, Length=165, Percent_Identity=32.7272727272727, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31982; Mature: 31982

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVAEHRHFTRAAEALHVSQPTLSQQIRQLEEALGAELFDRGSRRLRLTDA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEEECC
GEAYQVHARRALRDLDAGRRALHDVATLQRGQLRLAMTPTFTAWLAGPLLARFHRRHPGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ALTVREMSQEAMEAGLAEDILDIGIGFAPARTLDVEATPLLDERLALIAGDSHPLAAREA
EEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHEEECCCCCHHHHHH
VLSLADLEAMPLVLLSADFITRRHVDDYCLRHGIRPTVAVEVNSMGAAVEIIRHGELAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCHHHH
LPAAVAASQPGLAVLALSPTLPGRQAALLTKRDGYRSAAARAFAELARAGLGAMA
HHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVAEHRHFTRAAEALHVSQPTLSQQIRQLEEALGAELFDRGSRRLRLTDA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEEECC
GEAYQVHARRALRDLDAGRRALHDVATLQRGQLRLAMTPTFTAWLAGPLLARFHRRHPGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCE
ALTVREMSQEAMEAGLAEDILDIGIGFAPARTLDVEATPLLDERLALIAGDSHPLAAREA
EEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHEEECCCCCHHHHHH
VLSLADLEAMPLVLLSADFITRRHVDDYCLRHGIRPTVAVEVNSMGAAVEIIRHGELAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCHHHH
LPAAVAASQPGLAVLALSPTLPGRQAALLTKRDGYRSAAARAFAELARAGLGAMA
HHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]