Click here to switch to the map view.

The map label for this gene is thyX

Identifier: 161546628

GI number: 161546628

Start: 1090633

End: 1091283

Strand: Direct

Name: thyX

Synonym: HH1120

Alternate gene names: 161546628

Gene position: 1090633-1091283 (Clockwise)

Preceding gene: 32266618

Following gene: 32266624

Centisome position: 60.62

GC content: 37.17

Gene sequence:

>651_bases
ATGGAAAAAACCATACCTTGCAATATCATTATCACTCTTTTGCATTACACACCATTGCATATTTGCAGCAATGCCATTCG
CACCTGCTGGCAGAGCTTTGATAAGGGCGATAATGGTGGAGAAAAAGACATTGAACTCATTGATAGAGTGGGCAATAAAT
TTAAACACGCAAGCACTTTGGAACATTTATATTATAATTTTTATATTAAAGGGATTTCACGAGCGTGTTTGCAAGAACTT
GCGCGTCATCGCCTCGCAAGCTATAGCGTAAAATCATCGCGTTATACACTCAAAGAACTAAAAAACCTTCCAAGCTTTCT
CCCTGTTAATGATGAGAATCTTGCTCGTGCAGAGCAATTTGTTGTTTTTACAAATAATAAGGAAGTTGATATTGCCTCAC
TTAAAGCACTTGAAAACTTACGCGAGATTTTGTGTAATAATGTCAGCAATGACGTCGCTAAATTTGCTATGCCAGAATCT
TATCGCACAGAGCTAAGTTTTAGTATTAATGCACGAAGTTTGCAAAATTTCCTTTCTTTACGCACTTCTAAATCTGCGCT
TTGGGAGATTCGTGCTTTAGCCTTTAGCATATTTAACGCATTGCCAGAAGAACATCGTTTTATTTTTCAAGATTGTGTGC
AAGAATGTTGA

Upstream 100 bases:

>100_bases
TATCAAGCCAAATCATTTATACCTCATTTATATTAAATTTTTTAAATTGCGTTAAGATTGTATTCAAGCAAACCTCACAA
TATCCTAAAAGGAATCCCTA

Downstream 100 bases:

>100_bases
AAAAATTATAATGCTTTTAATACTTTATCAAGCACCTCATCACTTGCACGGGCAAATCCAAGAGCGATATTTTGGTCAGA
AATAGAATCTAAAGGCACTT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MEKTIPCNIIITLLHYTPLHICSNAIRTCWQSFDKGDNGGEKDIELIDRVGNKFKHASTLEHLYYNFYIKGISRACLQEL
ARHRLASYSVKSSRYTLKELKNLPSFLPVNDENLARAEQFVVFTNNKEVDIASLKALENLREILCNNVSNDVAKFAMPES
YRTELSFSINARSLQNFLSLRTSKSALWEIRALAFSIFNALPEEHRFIFQDCVQEC

Sequences:

>Translated_216_residues
MEKTIPCNIIITLLHYTPLHICSNAIRTCWQSFDKGDNGGEKDIELIDRVGNKFKHASTLEHLYYNFYIKGISRACLQEL
ARHRLASYSVKSSRYTLKELKNLPSFLPVNDENLARAEQFVVFTNNKEVDIASLKALENLREILCNNVSNDVAKFAMPES
YRTELSFSINARSLQNFLSLRTSKSALWEIRALAFSIFNALPEEHRFIFQDCVQEC
>Mature_216_residues
MEKTIPCNIIITLLHYTPLHICSNAIRTCWQSFDKGDNGGEKDIELIDRVGNKFKHASTLEHLYYNFYIKGISRACLQEL
ARHRLASYSVKSSRYTLKELKNLPSFLPVNDENLARAEQFVVFTNNKEVDIASLKALENLREILCNNVSNDVAKFAMPES
YRTELSFSINARSLQNFLSLRTSKSALWEIRALAFSIFNALPEEHRFIFQDCVQEC

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24876; Mature: 24876

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTIPCNIIITLLHYTPLHICSNAIRTCWQSFDKGDNGGEKDIELIDRVGNKFKHASTL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EHLYYNFYIKGISRACLQELARHRLASYSVKSSRYTLKELKNLPSFLPVNDENLARAEQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEE
VVFTNNKEVDIASLKALENLREILCNNVSNDVAKFAMPESYRTELSFSINARSLQNFLSL
EEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEEEEECHHHHHHHHHH
RTSKSALWEIRALAFSIFNALPEEHRFIFQDCVQEC
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MEKTIPCNIIITLLHYTPLHICSNAIRTCWQSFDKGDNGGEKDIELIDRVGNKFKHASTL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EHLYYNFYIKGISRACLQELARHRLASYSVKSSRYTLKELKNLPSFLPVNDENLARAEQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEE
VVFTNNKEVDIASLKALENLREILCNNVSNDVAKFAMPESYRTELSFSINARSLQNFLSL
EEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEEEEECHHHHHHHHHH
RTSKSALWEIRALAFSIFNALPEEHRFIFQDCVQEC
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]