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The map label for this gene is gor [H]

Identifier: 161526169

GI number: 161526169

Start: 3281534

End: 3282889

Strand: Reverse

Name: gor [H]

Synonym: Bmul_3000

Alternate gene names: 161526169

Gene position: 3282889-3281534 (Counterclockwise)

Preceding gene: 161526170

Following gene: 161526168

Centisome position: 95.2

GC content: 69.32

Gene sequence:

>1356_bases
ATGGACTTCGACTACGACCTGTTCGTGATCGGCGCCGGCTCGGGCGGCGTGAGGCTCGCGCGGATGTCCGCGTCGTACGG
CGCGCGCGTCGGCATTGCGGAGCAAGAACAGATCGGCGGCACGTGCGTGCTGCGCGGCTGCATCCCGAAGAAGCTGCTCG
TCTATGCCTCGCATTACCCGCACGACATCGAGGACGCGAAGGGCTTCGGCTGGACCTTCGGCGCCGGCACGCTCGACTGG
CACGCGCTGATCGCCGCGAAGGATCGCGAGATCAATCGGCTCAGCGACATCTATGTGAACCTGCTGCGGCAATCGGGCGT
CGACATGATCGCCGGGCGGGCGACGATCGTCGACGCGCATACGGTCGCTGTCGGCGAGCGGCGGATTCGCGCGCGCCATA
TCGCGATCGCGACCGGCTCGCGTCCGTCGCTGCCGCCGCGTCCGGGCATCGAGCACGCGATCACGTCGCGCGAGGCGCTG
TCGCTCGACGCACTGCCCGCGCGCATCGCGGTGGTCGGCGGCGGGTATATCGCCGTGGAGTTCGCGGGCATCTTCAACGG
CTTCGGCAGCCGCGTCGATCTCTTCTATCGCGGCGAAACGATCCTGCGCGGCTTCGACGACGACGTGCGGCAGTTCCTGT
CCGACGAGATGACGAAGCAGGGCATCGCGATTCATACGGGCGCGACGATCGAGGCGATCGAGCGCGCCGACGACGGCACG
CTGAGCCTGCGTGTCGGCGACGCAAAGCATGGCCCGTACGATGCGGTGCTGTACGCGACGGGCCGCGTGCCGAACGTCGA
AGGGCTCGGCCTCGAGGCGGCGGGCGTCGTGCTCGATGCGCGCGGCGCGATCGCGGTCGACGCGTATTCGGCGACGTCGG
TCGATTCGATCCACGCGATCGGCGACGTGACGTCGCGGCCGCAGCTCACGCCGGTCGCGACGCGCGACGGCGCGCTGCTC
GCGATGACGCTGTTCGGCGGCCGCCGTGTCGCGACCGATCACGAATGGGTGCCGTCGGCCGTGTTCAGCCAGCCGGAAGT
CGCGACGGTCGGCCTCACCGAGGCGCGTGCGCGCGAGCAGTACGGTGCGGTCGACATTTACCGCACGTCGTTCAAGGCGC
TGCGCCATACGCTGTCGGGGCGCGACGAGCGCACGCTGATGAAGCTCGTCGTCGCGCGCGACAGCCAGCGCGTGGTCGGC
GCGCACATGGTCGGCCGCGAGGCGGGCGAGATCATCCAGGGCATCGCGATCGCGATCCGCGCGGGTGCGACGAAGGCGCA
GTTCGACGAAACGATCGGCATTCATCCGACCGCGGCCGAGGAGTTCGTGACGATGCGGCAGAAGGTGGGCGAGTAG

Upstream 100 bases:

>100_bases
TCTCTCGCCGTTTTTTATGCGCGCCCGCCGCAGGGGCGTTCCGCACGAATTCCCGAATCTTGCTATCGTGCCGTCATCCT
GATCGAGATGAGGGCATGCG

Downstream 100 bases:

>100_bases
CGGGGCGGGCGTGCCGCGAGCAATGCGCGGCATGCGTTCCCGCGCGCTGCGCAAGCGGCGCTATTGCGCGCGATTCGACA
TGGGCGATATATCGGCGATA

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEQEQIGGTCVLRGCIPKKLLVYASHYPHDIEDAKGFGWTFGAGTLDW
HALIAAKDREINRLSDIYVNLLRQSGVDMIAGRATIVDAHTVAVGERRIRARHIAIATGSRPSLPPRPGIEHAITSREAL
SLDALPARIAVVGGGYIAVEFAGIFNGFGSRVDLFYRGETILRGFDDDVRQFLSDEMTKQGIAIHTGATIEAIERADDGT
LSLRVGDAKHGPYDAVLYATGRVPNVEGLGLEAAGVVLDARGAIAVDAYSATSVDSIHAIGDVTSRPQLTPVATRDGALL
AMTLFGGRRVATDHEWVPSAVFSQPEVATVGLTEARAREQYGAVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVG
AHMVGREAGEIIQGIAIAIRAGATKAQFDETIGIHPTAAEEFVTMRQKVGE

Sequences:

>Translated_451_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEQEQIGGTCVLRGCIPKKLLVYASHYPHDIEDAKGFGWTFGAGTLDW
HALIAAKDREINRLSDIYVNLLRQSGVDMIAGRATIVDAHTVAVGERRIRARHIAIATGSRPSLPPRPGIEHAITSREAL
SLDALPARIAVVGGGYIAVEFAGIFNGFGSRVDLFYRGETILRGFDDDVRQFLSDEMTKQGIAIHTGATIEAIERADDGT
LSLRVGDAKHGPYDAVLYATGRVPNVEGLGLEAAGVVLDARGAIAVDAYSATSVDSIHAIGDVTSRPQLTPVATRDGALL
AMTLFGGRRVATDHEWVPSAVFSQPEVATVGLTEARAREQYGAVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVG
AHMVGREAGEIIQGIAIAIRAGATKAQFDETIGIHPTAAEEFVTMRQKVGE
>Mature_451_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEQEQIGGTCVLRGCIPKKLLVYASHYPHDIEDAKGFGWTFGAGTLDW
HALIAAKDREINRLSDIYVNLLRQSGVDMIAGRATIVDAHTVAVGERRIRARHIAIATGSRPSLPPRPGIEHAITSREAL
SLDALPARIAVVGGGYIAVEFAGIFNGFGSRVDLFYRGETILRGFDDDVRQFLSDEMTKQGIAIHTGATIEAIERADDGT
LSLRVGDAKHGPYDAVLYATGRVPNVEGLGLEAAGVVLDARGAIAVDAYSATSVDSIHAIGDVTSRPQLTPVATRDGALL
AMTLFGGRRVATDHEWVPSAVFSQPEVATVGLTEARAREQYGAVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVG
AHMVGREAGEIIQGIAIAIRAGATKAQFDETIGIHPTAAEEFVTMRQKVGE

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=37.9084967320261, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=37.5796178343949, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=35.3065539112051, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=35.3065539112051, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=35.3065539112051, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=35.3065539112051, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=35.3065539112051, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI291045266, Length=475, Percent_Identity=33.6842105263158, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=31.2896405919662, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=30.5010893246187, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=41.8224299065421, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=31.3465783664459, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=30.1762114537445, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=31.4855875831486, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71983419, Length=455, Percent_Identity=38.6813186813187, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71983429, Length=455, Percent_Identity=38.6813186813187, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17557007, Length=467, Percent_Identity=32.762312633833, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=32.8482328482328, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=32.0960698689956, Blast_Score=202, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.3101952277657, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=28.755364806867, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=27.4678111587983, Blast_Score=156, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=37.1002132196162, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=37.1002132196162, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=37.1002132196162, Blast_Score=271, Evalue=9e-73,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=35.4564755838641, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=32.3076923076923, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48288; Mature: 48288

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEQEQIGGTCVLRGCIPKKLLVYASHYP
CCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHCCCEEEEECCCCCEEEEEECCCC
HDIEDAKGFGWTFGAGTLDWHALIAAKDREINRLSDIYVNLLRQSGVDMIAGRATIVDAH
CCCCCCCCCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCEEEEEEE
TVAVGERRIRARHIAIATGSRPSLPPRPGIEHAITSREALSLDALPARIAVVGGGYIAVE
EEEHHHHHEEEEEEEEEECCCCCCCCCCCCHHHHCCCHHHCCCCCCEEEEEEECCEEEEE
FAGIFNGFGSRVDLFYRGETILRGFDDDVRQFLSDEMTKQGIAIHTGATIEAIERADDGT
EEHHHCCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCE
LSLRVGDAKHGPYDAVLYATGRVPNVEGLGLEAAGVVLDARGAIAVDAYSATSVDSIHAI
EEEEECCCCCCCCEEEEEEECCCCCCCCCCCEECCEEEECCCCEEEEECCCCCCCHHHHH
GDVTSRPQLTPVATRDGALLAMTLFGGRRVATDHEWVPSAVFSQPEVATVGLTEARAREQ
CCCCCCCCCCEEECCCCCEEEEEEECCEEECCCCCCCCHHHCCCCCEEEECCHHHHHHHH
YGAVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVGAHMVGREAGEIIQGIAIAIR
CCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEE
AGATKAQFDETIGIHPTAAEEFVTMRQKVGE
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEQEQIGGTCVLRGCIPKKLLVYASHYP
CCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHCCCEEEEECCCCCEEEEEECCCC
HDIEDAKGFGWTFGAGTLDWHALIAAKDREINRLSDIYVNLLRQSGVDMIAGRATIVDAH
CCCCCCCCCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCEEEEEEE
TVAVGERRIRARHIAIATGSRPSLPPRPGIEHAITSREALSLDALPARIAVVGGGYIAVE
EEEHHHHHEEEEEEEEEECCCCCCCCCCCCHHHHCCCHHHCCCCCCEEEEEEECCEEEEE
FAGIFNGFGSRVDLFYRGETILRGFDDDVRQFLSDEMTKQGIAIHTGATIEAIERADDGT
EEHHHCCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCE
LSLRVGDAKHGPYDAVLYATGRVPNVEGLGLEAAGVVLDARGAIAVDAYSATSVDSIHAI
EEEEECCCCCCCCEEEEEEECCCCCCCCCCCEECCEEEECCCCEEEEECCCCCCCHHHHH
GDVTSRPQLTPVATRDGALLAMTLFGGRRVATDHEWVPSAVFSQPEVATVGLTEARAREQ
CCCCCCCCCCEEECCCCCEEEEEEECCEEECCCCCCCCHHHCCCCCEEEECCHHHHHHHH
YGAVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVGAHMVGREAGEIIQGIAIAIR
CCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEE
AGATKAQFDETIGIHPTAAEEFVTMRQKVGE
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]