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The map label for this gene is hslU [H]

Identifier: 161526256

GI number: 161526256

Start: 3370188

End: 3371531

Strand: Direct

Name: hslU [H]

Synonym: Bmul_3087

Alternate gene names: 161526256

Gene position: 3370188-3371531 (Clockwise)

Preceding gene: 161526255

Following gene: 161526257

Centisome position: 97.73

GC content: 63.39

Gene sequence:

>1344_bases
ATGAGCACCATGACCCCTGCCGAGATCGTCTCGGAACTCGACAAGCACATCATCGGCCAGGCCAAGGCGAAGAAGGCCGT
CGCGGTCGCGCTGCGCAACCGCTGGCGCCGCCAGCAGGTCGCCGAACCGCTGCGCCAGGAAATCACGCCGAAGAACATTC
TGATGATCGGGCCGACGGGTGTCGGCAAGACCGAAATCGCGCGCCGCCTCGCGAAGCTGGCCGACGCGCCGTTCATCAAG
ATCGAAGCGACCAAGTTCACCGAAGTCGGCTATGTCGGCCGCGACGTCGACAGCATCGTGCGCGACCTCGTCGAGATTTC
GGTCAAGCAGACGCGCGAAAGCGAAATGCGCAAGGTGCGCAGCAAGGCGACCGATCAGGCGGAAGACCGCATCCTCGACA
TCCTGCTGCCGCAGCCGCGCGCGGTCGGCTTCGGCGGCAACGCCGACCATGCGAACGACGACAACAACGCGACGCGCCAG
ACGTTCCGCAAGCGCCTGCGCGAAGGCCAGCTCGACGACAAGGAGATCGAACTCGATCTCGAGCAACCGAGCGTCGGGAT
GGACATCATGGCGCCGCCGGGCATGGAAGAGATGACCGAGCAGATCCGCTCGATGTTCTCGAACCTCGGCAGCGGCAAGA
AGCAGCGCCGCAAGGTGAAGATCAAGGAAGCGCTGAAGCTGCTGACCGACGAGGAAGCGGCGAAGATGCTCAACGACGAG
GAAGTGAAGACGAAGGCCGTGCAGAACGTCGAGCAGAACGGCATCGTGTTCCTCGACGAAATCGACAAGATCACGTCGCG
CAACAACGAAGGCAGCGGCGGCGAAGTGTCGCGTCAGGGCGTGCAGCGCGACCTGCTGCCGCTCGTCGAAGGCACGACGA
TCAACACGAAGTACGGGATGGTGAAGACCGATCACATCCTGTTCATCGCGAGCGGCGCGTTCCATCTCGCGAAGCCGAGC
GACCTGATCCCCGAACTGCAGGGCCGCTTCCCGATCCGCGTCGAGCTCGATTCGCTGTCGGTGAACGACTTCGAGGCGAT
CCTGGTCGCGACCGACGCGAGCCTCGTCAAGCAGTACCAGGCGCTGCTCGCCACCGAAGACGTCGAACTCGAATTCGCGG
ACGACGGCATTCGCCGCCTCGCGGAAATCGCGTATTCGGTGAACGAGAAGACCGAGAACATCGGCGCGCGCCGCCTGTAT
ACGGTGATCGAGAAGCTGCTCGAGGAAGTGTCGTTCTCGGCCGGCAATCACGCCGGCGAGCGCGTGACGATCGACGCGAA
GTATGTCGACCGTGCGCTCGGCGAAGTTTCGCAGGACGAGGATCTGTCGCGCTACGTGCTGTAA

Upstream 100 bases:

>100_bases
CCGCGCGAGATCGTCGAGAAGTCGCTCGAGATCGCCGGCGACATGTGCATCTACACGAACCACAACCGCGTCATCGAGAC
GATCGAGTAAGGACCGTACC

Downstream 100 bases:

>100_bases
CGCGCGGCGCACCGCGCACGGCGAAGCATGAAACGACGGGCGGCCCTTTGCGGGGCCGCCCGTTTTCGCTGTGGCGCGCG
AATTTCGGACGCGTCCAATG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSTMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLVEISVKQTRESEMRKVRSKATDQAEDRILDILLPQPRAVGFGGNADHANDDNNATRQ
TFRKRLREGQLDDKEIELDLEQPSVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQALLATEDVELEFADDGIRRLAEIAYSVNEKTENIGARRLY
TVIEKLLEEVSFSAGNHAGERVTIDAKYVDRALGEVSQDEDLSRYVL

Sequences:

>Translated_447_residues
MSTMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLVEISVKQTRESEMRKVRSKATDQAEDRILDILLPQPRAVGFGGNADHANDDNNATRQ
TFRKRLREGQLDDKEIELDLEQPSVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQALLATEDVELEFADDGIRRLAEIAYSVNEKTENIGARRLY
TVIEKLLEEVSFSAGNHAGERVTIDAKYVDRALGEVSQDEDLSRYVL
>Mature_446_residues
STMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKI
EATKFTEVGYVGRDVDSIVRDLVEISVKQTRESEMRKVRSKATDQAEDRILDILLPQPRAVGFGGNADHANDDNNATRQT
FRKRLREGQLDDKEIELDLEQPSVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDEE
VKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPSD
LIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQALLATEDVELEFADDGIRRLAEIAYSVNEKTENIGARRLYT
VIEKLLEEVSFSAGNHAGERVTIDAKYVDRALGEVSQDEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=447, Percent_Identity=64.8769574944072, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=47.0588235294118, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24648291, Length=274, Percent_Identity=30.2919708029197, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648289, Length=274, Percent_Identity=30.2919708029197, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49882; Mature: 49751

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLVEISVKQTRESEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKATDQAEDRILDILLPQPRAVGFGGNADHANDDNNATRQTFRKRLREGQLDDKEIELDL
HHCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
EQPSVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
CCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHH
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTINTKYGM
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCC
VKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQ
EEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHH
ALLATEDVELEFADDGIRRLAEIAYSVNEKTENIGARRLYTVIEKLLEEVSFSAGNHAGE
HHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RVTIDAKYVDRALGEVSQDEDLSRYVL
EEEEEHHHHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
STMTPAEIVSELDKHIIGQAKAKKAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLVEISVKQTRESEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKATDQAEDRILDILLPQPRAVGFGGNADHANDDNNATRQTFRKRLREGQLDDKEIELDL
HHCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
EQPSVGMDIMAPPGMEEMTEQIRSMFSNLGSGKKQRRKVKIKEALKLLTDEEAAKMLNDE
CCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHH
EVKTKAVQNVEQNGIVFLDEIDKITSRNNEGSGGEVSRQGVQRDLLPLVEGTTINTKYGM
HHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCC
VKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVNDFEAILVATDASLVKQYQ
EEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHH
ALLATEDVELEFADDGIRRLAEIAYSVNEKTENIGARRLYTVIEKLLEEVSFSAGNHAGE
HHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RVTIDAKYVDRALGEVSQDEDLSRYVL
EEEEEHHHHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA