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The map label for this gene is mrdA [H]

Identifier: 161526279

GI number: 161526279

Start: 3395924

End: 3398251

Strand: Direct

Name: mrdA [H]

Synonym: Bmul_3110

Alternate gene names: 161526279

Gene position: 3395924-3398251 (Clockwise)

Preceding gene: 161526278

Following gene: 161526280

Centisome position: 98.48

GC content: 68.3

Gene sequence:

>2328_bases
ATGACCGAATTCAACGACACCCAACAGCAGCTCTCGAAGTTCCGCCTGCGCGTCGCGGCGGCGGGCGTGTTCGTGTTCGT
CTGCTTCGGGCTGCTCGCGAGCCGCTTCTTCTATCTGCAGCTGATGCAGCACGGCAAATATGCGCTGCAGGCCGAGGAAA
ACCGCATCTCCGTCGCGCCGATCGTGCCGAACCGCGGGATCATCACCGACCGCAACGGCGTGATCCTCGCGAAGAACTAC
TCGGCCTACACGCTCGAGATCACGCCGTCGAAGCTCGACGACACGCTCGAGAACACGATCGACAAGCTGTCGCAGATCAT
CCCGATCGATGCGCGCGACCGCCGCCGCTTCAAGAAGCTGCAGGAAGACTCGAAGAACTTCGAAAGCCTGCCGATCCGCA
CGCGGCTCACCGACGACGAAGTCGCGCGCTTCACCGCGCAGCGTTTCCGCTTTCCGGGCGTCGACGTGCGCGCGCGGCTG
TTCCGCCAGTATCCGCTCGGCACGACCGCCGCGCACGTGATCGGCTATATCGGCCGGATCTCGAAGCGCGACCAGGACCG
GATCGACGCGATGAGCGACGAGAACGACAGCGACCAGGAAACCTACGATCCGCGGCGCGACGCGAACAACTACAAGGGCA
CCGACTACATCGGCAAGATCGGCGTCGAGCAGAGCTACGAAACGGAGCTGCACGGGCTGACGGGCTTCGAGGAAGTCGAG
GTGACGGCCGGCGGCCGGCCGGTGCGCACGCTCTCGCGTACGCAGGCGACGCCCGGCGACAACCTCGTGCTGTCGCTCGA
CATCGGGCTGCAGCAGGTGGCCGAGCAGGCGTTCGCGGGCAAGCGCGGCGCGCTCGTCGCGATCGAGCCGAAGACGGGCG
ACGTGCTCGCGTTCGTGTCGTCGCCGAGCTTCGATCCGAATTCGTTCGTCGACGGCATCGACCAGCAGACCTGGGACGAG
CTCAACAACTCGCCCGACAAGCCGCTCTTGAACCGTCCGCTGCACGGCACCTATCCGCCCGGCTCGACCTACAAGCCGTT
CATGGCGCTCGCGGGCCTGACGCTCGGCAAGCGCACGCCGGGCTGGGGCTTCCAGGATCCCGGCTACTTCACGTTCGGCG
GCCACACGTTCCGCAACGACGTGCGTTCGGGCCAGGGCTGGGTCGACATGAACAAGGCGATCATGGTGTCGAACGACACC
TACTTCTACATGCTCGCGCGCGATCTCGGCGTGAACGCGATCGCGAACTTCATGAAGCCGTTCGGCTTCGGCCAGATCAC
CGGCATCGACATCCAGGGCGAGGCGCGCGGCATCCTGCCGTCGACCGACTGGAAGAAGAAGGCGTTCAAGAAGGCCGCGC
AGCAGAAGTGGTTCGACGGCGAGACGATCAGCCTCGGCATCGGCCAGGGCTACAACTCGTTCACGATCCTGCAGCTCGCG
CACGCGACCGCGACGCTCGCGAACAACGGCATCGTCATGAAGCCGCACCTCGTGAAGGAGATCGAGGATCCGATCACGCG
CGCGCGCCATCTGACCGTGCCGAAGGAAAGCGGCGTGATCCCGCTAAAGCAGGCCGACATCGACGTCGTCAAGCGCGGGA
TGGAGAACGTGATCGAGAACCCGTCGGGCACCGCGTACAAGGTGTTCCGCGGCGCGCCGTATCTGGCGGCCGGCAAGACC
GGTACCGCGCAGGTGTTCTCGCTGCAGGGCGGCAACTACAAGGGCCACCTGCTCGCCGAGCATCTGCGCGACCACGCGCT
GTTCATCGCGTACGCGCCCGTCGACCATCCGCAGATCGCGCTCGCGCTGATCGTCGAGAACGGCGGCTGGGGTGCGCAGT
CGGCGGGCCCGATCGCACGGCGCGTGCTCGACTTCTACCTCGTCGAGCGCCAGAACGCGCAGAACGAGGCGGCGGCGGTC
GCGGCCGCCGCATCGGCGACGGAGCCCGTGAACGCGCCGGTGATCGGCGACGGATCGAAGCCCGTCACCGTCGCCGCGGG
CTTCAAGCCGCTGCCGCAGCCGGTCGTGCCGAATGCGGCCAGTGCGGCGCAGGCGGCGTCCGGCGCGTCGGCAACCGGCG
CATCGGACACGCCCGGCGCCGCGGGCGCGGCCGCTGCGAGCGCCGCGCCGCCGGTCGACGCGAGCGCAGCGGCACCGCTT
GCCGCGAGCCTGCCGCCGATGCGCCGCATGCACCGGCCGCACCGGCCGGCCGGCGACGATCCGCGCAAGCCGCCGCAGGA
CGGGCAGCCGTTCGCGGCCGGCCCGCGCGACGACCACTCTCGTGCCACGGCGGCCGCGGACGCGGCAAACGCCGGCACCG
CTCATTAA

Upstream 100 bases:

>100_bases
GACCGCACCTTGATGACCCGCCGCCTCCGCACCCGCCGCGCGCCGCGCCCCGGGGCGGCACCTCGCCCGTGCGCGCGCCG
GGCCGACCGACCGTAATCGC

Downstream 100 bases:

>100_bases
CGGAGAAAGGCATGCAATTCGACAAGCGCGCCTGGCTCGACAAGATCAAGCAGATGTTCGCGGGCTTCGACCGCCCGCTC
GCCCTCATCGTGTTCCTGCT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 775; Mature: 774

Protein sequence:

>775_residues
MTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNY
SAYTLEITPSKLDDTLENTIDKLSQIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVDVRARL
FRQYPLGTTAAHVIGYIGRISKRDQDRIDAMSDENDSDQETYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
VTAGGRPVRTLSRTQATPGDNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANNGIVMKPHLVKEIEDPITRARHLTVPKESGVIPLKQADIDVVKRGMENVIENPSGTAYKVFRGAPYLAAGKT
GTAQVFSLQGGNYKGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLVERQNAQNEAAAV
AAAASATEPVNAPVIGDGSKPVTVAAGFKPLPQPVVPNAASAAQAASGASATGASDTPGAAGAAAASAAPPVDASAAAPL
AASLPPMRRMHRPHRPAGDDPRKPPQDGQPFAAGPRDDHSRATAAADAANAGTAH

Sequences:

>Translated_775_residues
MTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNY
SAYTLEITPSKLDDTLENTIDKLSQIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVDVRARL
FRQYPLGTTAAHVIGYIGRISKRDQDRIDAMSDENDSDQETYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
VTAGGRPVRTLSRTQATPGDNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANNGIVMKPHLVKEIEDPITRARHLTVPKESGVIPLKQADIDVVKRGMENVIENPSGTAYKVFRGAPYLAAGKT
GTAQVFSLQGGNYKGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLVERQNAQNEAAAV
AAAASATEPVNAPVIGDGSKPVTVAAGFKPLPQPVVPNAASAAQAASGASATGASDTPGAAGAAAASAAPPVDASAAAPL
AASLPPMRRMHRPHRPAGDDPRKPPQDGQPFAAGPRDDHSRATAAADAANAGTAH
>Mature_774_residues
TEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNYS
AYTLEITPSKLDDTLENTIDKLSQIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVDVRARLF
RQYPLGTTAAHVIGYIGRISKRDQDRIDAMSDENDSDQETYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVEV
TAGGRPVRTLSRTQATPGDNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDEL
NNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTY
FYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLAH
ATATLANNGIVMKPHLVKEIEDPITRARHLTVPKESGVIPLKQADIDVVKRGMENVIENPSGTAYKVFRGAPYLAAGKTG
TAQVFSLQGGNYKGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLVERQNAQNEAAAVA
AAASATEPVNAPVIGDGSKPVTVAAGFKPLPQPVVPNAASAAQAASGASATGASDTPGAAGAAAASAAPPVDASAAAPLA
ASLPPMRRMHRPHRPAGDDPRKPPQDGQPFAAGPRDDHSRATAAADAANAGTAH

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=645, Percent_Identity=39.5348837209302, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=629, Percent_Identity=23.5294117647059, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 83687; Mature: 83556

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVILAKNYSAYTLEITPSKLDDTLENTIDKLSQIIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVDVRARLFRQYPLGTTAAHVIGYIGRI
HHHCCCHHCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDENDSDQETYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
CCCCHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGDNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVNAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHCHHHHHHHHCC
FGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGIVMKPHLVKEIEDPITRARHLTVPKESGVIPLKQADIDVVKRGMENVIEN
HHHHHHCCCCEEECCHHHHHHHHHHHHHHEECCCCCCCEEEEHHCCHHHHHHHHHHHHCC
PSGTAYKVFRGAPYLAAGKTGTAQVFSLQGGNYKGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARRVLDFYLVERQNAQNEAAAVAAAASATEPVNAPVIGDGSK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCC
PVTVAAGFKPLPQPVVPNAASAAQAASGASATGASDTPGAAGAAAASAAPPVDASAAAPL
CEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
AASLPPMRRMHRPHRPAGDDPRKPPQDGQPFAAGPRDDHSRATAAADAANAGTAH
HHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVILAKNYSAYTLEITPSKLDDTLENTIDKLSQIIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVDVRARLFRQYPLGTTAAHVIGYIGRI
HHHCCCHHCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDENDSDQETYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
CCCCHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGDNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVNAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHCHHHHHHHHCC
FGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGIVMKPHLVKEIEDPITRARHLTVPKESGVIPLKQADIDVVKRGMENVIEN
HHHHHHCCCCEEECCHHHHHHHHHHHHHHEECCCCCCCEEEEHHCCHHHHHHHHHHHHCC
PSGTAYKVFRGAPYLAAGKTGTAQVFSLQGGNYKGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARRVLDFYLVERQNAQNEAAAVAAAASATEPVNAPVIGDGSK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCC
PVTVAAGFKPLPQPVVPNAASAAQAASGASATGASDTPGAAGAAAASAAPPVDASAAAPL
CEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
AASLPPMRRMHRPHRPAGDDPRKPPQDGQPFAAGPRDDHSRATAAADAANAGTAH
HHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]